Putative ADP-ribosylation factor GTPase activating protein 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor GTPase activating protein 1 - putative

Species:

Leishmania infantum

UniProt:

A4I7U0_LEIIN

TriTrypDb:

LINF_320018000

Length:

403

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, ADP-ribosylation factor GTPase activating 1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I7U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7U0

Function

Biological processes
Term	Name	Level	Count
GO:0006901	vesicle coating	6	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048200	Golgi transport vesicle coating	7	1
GO:0048205	COPI coating of Golgi vesicle	8	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	12
GO:0008047	enzyme activator activity	3	12
GO:0030234	enzyme regulator activity	2	12
GO:0030695	GTPase regulator activity	4	12
GO:0060589	nucleoside-triphosphatase regulator activity	3	12
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.613
CLV_C14_Caspase3-7	276	280	PF00656	0.766
CLV_C14_Caspase3-7	294	298	PF00656	0.564
CLV_C14_Caspase3-7	68	72	PF00656	0.333
CLV_NRD_NRD_1	90	92	PF00675	0.306
CLV_PCSK_KEX2_1	90	92	PF00082	0.313
DEG_SPOP_SBC_1	65	69	PF00917	0.333
DOC_CDC14_PxL_1	110	118	PF14671	0.473
DOC_CKS1_1	102	107	PF01111	0.351
DOC_MAPK_gen_1	77	86	PF00069	0.297
DOC_MAPK_gen_1	90	96	PF00069	0.297
DOC_MAPK_MEF2A_6	56	64	PF00069	0.313
DOC_PP1_RVXF_1	322	328	PF00149	0.566
DOC_PP1_RVXF_1	91	97	PF00149	0.389
DOC_USP7_MATH_1	147	151	PF00917	0.558
DOC_USP7_MATH_1	156	160	PF00917	0.479
DOC_USP7_MATH_1	215	219	PF00917	0.703
DOC_USP7_MATH_1	233	237	PF00917	0.625
DOC_USP7_MATH_1	335	339	PF00917	0.700
DOC_USP7_MATH_1	341	345	PF00917	0.699
DOC_USP7_MATH_1	353	357	PF00917	0.617
DOC_USP7_MATH_1	364	368	PF00917	0.654
DOC_USP7_UBL2_3	103	107	PF12436	0.336
DOC_WW_Pin1_4	101	106	PF00397	0.418
DOC_WW_Pin1_4	152	157	PF00397	0.674
DOC_WW_Pin1_4	311	316	PF00397	0.751
DOC_WW_Pin1_4	32	37	PF00397	0.393
DOC_WW_Pin1_4	331	336	PF00397	0.726
DOC_WW_Pin1_4	346	351	PF00397	0.643
DOC_WW_Pin1_4	382	387	PF00397	0.710
DOC_WW_Pin1_4	5	10	PF00397	0.541
LIG_14-3-3_CanoR_1	225	229	PF00244	0.700
LIG_14-3-3_CanoR_1	270	278	PF00244	0.569
LIG_14-3-3_CanoR_1	66	71	PF00244	0.333
LIG_APCC_ABBAyCdc20_2	91	97	PF00400	0.389
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_CaM_NSCaTE_8	141	148	PF13499	0.526
LIG_deltaCOP1_diTrp_1	133	141	PF00928	0.408
LIG_deltaCOP1_diTrp_1	394	403	PF00928	0.644
LIG_deltaCOP1_diTrp_1	71	76	PF00928	0.297
LIG_FHA_1	203	209	PF00498	0.543
LIG_FHA_1	211	217	PF00498	0.600
LIG_FHA_1	338	344	PF00498	0.789
LIG_FHA_2	390	396	PF00498	0.654
LIG_Integrin_RGD_1	185	187	PF01839	0.438
LIG_LIR_Apic_2	133	139	PF02991	0.406
LIG_LIR_Apic_2	344	350	PF02991	0.704
LIG_LIR_Gen_1	12	23	PF02991	0.373
LIG_LIR_Gen_1	188	195	PF02991	0.530
LIG_LIR_Gen_1	196	206	PF02991	0.517
LIG_LIR_Gen_1	35	46	PF02991	0.433
LIG_LIR_Nem_3	12	18	PF02991	0.458
LIG_LIR_Nem_3	188	194	PF02991	0.512
LIG_LIR_Nem_3	196	201	PF02991	0.491
LIG_LIR_Nem_3	286	291	PF02991	0.695
LIG_LIR_Nem_3	35	41	PF02991	0.419
LIG_LIR_Nem_3	45	49	PF02991	0.367
LIG_PDZ_Class_3	398	403	PF00595	0.701
LIG_Pex14_1	398	402	PF04695	0.504
LIG_SH2_CRK	142	146	PF00017	0.503
LIG_SH2_CRK	191	195	PF00017	0.561
LIG_SH2_PTP2	6	9	PF00017	0.540
LIG_SH2_STAP1	118	122	PF00017	0.393
LIG_SH2_STAP1	191	195	PF00017	0.619
LIG_SH2_STAP1	242	246	PF00017	0.542
LIG_SH2_STAT5	142	145	PF00017	0.528
LIG_SH2_STAT5	6	9	PF00017	0.540
LIG_SH2_STAT5	95	98	PF00017	0.313
LIG_SH3_2	102	107	PF14604	0.357
LIG_SH3_3	306	312	PF00018	0.736
LIG_SH3_3	366	372	PF00018	0.763
LIG_SH3_3	383	389	PF00018	0.662
LIG_SH3_3	99	105	PF00018	0.297
LIG_TYR_ITSM	284	291	PF00017	0.635
MOD_CDC14_SPxK_1	349	352	PF00782	0.703
MOD_CDK_SPxK_1	101	107	PF00069	0.418
MOD_CDK_SPxK_1	346	352	PF00069	0.777
MOD_CK1_1	155	161	PF00069	0.742
MOD_CK1_1	181	187	PF00069	0.614
MOD_CK1_1	196	202	PF00069	0.526
MOD_CK1_1	314	320	PF00069	0.782
MOD_CK1_1	331	337	PF00069	0.481
MOD_CK1_1	342	348	PF00069	0.712
MOD_CK1_1	354	360	PF00069	0.700
MOD_CK2_1	331	337	PF00069	0.729
MOD_CK2_1	389	395	PF00069	0.541
MOD_CMANNOS	73	76	PF00535	0.297
MOD_GlcNHglycan	180	183	PF01048	0.643
MOD_GlcNHglycan	191	194	PF01048	0.547
MOD_GlcNHglycan	195	198	PF01048	0.513
MOD_GlcNHglycan	217	220	PF01048	0.685
MOD_GlcNHglycan	235	238	PF01048	0.551
MOD_GlcNHglycan	275	278	PF01048	0.589
MOD_GlcNHglycan	294	297	PF01048	0.563
MOD_GlcNHglycan	330	333	PF01048	0.713
MOD_GlcNHglycan	344	347	PF01048	0.635
MOD_GlcNHglycan	382	385	PF01048	0.556
MOD_GlcNHglycan	51	54	PF01048	0.317
MOD_GSK3_1	152	159	PF00069	0.664
MOD_GSK3_1	181	188	PF00069	0.644
MOD_GSK3_1	189	196	PF00069	0.537
MOD_GSK3_1	233	240	PF00069	0.537
MOD_GSK3_1	311	318	PF00069	0.710
MOD_GSK3_1	326	333	PF00069	0.591
MOD_GSK3_1	335	342	PF00069	0.737
MOD_GSK3_1	359	366	PF00069	0.790
MOD_GSK3_1	60	67	PF00069	0.297
MOD_N-GLC_1	49	54	PF02516	0.433
MOD_N-GLC_2	26	28	PF02516	0.362
MOD_NEK2_1	180	185	PF00069	0.701
MOD_NEK2_1	224	229	PF00069	0.631
MOD_NEK2_1	326	331	PF00069	0.713
MOD_NEK2_1	42	47	PF00069	0.327
MOD_NEK2_1	49	54	PF00069	0.266
MOD_NEK2_1	64	69	PF00069	0.297
MOD_PIKK_1	199	205	PF00454	0.562
MOD_PIKK_1	359	365	PF00454	0.717
MOD_PKA_2	224	230	PF00069	0.701
MOD_PKA_2	65	71	PF00069	0.333
MOD_Plk_1	132	138	PF00069	0.407
MOD_Plk_4	42	48	PF00069	0.409
MOD_Plk_4	60	66	PF00069	0.174
MOD_ProDKin_1	101	107	PF00069	0.418
MOD_ProDKin_1	152	158	PF00069	0.677
MOD_ProDKin_1	311	317	PF00069	0.749
MOD_ProDKin_1	32	38	PF00069	0.393
MOD_ProDKin_1	331	337	PF00069	0.728
MOD_ProDKin_1	346	352	PF00069	0.645
MOD_ProDKin_1	382	388	PF00069	0.711
MOD_ProDKin_1	5	11	PF00069	0.529
TRG_ENDOCYTIC_2	110	113	PF00928	0.367
TRG_ENDOCYTIC_2	118	121	PF00928	0.351
TRG_ENDOCYTIC_2	142	145	PF00928	0.442
TRG_ENDOCYTIC_2	191	194	PF00928	0.562
TRG_ENDOCYTIC_2	288	291	PF00928	0.750
TRG_ER_diArg_1	90	93	PF00400	0.310
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMX1	Leptomonas seymouri	60%	100%
A0A0S4KJM8	Bodo saltans	42%	72%
A0A1X0NUZ4	Trypanosomatidae	49%	100%
A0A3Q8IGX3	Leishmania donovani	99%	100%
A0A422P1B3	Trypanosoma rangeli	51%	100%
A4HKB0	Leishmania braziliensis	72%	99%
D0AA00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B2P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5F9	Leishmania major	89%	100%
V5BGP1	Trypanosoma cruzi	49%	100%