Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein kinase domain/Protein tyrosine kinase - putative

Species:

Leishmania infantum

UniProt:

A4I7U6_LEIIN

TriTrypDb:

LINF_320018600

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7U6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.611
CLV_C14_Caspase3-7	311	315	PF00656	0.669
CLV_C14_Caspase3-7	453	457	PF00656	0.607
CLV_C14_Caspase3-7	47	51	PF00656	0.634
CLV_NRD_NRD_1	408	410	PF00675	0.408
CLV_NRD_NRD_1	485	487	PF00675	0.556
CLV_NRD_NRD_1	532	534	PF00675	0.525
CLV_NRD_NRD_1	550	552	PF00675	0.442
CLV_PCSK_FUR_1	548	552	PF00082	0.399
CLV_PCSK_KEX2_1	408	410	PF00082	0.408
CLV_PCSK_KEX2_1	485	487	PF00082	0.525
CLV_PCSK_KEX2_1	492	494	PF00082	0.436
CLV_PCSK_KEX2_1	532	534	PF00082	0.563
CLV_PCSK_KEX2_1	550	552	PF00082	0.394
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.510
CLV_PCSK_SKI1_1	498	502	PF00082	0.479
CLV_PCSK_SKI1_1	540	544	PF00082	0.514
CLV_PCSK_SKI1_1	92	96	PF00082	0.557
CLV_Separin_Metazoa	515	519	PF03568	0.528
DEG_SCF_FBW7_1	395	402	PF00400	0.447
DEG_SPOP_SBC_1	127	131	PF00917	0.679
DEG_SPOP_SBC_1	313	317	PF00917	0.665
DEG_SPOP_SBC_1	322	326	PF00917	0.498
DOC_CKS1_1	238	243	PF01111	0.540
DOC_CYCLIN_yCln2_LP_2	63	66	PF00134	0.616
DOC_MAPK_gen_1	261	271	PF00069	0.399
DOC_MAPK_MEF2A_6	261	269	PF00069	0.488
DOC_MAPK_MEF2A_6	477	484	PF00069	0.537
DOC_PP1_RVXF_1	466	473	PF00149	0.585
DOC_PP2B_LxvP_1	251	254	PF13499	0.375
DOC_PP2B_LxvP_1	267	270	PF13499	0.366
DOC_PP2B_LxvP_1	63	66	PF13499	0.616
DOC_PP4_FxxP_1	238	241	PF00568	0.631
DOC_PP4_FxxP_1	67	70	PF00568	0.746
DOC_USP7_MATH_1	194	198	PF00917	0.642
DOC_USP7_MATH_1	291	295	PF00917	0.651
DOC_USP7_MATH_1	313	317	PF00917	0.720
DOC_USP7_MATH_1	322	326	PF00917	0.560
DOC_USP7_MATH_1	335	339	PF00917	0.412
DOC_USP7_MATH_1	399	403	PF00917	0.426
DOC_USP7_UBL2_3	200	204	PF12436	0.539
DOC_WW_Pin1_4	123	128	PF00397	0.664
DOC_WW_Pin1_4	233	238	PF00397	0.653
DOC_WW_Pin1_4	286	291	PF00397	0.602
DOC_WW_Pin1_4	395	400	PF00397	0.359
DOC_WW_Pin1_4	414	419	PF00397	0.335
LIG_14-3-3_CanoR_1	195	203	PF00244	0.396
LIG_14-3-3_CanoR_1	230	239	PF00244	0.556
LIG_14-3-3_CanoR_1	328	334	PF00244	0.510
LIG_14-3-3_CanoR_1	518	523	PF00244	0.491
LIG_14-3-3_CanoR_1	81	89	PF00244	0.599
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BRCT_BRCA1_1	2	6	PF00533	0.645
LIG_BRCT_BRCA1_1	234	238	PF00533	0.691
LIG_BRCT_BRCA1_1	323	327	PF00533	0.616
LIG_deltaCOP1_diTrp_1	427	431	PF00928	0.447
LIG_eIF4E_1	246	252	PF01652	0.491
LIG_FHA_1	445	451	PF00498	0.406
LIG_FHA_1	465	471	PF00498	0.573
LIG_FHA_1	537	543	PF00498	0.482
LIG_FHA_1	59	65	PF00498	0.518
LIG_FHA_2	130	136	PF00498	0.653
LIG_FHA_2	187	193	PF00498	0.669
LIG_FHA_2	238	244	PF00498	0.545
LIG_FHA_2	368	374	PF00498	0.355
LIG_FHA_2	438	444	PF00498	0.335
LIG_FHA_2	539	545	PF00498	0.535
LIG_LIR_Apic_2	235	241	PF02991	0.654
LIG_LIR_Gen_1	108	117	PF02991	0.721
LIG_LIR_Gen_1	243	254	PF02991	0.470
LIG_LIR_Gen_1	391	399	PF02991	0.335
LIG_LIR_Nem_3	108	112	PF02991	0.728
LIG_LIR_Nem_3	138	144	PF02991	0.620
LIG_LIR_Nem_3	243	249	PF02991	0.483
LIG_LIR_Nem_3	330	336	PF02991	0.469
LIG_LIR_Nem_3	391	395	PF02991	0.335
LIG_LIR_Nem_3	525	531	PF02991	0.435
LIG_MYND_1	237	241	PF01753	0.644
LIG_PCNA_TLS_4	92	99	PF02747	0.475
LIG_RPA_C_Fungi	481	493	PF08784	0.450
LIG_SH2_CRK	246	250	PF00017	0.496
LIG_SH2_STAT5	24	27	PF00017	0.706
LIG_SH2_STAT5	279	282	PF00017	0.502
LIG_SH2_STAT5	369	372	PF00017	0.451
LIG_SH3_3	166	172	PF00018	0.517
LIG_SH3_3	23	29	PF00018	0.655
LIG_SUMO_SIM_par_1	434	440	PF11976	0.338
LIG_TRAF2_1	240	243	PF00917	0.557
LIG_UBA3_1	500	506	PF00899	0.383
MOD_CDK_SPxK_1	397	403	PF00069	0.480
MOD_CK1_1	122	128	PF00069	0.709
MOD_CK1_1	129	135	PF00069	0.642
MOD_CK1_1	137	143	PF00069	0.617
MOD_CK1_1	216	222	PF00069	0.496
MOD_CK1_1	233	239	PF00069	0.345
MOD_CK1_1	329	335	PF00069	0.403
MOD_CK1_1	397	403	PF00069	0.449
MOD_CK1_1	414	420	PF00069	0.447
MOD_CK1_1	43	49	PF00069	0.684
MOD_CK1_1	437	443	PF00069	0.341
MOD_CK1_1	536	542	PF00069	0.449
MOD_CK1_1	58	64	PF00069	0.518
MOD_CK1_1	83	89	PF00069	0.731
MOD_CK2_1	107	113	PF00069	0.747
MOD_CK2_1	186	192	PF00069	0.571
MOD_CK2_1	208	214	PF00069	0.450
MOD_CK2_1	237	243	PF00069	0.579
MOD_CK2_1	272	278	PF00069	0.474
MOD_CK2_1	518	524	PF00069	0.485
MOD_CK2_1	538	544	PF00069	0.202
MOD_Cter_Amidation	490	493	PF01082	0.479
MOD_GlcNHglycan	101	104	PF01048	0.692
MOD_GlcNHglycan	108	112	PF01048	0.657
MOD_GlcNHglycan	2	5	PF01048	0.716
MOD_GlcNHglycan	342	345	PF01048	0.493
MOD_GSK3_1	107	114	PF00069	0.656
MOD_GSK3_1	119	126	PF00069	0.682
MOD_GSK3_1	127	134	PF00069	0.604
MOD_GSK3_1	213	220	PF00069	0.508
MOD_GSK3_1	233	240	PF00069	0.606
MOD_GSK3_1	296	303	PF00069	0.677
MOD_GSK3_1	322	329	PF00069	0.559
MOD_GSK3_1	363	370	PF00069	0.447
MOD_GSK3_1	395	402	PF00069	0.388
MOD_GSK3_1	410	417	PF00069	0.442
MOD_GSK3_1	79	86	PF00069	0.706
MOD_N-GLC_1	119	124	PF02516	0.736
MOD_N-GLC_1	272	277	PF02516	0.487
MOD_N-GLC_2	119	121	PF02516	0.703
MOD_NEK2_1	107	112	PF00069	0.560
MOD_NEK2_1	217	222	PF00069	0.507
MOD_NEK2_1	300	305	PF00069	0.735
MOD_NEK2_1	327	332	PF00069	0.524
MOD_NEK2_1	394	399	PF00069	0.406
MOD_NEK2_1	434	439	PF00069	0.466
MOD_NEK2_1	99	104	PF00069	0.627
MOD_NEK2_2	272	277	PF00069	0.483
MOD_NEK2_2	538	543	PF00069	0.476
MOD_PKA_2	161	167	PF00069	0.417
MOD_PKA_2	194	200	PF00069	0.565
MOD_PKA_2	327	333	PF00069	0.558
MOD_PKA_2	464	470	PF00069	0.605
MOD_PKA_2	80	86	PF00069	0.718
MOD_PKB_1	228	236	PF00069	0.562
MOD_Plk_1	107	113	PF00069	0.595
MOD_Plk_1	119	125	PF00069	0.629
MOD_Plk_1	213	219	PF00069	0.489
MOD_Plk_1	272	278	PF00069	0.407
MOD_Plk_1	533	539	PF00069	0.463
MOD_Plk_4	161	167	PF00069	0.417
MOD_Plk_4	186	192	PF00069	0.656
MOD_Plk_4	213	219	PF00069	0.508
MOD_Plk_4	434	440	PF00069	0.327
MOD_Plk_4	518	524	PF00069	0.529
MOD_ProDKin_1	123	129	PF00069	0.664
MOD_ProDKin_1	233	239	PF00069	0.641
MOD_ProDKin_1	286	292	PF00069	0.609
MOD_ProDKin_1	395	401	PF00069	0.359
MOD_ProDKin_1	414	420	PF00069	0.335
MOD_SUMO_rev_2	192	202	PF00179	0.564
TRG_DiLeu_BaEn_1	263	268	PF01217	0.526
TRG_DiLeu_BaEn_1	496	501	PF01217	0.512
TRG_DiLeu_BaEn_2	350	356	PF01217	0.480
TRG_DiLeu_BaEn_2	523	529	PF01217	0.535
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.598
TRG_ENDOCYTIC_2	109	112	PF00928	0.665
TRG_ENDOCYTIC_2	246	249	PF00928	0.405
TRG_ENDOCYTIC_2	333	336	PF00928	0.469
TRG_ER_diArg_1	407	409	PF00400	0.410
TRG_ER_diArg_1	484	486	PF00400	0.539
TRG_ER_diArg_1	531	533	PF00400	0.551
TRG_ER_diArg_1	548	551	PF00400	0.312
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.765

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEH1	Leptomonas seymouri	66%	100%
A0A1X0NUL0	Trypanosomatidae	38%	100%
A0A3S7X5E9	Leishmania donovani	97%	98%
A0A422P1A6	Trypanosoma rangeli	39%	100%
A4HKB7	Leishmania braziliensis	72%	99%
D0AA04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B2Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q5F3	Leishmania major	91%	100%
V5BGP5	Trypanosoma cruzi	40%	100%