LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
CRAL/TRIO domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I7U4_LEIIN
TriTrypDb:
LINF_320018400
Length:
766

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7U4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7U4

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 15 19 PF00656 0.457
CLV_C14_Caspase3-7 24 28 PF00656 0.369
CLV_C14_Caspase3-7 607 611 PF00656 0.462
CLV_C14_Caspase3-7 62 66 PF00656 0.579
CLV_C14_Caspase3-7 624 628 PF00656 0.517
CLV_NRD_NRD_1 118 120 PF00675 0.467
CLV_NRD_NRD_1 263 265 PF00675 0.692
CLV_NRD_NRD_1 312 314 PF00675 0.618
CLV_NRD_NRD_1 454 456 PF00675 0.324
CLV_NRD_NRD_1 494 496 PF00675 0.292
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P992 Leptomonas seymouri 46% 100%
A0A3S5H7R8 Leishmania donovani 99% 100%
A0A3S7X4P4 Leishmania donovani 25% 100%
A4HJI7 Leishmania braziliensis 24% 100%
A4HKB5 Leishmania braziliensis 62% 99%
A4I6Y2 Leishmania infantum 25% 100%
E9B204 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9B2Q2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q5F5 Leishmania major 86% 100%
Q4Q657 Leishmania major 25% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS