Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7V6_LEIIN

TriTrypDb:

LINF_320019600

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7V6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.602
CLV_NRD_NRD_1	382	384	PF00675	0.436
CLV_NRD_NRD_1	53	55	PF00675	0.744
CLV_NRD_NRD_1	676	678	PF00675	0.763
CLV_PCSK_KEX2_1	160	162	PF00082	0.602
CLV_PCSK_KEX2_1	314	316	PF00082	0.412
CLV_PCSK_KEX2_1	52	54	PF00082	0.749
CLV_PCSK_KEX2_1	676	678	PF00082	0.814
CLV_PCSK_KEX2_1	8	10	PF00082	0.672
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.412
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.672
CLV_PCSK_PC7_1	49	55	PF00082	0.589
CLV_PCSK_SKI1_1	210	214	PF00082	0.436
CLV_PCSK_SKI1_1	272	276	PF00082	0.543
CLV_PCSK_SKI1_1	310	314	PF00082	0.472
CLV_PCSK_SKI1_1	351	355	PF00082	0.620
CLV_PCSK_SKI1_1	400	404	PF00082	0.509
CLV_PCSK_SKI1_1	508	512	PF00082	0.462
CLV_PCSK_SKI1_1	74	78	PF00082	0.465
CLV_PCSK_SKI1_1	9	13	PF00082	0.576
DEG_APCC_DBOX_1	159	167	PF00400	0.581
DEG_APCC_DBOX_1	73	81	PF00400	0.451
DEG_MDM2_SWIB_1	276	283	PF02201	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DOC_ANK_TNKS_1	51	58	PF00023	0.776
DOC_CKS1_1	354	359	PF01111	0.623
DOC_CKS1_1	401	406	PF01111	0.463
DOC_CYCLIN_RxL_1	204	217	PF00134	0.447
DOC_CYCLIN_RxL_1	381	392	PF00134	0.510
DOC_MAPK_gen_1	666	675	PF00069	0.775
DOC_PP1_RVXF_1	280	286	PF00149	0.543
DOC_PP2B_LxvP_1	386	389	PF13499	0.522
DOC_PP2B_LxvP_1	418	421	PF13499	0.576
DOC_PP4_FxxP_1	646	649	PF00568	0.774
DOC_USP7_MATH_1	101	105	PF00917	0.748
DOC_USP7_MATH_1	108	112	PF00917	0.749
DOC_USP7_MATH_1	11	15	PF00917	0.583
DOC_USP7_MATH_1	122	126	PF00917	0.754
DOC_USP7_MATH_1	244	248	PF00917	0.457
DOC_USP7_MATH_1	332	336	PF00917	0.449
DOC_USP7_MATH_1	389	393	PF00917	0.571
DOC_USP7_MATH_1	438	442	PF00917	0.649
DOC_USP7_MATH_1	549	553	PF00917	0.525
DOC_USP7_MATH_1	564	568	PF00917	0.410
DOC_USP7_MATH_1	712	716	PF00917	0.758
DOC_USP7_MATH_1	741	745	PF00917	0.795
DOC_USP7_UBL2_3	268	272	PF12436	0.591
DOC_USP7_UBL2_3	310	314	PF12436	0.419
DOC_WW_Pin1_4	115	120	PF00397	0.805
DOC_WW_Pin1_4	18	23	PF00397	0.644
DOC_WW_Pin1_4	353	358	PF00397	0.637
DOC_WW_Pin1_4	360	365	PF00397	0.604
DOC_WW_Pin1_4	400	405	PF00397	0.494
DOC_WW_Pin1_4	436	441	PF00397	0.738
DOC_WW_Pin1_4	707	712	PF00397	0.678
LIG_14-3-3_CanoR_1	315	324	PF00244	0.441
LIG_14-3-3_CanoR_1	340	349	PF00244	0.391
LIG_14-3-3_CanoR_1	383	387	PF00244	0.520
LIG_14-3-3_CanoR_1	414	421	PF00244	0.494
LIG_14-3-3_CanoR_1	516	520	PF00244	0.497
LIG_14-3-3_CanoR_1	659	667	PF00244	0.646
LIG_14-3-3_CanoR_1	676	684	PF00244	0.802
LIG_14-3-3_CanoR_1	9	18	PF00244	0.626
LIG_Actin_WH2_2	401	416	PF00022	0.336
LIG_BIR_III_2	437	441	PF00653	0.621
LIG_BRCT_BRCA1_1	482	486	PF00533	0.415
LIG_BRCT_BRCA1_1	663	667	PF00533	0.637
LIG_BRCT_BRCA1_2	663	669	PF00533	0.598
LIG_CtBP_PxDLS_1	364	368	PF00389	0.532
LIG_EH1_1	205	213	PF00400	0.491
LIG_eIF4E_1	307	313	PF01652	0.457
LIG_FHA_1	10	16	PF00498	0.544
LIG_FHA_1	124	130	PF00498	0.750
LIG_FHA_1	165	171	PF00498	0.410
LIG_FHA_1	203	209	PF00498	0.528
LIG_FHA_1	222	228	PF00498	0.284
LIG_FHA_1	397	403	PF00498	0.580
LIG_FHA_1	414	420	PF00498	0.416
LIG_FHA_1	45	51	PF00498	0.554
LIG_FHA_1	540	546	PF00498	0.490
LIG_FHA_1	636	642	PF00498	0.669
LIG_FHA_2	116	122	PF00498	0.773
LIG_FHA_2	420	426	PF00498	0.558
LIG_FHA_2	731	737	PF00498	0.746
LIG_Integrin_RGD_1	54	56	PF01839	0.605
LIG_LIR_Apic_2	399	404	PF02991	0.417
LIG_LIR_Apic_2	644	649	PF02991	0.770
LIG_LIR_Gen_1	277	286	PF02991	0.478
LIG_LIR_Gen_1	463	473	PF02991	0.401
LIG_LIR_Gen_1	671	679	PF02991	0.717
LIG_LIR_Gen_1	718	727	PF02991	0.667
LIG_LIR_Nem_3	111	115	PF02991	0.721
LIG_LIR_Nem_3	277	283	PF02991	0.486
LIG_LIR_Nem_3	463	468	PF02991	0.398
LIG_LIR_Nem_3	483	489	PF02991	0.458
LIG_LIR_Nem_3	531	537	PF02991	0.431
LIG_LIR_Nem_3	671	675	PF02991	0.731
LIG_LIR_Nem_3	715	719	PF02991	0.637
LIG_LIR_Nem_3	85	91	PF02991	0.484
LIG_MLH1_MIPbox_1	482	486	PF16413	0.413
LIG_NRBOX	165	171	PF00104	0.412
LIG_NRBOX	86	92	PF00104	0.502
LIG_PCNA_APIM_2	533	539	PF02747	0.461
LIG_Pex14_2	216	220	PF04695	0.522
LIG_Pex14_2	276	280	PF04695	0.429
LIG_Pex14_2	663	667	PF04695	0.600
LIG_PTB_Apo_2	718	725	PF02174	0.657
LIG_Rb_LxCxE_1	339	358	PF01857	0.555
LIG_REV1ctd_RIR_1	306	314	PF16727	0.410
LIG_SH2_NCK_1	395	399	PF00017	0.582
LIG_SH2_PTP2	401	404	PF00017	0.492
LIG_SH2_PTP2	672	675	PF00017	0.718
LIG_SH2_SRC	292	295	PF00017	0.457
LIG_SH2_SRC	38	41	PF00017	0.521
LIG_SH2_STAP1	317	321	PF00017	0.508
LIG_SH2_STAT5	292	295	PF00017	0.408
LIG_SH2_STAT5	305	308	PF00017	0.402
LIG_SH2_STAT5	337	340	PF00017	0.469
