LeishMANIAdb
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Putative ubiquitin hydrolase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ubiquitin hydrolase
Gene product:
ubiquitin hydrolase - putative
Species:
Leishmania infantum
UniProt:
A4I7U2_LEIIN
TriTrypDb:
LINF_320018200 *
Length:
540

Annotations

Annotations by Jardim et al.

Protein modification, ubiquitin hydrolase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7U2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7U2

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 12
GO:0006511 ubiquitin-dependent protein catabolic process 7 10
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 10
GO:0009057 macromolecule catabolic process 4 10
GO:0009987 cellular process 1 10
GO:0016579 protein deubiquitination 6 12
GO:0019538 protein metabolic process 3 12
GO:0019941 modification-dependent protein catabolic process 6 10
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0043632 modification-dependent macromolecule catabolic process 5 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 12
GO:0044248 cellular catabolic process 3 10
GO:0044260 obsolete cellular macromolecule metabolic process 3 10
GO:0044265 obsolete cellular macromolecule catabolic process 4 10
GO:0051603 proteolysis involved in protein catabolic process 5 10
GO:0070646 protein modification by small protein removal 5 12
GO:0070647 protein modification by small protein conjugation or removal 5 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901575 organic substance catabolic process 3 10
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004843 cysteine-type deubiquitinase activity 5 12
GO:0008233 peptidase activity 3 12
GO:0008234 cysteine-type peptidase activity 4 12
GO:0016787 hydrolase activity 2 12
GO:0019783 ubiquitin-like protein peptidase activity 4 12
GO:0101005 deubiquitinase activity 5 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 101 103 PF00675 0.650
CLV_NRD_NRD_1 412 414 PF00675 0.334
CLV_PCSK_FUR_1 430 434 PF00082 0.286
CLV_PCSK_FUR_1 98 102 PF00082 0.569
CLV_PCSK_KEX2_1 100 102 PF00082 0.688
CLV_PCSK_KEX2_1 412 414 PF00082 0.330
CLV_PCSK_KEX2_1 432 434 PF00082 0.366
CLV_PCSK_PC1ET2_1 432 434 PF00082 0.411
CLV_PCSK_SKI1_1 107 111 PF00082 0.469
CLV_PCSK_SKI1_1 33 37 PF00082 0.490
CLV_PCSK_SKI1_1 392 396 PF00082 0.312
CLV_PCSK_SKI1_1 433 437 PF00082 0.425
DEG_SPOP_SBC_1 269 273 PF00917 0.303
DOC_CYCLIN_RxL_1 430 440 PF00134 0.339
DOC_MAPK_DCC_7 399 408 PF00069 0.320
DOC_MAPK_gen_1 308 315 PF00069 0.339
DOC_MAPK_gen_1 343 352 PF00069 0.327
DOC_MAPK_gen_1 392 400 PF00069 0.351
DOC_MAPK_gen_1 430 437 PF00069 0.414
DOC_MAPK_MEF2A_6 345 354 PF00069 0.425
DOC_MAPK_MEF2A_6 356 364 PF00069 0.390
DOC_MAPK_MEF2A_6 399 408 PF00069 0.320
