Proteophosphoglycan ppg4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7W8_LEIIN

TriTrypDb:

LINF_320021000

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4I7W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.420
CLV_C14_Caspase3-7	422	426	PF00656	0.434
CLV_NRD_NRD_1	213	215	PF00675	0.691
CLV_NRD_NRD_1	36	38	PF00675	0.471
CLV_NRD_NRD_1	441	443	PF00675	0.695
CLV_NRD_NRD_1	45	47	PF00675	0.462
CLV_NRD_NRD_1	81	83	PF00675	0.503
CLV_PCSK_FUR_1	439	443	PF00082	0.600
CLV_PCSK_FUR_1	79	83	PF00082	0.512
CLV_PCSK_KEX2_1	118	120	PF00082	0.735
CLV_PCSK_KEX2_1	281	283	PF00082	0.677
CLV_PCSK_KEX2_1	36	38	PF00082	0.471
CLV_PCSK_KEX2_1	441	443	PF00082	0.736
CLV_PCSK_KEX2_1	45	47	PF00082	0.462
CLV_PCSK_KEX2_1	490	492	PF00082	0.523
CLV_PCSK_KEX2_1	81	83	PF00082	0.503
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.709
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.645
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.523
CLV_PCSK_SKI1_1	10	14	PF00082	0.419
CLV_PCSK_SKI1_1	119	123	PF00082	0.708
CLV_PCSK_SKI1_1	146	150	PF00082	0.628
CLV_PCSK_SKI1_1	179	183	PF00082	0.623
CLV_PCSK_SKI1_1	288	292	PF00082	0.655
CLV_PCSK_SKI1_1	319	323	PF00082	0.686
CLV_PCSK_SKI1_1	404	408	PF00082	0.605
CLV_PCSK_SKI1_1	441	445	PF00082	0.642
CLV_PCSK_SKI1_1	563	567	PF00082	0.667
CLV_PCSK_SKI1_1	64	68	PF00082	0.408
DEG_APCC_DBOX_1	143	151	PF00400	0.437
DOC_CDC14_PxL_1	415	423	PF14671	0.409
DOC_CYCLIN_RxL_1	401	411	PF00134	0.353
DOC_CYCLIN_RxL_1	438	448	PF00134	0.438
DOC_MAPK_gen_1	146	156	PF00069	0.472
DOC_MAPK_gen_1	214	220	PF00069	0.420
DOC_PP2B_LxvP_1	112	115	PF13499	0.512
DOC_PP2B_LxvP_1	356	359	PF13499	0.487
DOC_PP2B_PxIxI_1	518	524	PF00149	0.447
DOC_USP7_MATH_1	27	31	PF00917	0.632
DOC_USP7_MATH_1	306	310	PF00917	0.490
DOC_USP7_MATH_1	393	397	PF00917	0.406
DOC_USP7_MATH_1	47	51	PF00917	0.635
DOC_USP7_MATH_1	486	490	PF00917	0.423
DOC_USP7_MATH_1	549	553	PF00917	0.534
DOC_WW_Pin1_4	16	21	PF00397	0.655
DOC_WW_Pin1_4	459	464	PF00397	0.395
DOC_WW_Pin1_4	470	475	PF00397	0.440
DOC_WW_Pin1_4	541	546	PF00397	0.508
LIG_14-3-3_CanoR_1	319	328	PF00244	0.463
LIG_14-3-3_CanoR_1	360	364	PF00244	0.482
LIG_14-3-3_CanoR_1	377	381	PF00244	0.300
LIG_14-3-3_CanoR_1	391	401	PF00244	0.398
LIG_14-3-3_CanoR_1	46	52	PF00244	0.636
LIG_14-3-3_CanoR_1	580	587	PF00244	0.456
LIG_Actin_WH2_2	181	196	PF00022	0.397
LIG_Actin_WH2_2	375	393	PF00022	0.420
LIG_BRCT_BRCA1_1	395	399	PF00533	0.383
LIG_Clathr_ClatBox_1	499	503	PF01394	0.351
LIG_CSL_BTD_1	348	351	PF09270	0.456
LIG_deltaCOP1_diTrp_1	453	461	PF00928	0.374
LIG_FHA_1	193	199	PF00498	0.499
LIG_FHA_1	227	233	PF00498	0.446
LIG_FHA_1	236	242	PF00498	0.378
LIG_FHA_1	518	524	PF00498	0.507
LIG_FHA_1	63	69	PF00498	0.608
LIG_FHA_2	289	295	PF00498	0.372
LIG_FHA_2	338	344	PF00498	0.453
LIG_FHA_2	393	399	PF00498	0.421
LIG_KLC1_Yacidic_2	59	63	PF13176	0.618
LIG_LIR_Apic_2	346	352	PF02991	0.438
LIG_LIR_Gen_1	239	250	PF02991	0.456
LIG_LIR_Gen_1	365	376	PF02991	0.495
LIG_LIR_Gen_1	379	388	PF02991	0.302
LIG_LIR_Gen_1	414	421	PF02991	0.391
LIG_LIR_Gen_1	579	587	PF02991	0.499
LIG_LIR_Gen_1	87	97	PF02991	0.512
LIG_LIR_Nem_3	239	245	PF02991	0.450
LIG_LIR_Nem_3	365	371	PF02991	0.471
LIG_LIR_Nem_3	379	383	PF02991	0.321
LIG_LIR_Nem_3	414	418	PF02991	0.378
LIG_LIR_Nem_3	453	459	PF02991	0.387
LIG_LIR_Nem_3	579	584	PF02991	0.502
LIG_LIR_Nem_3	87	92	PF02991	0.629
LIG_MYND_1	157	161	PF01753	0.460
LIG_NRBOX	402	408	PF00104	0.404
LIG_NRBOX	439	445	PF00104	0.386
LIG_PCNA_yPIPBox_3	404	416	PF02747	0.405
LIG_Pex14_1	174	178	PF04695	0.450
LIG_Pex14_1	455	459	PF04695	0.383
LIG_Pex14_2	493	497	PF04695	0.316
LIG_SH2_CRK	178	182	PF00017	0.452
LIG_SH2_CRK	368	372	PF00017	0.461
LIG_SH2_CRK	380	384	PF00017	0.353
LIG_SH2_CRK	89	93	PF00017	0.492
LIG_SH2_STAP1	285	289	PF00017	0.455
LIG_SH2_STAP1	368	372	PF00017	0.456
LIG_SH2_STAP1	452	456	PF00017	0.379
LIG_SH2_STAP1	89	93	PF00017	0.512
LIG_SH2_STAT5	158	161	PF00017	0.453
LIG_SH2_STAT5	227	230	PF00017	0.425
LIG_SH2_STAT5	240	243	PF00017	0.340
LIG_SH2_STAT5	355	358	PF00017	0.462
LIG_SH2_STAT5	54	57	PF00017	0.667
LIG_SH2_STAT5	61	64	PF00017	0.631
LIG_SH3_1	264	270	PF00018	0.461
LIG_SH3_3	264	270	PF00018	0.577
LIG_SH3_3	345	351	PF00018	0.529
LIG_Sin3_3	90	97	PF02671	0.468
LIG_SUMO_SIM_par_1	216	223	PF11976	0.451
LIG_SUMO_SIM_par_1	519	525	PF11976	0.488
LIG_TRAF2_1	372	375	PF00917	0.435
LIG_TRAF2_1	571	574	PF00917	0.418
LIG_TYR_ITIM	176	181	PF00017	0.410
LIG_TYR_ITIM	378	383	PF00017	0.402
LIG_UBA3_1	484	490	PF00899	0.380
LIG_WRC_WIRS_1	412	417	PF05994	0.388
MOD_CK1_1	207	213	PF00069	0.483
MOD_CK1_1	362	368	PF00069	0.480
MOD_CK1_1	540	546	PF00069	0.513
MOD_CK2_1	288	294	PF00069	0.371
MOD_CK2_1	337	343	PF00069	0.488
MOD_CK2_1	392	398	PF00069	0.437
MOD_CK2_1	573	579	PF00069	0.486
MOD_GlcNHglycan	206	209	PF01048	0.718
MOD_GlcNHglycan	246	249	PF01048	0.750
MOD_GlcNHglycan	38	41	PF01048	0.507
MOD_GlcNHglycan	395	398	PF01048	0.644
MOD_GlcNHglycan	49	52	PF01048	0.420
MOD_GlcNHglycan	526	529	PF01048	0.704
MOD_GlcNHglycan	538	542	PF01048	0.697
MOD_GSK3_1	134	141	PF00069	0.518
MOD_GSK3_1	193	200	PF00069	0.508
MOD_GSK3_1	236	243	PF00069	0.468
MOD_GSK3_1	313	320	PF00069	0.625
MOD_GSK3_1	330	337	PF00069	0.526
MOD_GSK3_1	359	366	PF00069	0.468
MOD_GSK3_1	537	544	PF00069	0.521
MOD_GSK3_1	545	552	PF00069	0.511
MOD_GSK3_1	62	69	PF00069	0.617
MOD_N-GLC_1	198	203	PF02516	0.690
MOD_N-GLC_1	363	368	PF02516	0.708
MOD_NEK2_1	134	139	PF00069	0.551
MOD_NEK2_1	177	182	PF00069	0.413
MOD_NEK2_1	193	198	PF00069	0.382
MOD_NEK2_1	363	368	PF00069	0.532
MOD_NEK2_1	376	381	PF00069	0.334
MOD_NEK2_1	77	82	PF00069	0.734
MOD_PIKK_1	306	312	PF00454	0.514
MOD_PIKK_1	335	341	PF00454	0.514
MOD_PIKK_1	343	349	PF00454	0.529
MOD_PKA_1	36	42	PF00069	0.636
MOD_PKA_2	359	365	PF00069	0.469
MOD_PKA_2	36	42	PF00069	0.656
MOD_PKA_2	376	382	PF00069	0.294
MOD_PKA_2	393	399	PF00069	0.357
MOD_PKA_2	579	585	PF00069	0.489
MOD_Plk_1	27	33	PF00069	0.631
MOD_Plk_1	363	369	PF00069	0.521
MOD_Plk_4	200	206	PF00069	0.476
MOD_Plk_4	236	242	PF00069	0.443
MOD_Plk_4	363	369	PF00069	0.474
MOD_Plk_4	411	417	PF00069	0.397
MOD_ProDKin_1	16	22	PF00069	0.657
MOD_ProDKin_1	459	465	PF00069	0.395
MOD_ProDKin_1	470	476	PF00069	0.436
MOD_ProDKin_1	541	547	PF00069	0.508
MOD_SUMO_for_1	84	87	PF00179	0.670
TRG_DiLeu_BaLyEn_6	439	444	PF01217	0.432
TRG_ENDOCYTIC_2	178	181	PF00928	0.472
TRG_ENDOCYTIC_2	355	358	PF00928	0.462
TRG_ENDOCYTIC_2	368	371	PF00928	0.432
TRG_ENDOCYTIC_2	380	383	PF00928	0.306
TRG_ENDOCYTIC_2	89	92	PF00928	0.666
TRG_ER_diArg_1	144	147	PF00400	0.436
TRG_ER_diArg_1	150	153	PF00400	0.420
TRG_ER_diArg_1	439	442	PF00400	0.500
TRG_ER_diArg_1	45	47	PF00400	0.655
TRG_ER_diArg_1	78	81	PF00400	0.723
TRG_Pf-PMV_PEXEL_1	179	184	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	404	409	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	441	446	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5J8	Leishmania donovani	99%	100%
A4HKE0	Leishmania braziliensis	50%	100%
E9B2S8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q5C9	Leishmania major	82%	100%