PHTB1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PTHB1 N-terminus/PTHB1 C-terminus - putative

Species:

Leishmania infantum

UniProt:

A4I7U1_LEIIN

TriTrypDb:

LINF_320018100

Length:

924

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0030666	endocytic vesicle membrane	5	1
GO:0030669	clathrin-coated endocytic vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I7U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7U1

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030001	metal ion transport	6	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0033572	transferrin transport	5	1
GO:0044782	cilium organization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0048870	cell motility	2	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0060271	cilium assembly	6	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.440
CLV_C14_Caspase3-7	804	808	PF00656	0.427
CLV_C14_Caspase3-7	859	863	PF00656	0.390
CLV_NRD_NRD_1	341	343	PF00675	0.391
CLV_NRD_NRD_1	615	617	PF00675	0.453
CLV_NRD_NRD_1	716	718	PF00675	0.322
CLV_NRD_NRD_1	752	754	PF00675	0.344
CLV_PCSK_KEX2_1	341	343	PF00082	0.306
CLV_PCSK_KEX2_1	491	493	PF00082	0.758
CLV_PCSK_KEX2_1	615	617	PF00082	0.453
CLV_PCSK_KEX2_1	716	718	PF00082	0.323
CLV_PCSK_KEX2_1	752	754	PF00082	0.376
CLV_PCSK_KEX2_1	774	776	PF00082	0.306
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.656
CLV_PCSK_PC1ET2_1	774	776	PF00082	0.306
CLV_PCSK_PC7_1	770	776	PF00082	0.341
CLV_PCSK_SKI1_1	224	228	PF00082	0.355
CLV_PCSK_SKI1_1	244	248	PF00082	0.452
CLV_PCSK_SKI1_1	311	315	PF00082	0.456
CLV_PCSK_SKI1_1	38	42	PF00082	0.391
CLV_PCSK_SKI1_1	585	589	PF00082	0.442
CLV_PCSK_SKI1_1	774	778	PF00082	0.318
CLV_PCSK_SKI1_1	84	88	PF00082	0.409
DEG_COP1_1	731	741	PF00400	0.453
DEG_SCF_FBW7_1	577	582	PF00400	0.427
DEG_SPOP_SBC_1	138	142	PF00917	0.356
DOC_CDC14_PxL_1	559	567	PF14671	0.415
DOC_CKS1_1	566	571	PF01111	0.434
DOC_CKS1_1	576	581	PF01111	0.307
DOC_CYCLIN_RxL_1	98	107	PF00134	0.427
DOC_MAPK_HePTP_8	66	78	PF00069	0.306
DOC_MAPK_MEF2A_6	101	108	PF00069	0.359
DOC_MAPK_MEF2A_6	69	78	PF00069	0.306
DOC_MAPK_NFAT4_5	101	109	PF00069	0.453
DOC_PP1_RVXF_1	477	484	PF00149	0.613
DOC_PP1_RVXF_1	99	106	PF00149	0.427
DOC_PP2B_LxvP_1	474	477	PF13499	0.738
DOC_PP2B_LxvP_1	597	600	PF13499	0.427
DOC_PP2B_LxvP_1	736	739	PF13499	0.407
DOC_PP2B_LxvP_1	840	843	PF13499	0.240
DOC_PP4_FxxP_1	232	235	PF00568	0.312
DOC_USP7_MATH_1	110	114	PF00917	0.439
DOC_USP7_MATH_1	124	128	PF00917	0.222
