LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I7W1_LEIIN
TriTrypDb:
LINF_320020100
Length:
147

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7W1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7W1

PDB structure(s): 7aih_BC , 7ane_BC

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 51 53 PF00675 0.415
CLV_PCSK_KEX2_1 51 53 PF00082 0.390
CLV_PCSK_KEX2_1 7 9 PF00082 0.381
CLV_PCSK_PC1ET2_1 7 9 PF00082 0.430
CLV_PCSK_PC7_1 47 53 PF00082 0.389
CLV_Separin_Metazoa 44 48 PF03568 0.437
DEG_Nend_UBRbox_3 1 3 PF02207 0.392
DOC_MAPK_gen_1 33 40 PF00069 0.514
DOC_MAPK_gen_1 51 58 PF00069 0.410
DOC_MAPK_MEF2A_6 33 40 PF00069 0.514
DOC_MAPK_MEF2A_6 51 58 PF00069 0.410
DOC_MAPK_NFAT4_5 33 41 PF00069 0.510
DOC_MAPK_NFAT4_5 51 59 PF00069 0.411
DOC_MAPK_RevD_3 36 52 PF00069 0.449
DOC_USP7_MATH_1 115 119 PF00917 0.470
DOC_WW_Pin1_4 90 95 PF00397 0.393
LIG_14-3-3_CanoR_1 8 18 PF00244 0.460
LIG_FHA_1 115 121 PF00498 0.518
LIG_FHA_1 94 100 PF00498 0.459
LIG_Integrin_isoDGR_2 49 51 PF01839 0.407
LIG_LIR_Gen_1 12 19 PF02991 0.390
LIG_LIR_Nem_3 12 18 PF02991 0.388
LIG_PCNA_PIPBox_1 119 128 PF02747 0.431
LIG_RPA_C_Fungi 80 92 PF08784 0.359
LIG_SH2_STAP1 5 9 PF00017 0.368
MOD_CK1_1 21 27 PF00069 0.504
MOD_CK2_1 130 136 PF00069 0.463
MOD_Cter_Amidation 49 52 PF01082 0.394
MOD_GlcNHglycan 82 85 PF01048 0.402
MOD_GSK3_1 107 114 PF00069 0.469
MOD_N-GLC_1 66 71 PF02516 0.521
MOD_NEK2_1 105 110 PF00069 0.447
MOD_NEK2_1 18 23 PF00069 0.493
MOD_NEK2_1 66 71 PF00069 0.414
MOD_NEK2_1 9 14 PF00069 0.500
MOD_PIKK_1 107 113 PF00454 0.543
MOD_PIKK_1 115 121 PF00454 0.463
MOD_PIKK_1 26 32 PF00454 0.377
MOD_PIKK_1 93 99 PF00454 0.408
MOD_Plk_1 66 72 PF00069 0.513
MOD_Plk_2-3 130 136 PF00069 0.559
MOD_Plk_4 21 27 PF00069 0.372
MOD_ProDKin_1 90 96 PF00069 0.396
MOD_SUMO_for_1 41 44 PF00179 0.507
TRG_DiLeu_BaLyEn_6 52 57 PF01217 0.396

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I494 Leptomonas seymouri 83% 100%
A0A0S4J787 Bodo saltans 67% 100%
A0A1X0NUE5 Trypanosomatidae 77% 100%
A0A3Q8IGY2 Leishmania donovani 99% 100%
A0A3S5IR91 Trypanosoma rangeli 73% 100%
A4HKD1 Leishmania braziliensis 89% 100%
D0AA24 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 72% 100%
E9B2R9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q5D8 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS