LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I7Z1_LEIIN
TriTrypDb:
LINF_320023300
Length:
499

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7Z1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7Z1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 434 438 PF00656 0.717
CLV_NRD_NRD_1 205 207 PF00675 0.612
CLV_NRD_NRD_1 295 297 PF00675 0.431
CLV_NRD_NRD_1 348 350 PF00675 0.524
CLV_NRD_NRD_1 362 364 PF00675 0.647
CLV_NRD_NRD_1 400 402 PF00675 0.590
CLV_PCSK_FUR_1 349 353 PF00082 0.553
CLV_PCSK_KEX2_1 118 120 PF00082 0.519
CLV_PCSK_KEX2_1 205 207 PF00082 0.612
CLV_PCSK_KEX2_1 295 297 PF00082 0.499
CLV_PCSK_KEX2_1 351 353 PF00082 0.578
CLV_PCSK_KEX2_1 362 364 PF00082 0.667
CLV_PCSK_KEX2_1 488 490 PF00082 0.510
CLV_PCSK_PC1ET2_1 118 120 PF00082 0.451
CLV_PCSK_PC1ET2_1 351 353 PF00082 0.578
CLV_PCSK_PC1ET2_1 488 490 PF00082 0.510
CLV_PCSK_PC7_1 114 120 PF00082 0.506
CLV_PCSK_PC7_1 347 353 PF00082 0.550
CLV_PCSK_SKI1_1 217 221 PF00082 0.637
CLV_PCSK_SKI1_1 23 27 PF00082 0.614
CLV_PCSK_SKI1_1 368 372 PF00082 0.530
CLV_PCSK_SKI1_1 468 472 PF00082 0.548
DEG_APCC_DBOX_1 233 241 PF00400 0.650
DEG_APCC_KENBOX_2 180 184 PF00400 0.479
DEG_Nend_UBRbox_1 1 4 PF02207 0.566
DEG_SPOP_SBC_1 428 432 PF00917 0.631
DOC_ANK_TNKS_1 332 339 PF00023 0.500
DOC_MAPK_gen_1 293 300 PF00069 0.385
DOC_MAPK_gen_1 301 309 PF00069 0.364
DOC_MAPK_MEF2A_6 142 151 PF00069 0.408
DOC_USP7_MATH_1 221 225 PF00917 0.609
DOC_USP7_MATH_1 230 234 PF00917 0.577
DOC_USP7_MATH_1 24 28 PF00917 0.630
DOC_USP7_MATH_1 397 401 PF00917 0.661
DOC_USP7_MATH_1 428 432 PF00917 0.664
DOC_USP7_UBL2_3 128 132 PF12436 0.424
DOC_USP7_UBL2_3 367 371 PF12436 0.644
DOC_WW_Pin1_4 11 16 PF00397 0.619
DOC_WW_Pin1_4 191 196 PF00397 0.479
DOC_WW_Pin1_4 25 30 PF00397 0.621
DOC_WW_Pin1_4 424 429 PF00397 0.676
DOC_WW_Pin1_4 437 442 PF00397 0.593
LIG_14-3-3_CanoR_1 23 29 PF00244 0.555
LIG_14-3-3_CanoR_1 401 410 PF00244 0.588
LIG_APCC_ABBA_1 136 141 PF00400 0.432
LIG_BRCT_BRCA1_1 27 31 PF00533 0.618
LIG_Clathr_ClatBox_1 146 150 PF01394 0.468
LIG_EH1_1 30 38 PF00400 0.574
LIG_FHA_1 270 276 PF00498 0.623
LIG_FHA_1 469 475 PF00498 0.546
LIG_FHA_1 87 93 PF00498 0.419
LIG_FHA_2 259 265 PF00498 0.622
LIG_FHA_2 330 336 PF00498 0.406
LIG_FHA_2 432 438 PF00498 0.723
LIG_FHA_2 450 456 PF00498 0.738
LIG_FHA_2 473 479 PF00498 0.524
LIG_LIR_Gen_1 150 159 PF02991 0.525
LIG_LIR_Gen_1 294 305 PF02991 0.455
LIG_LIR_Gen_1 463 474 PF02991 0.565
LIG_LIR_Gen_1 54 64 PF02991 0.494
LIG_LIR_Gen_1 85 96 PF02991 0.473
LIG_LIR_Nem_3 150 154 PF02991 0.538
LIG_LIR_Nem_3 294 300 PF02991 0.455
LIG_LIR_Nem_3 437 442 PF02991 0.587
LIG_LIR_Nem_3 463 469 PF02991 0.619
LIG_LIR_Nem_3 54 60 PF02991 0.504
LIG_LIR_Nem_3 85 91 PF02991 0.474
LIG_NRBOX 236 242 PF00104 0.596
LIG_Pex14_2 57 61 PF04695 0.494
LIG_REV1ctd_RIR_1 58 66 PF16727 0.461
LIG_SH2_PTP2 297 300 PF00017 0.367
LIG_SH2_STAT3 236 239 PF00017 0.538
LIG_SH2_STAT3 340 343 PF00017 0.527
LIG_SH2_STAT5 236 239 PF00017 0.522
LIG_SH2_STAT5 297 300 PF00017 0.571
LIG_SH2_STAT5 466 469 PF00017 0.549
LIG_SH3_1 26 32 PF00018 0.548
LIG_SH3_2 29 34 PF14604 0.566
LIG_SH3_3 26 32 PF00018 0.567
LIG_Sin3_3 109 116 PF02671 0.514
LIG_SUMO_SIM_par_1 145 150 PF11976 0.422
LIG_SUMO_SIM_par_1 255 261 PF11976 0.579
LIG_SUMO_SIM_par_1 305 311 PF11976 0.393
LIG_TRAF2_1 341 344 PF00917 0.647
LIG_TRAF2_1 403 406 PF00917 0.689
LIG_TRAF2_1 71 74 PF00917 0.528
LIG_TRAF2_1 82 85 PF00917 0.399
LIG_TYR_ITIM 464 469 PF00017 0.479
LIG_UBA3_1 126 132 PF00899 0.498
MOD_CK1_1 199 205 PF00069 0.605
MOD_CK1_1 244 250 PF00069 0.673
MOD_CK1_1 400 406 PF00069 0.664
MOD_CK1_1 427 433 PF00069 0.635
MOD_CK1_1 440 446 PF00069 0.606
MOD_CK2_1 191 197 PF00069 0.488
MOD_CK2_1 329 335 PF00069 0.407
MOD_CK2_1 400 406 PF00069 0.843
MOD_CK2_1 449 455 PF00069 0.724
MOD_CK2_1 472 478 PF00069 0.473
MOD_CK2_1 68 74 PF00069 0.485
MOD_GlcNHglycan 353 357 PF01048 0.499
MOD_GlcNHglycan 442 445 PF01048 0.706
MOD_GlcNHglycan 483 486 PF01048 0.513
MOD_GlcNHglycan 70 73 PF01048 0.458
MOD_GlcNHglycan 8 11 PF01048 0.606
MOD_GSK3_1 221 228 PF00069 0.702
MOD_GSK3_1 243 250 PF00069 0.547
MOD_GSK3_1 269 276 PF00069 0.557
MOD_GSK3_1 397 404 PF00069 0.766
MOD_GSK3_1 424 431 PF00069 0.640
MOD_GSK3_1 468 475 PF00069 0.558
MOD_N-GLC_1 437 442 PF02516 0.636
MOD_NEK2_1 213 218 PF00069 0.709
MOD_NEK2_1 241 246 PF00069 0.541
MOD_NEK2_1 269 274 PF00069 0.674
MOD_NEK2_1 329 334 PF00069 0.469
MOD_PKA_1 205 211 PF00069 0.615
MOD_PKA_1 401 407 PF00069 0.599
MOD_PKA_2 199 205 PF00069 0.606
MOD_PKA_2 225 231 PF00069 0.566
MOD_PKA_2 400 406 PF00069 0.687
MOD_Plk_1 196 202 PF00069 0.573
MOD_ProDKin_1 11 17 PF00069 0.620
MOD_ProDKin_1 191 197 PF00069 0.481
MOD_ProDKin_1 25 31 PF00069 0.615
MOD_ProDKin_1 424 430 PF00069 0.676
MOD_ProDKin_1 437 443 PF00069 0.594
MOD_SUMO_for_1 487 490 PF00179 0.456
TRG_DiLeu_BaEn_1 107 112 PF01217 0.563
TRG_DiLeu_BaEn_1 150 155 PF01217 0.480
TRG_DiLeu_BaEn_3 121 127 PF01217 0.404
TRG_DiLeu_BaLyEn_6 264 269 PF01217 0.604
TRG_DiLeu_BaLyEn_6 370 375 PF01217 0.514
TRG_ENDOCYTIC_2 297 300 PF00928 0.451
TRG_ENDOCYTIC_2 466 469 PF00928 0.721
TRG_ER_diArg_1 286 289 PF00400 0.503
TRG_ER_diArg_1 295 297 PF00400 0.494
TRG_ER_diArg_1 375 378 PF00400 0.626
TRG_NES_CRM1_1 124 140 PF08389 0.446
TRG_Pf-PMV_PEXEL_1 164 168 PF00026 0.503
TRG_Pf-PMV_PEXEL_1 373 377 PF00026 0.516
TRG_Pf-PMV_PEXEL_1 380 384 PF00026 0.575

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMW1 Leptomonas seymouri 41% 85%
A0A3Q8IG72 Leishmania donovani 99% 100%
A0A3R7MFC1 Trypanosoma rangeli 29% 82%
A4HKG3 Leishmania braziliensis 62% 100%
E9B2V2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4Q5A4 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS