Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translation initiation factor eIF3 subunit 135 - putative

Species:

Leishmania infantum

UniProt:

A4I7X1_LEIIN

TriTrypDb:

LINF_320021400

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4I7X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7X1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003743	translation initiation factor activity	4	2
GO:0005488	binding	1	2
GO:0008135	translation factor activity, RNA binding	3	2
GO:0045182	translation regulator activity	1	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.526
CLV_C14_Caspase3-7	432	436	PF00656	0.557
CLV_NRD_NRD_1	327	329	PF00675	0.288
CLV_NRD_NRD_1	42	44	PF00675	0.655
CLV_NRD_NRD_1	456	458	PF00675	0.295
CLV_NRD_NRD_1	652	654	PF00675	0.402
CLV_NRD_NRD_1	77	79	PF00675	0.698
CLV_NRD_NRD_1	809	811	PF00675	0.667
CLV_NRD_NRD_1	882	884	PF00675	0.501
CLV_PCSK_FUR_1	454	458	PF00082	0.295
CLV_PCSK_KEX2_1	327	329	PF00082	0.333
CLV_PCSK_KEX2_1	41	43	PF00082	0.662
CLV_PCSK_KEX2_1	456	458	PF00082	0.252
CLV_PCSK_KEX2_1	77	79	PF00082	0.698
CLV_PCSK_KEX2_1	808	810	PF00082	0.661
CLV_PCSK_KEX2_1	881	883	PF00082	0.517
CLV_PCSK_PC1ET2_1	881	883	PF00082	0.517
CLV_PCSK_SKI1_1	118	122	PF00082	0.500
CLV_PCSK_SKI1_1	181	185	PF00082	0.607
CLV_PCSK_SKI1_1	297	301	PF00082	0.284
CLV_PCSK_SKI1_1	422	426	PF00082	0.340
CLV_PCSK_SKI1_1	622	626	PF00082	0.419
CLV_PCSK_SKI1_1	704	708	PF00082	0.295
CLV_PCSK_SKI1_1	715	719	PF00082	0.295
CLV_PCSK_SKI1_1	886	890	PF00082	0.481
DEG_APCC_DBOX_1	885	893	PF00400	0.549
DOC_AGCK_PIF_1	376	381	PF00069	0.488
DOC_CDC14_PxL_1	658	666	PF14671	0.391
DOC_CYCLIN_RxL_1	704	713	PF00134	0.488
DOC_CYCLIN_yClb1_LxF_4	598	604	PF00134	0.326
DOC_CYCLIN_yCln2_LP_2	366	372	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	466	469	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	848	854	PF00134	0.397
DOC_MAPK_DCC_7	465	473	PF00069	0.533
DOC_MAPK_FxFP_2	575	578	PF00069	0.342
DOC_MAPK_gen_1	510	517	PF00069	0.574
DOC_MAPK_gen_1	653	661	PF00069	0.428
DOC_MAPK_gen_1	881	890	PF00069	0.469
DOC_MAPK_HePTP_8	838	850	PF00069	0.320
DOC_MAPK_MEF2A_6	363	370	PF00069	0.495
DOC_MAPK_MEF2A_6	465	473	PF00069	0.533
DOC_MAPK_MEF2A_6	475	482	PF00069	0.646
DOC_MAPK_MEF2A_6	510	517	PF00069	0.495
DOC_MAPK_MEF2A_6	841	850	PF00069	0.465
DOC_MAPK_RevD_3	796	810	PF00069	0.461
DOC_PP1_RVXF_1	884	891	PF00149	0.454
DOC_PP2B_LxvP_1	366	369	PF13499	0.479
DOC_PP2B_LxvP_1	466	469	PF13499	0.495
DOC_PP2B_LxvP_1	483	486	PF13499	0.616
DOC_PP2B_LxvP_1	659	662	PF13499	0.385
DOC_PP2B_LxvP_1	798	801	PF13499	0.456
DOC_PP2B_PxIxI_1	844	850	PF00149	0.356
DOC_PP4_FxxP_1	253	256	PF00568	0.463
DOC_PP4_FxxP_1	575	578	PF00568	0.496
DOC_PP4_FxxP_1	850	853	PF00568	0.506
DOC_PP4_MxPP_1	301	304	PF00568	0.460
DOC_PP4_MxPP_1	855	858	PF00568	0.506
DOC_SPAK_OSR1_1	602	606	PF12202	0.305
DOC_USP7_MATH_1	12	16	PF00917	0.676
DOC_USP7_MATH_1	169	173	PF00917	0.619
DOC_USP7_MATH_1	183	187	PF00917	0.701
DOC_USP7_MATH_1	196	200	PF00917	0.560
DOC_USP7_MATH_1	259	263	PF00917	0.579
DOC_USP7_MATH_1	283	287	PF00917	0.488
DOC_USP7_MATH_1	388	392	PF00917	0.448
DOC_USP7_MATH_1	396	400	PF00917	0.545
DOC_USP7_MATH_1	424	428	PF00917	0.488
DOC_USP7_MATH_1	476	480	PF00917	0.558
DOC_USP7_MATH_1	544	548	PF00917	0.603
DOC_USP7_MATH_1	549	553	PF00917	0.529
DOC_USP7_MATH_1	62	66	PF00917	0.721
DOC_USP7_MATH_1	753	757	PF00917	0.439
DOC_USP7_MATH_1	76	80	PF00917	0.462
DOC_USP7_MATH_1	858	862	PF00917	0.705
DOC_USP7_UBL2_3	9	13	PF12436	0.552
DOC_WW_Pin1_4	164	169	PF00397	0.642
DOC_WW_Pin1_4	176	181	PF00397	0.677
DOC_WW_Pin1_4	34	39	PF00397	0.832
DOC_WW_Pin1_4	412	417	PF00397	0.525
DOC_WW_Pin1_4	481	486	PF00397	0.668
DOC_WW_Pin1_4	537	542	PF00397	0.577
DOC_WW_Pin1_4	716	721	PF00397	0.488
DOC_WW_Pin1_4	760	765	PF00397	0.311
DOC_WW_Pin1_4	78	83	PF00397	0.638
DOC_WW_Pin1_4	875	880	PF00397	0.700
DOC_WW_Pin1_4	892	897	PF00397	0.502
LIG_14-3-3_CanoR_1	363	367	PF00244	0.436
LIG_14-3-3_CanoR_1	457	467	PF00244	0.591
LIG_14-3-3_CanoR_1	498	503	PF00244	0.554
LIG_14-3-3_CanoR_1	715	720	PF00244	0.482
LIG_BH_BH3_1	422	438	PF00452	0.460
LIG_BIR_III_2	31	35	PF00653	0.626
LIG_BIR_III_4	435	439	PF00653	0.442
LIG_BRCT_BRCA1_1	398	402	PF00533	0.527
LIG_BRCT_BRCA1_1	741	745	PF00533	0.511
LIG_BRCT_BRCA1_1	80	84	PF00533	0.539
LIG_Clathr_ClatBox_1	583	587	PF01394	0.432
LIG_deltaCOP1_diTrp_1	235	238	PF00928	0.472
LIG_deltaCOP1_diTrp_1	245	254	PF00928	0.504
LIG_DLG_GKlike_1	498	506	PF00625	0.447
LIG_eIF4E_1	389	395	PF01652	0.533
LIG_EVH1_1	850	854	PF00568	0.459
LIG_FHA_1	102	108	PF00498	0.595
LIG_FHA_1	363	369	PF00498	0.492
LIG_FHA_1	415	421	PF00498	0.538
LIG_FHA_1	461	467	PF00498	0.456
LIG_FHA_1	605	611	PF00498	0.494
LIG_FHA_1	619	625	PF00498	0.255
LIG_FHA_1	716	722	PF00498	0.489
LIG_FHA_1	730	736	PF00498	0.476
LIG_FHA_2	126	132	PF00498	0.513
LIG_FHA_2	145	151	PF00498	0.483
LIG_FHA_2	487	493	PF00498	0.646
LIG_FHA_2	529	535	PF00498	0.582
LIG_FHA_2	661	667	PF00498	0.344
LIG_FHA_2	717	723	PF00498	0.495
LIG_FHA_2	784	790	PF00498	0.556
LIG_FHA_2	809	815	PF00498	0.624
LIG_GBD_Chelix_1	425	433	PF00786	0.288
LIG_LIR_Apic_2	252	256	PF02991	0.461
LIG_LIR_Apic_2	572	578	PF02991	0.382
LIG_LIR_Gen_1	500	511	PF02991	0.544
LIG_LIR_Gen_1	657	664	PF02991	0.344
LIG_LIR_Gen_1	694	703	PF02991	0.496
LIG_LIR_Nem_3	115	120	PF02991	0.439
LIG_LIR_Nem_3	134	140	PF02991	0.249
LIG_LIR_Nem_3	217	222	PF02991	0.349
LIG_LIR_Nem_3	375	379	PF02991	0.470
LIG_LIR_Nem_3	447	451	PF02991	0.514
LIG_LIR_Nem_3	500	506	PF02991	0.543
LIG_LIR_Nem_3	657	661	PF02991	0.341
LIG_LIR_Nem_3	694	699	PF02991	0.496
LIG_NRBOX	730	736	PF00104	0.439
LIG_PCNA_yPIPBox_3	352	360	PF02747	0.536
LIG_Pex14_1	158	162	PF04695	0.405
LIG_Pex14_1	236	240	PF04695	0.335
LIG_Pex14_1	250	254	PF04695	0.403
LIG_Pex14_2	121	125	PF04695	0.369
LIG_REV1ctd_RIR_1	251	255	PF16727	0.388
LIG_SH2_CRK	503	507	PF00017	0.566
LIG_SH2_CRK	620	624	PF00017	0.456
LIG_SH2_CRK	94	98	PF00017	0.404
LIG_SH2_STAP1	140	144	PF00017	0.475
LIG_SH2_STAP1	162	166	PF00017	0.487
LIG_SH2_STAP1	219	223	PF00017	0.389
LIG_SH2_STAP1	503	507	PF00017	0.454
LIG_SH2_STAP1	620	624	PF00017	0.342
LIG_SH2_STAT3	351	354	PF00017	0.488
LIG_SH2_STAT3	459	462	PF00017	0.488
LIG_SH2_STAT5	319	322	PF00017	0.488
LIG_SH2_STAT5	459	462	PF00017	0.436
LIG_SH2_STAT5	620	623	PF00017	0.372
LIG_SH2_STAT5	677	680	PF00017	0.479
LIG_SH2_STAT5	907	910	PF00017	0.484
LIG_SH3_3	172	178	PF00018	0.732
LIG_SH3_3	20	26	PF00018	0.729
LIG_SH3_3	253	259	PF00018	0.558
LIG_SH3_3	309	315	PF00018	0.472
LIG_SH3_3	356	362	PF00018	0.522
LIG_SH3_3	413	419	PF00018	0.533
LIG_SH3_3	466	472	PF00018	0.474
LIG_SH3_3	479	485	PF00018	0.597
LIG_SH3_3	576	582	PF00018	0.379
LIG_SH3_3	798	804	PF00018	0.599
LIG_SH3_3	848	854	PF00018	0.559
LIG_SH3_3	857	863	PF00018	0.738
LIG_SUMO_SIM_anti_2	355	361	PF11976	0.488
LIG_SUMO_SIM_anti_2	479	484	PF11976	0.564
LIG_TRAF2_1	531	534	PF00917	0.515
LIG_WW_2	418	421	PF00397	0.442
LIG_WW_2	857	860	PF00397	0.516
LIG_WW_3	24	28	PF00397	0.684
MOD_CDC14_SPxK_1	878	881	PF00782	0.406
