LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Putative GTPase activating protein for Arf - putative
Species:
Leishmania infantum
UniProt:
A4I7X2_LEIIN
TriTrypDb:
LINF_320021500
Length:
731

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7X2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7X2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005096 GTPase activator activity 4 6
GO:0008047 enzyme activator activity 3 6
GO:0030234 enzyme regulator activity 2 6
GO:0030695 GTPase regulator activity 4 6
GO:0060589 nucleoside-triphosphatase regulator activity 3 6
GO:0098772 molecular function regulator activity 1 6
GO:0140677 molecular function activator activity 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 136 140 PF00656 0.561
CLV_C14_Caspase3-7 285 289 PF00656 0.598
CLV_C14_Caspase3-7 642 646 PF00656 0.609
CLV_NRD_NRD_1 127 129 PF00675 0.530
CLV_NRD_NRD_1 314 316 PF00675 0.660
CLV_NRD_NRD_1 396 398 PF00675 0.818
CLV_NRD_NRD_1 399 401 PF00675 0.815
CLV_NRD_NRD_1 467 469 PF00675 0.738
CLV_NRD_NRD_1 564 566 PF00675 0.613
CLV_NRD_NRD_1 616 618 PF00675 0.717
CLV_NRD_NRD_1 711 713 PF00675 0.598
CLV_PCSK_FUR_1 312 316 PF00082 0.632
CLV_PCSK_FUR_1 319 323 PF00082 0.614
CLV_PCSK_FUR_1 394 398 PF00082 0.821
CLV_PCSK_FUR_1 399 403 PF00082 0.776
CLV_PCSK_FUR_1 91 95 PF00082 0.530
CLV_PCSK_KEX2_1 127 129 PF00082 0.530
CLV_PCSK_KEX2_1 312 314 PF00082 0.675
CLV_PCSK_KEX2_1 318 320 PF00082 0.629
CLV_PCSK_KEX2_1 321 323 PF00082 0.639
CLV_PCSK_KEX2_1 324 326 PF00082 0.634
CLV_PCSK_KEX2_1 396 398 PF00082 0.823
CLV_PCSK_KEX2_1 399 401 PF00082 0.810
CLV_PCSK_KEX2_1 564 566 PF00082 0.613
CLV_PCSK_KEX2_1 616 618 PF00082 0.717
CLV_PCSK_KEX2_1 711 713 PF00082 0.598
CLV_PCSK_KEX2_1 93 95 PF00082 0.512
CLV_PCSK_PC1ET2_1 318 320 PF00082 0.749
CLV_PCSK_PC1ET2_1 321 323 PF00082 0.723
CLV_PCSK_PC1ET2_1 324 326 PF00082 0.686
CLV_PCSK_PC1ET2_1 401 403 PF00082 0.835
CLV_PCSK_PC1ET2_1 93 95 PF00082 0.512
CLV_PCSK_PC7_1 314 320 PF00082 0.756
CLV_PCSK_PC7_1 397 403 PF00082 0.799
CLV_PCSK_SKI1_1 17 21 PF00082 0.427
CLV_PCSK_SKI1_1 208 212 PF00082 0.679
CLV_PCSK_SKI1_1 229 233 PF00082 0.573
CLV_PCSK_SKI1_1 315 319 PF00082 0.777
CLV_PCSK_SKI1_1 357 361 PF00082 0.711
CLV_PCSK_SKI1_1 443 447 PF00082 0.714
CLV_PCSK_SKI1_1 484 488 PF00082 0.723
CLV_PCSK_SKI1_1 504 508 PF00082 0.500
CLV_PCSK_SKI1_1 603 607 PF00082 0.724
CLV_PCSK_SKI1_1 616 620 PF00082 0.638
CLV_PCSK_SKI1_1 718 722 PF00082 0.654
DEG_APCC_DBOX_1 16 24 PF00400 0.394
DEG_APCC_DBOX_1 401 409 PF00400 0.756
DEG_ODPH_VHL_1 436 447 PF01847 0.627
DEG_SCF_FBW7_1 169 175 PF00400 0.706
DEG_SCF_FBW7_1 546 553 PF00400 0.569
DEG_SPOP_SBC_1 521 525 PF00917 0.802
DOC_CDC14_PxL_1 434 442 PF14671 0.653
DOC_CKS1_1 169 174 PF01111 0.699
DOC_CYCLIN_yCln2_LP_2 606 612 PF00134 0.614
DOC_MAPK_DCC_7 427 436 PF00069 0.634
DOC_MAPK_gen_1 14 22 PF00069 0.478
DOC_MAPK_gen_1 174 182 PF00069 0.596
DOC_MAPK_gen_1 321 332 PF00069 0.613
DOC_MAPK_gen_1 67 75 PF00069 0.530
DOC_MAPK_gen_1 711 719 PF00069 0.594
DOC_MAPK_MEF2A_6 229 237 PF00069 0.663
DOC_MAPK_MEF2A_6 324 332 PF00069 0.637
DOC_MAPK_MEF2A_6 427 436 PF00069 0.731
DOC_PP2B_LxvP_1 237 240 PF13499 0.604
DOC_PP2B_LxvP_1 620 623 PF13499 0.712
DOC_PP4_FxxP_1 581 584 PF00568 0.810
DOC_PP4_MxPP_1 326 329 PF00568 0.643
DOC_USP7_MATH_1 137 141 PF00917 0.671
DOC_USP7_MATH_1 172 176 PF00917 0.717
DOC_USP7_MATH_1 181 185 PF00917 0.657
DOC_USP7_MATH_1 194 198 PF00917 0.702
DOC_USP7_MATH_1 254 258 PF00917 0.611
DOC_USP7_MATH_1 273 277 PF00917 0.757
DOC_USP7_MATH_1 304 308 PF00917 0.832
DOC_USP7_MATH_1 413 417 PF00917 0.618
DOC_USP7_MATH_1 449 453 PF00917 0.778
DOC_USP7_MATH_1 456 460 PF00917 0.678
DOC_USP7_MATH_1 461 465 PF00917 0.529
DOC_USP7_MATH_1 521 525 PF00917 0.595
DOC_USP7_MATH_1 550 554 PF00917 0.574
DOC_USP7_MATH_1 556 560 PF00917 0.572
DOC_USP7_MATH_1 589 593 PF00917 0.804
DOC_USP7_MATH_1 659 663 PF00917 0.801
DOC_WW_Pin1_4 168 173 PF00397 0.817
DOC_WW_Pin1_4 203 208 PF00397 0.694
DOC_WW_Pin1_4 229 234 PF00397 0.693
DOC_WW_Pin1_4 261 266 PF00397 0.706
DOC_WW_Pin1_4 271 276 PF00397 0.574
DOC_WW_Pin1_4 357 362 PF00397 0.745
DOC_WW_Pin1_4 427 432 PF00397 0.768
DOC_WW_Pin1_4 478 483 PF00397 0.770
DOC_WW_Pin1_4 499 504 PF00397 0.667
DOC_WW_Pin1_4 507 512 PF00397 0.685
DOC_WW_Pin1_4 517 522 PF00397 0.599
DOC_WW_Pin1_4 546 551 PF00397 0.608
DOC_WW_Pin1_4 570 575 PF00397 0.759
DOC_WW_Pin1_4 618 623 PF00397 0.694
DOC_WW_Pin1_4 657 662 PF00397 0.718
DOC_WW_Pin1_4 672 677 PF00397 0.583
LIG_14-3-3_CanoR_1 355 364 PF00244 0.666
LIG_14-3-3_CanoR_1 462 466 PF00244 0.621
LIG_14-3-3_CanoR_1 484 492 PF00244 0.660
LIG_14-3-3_CanoR_1 531 536 PF00244 0.675
LIG_14-3-3_CanoR_1 564 569 PF00244 0.704
LIG_14-3-3_CanoR_1 637 641 PF00244 0.672
LIG_14-3-3_CanoR_1 725 730 PF00244 0.669
LIG_ActinCP_TwfCPI_2 581 591 PF01115 0.599
LIG_BIR_II_1 1 5 PF00653 0.765
LIG_BIR_III_2 547 551 PF00653 0.564
LIG_BRCT_BRCA1_1 688 692 PF00533 0.757
LIG_CaM_IQ_9 1 16 PF13499 0.631
LIG_deltaCOP1_diTrp_1 74 83 PF00928 0.530
LIG_FHA_1 100 106 PF00498 0.316
LIG_FHA_1 171 177 PF00498 0.768
LIG_FHA_1 190 196 PF00498 0.495
LIG_FHA_1 230 236 PF00498 0.659
LIG_FHA_1 264 270 PF00498 0.711
LIG_FHA_1 278 284 PF00498 0.596
LIG_FHA_1 358 364 PF00498 0.786
LIG_FHA_1 373 379 PF00498 0.523
LIG_FHA_1 404 410 PF00498 0.661
LIG_FHA_1 442 448 PF00498 0.793
LIG_FHA_1 485 491 PF00498 0.779
LIG_FHA_1 508 514 PF00498 0.727
LIG_FHA_1 6 12 PF00498 0.614
LIG_FHA_1 698 704 PF00498 0.747
LIG_FHA_1 70 76 PF00498 0.530
LIG_FHA_2 283 289 PF00498 0.713
LIG_FHA_2 531 537 PF00498 0.736
LIG_LIR_Apic_2 102 107 PF02991 0.519
LIG_LIR_Apic_2 627 633 PF02991 0.678
LIG_LIR_Gen_1 40 49 PF02991 0.516
LIG_LIR_Gen_1 665 674 PF02991 0.664
LIG_LIR_Nem_3 40 44 PF02991 0.516
LIG_LIR_Nem_3 417 423 PF02991 0.730
LIG_LIR_Nem_3 665 669 PF02991 0.658
LIG_NRBOX 18 24 PF00104 0.530
LIG_PCNA_yPIPBox_3 9 23 PF02747 0.571
LIG_SH2_CRK 130 134 PF00017 0.656
LIG_SH2_PTP2 104 107 PF00017 0.530
LIG_SH2_PTP2 630 633 PF00017 0.602
LIG_SH2_SRC 630 633 PF00017 0.602
LIG_SH2_STAP1 96 100 PF00017 0.413
LIG_SH2_STAT5 104 107 PF00017 0.530
LIG_SH2_STAT5 124 127 PF00017 0.199
LIG_SH2_STAT5 215 218 PF00017 0.523
LIG_SH2_STAT5 611 614 PF00017 0.613
LIG_SH2_STAT5 630 633 PF00017 0.588
LIG_SH3_1 129 135 PF00018 0.578
LIG_SH3_1 166 172 PF00018 0.709
LIG_SH3_1 325 331 PF00018 0.604
LIG_SH3_2 169 174 PF14604 0.602
LIG_SH3_3 129 135 PF00018 0.601
LIG_SH3_3 166 172 PF00018 0.760
LIG_SH3_3 244 250 PF00018 0.797
LIG_SH3_3 259 265 PF00018 0.604
LIG_SH3_3 284 290 PF00018 0.678
LIG_SH3_3 325 331 PF00018 0.607
LIG_SH3_3 344 350 PF00018 0.784
LIG_SH3_3 429 435 PF00018 0.609
LIG_SH3_3 479 485 PF00018 0.815
LIG_SH3_3 515 521 PF00018 0.680
LIG_SH3_3 619 625 PF00018 0.662
LIG_SUMO_SIM_anti_2 276 283 PF11976 0.729
LIG_SUMO_SIM_par_1 263 271 PF11976 0.733
LIG_SUMO_SIM_par_1 276 286 PF11976 0.566
LIG_SUMO_SIM_par_1 443 448 PF11976 0.714
LIG_TRAF2_1 303 306 PF00917 0.624
LIG_TRAF2_1 371 374 PF00917 0.616
LIG_TRAF2_1 385 388 PF00917 0.650
LIG_TRAF2_1 534 537 PF00917 0.553
LIG_UBA3_1 19 24 PF00899 0.394
LIG_WW_3 490 494 PF00397 0.784
MOD_CDC14_SPxK_1 481 484 PF00782 0.730
MOD_CDK_SPK_2 203 208 PF00069 0.694
MOD_CDK_SPK_2 499 504 PF00069 0.611
MOD_CDK_SPxK_1 168 174 PF00069 0.682
MOD_CDK_SPxK_1 478 484 PF00069 0.733
MOD_CK1_1 214 220 PF00069 0.587
MOD_CK1_1 261 267 PF00069 0.650
MOD_CK1_1 274 280 PF00069 0.734
MOD_CK1_1 389 395 PF00069 0.819
MOD_CK1_1 416 422 PF00069 0.647
MOD_CK1_1 426 432 PF00069 0.801
MOD_CK1_1 520 526 PF00069 0.697
MOD_CK1_1 560 566 PF00069 0.790
MOD_CK1_1 639 645 PF00069 0.744
MOD_CK1_1 662 668 PF00069 0.631
MOD_CK1_1 672 678 PF00069 0.684
MOD_CK2_1 147 153 PF00069 0.614
MOD_CK2_1 530 536 PF00069 0.741
MOD_GlcNHglycan 111 115 PF01048 0.452
MOD_GlcNHglycan 135 138 PF01048 0.550
MOD_GlcNHglycan 139 143 PF01048 0.555
MOD_GlcNHglycan 243 246 PF01048 0.661
MOD_GlcNHglycan 305 309 PF01048 0.805
MOD_GlcNHglycan 33 37 PF01048 0.413
MOD_GlcNHglycan 423 426 PF01048 0.687
MOD_GlcNHglycan 524 527 PF01048 0.736
MOD_GlcNHglycan 54 57 PF01048 0.530
MOD_GlcNHglycan 552 555 PF01048 0.745
MOD_GlcNHglycan 560 563 PF01048 0.656
MOD_GlcNHglycan 679 684 PF01048 0.668
MOD_GSK3_1 133 140 PF00069 0.497
MOD_GSK3_1 168 175 PF00069 0.705
MOD_GSK3_1 176 183 PF00069 0.639
MOD_GSK3_1 254 261 PF00069 0.644
MOD_GSK3_1 271 278 PF00069 0.747
MOD_GSK3_1 313 320 PF00069 0.712
MOD_GSK3_1 423 430 PF00069 0.668
MOD_GSK3_1 517 524 PF00069 0.713
MOD_GSK3_1 546 553 PF00069 0.698
MOD_GSK3_1 556 563 PF00069 0.634
MOD_GSK3_1 566 573 PF00069 0.546
MOD_GSK3_1 63 70 PF00069 0.455
MOD_GSK3_1 635 642 PF00069 0.818
MOD_GSK3_1 651 658 PF00069 0.549
MOD_GSK3_1 693 700 PF00069 0.746
MOD_GSK3_1 96 103 PF00069 0.522
MOD_N-GLC_1 203 208 PF02516 0.701
MOD_N-GLC_1 241 246 PF02516 0.666
MOD_N-GLC_1 557 562 PF02516 0.747
MOD_N-GLC_1 662 667 PF02516 0.693
MOD_NEK2_1 211 216 PF00069 0.654
MOD_NEK2_1 241 246 PF00069 0.735
MOD_NEK2_1 258 263 PF00069 0.504
MOD_NEK2_1 32 37 PF00069 0.332
MOD_NEK2_1 423 428 PF00069 0.792
MOD_NEK2_1 557 562 PF00069 0.755
MOD_NEK2_1 612 617 PF00069 0.745
MOD_NEK2_1 669 674 PF00069 0.586
MOD_NEK2_1 692 697 PF00069 0.609
MOD_NEK2_2 172 177 PF00069 0.697
MOD_NEK2_2 438 443 PF00069 0.595
MOD_PIKK_1 450 456 PF00454 0.567
MOD_PIKK_1 484 490 PF00454 0.840
MOD_PIKK_1 687 693 PF00454 0.742
MOD_PK_1 531 537 PF00069 0.561
MOD_PKA_1 313 319 PF00069 0.760
MOD_PKA_1 564 570 PF00069 0.611
MOD_PKA_2 109 115 PF00069 0.355
MOD_PKA_2 176 182 PF00069 0.713
MOD_PKA_2 313 319 PF00069 0.760
MOD_PKA_2 426 432 PF00069 0.728
MOD_PKA_2 461 467 PF00069 0.619
MOD_PKA_2 5 11 PF00069 0.670
MOD_PKA_2 52 58 PF00069 0.530
MOD_PKA_2 530 536 PF00069 0.615
MOD_PKA_2 563 569 PF00069 0.702
MOD_PKA_2 582 588 PF00069 0.522
MOD_PKA_2 636 642 PF00069 0.740
MOD_PKA_2 655 661 PF00069 0.527
MOD_PKA_2 669 675 PF00069 0.650
MOD_PKB_1 353 361 PF00069 0.710
MOD_PKB_1 723 731 PF00069 0.671
MOD_Plk_1 211 217 PF00069 0.610
MOD_Plk_1 373 379 PF00069 0.625
MOD_Plk_1 416 422 PF00069 0.690
MOD_Plk_1 662 668 PF00069 0.615
MOD_Plk_1 96 102 PF00069 0.394
MOD_Plk_2-3 147 153 PF00069 0.546
MOD_Plk_4 100 106 PF00069 0.420
MOD_Plk_4 211 217 PF00069 0.653
MOD_Plk_4 248 254 PF00069 0.646
MOD_Plk_4 263 269 PF00069 0.638
MOD_Plk_4 277 283 PF00069 0.570
MOD_Plk_4 373 379 PF00069 0.691
MOD_Plk_4 669 675 PF00069 0.707
MOD_ProDKin_1 168 174 PF00069 0.817
MOD_ProDKin_1 203 209 PF00069 0.692
MOD_ProDKin_1 229 235 PF00069 0.700
MOD_ProDKin_1 261 267 PF00069 0.708
MOD_ProDKin_1 271 277 PF00069 0.574
MOD_ProDKin_1 357 363 PF00069 0.747
MOD_ProDKin_1 427 433 PF00069 0.768
MOD_ProDKin_1 478 484 PF00069 0.772
MOD_ProDKin_1 499 505 PF00069 0.667
MOD_ProDKin_1 507 513 PF00069 0.689
MOD_ProDKin_1 517 523 PF00069 0.598
MOD_ProDKin_1 546 552 PF00069 0.608
MOD_ProDKin_1 570 576 PF00069 0.759
MOD_ProDKin_1 618 624 PF00069 0.695
MOD_ProDKin_1 657 663 PF00069 0.716
MOD_ProDKin_1 672 678 PF00069 0.582
MOD_SUMO_for_1 371 374 PF00179 0.616
MOD_SUMO_rev_2 382 392 PF00179 0.664
MOD_SUMO_rev_2 621 631 PF00179 0.667
TRG_DiLeu_BaEn_1 715 720 PF01217 0.460
TRG_DiLeu_BaEn_2 78 84 PF01217 0.530
TRG_DiLeu_BaEn_3 536 542 PF01217 0.566
TRG_DiLeu_BaLyEn_6 359 364 PF01217 0.609
TRG_DiLeu_LyEn_5 509 514 PF01217 0.710
TRG_DiLeu_LyEn_5 715 720 PF01217 0.460
TRG_ENDOCYTIC_2 130 133 PF00928 0.477
TRG_ER_diArg_1 127 129 PF00400 0.530
TRG_ER_diArg_1 311 314 PF00400 0.675
TRG_ER_diArg_1 394 397 PF00400 0.688
TRG_ER_diArg_1 399 402 PF00400 0.701
TRG_ER_diArg_1 465 468 PF00400 0.605
TRG_ER_diArg_1 590 593 PF00400 0.663
TRG_ER_diArg_1 711 713 PF00400 0.656
TRG_NES_CRM1_1 708 722 PF08389 0.599
TRG_NLS_MonoExtC_3 317 322 PF00514 0.620
TRG_NLS_MonoExtC_3 399 404 PF00514 0.759
TRG_NLS_MonoExtN_4 315 322 PF00514 0.621
TRG_NLS_MonoExtN_4 397 404 PF00514 0.833
TRG_NLS_MonoExtN_4 466 472 PF00514 0.608
TRG_Pf-PMV_PEXEL_1 17 21 PF00026 0.452
TRG_Pf-PMV_PEXEL_1 711 715 PF00026 0.670
TRG_Pf-PMV_PEXEL_1 718 722 PF00026 0.565

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X5J1 Leishmania donovani 99% 100%
A4HKE4 Leishmania braziliensis 48% 100%
E9B2T3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
Q4Q5C4 Leishmania major 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS