NYN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7X6_LEIIN

TriTrypDb:

LINF_320021800

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7X6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.618
CLV_C14_Caspase3-7	56	60	PF00656	0.633
CLV_NRD_NRD_1	231	233	PF00675	0.477
CLV_NRD_NRD_1	239	241	PF00675	0.563
CLV_PCSK_FUR_1	229	233	PF00082	0.572
CLV_PCSK_KEX2_1	173	175	PF00082	0.439
CLV_PCSK_KEX2_1	231	233	PF00082	0.479
CLV_PCSK_KEX2_1	239	241	PF00082	0.565
CLV_PCSK_KEX2_1	260	262	PF00082	0.417
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.502
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.417
CLV_PCSK_SKI1_1	231	235	PF00082	0.542
DEG_APCC_DBOX_1	273	281	PF00400	0.501
DEG_Nend_Nbox_1	1	3	PF02207	0.571
DOC_CKS1_1	187	192	PF01111	0.500
DOC_CYCLIN_RxL_1	228	238	PF00134	0.540
DOC_MAPK_DCC_7	95	105	PF00069	0.494
DOC_MAPK_gen_1	173	181	PF00069	0.451
DOC_PP1_RVXF_1	1	8	PF00149	0.663
DOC_PP4_FxxP_1	187	190	PF00568	0.487
DOC_PP4_FxxP_1	40	43	PF00568	0.467
DOC_USP7_MATH_1	148	152	PF00917	0.563
DOC_USP7_MATH_1	282	286	PF00917	0.523
DOC_USP7_MATH_1	71	75	PF00917	0.572
DOC_WW_Pin1_4	186	191	PF00397	0.365
DOC_WW_Pin1_4	98	103	PF00397	0.449
LIG_14-3-3_CanoR_1	162	167	PF00244	0.576
LIG_14-3-3_CanoR_1	90	98	PF00244	0.410
LIG_APCC_ABBA_1	120	125	PF00400	0.516
LIG_Clathr_ClatBox_1	106	110	PF01394	0.344
LIG_eIF4E_1	123	129	PF01652	0.456
LIG_eIF4E_1	228	234	PF01652	0.587
LIG_FHA_1	212	218	PF00498	0.470
LIG_FHA_1	82	88	PF00498	0.396
LIG_FHA_2	152	158	PF00498	0.549
LIG_FHA_2	274	280	PF00498	0.526
LIG_LIR_Gen_1	175	181	PF02991	0.391
LIG_LIR_Gen_1	4	15	PF02991	0.676
LIG_LIR_Gen_1	45	54	PF02991	0.433
LIG_LIR_Gen_1	89	98	PF02991	0.522
LIG_LIR_Nem_3	175	180	PF02991	0.346
LIG_LIR_Nem_3	259	265	PF02991	0.517
LIG_LIR_Nem_3	4	10	PF02991	0.658
LIG_LIR_Nem_3	45	51	PF02991	0.433
LIG_LYPXL_yS_3	123	126	PF13949	0.352
LIG_PDZ_Class_1	286	291	PF00595	0.526
LIG_Pex14_2	138	142	PF04695	0.394
LIG_Pex14_2	262	266	PF04695	0.392
LIG_PTB_Apo_2	108	115	PF02174	0.373
LIG_PTB_Apo_2	222	229	PF02174	0.450
LIG_PTB_Phospho_1	222	228	PF10480	0.442
LIG_SH3_1	118	124	PF00018	0.342
LIG_SH3_3	118	124	PF00018	0.342
LIG_SH3_3	152	158	PF00018	0.542
LIG_SUMO_SIM_anti_2	101	108	PF11976	0.335
LIG_SUMO_SIM_anti_2	125	130	PF11976	0.475
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.475
LIG_SUMO_SIM_par_1	101	108	PF11976	0.344
LIG_SUMO_SIM_par_1	213	218	PF11976	0.356
LIG_TRAF2_1	43	46	PF00917	0.580
LIG_UBA3_1	233	237	PF00899	0.634
LIG_WRC_WIRS_1	134	139	PF05994	0.441
MOD_CK1_1	13	19	PF00069	0.658
MOD_CK1_1	140	146	PF00069	0.442
MOD_CK1_1	151	157	PF00069	0.448
MOD_CK1_1	89	95	PF00069	0.507
MOD_CK2_1	151	157	PF00069	0.492
MOD_CK2_1	172	178	PF00069	0.521
MOD_GlcNHglycan	67	70	PF01048	0.579
MOD_GSK3_1	133	140	PF00069	0.444
MOD_GSK3_1	168	175	PF00069	0.604
MOD_GSK3_1	211	218	PF00069	0.460
MOD_GSK3_1	244	251	PF00069	0.570
MOD_GSK3_1	282	289	PF00069	0.651
MOD_N-GLC_1	286	291	PF02516	0.614
MOD_N-GLC_1	98	103	PF02516	0.527
MOD_NEK2_1	133	138	PF00069	0.336
MOD_NEK2_1	273	278	PF00069	0.526
MOD_PIKK_1	192	198	PF00454	0.436
MOD_PK_1	162	168	PF00069	0.620
MOD_PKA_2	273	279	PF00069	0.537
MOD_PKA_2	89	95	PF00069	0.415
MOD_Plk_1	151	157	PF00069	0.513
MOD_Plk_1	3	9	PF00069	0.623
MOD_Plk_4	211	217	PF00069	0.436
MOD_Plk_4	248	254	PF00069	0.539
MOD_ProDKin_1	186	192	PF00069	0.374
MOD_ProDKin_1	98	104	PF00069	0.441
TRG_DiLeu_BaEn_1	18	23	PF01217	0.519
TRG_DiLeu_BaEn_3	45	51	PF01217	0.550
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.592
TRG_ENDOCYTIC_2	123	126	PF00928	0.545
TRG_ENDOCYTIC_2	91	94	PF00928	0.534
TRG_ER_diArg_1	228	231	PF00400	0.481
TRG_NES_CRM1_1	207	220	PF08389	0.512
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW3	Leptomonas seymouri	68%	98%
A0A1X0NUU9	Trypanosomatidae	47%	94%
A0A3S7X5I4	Leishmania donovani	100%	100%
A0A422NL68	Trypanosoma rangeli	40%	100%
A4HKE8	Leishmania braziliensis	80%	100%
D0AA41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	93%
E9B2T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q5C0	Leishmania major	96%	100%
V5BF01	Trypanosoma cruzi	39%	100%