LeishMANIAdb
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DNA polymerase alpha subunit B

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA polymerase alpha subunit B
Gene product:
DNA polymerase alpha/epsilon subunit B - putative
Species:
Leishmania infantum
UniProt:
A4I7Y7_LEIIN
TriTrypDb:
LINF_320022900
Length:
726

Annotations

Annotations by Jardim et al.

DNA replication, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 11
GO:0000428 DNA-directed RNA polymerase complex 4 1
GO:0005658 alpha DNA polymerase:primase complex 4 1
GO:0030880 RNA polymerase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0042575 DNA polymerase complex 3 1
GO:0055029 nuclear DNA-directed RNA polymerase complex 3 1
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 1
GO:0140513 nuclear protein-containing complex 2 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

A4I7Y7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7Y7

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006259 DNA metabolic process 4 12
GO:0006260 DNA replication 5 11
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0006270 DNA replication initiation 5 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003677 DNA binding 4 12
GO:0005488 binding 1 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003824 catalytic activity 1 1
GO:0016740 transferase activity 2 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1
GO:0016779 nucleotidyltransferase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 113 117 PF00656 0.686
CLV_C14_Caspase3-7 559 563 PF00656 0.804
CLV_C14_Caspase3-7 611 615 PF00656 0.730
CLV_C14_Caspase3-7 658 662 PF00656 0.667
CLV_NRD_NRD_1 343 345 PF00675 0.363
CLV_NRD_NRD_1 492 494 PF00675 0.343
CLV_NRD_NRD_1 554 556 PF00675 0.670
CLV_NRD_NRD_1 707 709 PF00675 0.493
CLV_NRD_NRD_1 71 73 PF00675 0.520
CLV_PCSK_KEX2_1 343 345 PF00082 0.363
CLV_PCSK_KEX2_1 492 494 PF00082 0.344
CLV_PCSK_KEX2_1 554 556 PF00082 0.791
CLV_PCSK_KEX2_1 599 601 PF00082 0.650
CLV_PCSK_KEX2_1 707 709 PF00082 0.493
CLV_PCSK_KEX2_1 71 73 PF00082 0.518
CLV_PCSK_PC1ET2_1 599 601 PF00082 0.650
CLV_PCSK_SKI1_1 28 32 PF00082 0.701
CLV_PCSK_SKI1_1 283 287 PF00082 0.500
CLV_PCSK_SKI1_1 308 312 PF00082 0.659
CLV_PCSK_SKI1_1 351 355 PF00082 0.383
CLV_PCSK_SKI1_1 381 385 PF00082 0.384
CLV_PCSK_SKI1_1 413 417 PF00082 0.374
CLV_PCSK_SKI1_1 420 424 PF00082 0.296
CLV_PCSK_SKI1_1 599 603 PF00082 0.646
CLV_PCSK_SKI1_1 708 712 PF00082 0.511
CLV_PCSK_SKI1_1 79 83 PF00082 0.406
DEG_APCC_DBOX_1 282 290 PF00400 0.541
DEG_APCC_DBOX_1 380 388 PF00400 0.449
DEG_APCC_DBOX_1 412 420 PF00400 0.423
DEG_Nend_UBRbox_3 1 3 PF02207 0.670
DEG_SCF_FBW7_1 565 571 PF00400 0.573
DEG_SPOP_SBC_1 214 218 PF00917 0.740
DEG_SPOP_SBC_1 220 224 PF00917 0.776
DEG_SPOP_SBC_1 314 318 PF00917 0.595
DOC_ANK_TNKS_1 554 561 PF00023 0.677
