Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I7X0_LEIIN

TriTrypDb:

LINF_320021300

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I7X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7X0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.491
CLV_NRD_NRD_1	200	202	PF00675	0.543
CLV_NRD_NRD_1	221	223	PF00675	0.413
CLV_NRD_NRD_1	385	387	PF00675	0.701
CLV_NRD_NRD_1	69	71	PF00675	0.603
CLV_NRD_NRD_1	88	90	PF00675	0.404
CLV_PCSK_FUR_1	198	202	PF00082	0.441
CLV_PCSK_FUR_1	219	223	PF00082	0.418
CLV_PCSK_KEX2_1	131	133	PF00082	0.723
CLV_PCSK_KEX2_1	198	200	PF00082	0.670
CLV_PCSK_KEX2_1	216	218	PF00082	0.303
CLV_PCSK_KEX2_1	221	223	PF00082	0.413
CLV_PCSK_KEX2_1	385	387	PF00082	0.704
CLV_PCSK_KEX2_1	69	71	PF00082	0.603
CLV_PCSK_KEX2_1	88	90	PF00082	0.404
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.723
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.429
CLV_PCSK_PC7_1	217	223	PF00082	0.424
CLV_PCSK_SKI1_1	160	164	PF00082	0.699
CLV_PCSK_SKI1_1	221	225	PF00082	0.399
CLV_PCSK_SKI1_1	287	291	PF00082	0.511
CLV_PCSK_SKI1_1	306	310	PF00082	0.196
CLV_PCSK_SKI1_1	354	358	PF00082	0.453
CLV_PCSK_SKI1_1	74	78	PF00082	0.574
DEG_APCC_DBOX_1	146	154	PF00400	0.634
DEG_APCC_DBOX_1	220	228	PF00400	0.536
DEG_APCC_DBOX_1	73	81	PF00400	0.521
DOC_MAPK_DCC_7	219	229	PF00069	0.531
DOC_MAPK_gen_1	219	229	PF00069	0.499
DOC_MAPK_gen_1	385	392	PF00069	0.566
DOC_MAPK_GRA24_9	213	229	PF00069	0.525
DOC_PP1_RVXF_1	334	340	PF00149	0.335
DOC_PP1_RVXF_1	387	393	PF00149	0.634
DOC_PP4_FxxP_1	223	226	PF00568	0.516
DOC_USP7_MATH_1	130	134	PF00917	0.742
DOC_USP7_MATH_1	146	150	PF00917	0.551
DOC_USP7_MATH_1	180	184	PF00917	0.661
DOC_USP7_MATH_1	47	51	PF00917	0.746
DOC_USP7_MATH_2	3	9	PF00917	0.601
DOC_WW_Pin1_4	122	127	PF00397	0.662
DOC_WW_Pin1_4	154	159	PF00397	0.656
DOC_WW_Pin1_4	161	166	PF00397	0.745
DOC_WW_Pin1_4	175	180	PF00397	0.640
DOC_WW_Pin1_4	222	227	PF00397	0.529
DOC_WW_Pin1_4	38	43	PF00397	0.622
LIG_14-3-3_CanoR_1	147	151	PF00244	0.723
LIG_14-3-3_CanoR_1	177	187	PF00244	0.683
LIG_14-3-3_CanoR_1	201	210	PF00244	0.450
LIG_14-3-3_CanoR_1	287	294	PF00244	0.335
LIG_14-3-3_CanoR_1	306	315	PF00244	0.335
LIG_14-3-3_CanoR_1	318	324	PF00244	0.291
LIG_14-3-3_CanoR_1	69	78	PF00244	0.530
LIG_Actin_WH2_1	147	162	PF00022	0.548
LIG_Actin_WH2_2	144	162	PF00022	0.548
LIG_BRCT_BRCA1_1	337	341	PF00533	0.335
LIG_FHA_1	162	168	PF00498	0.551
LIG_FHA_1	85	91	PF00498	0.511
LIG_FHA_2	209	215	PF00498	0.490
LIG_FHA_2	288	294	PF00498	0.387
LIG_FHA_2	309	315	PF00498	0.313
LIG_FHA_2	80	86	PF00498	0.542
LIG_GBD_Chelix_1	315	323	PF00786	0.313
LIG_HP1_1	146	150	PF01393	0.634
LIG_LIR_Gen_1	205	215	PF02991	0.442
LIG_LIR_LC3C_4	244	249	PF02991	0.480
LIG_LIR_Nem_3	348	352	PF02991	0.340
LIG_LIR_Nem_3	355	360	PF02991	0.362
LIG_MLH1_MIPbox_1	337	341	PF16413	0.335