DOC_USP7_MATH_1	153	157	PF00917	0.427
DOC_USP7_MATH_1	30	34	PF00917	0.427
DOC_USP7_MATH_1	384	388	PF00917	0.372
DOC_USP7_MATH_1	411	415	PF00917	0.400
DOC_USP7_MATH_1	501	505	PF00917	0.762
DOC_USP7_MATH_1	510	514	PF00917	0.472
DOC_USP7_MATH_1	519	523	PF00917	0.424
DOC_USP7_MATH_1	528	532	PF00917	0.263
DOC_USP7_MATH_1	579	583	PF00917	0.424
DOC_USP7_MATH_1	85	89	PF00917	0.413
DOC_USP7_UBL2_3	487	491	PF12436	0.749
DOC_WW_Pin1_4	140	145	PF00397	0.396
DOC_WW_Pin1_4	18	23	PF00397	0.427
DOC_WW_Pin1_4	565	570	PF00397	0.445
DOC_WW_Pin1_4	575	580	PF00397	0.388
DOC_WW_Pin1_4	781	786	PF00397	0.400
DOC_WW_Pin1_4	835	840	PF00397	0.465
LIG_14-3-3_CanoR_1	183	191	PF00244	0.318
LIG_14-3-3_CanoR_1	285	290	PF00244	0.420
LIG_14-3-3_CanoR_1	533	541	PF00244	0.567
LIG_14-3-3_CanoR_1	585	590	PF00244	0.417
LIG_14-3-3_CanoR_1	854	858	PF00244	0.427
LIG_APCC_ABBA_1	372	377	PF00400	0.306
LIG_APCC_ABBA_1	659	664	PF00400	0.341
LIG_APCC_ABBAyCdc20_2	101	107	PF00400	0.427
LIG_BRCT_BRCA1_1	11	15	PF00533	0.240
LIG_BRCT_BRCA1_1	257	261	PF00533	0.414
LIG_BRCT_BRCA1_1	32	36	PF00533	0.427
LIG_BRCT_BRCA1_1	849	853	PF00533	0.453
LIG_BRCT_BRCA1_2	32	38	PF00533	0.427
LIG_Clathr_ClatBox_1	103	107	PF01394	0.427
LIG_deltaCOP1_diTrp_1	9	15	PF00928	0.391
LIG_eIF4E_1	259	265	PF01652	0.427
LIG_FHA_1	173	179	PF00498	0.395
LIG_FHA_1	292	298	PF00498	0.342
LIG_FHA_1	308	314	PF00498	0.331
LIG_FHA_1	323	329	PF00498	0.286
LIG_FHA_1	421	427	PF00498	0.417
LIG_FHA_1	433	439	PF00498	0.361
LIG_FHA_1	540	546	PF00498	0.429
LIG_FHA_1	584	590	PF00498	0.383
LIG_FHA_1	670	676	PF00498	0.400
LIG_FHA_1	685	691	PF00498	0.241
LIG_FHA_1	713	719	PF00498	0.435
LIG_FHA_1	867	873	PF00498	0.385
LIG_FHA_1	879	885	PF00498	0.333
LIG_FHA_1	893	899	PF00498	0.396
LIG_FHA_2	212	218	PF00498	0.363
LIG_FHA_2	267	273	PF00498	0.403
LIG_FHA_2	312	318	PF00498	0.376
LIG_GBD_Chelix_1	710	718	PF00786	0.252
LIG_LIR_Apic_2	68	74	PF02991	0.306
LIG_LIR_Gen_1	102	110	PF02991	0.415
LIG_LIR_Gen_1	162	172	PF02991	0.436
LIG_LIR_Gen_1	258	266	PF02991	0.349
LIG_LIR_Gen_1	284	292	PF02991	0.409
LIG_LIR_Gen_1	33	44	PF02991	0.421
LIG_LIR_Gen_1	437	447	PF02991	0.319
LIG_LIR_Gen_1	526	536	PF02991	0.544
LIG_LIR_Gen_1	617	626	PF02991	0.453
LIG_LIR_Gen_1	660	668	PF02991	0.327
LIG_LIR_Gen_1	740	745	PF02991	0.358
LIG_LIR_Gen_1	862	873	PF02991	0.320
LIG_LIR_Nem_3	102	108	PF02991	0.415
LIG_LIR_Nem_3	162	167	PF02991	0.397
LIG_LIR_Nem_3	199	204	PF02991	0.371
LIG_LIR_Nem_3	217	221	PF02991	0.427
LIG_LIR_Nem_3	258	264	PF02991	0.349
LIG_LIR_Nem_3	284	289	PF02991	0.409
LIG_LIR_Nem_3	33	39	PF02991	0.387
LIG_LIR_Nem_3	367	371	PF02991	0.408
LIG_LIR_Nem_3	437	443	PF02991	0.426
LIG_LIR_Nem_3	526	532	PF02991	0.494
LIG_LIR_Nem_3	617	621	PF02991	0.337
LIG_LIR_Nem_3	740	744	PF02991	0.326
LIG_LIR_Nem_3	797	802	PF02991	0.325
LIG_LIR_Nem_3	862	868	PF02991	0.320
LIG_MYND_1	839	843	PF01753	0.376
LIG_MYND_2	655	659	PF01753	0.415
LIG_Pex14_1	11	15	PF04695	0.322
LIG_PTB_Apo_2	195	202	PF02174	0.376
LIG_PTB_Phospho_1	195	201	PF10480	0.376
LIG_Rb_pABgroove_1	30	38	PF01858	0.427
LIG_SH2_CRK	201	205	PF00017	0.427
LIG_SH2_CRK	218	222	PF00017	0.427
LIG_SH2_CRK	360	364	PF00017	0.435
LIG_SH2_CRK	799	803	PF00017	0.322
LIG_SH2_GRB2like	360	363	PF00017	0.453
LIG_SH2_GRB2like	680	683	PF00017	0.322
LIG_SH2_NCK_1	618	622	PF00017	0.391
LIG_SH2_SRC	152	155	PF00017	0.368
LIG_SH2_SRC	680	683	PF00017	0.341
LIG_SH2_SRC	71	74	PF00017	0.368
LIG_SH2_STAP1	174	178	PF00017	0.380
LIG_SH2_STAP1	360	364	PF00017	0.453
LIG_SH2_STAP1	440	444	PF00017	0.415
LIG_SH2_STAP1	450	454	PF00017	0.415
LIG_SH2_STAT3	611	614	PF00017	0.376
LIG_SH2_STAT5	174	177	PF00017	0.427
LIG_SH2_STAT5	329	332	PF00017	0.382
LIG_SH2_STAT5	420	423	PF00017	0.306
LIG_SH2_STAT5	440	443	PF00017	0.123
LIG_SH2_STAT5	680	683	PF00017	0.306
LIG_SH3_2	635	640	PF14604	0.322
LIG_SH3_2	82	87	PF14604	0.435
LIG_SH3_3	474	480	PF00018	0.698
LIG_SH3_3	56	62	PF00018	0.373
LIG_SH3_3	629	635	PF00018	0.312
LIG_SH3_3	79	85	PF00018	0.321
LIG_SH3_3	94	100	PF00018	0.264
LIG_SUMO_SIM_anti_2	212	217	PF11976	0.240
LIG_SUMO_SIM_anti_2	319	326	PF11976	0.311
LIG_SUMO_SIM_anti_2	553	559	PF11976	0.380
LIG_SUMO_SIM_anti_2	601	607	PF11976	0.427
LIG_SUMO_SIM_anti_2	740	747	PF11976	0.424
LIG_SUMO_SIM_par_1	174	181	PF11976	0.411
LIG_SUMO_SIM_par_1	319	326	PF11976	0.391
LIG_SUMO_SIM_par_1	540	547	PF11976	0.508
LIG_SUMO_SIM_par_1	685	691	PF11976	0.354
LIG_TRAF2_1	16	19	PF00917	0.391
LIG_TRAF2_1	314	317	PF00917	0.453
LIG_TYR_ITIM	216	221	PF00017	0.453
LIG_TYR_ITIM	358	363	PF00017	0.453
LIG_TYR_ITIM	438	443	PF00017	0.415
LIG_WRC_WIRS_1	223	228	PF05994	0.427
LIG_WRC_WIRS_1	292	297	PF05994	0.415
LIG_WRC_WIRS_1	365	370	PF05994	0.427
LIG_WRPW_2	83	86	PF00400	0.427
MOD_CK1_1	126	132	PF00069	0.326
MOD_CK1_1	140	146	PF00069	0.412
MOD_CK1_1	260	266	PF00069	0.315
MOD_CK1_1	284	290	PF00069	0.399
MOD_CK1_1	412	418	PF00069	0.359
MOD_CK1_1	432	438	PF00069	0.353
MOD_CK1_1	513	519	PF00069	0.701
MOD_CK1_1	527	533	PF00069	0.469
MOD_CK1_1	892	898	PF00069	0.415
MOD_CK2_1	163	169	PF00069	0.444