DOC_MAPK_RevD_3 398 413 PF00069 0.390
DOC_PP2B_LxvP_1 265 268 PF13499 0.245
DOC_PP2B_LxvP_1 435 438 PF13499 0.304
DOC_PP4_FxxP_1 58 61 PF00568 0.571
DOC_USP7_MATH_1 199 203 PF00917 0.368
DOC_USP7_MATH_1 252 256 PF00917 0.346
DOC_USP7_MATH_1 258 262 PF00917 0.330
DOC_USP7_MATH_1 294 298 PF00917 0.391
DOC_USP7_UBL2_3 308 312 PF12436 0.362
DOC_USP7_UBL2_3 392 396 PF12436 0.309
DOC_USP7_UBL2_3 524 528 PF12436 0.425
DOC_WW_Pin1_4 479 484 PF00397 0.391
DOC_WW_Pin1_4 500 505 PF00397 0.430
DOC_WW_Pin1_4 51 56 PF00397 0.601
LIG_14-3-3_CanoR_1 107 112 PF00244 0.588
LIG_14-3-3_CanoR_1 349 353 PF00244 0.384
LIG_14-3-3_CanoR_1 378 386 PF00244 0.376
LIG_14-3-3_CanoR_1 430 436 PF00244 0.419
LIG_14-3-3_CanoR_1 455 460 PF00244 0.417
LIG_14-3-3_CanoR_1 81 87 PF00244 0.585
LIG_BRCT_BRCA1_1 404 408 PF00533 0.450
LIG_Clathr_ClatBox_1 242 246 PF01394 0.425
LIG_Clathr_ClatBox_1 422 426 PF01394 0.339
LIG_FHA_1 148 154 PF00498 0.400
LIG_FHA_1 380 386 PF00498 0.364
LIG_FHA_1 395 401 PF00498 0.314
LIG_FHA_1 432 438 PF00498 0.281
LIG_FHA_1 472 478 PF00498 0.342
LIG_FHA_1 480 486 PF00498 0.329
LIG_FHA_1 496 502 PF00498 0.404
LIG_FHA_1 507 513 PF00498 0.402
LIG_FHA_2 257 263 PF00498 0.389
LIG_Integrin_RGD_1 463 465 PF01839 0.425
LIG_LIR_Apic_2 173 179 PF02991 0.354
LIG_LIR_Apic_2 355 361 PF02991 0.425
LIG_LIR_Apic_2 56 61 PF02991 0.591
LIG_LIR_Gen_1 114 121 PF02991 0.430
LIG_LIR_Gen_1 128 137 PF02991 0.267
LIG_LIR_Gen_1 145 153 PF02991 0.409
LIG_LIR_Gen_1 405 416 PF02991 0.405
LIG_LIR_Gen_1 75 82 PF02991 0.330
LIG_LIR_Nem_3 114 118 PF02991 0.453
LIG_LIR_Nem_3 145 149 PF02991 0.409
LIG_LIR_Nem_3 355 360 PF02991 0.311
LIG_LIR_Nem_3 405 411 PF02991 0.405
LIG_LIR_Nem_3 451 457 PF02991 0.313
LIG_LIR_Nem_3 529 535 PF02991 0.299
LIG_LIR_Nem_3 75 80 PF02991 0.301
LIG_MYND_1 189 193 PF01753 0.451
LIG_NRBOX 230 236 PF00104 0.362
LIG_Pex14_1 172 176 PF04695 0.320
LIG_Pex14_1 177 181 PF04695 0.320
LIG_Pex14_2 142 146 PF04695 0.339
LIG_PTB_Apo_2 124 131 PF02174 0.238
LIG_Rb_pABgroove_1 71 79 PF01858 0.328
LIG_SH2_CRK 358 362 PF00017 0.451
LIG_SH2_CRK 454 458 PF00017 0.339
LIG_SH2_CRK 77 81 PF00017 0.412
LIG_SH2_STAP1 67 71 PF00017 0.545
LIG_SH2_STAT5 358 361 PF00017 0.427
LIG_SH2_STAT5 472 475 PF00017 0.304
LIG_SH2_STAT5 532 535 PF00017 0.304
LIG_SH2_STAT5 67 70 PF00017 0.487
LIG_SH3_2 57 62 PF14604 0.468
LIG_SH3_3 11 17 PF00018 0.623
LIG_SH3_3 190 196 PF00018 0.451
LIG_SH3_3 54 60 PF00018 0.617
LIG_SUMO_SIM_anti_2 348 355 PF11976 0.394
LIG_SUMO_SIM_par_1 149 154 PF11976 0.443
LIG_TRAF2_1 222 225 PF00917 0.339
LIG_TYR_ITSM 528 535 PF00017 0.425
LIG_WRC_WIRS_1 143 148 PF05994 0.409
LIG_WW_3 59 63 PF00397 0.573
MOD_CK2_1 111 117 PF00069 0.420
MOD_CK2_1 219 225 PF00069 0.325
MOD_CK2_1 256 262 PF00069 0.389
MOD_CK2_1 385 391 PF00069 0.382
MOD_GlcNHglycan 203 206 PF01048 0.406
