Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WLM domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I7U8_LEIIN

TriTrypDb:

LINF_320018800

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7U8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.709
CLV_NRD_NRD_1	14	16	PF00675	0.430
CLV_NRD_NRD_1	146	148	PF00675	0.513
CLV_NRD_NRD_1	200	202	PF00675	0.376
CLV_NRD_NRD_1	224	226	PF00675	0.408
CLV_NRD_NRD_1	233	235	PF00675	0.358
CLV_NRD_NRD_1	326	328	PF00675	0.713
CLV_PCSK_KEX2_1	14	16	PF00082	0.430
CLV_PCSK_KEX2_1	146	148	PF00082	0.513
CLV_PCSK_KEX2_1	200	202	PF00082	0.365
CLV_PCSK_KEX2_1	224	226	PF00082	0.408
CLV_PCSK_KEX2_1	233	235	PF00082	0.358
CLV_PCSK_KEX2_1	328	330	PF00082	0.738
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.738
CLV_PCSK_PC7_1	142	148	PF00082	0.424
CLV_PCSK_PC7_1	220	226	PF00082	0.501
CLV_PCSK_SKI1_1	169	173	PF00082	0.432
CLV_PCSK_SKI1_1	220	224	PF00082	0.444
CLV_PCSK_SKI1_1	28	32	PF00082	0.376
CLV_PCSK_SKI1_1	297	301	PF00082	0.399
CLV_PCSK_SKI1_1	9	13	PF00082	0.376
DEG_APCC_DBOX_1	219	227	PF00400	0.501
DEG_COP1_1	340	349	PF00400	0.579
DEG_Nend_UBRbox_2	1	3	PF02207	0.518
DEG_SPOP_SBC_1	110	114	PF00917	0.472
DEG_SPOP_SBC_1	181	185	PF00917	0.446
DOC_ANK_TNKS_1	45	52	PF00023	0.430
DOC_CKS1_1	210	215	PF01111	0.287
DOC_CKS1_1	339	344	PF01111	0.771
DOC_MAPK_gen_1	14	21	PF00069	0.411
DOC_MAPK_gen_1	52	59	PF00069	0.430
DOC_MAPK_MEF2A_6	28	37	PF00069	0.376
DOC_MAPK_MEF2A_6	91	100	PF00069	0.430
DOC_PP4_FxxP_1	47	50	PF00568	0.376
DOC_SPAK_OSR1_1	46	50	PF12202	0.430
DOC_USP7_MATH_1	110	114	PF00917	0.469
DOC_USP7_MATH_1	181	185	PF00917	0.513
DOC_USP7_MATH_1	189	193	PF00917	0.299
DOC_USP7_MATH_1	345	349	PF00917	0.719
DOC_USP7_MATH_1	357	361	PF00917	0.618
DOC_WW_Pin1_4	111	116	PF00397	0.398
DOC_WW_Pin1_4	185	190	PF00397	0.424
DOC_WW_Pin1_4	209	214	PF00397	0.421
DOC_WW_Pin1_4	334	339	PF00397	0.799
LIG_14-3-3_CanoR_1	169	177	PF00244	0.454
LIG_14-3-3_CanoR_1	180	189	PF00244	0.404
LIG_14-3-3_CanoR_1	234	240	PF00244	0.521
LIG_14-3-3_CanoR_1	28	33	PF00244	0.410
LIG_APCC_ABBA_1	56	61	PF00400	0.430
LIG_BRCT_BRCA1_1	191	195	PF00533	0.501
LIG_BRCT_BRCA1_1	257	261	PF00533	0.591
LIG_BRCT_BRCA1_1	308	312	PF00533	0.625
LIG_FHA_1	170	176	PF00498	0.330
LIG_FHA_1	242	248	PF00498	0.737
LIG_FHA_1	339	345	PF00498	0.729
LIG_FHA_1	69	75	PF00498	0.424
LIG_FHA_2	366	372	PF00498	0.700
LIG_LIR_Gen_1	370	380	PF02991	0.661
LIG_LIR_Nem_3	370	376	PF02991	0.655
LIG_LIR_Nem_3	55	59	PF02991	0.340
LIG_LIR_Nem_3	79	85	PF02991	0.392
LIG_LYPXL_S_1	107	111	PF13949	0.501
LIG_LYPXL_yS_3	108	111	PF13949	0.501
LIG_Pex14_1	83	87	PF04695	0.430
LIG_PTB_Apo_2	81	88	PF02174	0.430
LIG_PTB_Phospho_1	81	87	PF10480	0.430
LIG_SH2_CRK	210	214	PF00017	0.410
LIG_SH2_CRK	87	91	PF00017	0.378
LIG_SH2_PTP2	373	376	PF00017	0.627
LIG_SH2_STAT5	373	376	PF00017	0.627
LIG_SH3_3	7	13	PF00018	0.420
LIG_SUMO_SIM_par_1	243	249	PF11976	0.766
LIG_SUMO_SIM_par_1	250	255	PF11976	0.692
LIG_SUMO_SIM_par_1	340	348	PF11976	0.677
LIG_TRAF2_1	368	371	PF00917	0.707
LIG_TYR_ITIM	85	90	PF00017	0.501
MOD_CDK_SPxK_1	214	220	PF00069	0.424
MOD_CK1_1	123	129	PF00069	0.425
MOD_CK1_1	165	171	PF00069	0.402
MOD_CK1_1	183	189	PF00069	0.354
MOD_CK1_1	241	247	PF00069	0.632
MOD_CK1_1	255	261	PF00069	0.773
MOD_CK1_1	334	340	PF00069	0.718
MOD_CK2_1	125	131	PF00069	0.424
MOD_CK2_1	282	288	PF00069	0.734
MOD_CK2_1	334	340	PF00069	0.699
MOD_CK2_1	365	371	PF00069	0.720
MOD_Cter_Amidation	144	147	PF01082	0.415
MOD_Cter_Amidation	198	201	PF01082	0.376
MOD_Cter_Amidation	50	53	PF01082	0.430
MOD_GlcNHglycan	118	121	PF01048	0.329
MOD_GlcNHglycan	139	142	PF01048	0.427
MOD_GlcNHglycan	191	194	PF01048	0.486
MOD_GlcNHglycan	240	243	PF01048	0.724
MOD_GlcNHglycan	257	260	PF01048	0.691
MOD_GlcNHglycan	284	287	PF01048	0.677
MOD_GlcNHglycan	347	350	PF01048	0.615
MOD_GSK3_1	110	117	PF00069	0.404
MOD_GSK3_1	165	172	PF00069	0.329
MOD_GSK3_1	180	187	PF00069	0.371
MOD_GSK3_1	334	341	PF00069	0.729
MOD_GSK3_1	345	352	PF00069	0.684
MOD_NEK2_1	116	121	PF00069	0.171
MOD_NEK2_1	137	142	PF00069	0.287
MOD_NEK2_1	235	240	PF00069	0.626
MOD_NEK2_1	96	101	PF00069	0.387
MOD_PIKK_1	120	126	PF00454	0.487
MOD_PIKK_1	169	175	PF00454	0.326
MOD_PIKK_1	246	252	PF00454	0.776
MOD_PIKK_1	357	363	PF00454	0.670
MOD_PKB_1	329	337	PF00069	0.682
MOD_Plk_1	96	102	PF00069	0.503
MOD_Plk_4	171	177	PF00069	0.401
MOD_Plk_4	28	34	PF00069	0.430
MOD_ProDKin_1	111	117	PF00069	0.398
MOD_ProDKin_1	185	191	PF00069	0.424
MOD_ProDKin_1	209	215	PF00069	0.421
MOD_ProDKin_1	334	340	PF00069	0.801
TRG_ENDOCYTIC_2	108	111	PF00928	0.501
TRG_ENDOCYTIC_2	373	376	PF00928	0.627
TRG_ENDOCYTIC_2	86	89	PF00928	0.376
TRG_ER_diArg_1	13	15	PF00400	0.430
TRG_ER_diArg_1	146	148	PF00400	0.424
TRG_ER_diArg_1	200	202	PF00400	0.376
TRG_ER_diArg_1	223	225	PF00400	0.408
TRG_ER_diArg_1	233	235	PF00400	0.350
TRG_ER_diArg_1	326	329	PF00400	0.735
TRG_ER_diArg_1	7	10	PF00400	0.436
TRG_NLS_MonoCore_2	327	332	PF00514	0.733
TRG_NLS_MonoExtC_3	326	331	PF00514	0.736
TRG_NLS_MonoExtN_4	327	332	PF00514	0.695
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAV8	Leptomonas seymouri	52%	89%
A0A0S4JA65	Bodo saltans	28%	89%
A0A3Q8IFF9	Leishmania donovani	99%	100%
A4HKB9	Leishmania braziliensis	66%	100%
E9B2Q6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q5F1	Leishmania major	90%	100%