MOD_CK2_1	265	271	PF00069	0.463
MOD_CK2_1	311	317	PF00069	0.466
MOD_CK2_1	373	379	PF00069	0.395
MOD_CK2_1	460	466	PF00069	0.605
MOD_CK2_1	699	705	PF00069	0.306
MOD_CK2_1	914	920	PF00069	0.645
MOD_GlcNHglycan	126	129	PF01048	0.468
MOD_GlcNHglycan	22	25	PF01048	0.340
MOD_GlcNHglycan	325	328	PF01048	0.368
MOD_GlcNHglycan	333	336	PF01048	0.385
MOD_GlcNHglycan	346	350	PF01048	0.347
MOD_GlcNHglycan	382	385	PF01048	0.304
MOD_GlcNHglycan	387	390	PF01048	0.308
MOD_GlcNHglycan	462	465	PF01048	0.641
MOD_GlcNHglycan	503	506	PF01048	0.698
MOD_GlcNHglycan	526	529	PF01048	0.487
MOD_GlcNHglycan	53	56	PF01048	0.363
MOD_GlcNHglycan	536	540	PF01048	0.433
MOD_GlcNHglycan	758	761	PF01048	0.431
MOD_GlcNHglycan	819	822	PF01048	0.408
MOD_GlcNHglycan	87	90	PF01048	0.417
MOD_GlcNHglycan	910	913	PF01048	0.505
MOD_GlcNHglycan	916	919	PF01048	0.591
MOD_GSK3_1	122	129	PF00069	0.394
MOD_GSK3_1	136	143	PF00069	0.442
MOD_GSK3_1	205	212	PF00069	0.398
MOD_GSK3_1	246	253	PF00069	0.380
MOD_GSK3_1	255	262	PF00069	0.325
MOD_GSK3_1	281	288	PF00069	0.388
MOD_GSK3_1	307	314	PF00069	0.342
MOD_GSK3_1	380	387	PF00069	0.270
MOD_GSK3_1	434	441	PF00069	0.457
MOD_GSK3_1	501	508	PF00069	0.673
MOD_GSK3_1	519	526	PF00069	0.592
MOD_GSK3_1	527	534	PF00069	0.502
MOD_GSK3_1	535	542	PF00069	0.344
MOD_GSK3_1	575	582	PF00069	0.387
MOD_GSK3_1	650	657	PF00069	0.341
MOD_GSK3_1	684	691	PF00069	0.331
MOD_GSK3_1	807	814	PF00069	0.415
MOD_GSK3_1	904	911	PF00069	0.371
MOD_N-GLC_1	250	255	PF02516	0.325
MOD_N-GLC_1	266	271	PF02516	0.336
MOD_N-GLC_2	824	826	PF02516	0.453
MOD_NEK2_1	10	15	PF00069	0.408
MOD_NEK2_1	184	189	PF00069	0.367
MOD_NEK2_1	209	214	PF00069	0.404
MOD_NEK2_1	222	227	PF00069	0.401
MOD_NEK2_1	238	243	PF00069	0.276
MOD_NEK2_1	255	260	PF00069	0.224
MOD_NEK2_1	323	328	PF00069	0.345
MOD_NEK2_1	364	369	PF00069	0.398
MOD_NEK2_1	380	385	PF00069	0.326
MOD_NEK2_1	393	398	PF00069	0.302
MOD_NEK2_1	523	528	PF00069	0.504
MOD_NEK2_1	541	546	PF00069	0.367
MOD_NEK2_1	699	704	PF00069	0.343
MOD_NEK2_1	853	858	PF00069	0.384
MOD_NEK2_1	889	894	PF00069	0.431
MOD_NEK2_1	908	913	PF00069	0.328
MOD_NEK2_2	250	255	PF00069	0.391
MOD_NEK2_2	519	524	PF00069	0.380
MOD_NEK2_2	528	533	PF00069	0.290
MOD_PIKK_1	53	59	PF00454	0.337
MOD_PIKK_1	650	656	PF00454	0.337
MOD_PKA_2	284	290	PF00069	0.379
MOD_PKA_2	307	313	PF00069	0.322
MOD_PKA_2	513	519	PF00069	0.667
MOD_PKA_2	532	538	PF00069	0.550
MOD_PKA_2	853	859	PF00069	0.453
MOD_PKB_1	815	823	PF00069	0.427
MOD_Plk_1	250	256	PF00069	0.325
MOD_Plk_1	345	351	PF00069	0.463