MOD_CDK_SPK_2	176	181	PF00069	0.582
MOD_CDK_SPxK_1	875	881	PF00069	0.444
MOD_CDK_SPxxK_3	34	41	PF00069	0.679
MOD_CDK_SPxxK_3	481	488	PF00069	0.567
MOD_CDK_SPxxK_3	875	882	PF00069	0.485
MOD_CK1_1	143	149	PF00069	0.686
MOD_CK1_1	15	21	PF00069	0.785
MOD_CK1_1	262	268	PF00069	0.656
MOD_CK1_1	484	490	PF00069	0.708
MOD_CK1_1	497	503	PF00069	0.317
MOD_CK1_1	532	538	PF00069	0.645
MOD_CK1_1	65	71	PF00069	0.622
MOD_CK1_1	716	722	PF00069	0.522
MOD_CK1_1	790	796	PF00069	0.390
MOD_CK1_1	799	805	PF00069	0.556
MOD_CK2_1	144	150	PF00069	0.633
MOD_CK2_1	283	289	PF00069	0.583
MOD_CK2_1	486	492	PF00069	0.643
MOD_CK2_1	528	534	PF00069	0.573
MOD_CK2_1	660	666	PF00069	0.344
MOD_CK2_1	716	722	PF00069	0.470
MOD_CK2_1	783	789	PF00069	0.480
MOD_CK2_1	810	816	PF00069	0.648
MOD_DYRK1A_RPxSP_1	78	82	PF00069	0.494
MOD_GlcNHglycan	15	18	PF01048	0.816
MOD_GlcNHglycan	265	268	PF01048	0.349
MOD_GlcNHglycan	390	393	PF01048	0.321
MOD_GlcNHglycan	422	425	PF01048	0.349
MOD_GlcNHglycan	47	50	PF01048	0.639
MOD_GlcNHglycan	534	537	PF01048	0.548
MOD_GlcNHglycan	546	549	PF01048	0.429
MOD_GlcNHglycan	569	572	PF01048	0.245
MOD_GlcNHglycan	628	631	PF01048	0.647
MOD_GlcNHglycan	68	71	PF01048	0.666
MOD_GlcNHglycan	715	718	PF01048	0.297
MOD_GlcNHglycan	798	801	PF01048	0.530
MOD_GlcNHglycan	8	12	PF01048	0.779
MOD_GlcNHglycan	870	874	PF01048	0.685
MOD_GSK3_1	140	147	PF00069	0.597
MOD_GSK3_1	190	197	PF00069	0.585
MOD_GSK3_1	258	265	PF00069	0.565
MOD_GSK3_1	377	384	PF00069	0.481
MOD_GSK3_1	420	427	PF00069	0.480
MOD_GSK3_1	494	501	PF00069	0.662
MOD_GSK3_1	52	59	PF00069	0.629
MOD_GSK3_1	528	535	PF00069	0.526
MOD_GSK3_1	556	563	PF00069	0.535
MOD_GSK3_1	61	68	PF00069	0.691
MOD_GSK3_1	735	742	PF00069	0.633
MOD_GSK3_1	783	790	PF00069	0.412
MOD_GSK3_1	808	815	PF00069	0.598
MOD_GSK3_1	824	831	PF00069	0.745
MOD_GSK3_1	858	865	PF00069	0.796
MOD_N-GLC_1	494	499	PF02516	0.678
MOD_N-GLC_2	526	528	PF02516	0.546
MOD_N-GLC_2	590	592	PF02516	0.475
MOD_NEK2_1	112	117	PF00069	0.484
MOD_NEK2_1	203	208	PF00069	0.503
MOD_NEK2_1	381	386	PF00069	0.502
MOD_NEK2_1	429	434	PF00069	0.470
MOD_NEK2_1	458	463	PF00069	0.467
MOD_NEK2_1	502	507	PF00069	0.515
MOD_NEK2_1	66	71	PF00069	0.693
MOD_NEK2_1	730	735	PF00069	0.534
MOD_NEK2_1	745	750	PF00069	0.311
MOD_NEK2_1	765	770	PF00069	0.309
MOD_NEK2_1	787	792	PF00069	0.529
MOD_NEK2_1	908	913	PF00069	0.520