DOC_CDC14_PxL_1 517 525 PF14671 0.554
DOC_CKS1_1 565 570 PF01111 0.579
DOC_CYCLIN_RxL_1 378 386 PF00134 0.364
DOC_CYCLIN_RxL_1 417 425 PF00134 0.449
DOC_CYCLIN_yCln2_LP_2 26 32 PF00134 0.630
DOC_MAPK_DCC_7 633 642 PF00069 0.506
DOC_MAPK_MEF2A_6 518 525 PF00069 0.558
DOC_MAPK_MEF2A_6 633 642 PF00069 0.506
DOC_MAPK_MEF2A_6 8 17 PF00069 0.575
DOC_MAPK_RevD_3 692 708 PF00069 0.488
DOC_PP1_RVXF_1 331 337 PF00149 0.409
DOC_PP2B_LxvP_1 30 33 PF13499 0.646
DOC_PP2B_LxvP_1 503 506 PF13499 0.363
DOC_PP4_FxxP_1 294 297 PF00568 0.406
DOC_PP4_FxxP_1 371 374 PF00568 0.449
DOC_USP7_MATH_1 126 130 PF00917 0.746
DOC_USP7_MATH_1 186 190 PF00917 0.655
DOC_USP7_MATH_1 203 207 PF00917 0.757
DOC_USP7_MATH_1 214 218 PF00917 0.697
DOC_USP7_MATH_1 221 225 PF00917 0.584
DOC_USP7_MATH_1 314 318 PF00917 0.600
DOC_USP7_MATH_1 325 329 PF00917 0.663
DOC_USP7_MATH_1 374 378 PF00917 0.435
DOC_USP7_MATH_1 38 42 PF00917 0.647
DOC_USP7_MATH_1 487 491 PF00917 0.418
DOC_USP7_MATH_1 550 554 PF00917 0.753
DOC_USP7_MATH_1 563 567 PF00917 0.754
DOC_USP7_MATH_1 568 572 PF00917 0.652
DOC_USP7_MATH_1 628 632 PF00917 0.673
DOC_WW_Pin1_4 230 235 PF00397 0.590
DOC_WW_Pin1_4 535 540 PF00397 0.636
DOC_WW_Pin1_4 564 569 PF00397 0.759
DOC_WW_Pin1_4 618 623 PF00397 0.774
DOC_WW_Pin1_4 624 629 PF00397 0.768
DOC_WW_Pin1_4 684 689 PF00397 0.624
LIG_14-3-3_CanoR_1 251 255 PF00244 0.398
LIG_14-3-3_CanoR_1 257 262 PF00244 0.450
LIG_14-3-3_CanoR_1 351 358 PF00244 0.455
LIG_14-3-3_CanoR_1 457 461 PF00244 0.352
LIG_14-3-3_CanoR_1 55 60 PF00244 0.582
LIG_14-3-3_CanoR_1 707 716 PF00244 0.475
LIG_AP2alpha_2 276 278 PF02296 0.540
LIG_BIR_III_4 114 118 PF00653 0.683
LIG_BIR_III_4 557 561 PF00653 0.727
LIG_BIR_III_4 605 609 PF00653 0.706
LIG_BRCT_BRCA1_1 337 341 PF00533 0.318
LIG_BRCT_BRCA1_1 686 690 PF00533 0.607
LIG_Clathr_ClatBox_1 16 20 PF01394 0.712
LIG_Clathr_ClatBox_1 43 47 PF01394 0.571
LIG_DLG_GKlike_1 55 62 PF00625 0.620
LIG_eIF4E_1 410 416 PF01652 0.449
LIG_FHA_1 221 227 PF00498 0.760
LIG_FHA_1 285 291 PF00498 0.385
LIG_FHA_1 353 359 PF00498 0.345
LIG_FHA_1 410 416 PF00498 0.449
LIG_FHA_1 444 450 PF00498 0.387
LIG_FHA_1 512 518 PF00498 0.551
LIG_FHA_1 700 706 PF00498 0.554
LIG_FHA_1 711 717 PF00498 0.558
LIG_FHA_2 234 240 PF00498 0.549
LIG_FHA_2 388 394 PF00498 0.337
LIG_FHA_2 399 405 PF00498 0.328
LIG_FHA_2 92 98 PF00498 0.721
LIG_Integrin_isoDGR_2 500 502 PF01839 0.475
LIG_Integrin_RGD_1 427 429 PF01839 0.398
LIG_Integrin_RGD_1 555 557 PF01839 0.682
LIG_LIR_Apic_2 293 297 PF02991 0.521
LIG_LIR_Gen_1 187 196 PF02991 0.654
LIG_LIR_Gen_1 390 399 PF02991 0.359
LIG_LIR_Gen_1 573 583 PF02991 0.567
LIG_LIR_LC3C_4 672 677 PF02991 0.465
LIG_LIR_Nem_3 159 163 PF02991 0.371
LIG_LIR_Nem_3 187 193 PF02991 0.643
LIG_LIR_Nem_3 260 265 PF02991 0.434
LIG_LIR_Nem_3 390 394 PF02991 0.402
LIG_LIR_Nem_3 56 62 PF02991 0.659
LIG_LIR_Nem_3 573 579 PF02991 0.543
LIG_MYND_1 29 33 PF01753 0.727
LIG_NRBOX 12 18 PF00104 0.596
LIG_PALB2_WD40_1 257 265 PF16756 0.485
LIG_PDZ_Class_2 721 726 PF00595 0.579
LIG_Pex14_1 576 580 PF04695 0.642
LIG_Pex14_2 371 375 PF04695 0.449
LIG_Rb_LxCxE_1 661 683 PF01857 0.365
LIG_SH2_CRK 508 512 PF00017 0.358
LIG_SH2_CRK 59 63 PF00017 0.652
LIG_SH2_NCK_1 441 445 PF00017 0.449
LIG_SH2_PTP2 504 507 PF00017 0.398
LIG_SH2_SRC 441 444 PF00017 0.449
LIG_SH2_SRC 527 530 PF00017 0.619
LIG_SH2_SRC 636 639 PF00017 0.533
LIG_SH2_STAP1 255 259 PF00017 0.449
LIG_SH2_STAT3 255 258 PF00017 0.542
LIG_SH2_STAT5 161 164 PF00017 0.503
LIG_SH2_STAT5 172 175 PF00017 0.458
LIG_SH2_STAT5 255 258 PF00017 0.427
LIG_SH2_STAT5 504 507 PF00017 0.371
LIG_SH2_STAT5 527 530 PF00017 0.581
LIG_SH2_STAT5 59 62 PF00017 0.544
LIG_SH2_STAT5 636 639 PF00017 0.533
LIG_SH3_2 300 305 PF14604 0.581
LIG_SH3_3 294 300 PF00018 0.402
LIG_SH3_3 303 309 PF00018 0.499
LIG_SH3_3 411 417 PF00018 0.409
LIG_SH3_3 431 437 PF00018 0.339
LIG_SH3_3 616 622 PF00018 0.794
LIG_SH3_3 694 700 PF00018 0.425
LIG_SUMO_SIM_anti_2 363 368 PF11976 0.361
LIG_SUMO_SIM_anti_2 672 678 PF11976 0.408
LIG_SUMO_SIM_par_1 40 47 PF11976 0.642
LIG_SUMO_SIM_par_1 420 425 PF11976 0.344
LIG_SUMO_SIM_par_1 533 538 PF11976 0.623
LIG_TRAF2_1 229 232 PF00917 0.754
LIG_TRAF2_1 240 243 PF00917 0.659
LIG_TRAF2_1 401 404 PF00917 0.364
LIG_TRAF2_1 94 97 PF00917 0.750
LIG_UBA3_1 415 420 PF00899 0.449
LIG_WRC_WIRS_1 395 400 PF05994 0.437
MOD_CDK_SPK_2 684 689 PF00069 0.606
MOD_CK1_1 129 135 PF00069 0.568
MOD_CK1_1 147 153 PF00069 0.592
MOD_CK1_1 253 259 PF00069 0.399
MOD_CK1_1 260 266 PF00069 0.391
MOD_CK1_1 298 304 PF00069 0.495
MOD_CK1_1 37 43 PF00069 0.667
MOD_CK1_1 566 572 PF00069 0.686
MOD_CK1_1 626 632 PF00069 0.647
MOD_CK1_1 66 72 PF00069 0.528
MOD_CK1_1 683 689 PF00069 0.591
MOD_CK2_1 104 110 PF00069 0.654
MOD_CK2_1 233 239 PF00069 0.629
MOD_CK2_1 374 380 PF00069 0.365
MOD_CK2_1 387 393 PF00069 0.250
MOD_CK2_1 398 404 PF00069 0.344
MOD_CK2_1 527 533 PF00069 0.557
MOD_CK2_1 629 635 PF00069 0.564
MOD_CK2_1 91 97 PF00069 0.678
MOD_GlcNHglycan 128 131 PF01048 0.671
MOD_GlcNHglycan 145 149 PF01048 0.635
MOD_GlcNHglycan 205 208 PF01048 0.710
MOD_GlcNHglycan 223 226 PF01048 0.539
MOD_GlcNHglycan 280 283 PF01048 0.495
MOD_GlcNHglycan 311 314 PF01048 0.643
MOD_GlcNHglycan 318 321 PF01048 0.649
MOD_GlcNHglycan 326 330 PF01048 0.477
MOD_GlcNHglycan 337 340 PF01048 0.226
MOD_GlcNHglycan 345 349 PF01048 0.475
MOD_GlcNHglycan 36 39 PF01048 0.654
MOD_GlcNHglycan 40 43 PF01048 0.609
MOD_GlcNHglycan 547 550 PF01048 0.754
MOD_GlcNHglycan 568 571 PF01048 0.725
MOD_GlcNHglycan 64 68 PF01048 0.580
MOD_GlcNHglycan 669 672 PF01048 0.499
MOD_GSK3_1 182 189 PF00069 0.642
MOD_GSK3_1 209 216 PF00069 0.642
MOD_GSK3_1 253 260 PF00069 0.492
MOD_GSK3_1 309 316 PF00069 0.540
MOD_GSK3_1 34 41 PF00069 0.707
MOD_GSK3_1 383 390 PF00069 0.342
MOD_GSK3_1 394 401 PF00069 0.312
MOD_GSK3_1 483 490 PF00069 0.348
MOD_GSK3_1 564 571 PF00069 0.710
MOD_GSK3_1 614 621 PF00069 0.699
MOD_GSK3_1 624 631 PF00069 0.667
MOD_GSK3_1 680 687 PF00069 0.595
MOD_GSK3_1 695 702 PF00069 0.300
MOD_GSK3_1 96 103 PF00069 0.743
MOD_N-GLC_1 550 555 PF02516 0.605
MOD_NEK2_1 209 214 PF00069 0.720
MOD_NEK2_1 278 283 PF00069 0.451
MOD_NEK2_1 349 354 PF00069 0.451
MOD_NEK2_1 387 392 PF00069 0.355
MOD_NEK2_1 402 407 PF00069 0.312
MOD_NEK2_1 422 427 PF00069 0.441
MOD_NEK2_1 450 455 PF00069 0.449
MOD_NEK2_1 54 59 PF00069 0.544
MOD_NEK2_1 590 595 PF00069 0.721
MOD_NEK2_1 623 628 PF00069 0.767
MOD_NEK2_1 91 96 PF00069 0.656
MOD_NEK2_2 487 492 PF00069 0.449
MOD_PIKK_1 150 156 PF00454 0.563
MOD_PIKK_1 352 358 PF00454 0.369
MOD_PIKK_1 428 434 PF00454 0.328
MOD_PIKK_1 527 533 PF00454 0.604
MOD_PIKK_1 91 97 PF00454 0.707
MOD_PKA_2 100 106 PF00069 0.670
MOD_PKA_2 203 209 PF00069 0.673
MOD_PKA_2 214 220 PF00069 0.596
MOD_PKA_2 250 256 PF00069 0.390
MOD_PKA_2 298 304 PF00069 0.513
MOD_PKA_2 456 462 PF00069 0.358
MOD_PKA_2 48 54 PF00069 0.505
MOD_Plk_1 144 150 PF00069 0.615
MOD_Plk_1 186 192 PF00069 0.698
MOD_Plk_1 402 408 PF00069 0.350
MOD_Plk_1 428 434 PF00069 0.315
MOD_Plk_1 561 567 PF00069 0.589
MOD_Plk_1 695 701 PF00069 0.414
MOD_Plk_4 100 106 PF00069 0.668
MOD_Plk_4 129 135 PF00069 0.500
MOD_Plk_4 250 256 PF00069 0.389
MOD_Plk_4 257 263 PF00069 0.428
MOD_Plk_4 394 400 PF00069 0.358
MOD_Plk_4 436 442 PF00069 0.343
MOD_Plk_4 494 500 PF00069 0.298
MOD_ProDKin_1 230 236 PF00069 0.586
MOD_ProDKin_1 535 541 PF00069 0.637
MOD_ProDKin_1 564 570 PF00069 0.757
MOD_ProDKin_1 618 624 PF00069 0.774
MOD_ProDKin_1 684 690 PF00069 0.615
MOD_SUMO_for_1 105 108 PF00179 0.617
MOD_SUMO_for_1 601 604 PF00179 0.649
MOD_SUMO_for_1 688 691 PF00179 0.566
TRG_DiLeu_BaEn_1 27 32 PF01217 0.637
TRG_DiLeu_BaLyEn_6 26 31 PF01217 0.666
TRG_DiLeu_BaLyEn_6 306 311 PF01217 0.680
TRG_DiLeu_BaLyEn_6 411 416 PF01217 0.449
TRG_ENDOCYTIC_2 504 507 PF00928 0.328
TRG_ENDOCYTIC_2 59 62 PF00928 0.622
TRG_ENDOCYTIC_2 78 81 PF00928 0.223
TRG_ER_diArg_1 342 344 PF00400 0.363
TRG_ER_diArg_1 491 493 PF00400 0.344
TRG_ER_diArg_1 70 72 PF00400 0.484
TRG_ER_diArg_1 706 708 PF00400 0.501
TRG_NLS_MonoExtC_3 598 604 PF00514 0.643
TRG_NLS_MonoExtN_4 597 603 PF00514 0.717

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAT5 Leptomonas seymouri 64% 100%
A0A0S4JBE4 Bodo saltans 31% 100%
A0A1X0NW10 Trypanosomatidae 42% 100%
A0A3Q8IL35 Leishmania donovani 99% 100%
A0A3R7NGI8 Trypanosoma rangeli 42% 100%
A4HKF9 Leishmania braziliensis 76% 100%
D0AA49 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9B2U8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q5A8 Leishmania major 91% 100%
V5DFV4 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS