WD domain, G-beta repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7Y0_LEIIN

TriTrypDb:

LINF_320022200

Length:

920

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	7
GO:0008287	protein serine/threonine phosphatase complex	4	7
GO:0032991	protein-containing complex	1	7
GO:1902494	catalytic complex	2	7
GO:1903293	phosphatase complex	3	7
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I7Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7Y0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	7
GO:0019888	protein phosphatase regulator activity	4	7
GO:0030234	enzyme regulator activity	2	7
GO:0098772	molecular function regulator activity	1	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.615
CLV_C14_Caspase3-7	291	295	PF00656	0.776
CLV_C14_Caspase3-7	53	57	PF00656	0.657
CLV_C14_Caspase3-7	844	848	PF00656	0.474
CLV_NRD_NRD_1	3	5	PF00675	0.730
CLV_NRD_NRD_1	435	437	PF00675	0.623
CLV_NRD_NRD_1	504	506	PF00675	0.503
CLV_NRD_NRD_1	558	560	PF00675	0.496
CLV_NRD_NRD_1	695	697	PF00675	0.579
CLV_NRD_NRD_1	747	749	PF00675	0.505
CLV_NRD_NRD_1	86	88	PF00675	0.734
CLV_NRD_NRD_1	914	916	PF00675	0.520
CLV_PCSK_KEX2_1	141	143	PF00082	0.748
CLV_PCSK_KEX2_1	435	437	PF00082	0.625
CLV_PCSK_KEX2_1	504	506	PF00082	0.476
CLV_PCSK_KEX2_1	558	560	PF00082	0.496
CLV_PCSK_KEX2_1	86	88	PF00082	0.734
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.748
CLV_PCSK_PC7_1	500	506	PF00082	0.549
CLV_PCSK_SKI1_1	161	165	PF00082	0.814
CLV_PCSK_SKI1_1	500	504	PF00082	0.567
CLV_PCSK_SKI1_1	528	532	PF00082	0.410
CLV_PCSK_SKI1_1	550	554	PF00082	0.455
CLV_PCSK_SKI1_1	887	891	PF00082	0.465
CLV_Separin_Metazoa	279	283	PF03568	0.706
CLV_Separin_Metazoa	501	505	PF03568	0.553
DEG_APCC_DBOX_1	160	168	PF00400	0.816
DEG_Nend_UBRbox_2	1	3	PF02207	0.718
DEG_SCF_FBW7_1	140	147	PF00400	0.719
DEG_SPOP_SBC_1	311	315	PF00917	0.730
DOC_CDC14_PxL_1	402	410	PF14671	0.510
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.634
DOC_MAPK_MEF2A_6	737	744	PF00069	0.444
DOC_MAPK_NFAT4_5	737	745	PF00069	0.444
DOC_PP1_RVXF_1	526	533	PF00149	0.452
DOC_PP2B_LxvP_1	646	649	PF13499	0.533
DOC_PP4_FxxP_1	374	377	PF00568	0.832
DOC_PP4_FxxP_1	728	731	PF00568	0.461
DOC_PP4_FxxP_1	824	827	PF00568	0.540
DOC_USP7_MATH_1	117	121	PF00917	0.740
DOC_USP7_MATH_1	163	167	PF00917	0.760
DOC_USP7_MATH_1	176	180	PF00917	0.639
DOC_USP7_MATH_1	274	278	PF00917	0.749
DOC_USP7_MATH_1	304	308	PF00917	0.735
DOC_USP7_MATH_1	311	315	PF00917	0.664
DOC_USP7_MATH_1	386	390	PF00917	0.560
DOC_USP7_MATH_1	517	521	PF00917	0.526
DOC_USP7_MATH_1	61	65	PF00917	0.780
DOC_USP7_MATH_1	667	671	PF00917	0.491
DOC_USP7_MATH_1	699	703	PF00917	0.542
DOC_USP7_MATH_1	79	83	PF00917	0.665
DOC_USP7_MATH_1	805	809	PF00917	0.614
DOC_USP7_MATH_1	855	859	PF00917	0.585
DOC_USP7_MATH_1	89	93	PF00917	0.676
DOC_USP7_MATH_2	111	117	PF00917	0.850
DOC_USP7_UBL2_3	5	9	PF12436	0.736
DOC_USP7_UBL2_3	509	513	PF12436	0.502
DOC_WW_Pin1_4	12	17	PF00397	0.736
DOC_WW_Pin1_4	136	141	PF00397	0.738
DOC_WW_Pin1_4	261	266	PF00397	0.735
DOC_WW_Pin1_4	281	286	PF00397	0.493
DOC_WW_Pin1_4	340	345	PF00397	0.683
DOC_WW_Pin1_4	446	451	PF00397	0.590
DOC_WW_Pin1_4	475	480	PF00397	0.710
DOC_WW_Pin1_4	535	540	PF00397	0.542
DOC_WW_Pin1_4	560	565	PF00397	0.532
DOC_WW_Pin1_4	77	82	PF00397	0.737
LIG_14-3-3_CanoR_1	190	196	PF00244	0.800
LIG_14-3-3_CanoR_1	212	218	PF00244	0.585
LIG_14-3-3_CanoR_1	312	321	PF00244	0.738
LIG_14-3-3_CanoR_1	435	441	PF00244	0.682
LIG_14-3-3_CanoR_1	504	512	PF00244	0.437
LIG_14-3-3_CanoR_1	899	905	PF00244	0.453
LIG_14-3-3_CanoR_1	915	919	PF00244	0.444
LIG_Actin_WH2_2	450	468	PF00022	0.581
LIG_AP2alpha_2	822	824	PF02296	0.541
LIG_BRCT_BRCA1_1	344	348	PF00533	0.690
LIG_BRCT_BRCA1_1	370	374	PF00533	0.695
LIG_BRCT_BRCA1_1	50	54	PF00533	0.718
LIG_BRCT_BRCA1_1	581	585	PF00533	0.548
LIG_BRCT_BRCA1_1	669	673	PF00533	0.476
LIG_EH_1	708	712	PF12763	0.628
LIG_eIF4E_1	904	910	PF01652	0.497
LIG_FHA_1	358	364	PF00498	0.579
LIG_FHA_1	488	494	PF00498	0.612
LIG_FHA_1	602	608	PF00498	0.466
LIG_FHA_1	883	889	PF00498	0.510
LIG_FHA_2	241	247	PF00498	0.805
LIG_FHA_2	378	384	PF00498	0.805
LIG_FHA_2	395	401	PF00498	0.425
LIG_FHA_2	544	550	PF00498	0.448
LIG_FHA_2	83	89	PF00498	0.837
LIG_FHA_2	863	869	PF00498	0.681
LIG_Integrin_isoDGR_2	906	908	PF01839	0.509
LIG_LIR_Apic_2	371	377	PF02991	0.825
LIG_LIR_Apic_2	727	731	PF02991	0.471
LIG_LIR_Apic_2	822	827	PF02991	0.535
LIG_LIR_Gen_1	563	571	PF02991	0.542
LIG_LIR_Gen_1	582	593	PF02991	0.555
LIG_LIR_Gen_1	617	627	PF02991	0.443
LIG_LIR_Gen_1	736	747	PF02991	0.446
LIG_LIR_Gen_1	774	784	PF02991	0.474
LIG_LIR_Nem_3	214	220	PF02991	0.551
LIG_LIR_Nem_3	420	424	PF02991	0.467
LIG_LIR_Nem_3	560	565	PF02991	0.532
LIG_LIR_Nem_3	582	588	PF02991	0.555
LIG_LIR_Nem_3	599	603	PF02991	0.488
LIG_LIR_Nem_3	617	622	PF02991	0.446
LIG_LIR_Nem_3	736	742	PF02991	0.440
LIG_LIR_Nem_3	774	780	PF02991	0.478
LIG_LIR_Nem_3	88	93	PF02991	0.691
LIG_MAD2	887	895	PF02301	0.481
LIG_MLH1_MIPbox_1	581	585	PF16413	0.548
LIG_MYND_1	12	16	PF01753	0.736
LIG_PCNA_yPIPBox_3	548	559	PF02747	0.461
LIG_Pex14_2	353	357	PF04695	0.647
LIG_Pex14_2	50	54	PF04695	0.626
LIG_Pex14_2	628	632	PF04695	0.460
LIG_PTB_Apo_2	356	363	PF02174	0.706
LIG_Rb_pABgroove_1	790	798	PF01858	0.444
LIG_SH2_CRK	207	211	PF00017	0.669
LIG_SH2_CRK	220	224	PF00017	0.539
LIG_SH2_GRB2like	771	774	PF00017	0.501
LIG_SH2_NCK_1	132	136	PF00017	0.664
LIG_SH2_SRC	698	701	PF00017	0.654
LIG_SH2_SRC	716	719	PF00017	0.308
LIG_SH2_SRC	766	769	PF00017	0.454
LIG_SH2_STAP1	250	254	PF00017	0.636
LIG_SH2_STAP1	716	720	PF00017	0.473
LIG_SH2_STAP1	796	800	PF00017	0.472
LIG_SH2_STAT5	421	424	PF00017	0.470
LIG_SH2_STAT5	526	529	PF00017	0.447
LIG_SH2_STAT5	544	547	PF00017	0.208
LIG_SH2_STAT5	584	587	PF00017	0.561
LIG_SH2_STAT5	739	742	PF00017	0.445
LIG_SH2_STAT5	762	765	PF00017	0.479
LIG_SH2_STAT5	766	769	PF00017	0.476
LIG_SH2_STAT5	902	905	PF00017	0.416
LIG_SH2_STAT5	911	914	PF00017	0.415
LIG_SH3_1	132	138	PF00018	0.764
LIG_SH3_3	132	138	PF00018	0.764
LIG_SH3_3	15	21	PF00018	0.733
LIG_SH3_3	254	260	PF00018	0.751
LIG_SH3_3	43	49	PF00018	0.704
LIG_SH3_3	586	592	PF00018	0.562
LIG_SH3_3	747	753	PF00018	0.484
LIG_SH3_3	799	805	PF00018	0.445
LIG_SH3_CIN85_PxpxPR_1	263	268	PF14604	0.734
LIG_SUMO_SIM_anti_2	389	394	PF11976	0.487
LIG_SUMO_SIM_par_1	780	786	PF11976	0.466
LIG_TRAF2_1	865	868	PF00917	0.692
LIG_TYR_ITIM	419	424	PF00017	0.463
LIG_UBA3_1	594	598	PF00899	0.507
LIG_UBA3_1	756	765	PF00899	0.480
MOD_CDC14_SPxK_1	139	142	PF00782	0.722
MOD_CDK_SPK_2	136	141	PF00069	0.719
MOD_CDK_SPxK_1	136	142	PF00069	0.739
MOD_CDK_SPxK_1	475	481	PF00069	0.602
MOD_CDK_SPxxK_3	261	268	PF00069	0.735
MOD_CK1_1	116	122	PF00069	0.738
MOD_CK1_1	157	163	PF00069	0.807
MOD_CK1_1	30	36	PF00069	0.738
MOD_CK1_1	313	319	PF00069	0.707
MOD_CK1_1	340	346	PF00069	0.796
MOD_CK1_1	484	490	PF00069	0.670
MOD_CK1_1	540	546	PF00069	0.481
MOD_CK1_1	692	698	PF00069	0.626
MOD_CK1_1	702	708	PF00069	0.510
MOD_CK1_1	724	730	PF00069	0.450
MOD_CK1_1	80	86	PF00069	0.853
MOD_CK1_1	808	814	PF00069	0.645
MOD_CK1_1	859	865	PF00069	0.790
MOD_CK1_1	92	98	PF00069	0.648
MOD_CK2_1	191	197	PF00069	0.687
MOD_CK2_1	240	246	PF00069	0.693
MOD_CK2_1	377	383	PF00069	0.698
MOD_CK2_1	543	549	PF00069	0.445
MOD_CK2_1	766	772	PF00069	0.479
MOD_CK2_1	862	868	PF00069	0.671
MOD_GlcNHglycan	113	118	PF01048	0.749
MOD_GlcNHglycan	161	164	PF01048	0.756
MOD_GlcNHglycan	173	176	PF01048	0.822
MOD_GlcNHglycan	178	181	PF01048	0.743
MOD_GlcNHglycan	306	309	PF01048	0.724
MOD_GlcNHglycan	334	337	PF01048	0.698
MOD_GlcNHglycan	364	368	PF01048	0.687
MOD_GlcNHglycan	383	387	PF01048	0.649
MOD_GlcNHglycan	402	405	PF01048	0.543
MOD_GlcNHglycan	414	418	PF01048	0.460
MOD_GlcNHglycan	475	478	PF01048	0.774
MOD_GlcNHglycan	486	489	PF01048	0.551
MOD_GlcNHglycan	50	53	PF01048	0.761
MOD_GlcNHglycan	612	615	PF01048	0.476
MOD_GlcNHglycan	649	652	PF01048	0.545
MOD_GlcNHglycan	678	681	PF01048	0.466
MOD_GlcNHglycan	723	726	PF01048	0.550
MOD_GlcNHglycan	785	790	PF01048	0.452
MOD_GlcNHglycan	797	800	PF01048	0.303
MOD_GlcNHglycan	82	85	PF01048	0.844
MOD_GSK3_1	113	120	PF00069	0.784
MOD_GSK3_1	136	143	PF00069	0.735
MOD_GSK3_1	155	162	PF00069	0.752
MOD_GSK3_1	27	34	PF00069	0.742
MOD_GSK3_1	306	313	PF00069	0.706
MOD_GSK3_1	338	345	PF00069	0.801
MOD_GSK3_1	35	42	PF00069	0.738
MOD_GSK3_1	353	360	PF00069	0.662
MOD_GSK3_1	382	389	PF00069	0.675
MOD_GSK3_1	422	429	PF00069	0.630
MOD_GSK3_1	430	437	PF00069	0.746
MOD_GSK3_1	461	468	PF00069	0.719
MOD_GSK3_1	487	494	PF00069	0.669
MOD_GSK3_1	575	582	PF00069	0.546
MOD_GSK3_1	62	69	PF00069	0.807
MOD_GSK3_1	628	635	PF00069	0.507
MOD_GSK3_1	661	668	PF00069	0.466
MOD_GSK3_1	698	705	PF00069	0.639
MOD_GSK3_1	73	80	PF00069	0.780
MOD_GSK3_1	808	815	PF00069	0.539
MOD_GSK3_1	855	862	PF00069	0.697
MOD_GSK3_1	89	96	PF00069	0.647
MOD_N-GLC_1	294	299	PF02516	0.739
MOD_N-GLC_1	331	336	PF02516	0.674
MOD_N-GLC_1	353	358	PF02516	0.684
MOD_N-GLC_1	430	435	PF02516	0.760
MOD_N-GLC_1	491	496	PF02516	0.726
MOD_N-GLC_1	772	777	PF02516	0.487
MOD_N-GLC_2	480	482	PF02516	0.822
MOD_NEK2_1	154	159	PF00069	0.800
MOD_NEK2_1	206	211	PF00069	0.667
MOD_NEK2_1	31	36	PF00069	0.739
MOD_NEK2_1	357	362	PF00069	0.702
MOD_NEK2_1	370	375	PF00069	0.658
MOD_NEK2_1	422	427	PF00069	0.497
MOD_NEK2_1	50	55	PF00069	0.735
MOD_NEK2_1	511	516	PF00069	0.462
MOD_NEK2_1	579	584	PF00069	0.555
MOD_NEK2_1	673	678	PF00069	0.444
MOD_NEK2_1	795	800	PF00069	0.492
MOD_NEK2_1	806	811	PF00069	0.500
MOD_NEK2_1	812	817	PF00069	0.442
MOD_NEK2_1	841	846	PF00069	0.492
MOD_NEK2_1	900	905	PF00069	0.464
MOD_NEK2_2	163	168	PF00069	0.807
MOD_NEK2_2	430	435	PF00069	0.760
MOD_NEK2_2	766	771	PF00069	0.472
MOD_PIKK_1	699	705	PF00454	0.640
MOD_PIKK_1	847	853	PF00454	0.575
MOD_PIKK_1	860	866	PF00454	0.627
MOD_PKA_1	504	510	PF00069	0.495
MOD_PKA_2	117	123	PF00069	0.729
MOD_PKA_2	211	217	PF00069	0.579
MOD_PKA_2	31	37	PF00069	0.738
MOD_PKA_2	311	317	PF00069	0.737
MOD_PKA_2	434	440	PF00069	0.678
MOD_PKA_2	461	467	PF00069	0.770
MOD_PKA_2	504	510	PF00069	0.495
MOD_PKA_2	62	68	PF00069	0.736
MOD_PKA_2	676	682	PF00069	0.459
MOD_PKA_2	692	698	PF00069	0.590
MOD_PKA_2	73	79	PF00069	0.747
MOD_PKA_2	856	862	PF00069	0.658
MOD_PKA_2	914	920	PF00069	0.593
MOD_PKA_2	93	99	PF00069	0.609
MOD_Plk_1	353	359	PF00069	0.682
MOD_Plk_1	382	388	PF00069	0.646
MOD_Plk_1	430	436	PF00069	0.767
MOD_Plk_1	772	778	PF00069	0.478
MOD_Plk_1	841	847	PF00069	0.496
MOD_Plk_2-3	240	246	PF00069	0.808
MOD_Plk_2-3	772	778	PF00069	0.486
MOD_Plk_4	316	322	PF00069	0.589
MOD_Plk_4	388	394	PF00069	0.500
MOD_Plk_4	436	442	PF00069	0.686
MOD_Plk_4	528	534	PF00069	0.466
MOD_Plk_4	537	543	PF00069	0.506
MOD_Plk_4	615	621	PF00069	0.459
MOD_Plk_4	668	674	PF00069	0.476
MOD_Plk_4	724	730	PF00069	0.450
MOD_Plk_4	766	772	PF00069	0.479
MOD_Plk_4	787	793	PF00069	0.463
MOD_Plk_4	812	818	PF00069	0.613
MOD_ProDKin_1	12	18	PF00069	0.733
MOD_ProDKin_1	136	142	PF00069	0.739
MOD_ProDKin_1	261	267	PF00069	0.734
MOD_ProDKin_1	281	287	PF00069	0.491
MOD_ProDKin_1	340	346	PF00069	0.683
MOD_ProDKin_1	446	452	PF00069	0.590
MOD_ProDKin_1	475	481	PF00069	0.714
MOD_ProDKin_1	535	541	PF00069	0.536
MOD_ProDKin_1	560	566	PF00069	0.530
MOD_ProDKin_1	77	83	PF00069	0.738
MOD_SUMO_rev_2	253	263	PF00179	0.705
TRG_DiLeu_BaEn_1	655	660	PF01217	0.520
TRG_DiLeu_BaEn_2	357	363	PF01217	0.575
TRG_ENDOCYTIC_2	207	210	PF00928	0.668
TRG_ENDOCYTIC_2	220	223	PF00928	0.527
TRG_ENDOCYTIC_2	421	424	PF00928	0.470
TRG_ENDOCYTIC_2	716	719	PF00928	0.482
TRG_ENDOCYTIC_2	739	742	PF00928	0.445
TRG_ER_diArg_1	434	436	PF00400	0.619
TRG_ER_diArg_1	497	500	PF00400	0.602
TRG_ER_diArg_1	503	505	PF00400	0.530
TRG_ER_diArg_1	533	536	PF00400	0.528
TRG_ER_diArg_1	557	559	PF00400	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN7	Leptomonas seymouri	70%	99%
A0A3S7X5H5	Leishmania donovani	99%	100%
A4HKF2	Leishmania braziliensis	82%	100%
E9B2U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5B5	Leishmania major	93%	100%