MOD_NEK2_2	222	227	PF00069	0.468
MOD_NEK2_2	362	367	PF00069	0.396
MOD_PIKK_1	184	190	PF00454	0.518
MOD_PIKK_1	458	464	PF00454	0.488
MOD_PIKK_1	529	535	PF00454	0.503
MOD_PIKK_1	549	555	PF00454	0.436
MOD_PKA_1	42	48	PF00069	0.678
MOD_PKA_1	808	814	PF00069	0.654
MOD_PKA_2	26	32	PF00069	0.724
MOD_PKA_2	362	368	PF00069	0.520
MOD_PKA_2	42	48	PF00069	0.533
MOD_PKA_2	497	503	PF00069	0.566
MOD_PKA_2	567	573	PF00069	0.259
MOD_PKA_2	646	652	PF00069	0.391
MOD_PKA_2	76	82	PF00069	0.572
MOD_PKA_2	808	814	PF00069	0.654
MOD_PKB_1	808	816	PF00069	0.624
MOD_Plk_1	112	118	PF00069	0.467
MOD_Plk_1	297	303	PF00069	0.543
MOD_Plk_1	407	413	PF00069	0.460
MOD_Plk_1	476	482	PF00069	0.676
MOD_Plk_1	908	914	PF00069	0.434
MOD_Plk_4	190	196	PF00069	0.476
MOD_Plk_4	259	265	PF00069	0.704
MOD_Plk_4	498	504	PF00069	0.494
MOD_Plk_4	556	562	PF00069	0.504
MOD_Plk_4	654	660	PF00069	0.359
MOD_Plk_4	730	736	PF00069	0.544
MOD_Plk_4	908	914	PF00069	0.529
MOD_ProDKin_1	164	170	PF00069	0.649
MOD_ProDKin_1	176	182	PF00069	0.674
MOD_ProDKin_1	34	40	PF00069	0.831
MOD_ProDKin_1	412	418	PF00069	0.525
MOD_ProDKin_1	481	487	PF00069	0.668
MOD_ProDKin_1	537	543	PF00069	0.573
MOD_ProDKin_1	716	722	PF00069	0.488
MOD_ProDKin_1	760	766	PF00069	0.318
MOD_ProDKin_1	78	84	PF00069	0.627
MOD_ProDKin_1	875	881	PF00069	0.687
MOD_ProDKin_1	892	898	PF00069	0.504
MOD_SUMO_for_1	561	564	PF00179	0.356
MOD_SUMO_rev_2	224	233	PF00179	0.342
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.495
TRG_DiLeu_BaLyEn_6	842	847	PF01217	0.433
TRG_DiLeu_BaLyEn_6	883	888	PF01217	0.459
TRG_ENDOCYTIC_2	117	120	PF00928	0.425
TRG_ENDOCYTIC_2	503	506	PF00928	0.517
TRG_ENDOCYTIC_2	620	623	PF00928	0.462
TRG_ER_diArg_1	326	328	PF00400	0.488
TRG_ER_diArg_1	40	43	PF00400	0.676
TRG_ER_diArg_1	456	458	PF00400	0.495
TRG_ER_diArg_1	509	512	PF00400	0.440
TRG_ER_diArg_1	746	749	PF00400	0.517
TRG_ER_diArg_1	76	78	PF00400	0.688
TRG_ER_diArg_1	807	810	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B5	Leptomonas seymouri	45%	100%
A0A0S4IN68	Bodo saltans	26%	100%
A0A1X0NUD8	Trypanosomatidae	28%	100%
A0A3S7X5I2	Leishmania donovani	100%	100%
A0A422NLC9	Trypanosoma rangeli	29%	100%
A4HKE3	Leishmania braziliensis	70%	100%
E9B2T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q5C5	Leishmania major	92%	100%
V5BP08	Trypanosoma cruzi	30%	100%