LIG_SH2_STAT5	38	41	PF00017	0.527
LIG_SH2_STAT5	401	404	PF00017	0.492
LIG_SH2_STAT5	536	539	PF00017	0.468
LIG_SH2_STAT5	672	675	PF00017	0.664
LIG_SH2_STAT5	79	82	PF00017	0.497
LIG_SH3_3	681	687	PF00018	0.811
LIG_SH3_4	268	275	PF00018	0.477
LIG_Sin3_3	147	154	PF02671	0.638
LIG_SUMO_SIM_anti_2	403	409	PF11976	0.506
LIG_SUMO_SIM_par_1	125	132	PF11976	0.619
LIG_SUMO_SIM_par_1	293	299	PF11976	0.464
LIG_SUMO_SIM_par_1	690	696	PF11976	0.670
LIG_TRAF2_1	154	157	PF00917	0.553
LIG_TRAF2_1	422	425	PF00917	0.629
LIG_TRAF2_1	605	608	PF00917	0.595
LIG_TRFH_1	452	456	PF08558	0.605
LIG_UBA3_1	378	384	PF00899	0.466
LIG_UBA3_1	87	94	PF00899	0.513
LIG_WRC_WIRS_1	169	174	PF05994	0.420
LIG_WRC_WIRS_1	716	721	PF05994	0.657
MOD_CK1_1	111	117	PF00069	0.788
MOD_CK1_1	202	208	PF00069	0.419
MOD_CK1_1	21	27	PF00069	0.615
MOD_CK1_1	259	265	PF00069	0.533
MOD_CK1_1	41	47	PF00069	0.564
MOD_CK1_1	441	447	PF00069	0.632
MOD_CK1_1	567	573	PF00069	0.382
MOD_CK1_1	655	661	PF00069	0.705
MOD_CK1_1	665	671	PF00069	0.679
MOD_CK1_1	715	721	PF00069	0.656
MOD_CK2_1	11	17	PF00069	0.628
MOD_CK2_1	115	121	PF00069	0.778
MOD_CK2_1	340	346	PF00069	0.476
MOD_CK2_1	419	425	PF00069	0.542
MOD_CK2_1	92	98	PF00069	0.546
MOD_GlcNHglycan	145	148	PF01048	0.758
MOD_GlcNHglycan	258	261	PF01048	0.502
MOD_GlcNHglycan	319	322	PF01048	0.431
MOD_GlcNHglycan	351	354	PF01048	0.607
MOD_GlcNHglycan	434	437	PF01048	0.706
MOD_GlcNHglycan	443	446	PF01048	0.601
MOD_GlcNHglycan	482	485	PF01048	0.473
MOD_GlcNHglycan	524	527	PF01048	0.561
MOD_GlcNHglycan	677	680	PF01048	0.623
MOD_GlcNHglycan	70	73	PF01048	0.566
MOD_GlcNHglycan	727	730	PF01048	0.798
MOD_GSK3_1	111	118	PF00069	0.783
MOD_GSK3_1	164	171	PF00069	0.475
MOD_GSK3_1	174	181	PF00069	0.459
MOD_GSK3_1	192	199	PF00069	0.304
MOD_GSK3_1	227	234	PF00069	0.561
MOD_GSK3_1	270	277	PF00069	0.454
MOD_GSK3_1	349	356	PF00069	0.588
MOD_GSK3_1	396	403	PF00069	0.453
MOD_GSK3_1	432	439	PF00069	0.663
MOD_GSK3_1	472	479	PF00069	0.478
MOD_GSK3_1	563	570	PF00069	0.472
MOD_GSK3_1	574	581	PF00069	0.462
MOD_GSK3_1	658	665	PF00069	0.718
MOD_GSK3_1	737	744	PF00069	0.730
MOD_N-GLC_1	164	169	PF02516	0.406
MOD_N-GLC_1	564	569	PF02516	0.494
MOD_N-GLC_1	577	582	PF02516	0.314
MOD_N-GLC_1	737	742	PF02516	0.730
MOD_NEK2_1	172	177	PF00069	0.484
MOD_NEK2_1	220	225	PF00069	0.478
MOD_NEK2_1	231	236	PF00069	0.496
MOD_NEK2_1	256	261	PF00069	0.508
MOD_NEK2_1	275	280	PF00069	0.237
MOD_NEK2_1	394	399	PF00069	0.458
MOD_NEK2_1	413	418	PF00069	0.283
MOD_NEK2_1	480	485	PF00069	0.451
MOD_NEK2_1	584	589	PF00069	0.562
MOD_NEK2_2	38	43	PF00069	0.355
MOD_NEK2_2	509	514	PF00069	0.520
MOD_PIKK_1	174	180	PF00454	0.510
MOD_PIKK_1	199	205	PF00454	0.483
MOD_PIKK_1	221	227	PF00454	0.506
MOD_PIKK_1	275	281	PF00454	0.566
MOD_PIKK_1	739	745	PF00454	0.761
MOD_PIKK_1	92	98	PF00454	0.517
MOD_PKA_2	382	388	PF00069	0.460
MOD_PKA_2	413	419	PF00069	0.486
MOD_PKA_2	515	521	PF00069	0.494
MOD_PKA_2	624	630	PF00069	0.702
MOD_PKA_2	635	641	PF00069	0.551
MOD_PKA_2	655	661	PF00069	0.726
MOD_PKA_2	675	681	PF00069	0.472
MOD_Plk_1	196	202	PF00069	0.528
MOD_Plk_1	389	395	PF00069	0.505
MOD_Plk_1	466	472	PF00069	0.445
MOD_Plk_1	476	482	PF00069	0.524
MOD_Plk_1	564	570	PF00069	0.573
MOD_Plk_1	577	583	PF00069	0.347
MOD_Plk_2-3	192	198	PF00069	0.381
MOD_Plk_2-3	730	736	PF00069	0.741
MOD_Plk_4	244	250	PF00069	0.412
MOD_Plk_4	374	380	PF00069	0.397
MOD_Plk_4	382	388	PF00069	0.443
MOD_Plk_4	466	472	PF00069	0.320
MOD_Plk_4	476	482	PF00069	0.533
MOD_Plk_4	509	515	PF00069	0.425
MOD_Plk_4	539	545	PF00069	0.566
MOD_Plk_4	549	555	PF00069	0.378
MOD_Plk_4	668	674	PF00069	0.700
MOD_Plk_4	83	89	PF00069	0.492
MOD_ProDKin_1	115	121	PF00069	0.805
MOD_ProDKin_1	18	24	PF00069	0.639
MOD_ProDKin_1	353	359	PF00069	0.636
MOD_ProDKin_1	360	366	PF00069	0.590
MOD_ProDKin_1	400	406	PF00069	0.492
MOD_ProDKin_1	436	442	PF00069	0.737
MOD_ProDKin_1	707	713	PF00069	0.683
MOD_SUMO_for_1	698	701	PF00179	0.640
TRG_DiLeu_BaEn_4	700	706	PF01217	0.651
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.426
TRG_ENDOCYTIC_2	292	295	PF00928	0.444
TRG_ENDOCYTIC_2	303	306	PF00928	0.394
TRG_ENDOCYTIC_2	672	675	PF00928	0.718
TRG_ENDOCYTIC_2	716	719	PF00928	0.619
TRG_ER_diArg_1	52	54	PF00400	0.706
TRG_ER_diArg_1	675	677	PF00400	0.809
TRG_NES_CRM1_1	463	477	PF08389	0.420
TRG_NES_CRM1_1	574	586	PF08389	0.555
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J2	Leptomonas seymouri	58%	98%
A0A1X0NUI7	Trypanosomatidae	31%	100%
A0A3S7X5F7	Leishmania donovani	99%	100%
A4HKC7	Leishmania braziliensis	74%	100%
E9B2R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q5E3	Leishmania major	93%	100%