LIG_PCNA_yPIPBox_3	350	360	PF02747	0.313
LIG_PCNA_yPIPBox_3	88	102	PF02747	0.544
LIG_SH2_PTP2	234	237	PF00017	0.487
LIG_SH2_SRC	234	237	PF00017	0.487
LIG_SH2_STAT3	78	81	PF00017	0.601
LIG_SH2_STAT5	16	19	PF00017	0.517
LIG_SH2_STAT5	234	237	PF00017	0.487
LIG_SH2_STAT5	78	81	PF00017	0.552
LIG_SH3_3	232	238	PF00018	0.494
LIG_SH3_3	270	276	PF00018	0.590
LIG_SH3_3	53	59	PF00018	0.669
LIG_SUMO_SIM_par_1	2	9	PF11976	0.567
LIG_TRAF2_1	290	293	PF00917	0.389
LIG_ULM_U2AF65_1	198	203	PF00076	0.431
MOD_CDC14_SPxK_1	157	160	PF00782	0.713
MOD_CDK_SPxK_1	154	160	PF00069	0.716
MOD_CK1_1	103	109	PF00069	0.548
MOD_CK1_1	225	231	PF00069	0.529
MOD_CK1_1	33	39	PF00069	0.672
MOD_CK2_1	118	124	PF00069	0.731
MOD_CK2_1	208	214	PF00069	0.495
MOD_CK2_1	278	284	PF00069	0.438
MOD_CK2_1	287	293	PF00069	0.367
MOD_CK2_1	79	85	PF00069	0.467
MOD_GlcNHglycan	108	111	PF01048	0.700
MOD_GlcNHglycan	180	183	PF01048	0.694
MOD_GlcNHglycan	32	35	PF01048	0.688
MOD_GlcNHglycan	342	345	PF01048	0.412
MOD_GlcNHglycan	398	401	PF01048	0.627
MOD_GlcNHglycan	45	48	PF01048	0.570
MOD_GlcNHglycan	49	52	PF01048	0.556
MOD_GSK3_1	105	112	PF00069	0.599
MOD_GSK3_1	114	121	PF00069	0.702
MOD_GSK3_1	163	170	PF00069	0.700
MOD_GSK3_1	178	185	PF00069	0.537
MOD_GSK3_1	36	43	PF00069	0.636
MOD_NEK2_1	307	312	PF00069	0.453
MOD_NEK2_1	366	371	PF00069	0.556
MOD_NEK2_1	394	399	PF00069	0.662
MOD_NEK2_1	79	84	PF00069	0.534
MOD_NEK2_2	308	313	PF00069	0.313
MOD_PIKK_1	182	188	PF00454	0.672
MOD_PIKK_1	202	208	PF00454	0.496
MOD_PIKK_1	59	65	PF00454	0.701
MOD_PIKK_1	91	97	PF00454	0.573
MOD_PKA_1	69	75	PF00069	0.548
MOD_PKA_2	103	109	PF00069	0.538
MOD_PKA_2	146	152	PF00069	0.667
MOD_PKA_2	172	178	PF00069	0.730
MOD_PKA_2	187	193	PF00069	0.525
MOD_PKA_2	69	75	PF00069	0.548
MOD_Plk_2-3	300	306	PF00069	0.313
MOD_Plk_4	146	152	PF00069	0.667
MOD_Plk_4	278	284	PF00069	0.454
MOD_Plk_4	79	85	PF00069	0.595
MOD_Plk_4	97	103	PF00069	0.351
MOD_ProDKin_1	122	128	PF00069	0.662
MOD_ProDKin_1	154	160	PF00069	0.658
MOD_ProDKin_1	161	167	PF00069	0.747
MOD_ProDKin_1	175	181	PF00069	0.641
MOD_ProDKin_1	222	228	PF00069	0.531
MOD_ProDKin_1	38	44	PF00069	0.622
TRG_DiLeu_BaEn_4	292	298	PF01217	0.389
TRG_ENDOCYTIC_2	16	19	PF00928	0.517
TRG_ENDOCYTIC_2	234	237	PF00928	0.369
TRG_ER_diArg_1	197	200	PF00400	0.505
TRG_ER_diArg_1	217	220	PF00400	0.523
TRG_ER_diArg_1	221	223	PF00400	0.413
TRG_ER_diArg_1	389	392	PF00400	0.637
TRG_ER_diArg_1	68	70	PF00400	0.622
TRG_ER_diArg_1	88	90	PF00400	0.396
TRG_NES_CRM1_1	314	329	PF08389	0.389
TRG_NLS_Bipartite_1	198	220	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	350	355	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P982	Leptomonas seymouri	48%	93%
A0A3S7X5G4	Leishmania donovani	100%	100%
A4HKE2	Leishmania braziliensis	70%	100%
E9B2T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q5C6	Leishmania major	93%	100%