MOD_Plk_1	412	418	PF00069	0.421
MOD_Plk_1	539	545	PF00069	0.463
MOD_Plk_1	579	585	PF00069	0.415
MOD_Plk_1	684	690	PF00069	0.322
MOD_Plk_1	786	792	PF00069	0.373
MOD_Plk_4	211	217	PF00069	0.320
MOD_Plk_4	250	256	PF00069	0.421
MOD_Plk_4	260	266	PF00069	0.382
MOD_Plk_4	479	485	PF00069	0.528
MOD_Plk_4	519	525	PF00069	0.503
MOD_Plk_4	553	559	PF00069	0.332
MOD_Plk_4	654	660	PF00069	0.341
MOD_Plk_4	684	690	PF00069	0.322
MOD_Plk_4	848	854	PF00069	0.326
MOD_Plk_4	901	907	PF00069	0.367
MOD_ProDKin_1	140	146	PF00069	0.396
MOD_ProDKin_1	18	24	PF00069	0.427
MOD_ProDKin_1	565	571	PF00069	0.445
MOD_ProDKin_1	575	581	PF00069	0.388
MOD_ProDKin_1	781	787	PF00069	0.400
MOD_ProDKin_1	835	841	PF00069	0.465
MOD_SUMO_for_1	728	731	PF00179	0.453
MOD_SUMO_rev_2	199	204	PF00179	0.376
MOD_SUMO_rev_2	431	438	PF00179	0.408
TRG_DiLeu_BaEn_1	553	558	PF01217	0.463
TRG_DiLeu_BaEn_1	705	710	PF01217	0.363
TRG_DiLeu_BaEn_1	797	802	PF01217	0.427
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.240
TRG_DiLeu_BaLyEn_6	561	566	PF01217	0.422
TRG_DiLeu_BaLyEn_6	772	777	PF01217	0.306
TRG_DiLeu_BaLyEn_6	836	841	PF01217	0.342
TRG_ENDOCYTIC_2	201	204	PF00928	0.427
TRG_ENDOCYTIC_2	218	221	PF00928	0.427
TRG_ENDOCYTIC_2	223	226	PF00928	0.414
TRG_ENDOCYTIC_2	360	363	PF00928	0.453
TRG_ENDOCYTIC_2	44	47	PF00928	0.453
TRG_ENDOCYTIC_2	440	443	PF00928	0.322
TRG_ENDOCYTIC_2	450	453	PF00928	0.322
TRG_ENDOCYTIC_2	618	621	PF00928	0.427
TRG_ENDOCYTIC_2	799	802	PF00928	0.306
TRG_ER_diArg_1	148	151	PF00400	0.411
TRG_ER_diArg_1	340	342	PF00400	0.393
TRG_ER_diArg_1	716	719	PF00400	0.326
TRG_ER_diArg_1	751	753	PF00400	0.376
TRG_NES_CRM1_1	169	181	PF08389	0.393
TRG_NLS_MonoCore_2	488	493	PF00514	0.537
TRG_NLS_MonoExtN_4	487	494	PF00514	0.751
TRG_Pf-PMV_PEXEL_1	311	316	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	341	346	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	800	804	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFT7	Leptomonas seymouri	60%	100%
A0A0S4KJV3	Bodo saltans	34%	100%
A0A1X0NUH9	Trypanosomatidae	36%	100%
A0A3S7X5H2	Leishmania donovani	100%	100%
A0A422P1E8	Trypanosoma rangeli	39%	100%
A4HKB1	Leishmania braziliensis	77%	100%
D0AA01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B2P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
O01514	Caenorhabditis elegans	22%	100%
Q3SYG4	Homo sapiens	27%	100%
Q4Q5F8	Leishmania major	91%	100%
Q6AX60	Xenopus laevis	27%	100%
Q811G0	Mus musculus	27%	100%
V5B167	Trypanosoma cruzi	37%	100%