MOD_GlcNHglycan 208 211 PF01048 0.412
MOD_GlcNHglycan 275 278 PF01048 0.431
MOD_GlcNHglycan 30 33 PF01048 0.710
MOD_GSK3_1 107 114 PF00069 0.608
MOD_GSK3_1 147 154 PF00069 0.417
MOD_GSK3_1 252 259 PF00069 0.329
MOD_GSK3_1 269 276 PF00069 0.455
MOD_GSK3_1 33 40 PF00069 0.588
MOD_GSK3_1 443 450 PF00069 0.350
MOD_LATS_1 300 306 PF00433 0.245
MOD_N-GLC_1 125 130 PF02516 0.274
MOD_N-GLC_1 199 204 PF02516 0.413
MOD_N-GLC_1 516 521 PF02516 0.429
MOD_N-GLC_2 129 131 PF02516 0.320
MOD_N-GLC_2 42 44 PF02516 0.543
MOD_NEK2_1 111 116 PF00069 0.490
MOD_NEK2_1 125 130 PF00069 0.355
MOD_NEK2_1 132 137 PF00069 0.319
MOD_NEK2_1 149 154 PF00069 0.121
MOD_NEK2_1 219 224 PF00069 0.331
MOD_NEK2_1 327 332 PF00069 0.387
MOD_NEK2_1 376 381 PF00069 0.305
MOD_NEK2_1 38 43 PF00069 0.661
MOD_NEK2_1 394 399 PF00069 0.320
MOD_NMyristoyl 1 7 PF02799 0.586
MOD_PIKK_1 212 218 PF00454 0.378
MOD_PIKK_1 4 10 PF00454 0.678
MOD_PK_1 402 408 PF00069 0.245
MOD_PK_1 455 461 PF00069 0.451
MOD_PKA_2 348 354 PF00069 0.451
MOD_PKA_2 80 86 PF00069 0.522
MOD_Plk_1 368 374 PF00069 0.320
MOD_Plk_1 376 382 PF00069 0.194
MOD_Plk_1 443 449 PF00069 0.299
MOD_Plk_1 516 522 PF00069 0.425
MOD_Plk_2-3 256 262 PF00069 0.440
MOD_Plk_4 132 138 PF00069 0.417
MOD_Plk_4 187 193 PF00069 0.374
MOD_Plk_4 327 333 PF00069 0.398
MOD_Plk_4 348 354 PF00069 0.308
MOD_Plk_4 402 408 PF00069 0.364
MOD_Plk_4 455 461 PF00069 0.363
MOD_Plk_4 471 477 PF00069 0.336
MOD_Plk_4 506 512 PF00069 0.390
MOD_Plk_4 527 533 PF00069 0.425
MOD_ProDKin_1 479 485 PF00069 0.391
MOD_ProDKin_1 500 506 PF00069 0.430
MOD_ProDKin_1 51 57 PF00069 0.602
MOD_SUMO_rev_2 387 394 PF00179 0.245
TRG_DiLeu_BaEn_2 528 534 PF01217 0.390
TRG_DiLeu_BaEn_4 240 246 PF01217 0.451
TRG_DiLeu_BaLyEn_6 452 457 PF01217 0.425
TRG_ENDOCYTIC_2 357 360 PF00928 0.425
TRG_ENDOCYTIC_2 454 457 PF00928 0.304
TRG_ENDOCYTIC_2 532 535 PF00928 0.304
TRG_ENDOCYTIC_2 77 80 PF00928 0.318
TRG_ER_diArg_1 411 413 PF00400 0.351
TRG_ER_diArg_1 98 101 PF00400 0.708
TRG_Pf-PMV_PEXEL_1 74 78 PF00026 0.318

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMP3 Leptomonas seymouri 57% 100%
A0A0S4IXL6 Bodo saltans 33% 99%
A0A1X0NUI1 Trypanosomatidae 45% 100%
A0A3S7X5G6 Leishmania donovani 98% 100%
A0A422P1B8 Trypanosoma rangeli 43% 100%
A4HKB2 Leishmania braziliensis 78% 99%
A5PJS6 Bos taurus 24% 68%
D0AA02 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9B2Q0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 98%
P52479 Mus musculus 25% 68%
Q14694 Homo sapiens 24% 68%
Q2NL57 Xenopus laevis 24% 68%
Q3KR59 Rattus norvegicus 25% 68%
Q4Q5F7 Leishmania major 92% 98%
Q5ZJN4 Gallus gallus 24% 69%
Q6DIJ4 Xenopus tropicalis 25% 67%
Q7ZXR7 Xenopus laevis 25% 67%
Q9FPS3 Arabidopsis thaliana 26% 98%
V5DHM6 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS