Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7T6_LEIIN

TriTrypDb:

LINF_320017600

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7T6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.555
CLV_C14_Caspase3-7	389	393	PF00656	0.558
CLV_C14_Caspase3-7	451	455	PF00656	0.676
CLV_NRD_NRD_1	103	105	PF00675	0.662
CLV_NRD_NRD_1	352	354	PF00675	0.661
CLV_NRD_NRD_1	442	444	PF00675	0.633
CLV_NRD_NRD_1	446	448	PF00675	0.611
CLV_NRD_NRD_1	517	519	PF00675	0.633
CLV_PCSK_KEX2_1	103	105	PF00082	0.661
CLV_PCSK_KEX2_1	267	269	PF00082	0.572
CLV_PCSK_KEX2_1	27	29	PF00082	0.507
CLV_PCSK_KEX2_1	352	354	PF00082	0.661
CLV_PCSK_KEX2_1	380	382	PF00082	0.568
CLV_PCSK_KEX2_1	442	444	PF00082	0.633
CLV_PCSK_KEX2_1	446	448	PF00082	0.611
CLV_PCSK_KEX2_1	515	517	PF00082	0.670
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.585
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.390
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.568
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.670
CLV_PCSK_PC7_1	348	354	PF00082	0.644
CLV_PCSK_PC7_1	442	448	PF00082	0.696
DEG_APCC_DBOX_1	27	35	PF00400	0.384
DOC_ANK_TNKS_1	212	219	PF00023	0.626
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.570
DOC_MAPK_gen_1	380	386	PF00069	0.507
DOC_MAPK_gen_1	491	498	PF00069	0.566
DOC_MAPK_gen_1	55	65	PF00069	0.630
DOC_MAPK_MEF2A_6	267	276	PF00069	0.708
DOC_MAPK_MEF2A_6	58	65	PF00069	0.688
DOC_PP1_RVXF_1	115	122	PF00149	0.542
DOC_PP1_RVXF_1	218	225	PF00149	0.605
DOC_PP1_RVXF_1	492	499	PF00149	0.603
DOC_PP2B_LxvP_1	330	333	PF13499	0.630
DOC_PP2B_LxvP_1	357	360	PF13499	0.596
DOC_PP2B_LxvP_1	412	415	PF13499	0.643
DOC_PP4_FxxP_1	51	54	PF00568	0.514
DOC_USP7_MATH_1	132	136	PF00917	0.661
DOC_USP7_MATH_1	187	191	PF00917	0.609
DOC_USP7_MATH_1	229	233	PF00917	0.599
DOC_USP7_MATH_1	258	262	PF00917	0.693
DOC_USP7_MATH_1	299	303	PF00917	0.646
DOC_USP7_MATH_1	331	335	PF00917	0.544
DOC_USP7_MATH_1	415	419	PF00917	0.679
DOC_USP7_MATH_1	448	452	PF00917	0.594
DOC_WW_Pin1_4	130	135	PF00397	0.592
DOC_WW_Pin1_4	169	174	PF00397	0.782
DOC_WW_Pin1_4	225	230	PF00397	0.588
DOC_WW_Pin1_4	254	259	PF00397	0.669
DOC_WW_Pin1_4	266	271	PF00397	0.704
DOC_WW_Pin1_4	295	300	PF00397	0.684
DOC_WW_Pin1_4	307	312	PF00397	0.555
DOC_WW_Pin1_4	374	379	PF00397	0.620
DOC_WW_Pin1_4	384	389	PF00397	0.544
DOC_WW_Pin1_4	434	439	PF00397	0.610
DOC_WW_Pin1_4	455	460	PF00397	0.769
DOC_WW_Pin1_4	65	70	PF00397	0.758
DOC_WW_Pin1_4	79	84	PF00397	0.652
LIG_14-3-3_CanoR_1	124	134	PF00244	0.553
LIG_14-3-3_CanoR_1	223	231	PF00244	0.602
LIG_14-3-3_CanoR_1	312	322	PF00244	0.478
LIG_14-3-3_CanoR_1	326	330	PF00244	0.574
LIG_14-3-3_CanoR_1	381	385	PF00244	0.557
LIG_14-3-3_CanoR_1	77	85	PF00244	0.640
LIG_14-3-3_CanoR_1	88	97	PF00244	0.550
LIG_BIR_III_4	215	219	PF00653	0.541
LIG_BRCT_BRCA1_1	134	138	PF00533	0.608
LIG_BRCT_BRCA1_1	198	202	PF00533	0.652
LIG_BRCT_BRCA1_1	302	306	PF00533	0.524
LIG_BRCT_BRCA1_1	436	440	PF00533	0.615
LIG_BRCT_BRCA1_1	9	13	PF00533	0.658
LIG_BRCT_BRCA1_1	92	96	PF00533	0.598
LIG_EVH1_1	471	475	PF00568	0.573
LIG_FHA_1	231	237	PF00498	0.617
LIG_FHA_1	381	387	PF00498	0.730
LIG_FHA_1	97	103	PF00498	0.528
LIG_FHA_2	153	159	PF00498	0.629
LIG_FHA_2	318	324	PF00498	0.496
LIG_GBD_Chelix_1	94	102	PF00786	0.520
LIG_Integrin_RGD_1	213	215	PF01839	0.629
LIG_LIR_Apic_2	50	54	PF02991	0.510
LIG_LIR_Gen_1	245	255	PF02991	0.606
LIG_LIR_Gen_1	303	311	PF02991	0.648
LIG_LIR_Nem_3	303	309	PF02991	0.657
LIG_RPA_C_Fungi	477	489	PF08784	0.557
LIG_SH2_STAT3	35	38	PF00017	0.445
LIG_SH2_STAT5	194	197	PF00017	0.609
LIG_SH3_1	108	114	PF00018	0.625
LIG_SH3_2	472	477	PF14604	0.576
LIG_SH3_3	108	114	PF00018	0.625
LIG_SH3_3	305	311	PF00018	0.589
LIG_SH3_3	357	363	PF00018	0.608
LIG_SH3_3	418	424	PF00018	0.578
LIG_SH3_3	466	472	PF00018	0.671
LIG_SH3_3	486	492	PF00018	0.557
LIG_SUMO_SIM_anti_2	273	278	PF11976	0.679
LIG_SUMO_SIM_par_1	382	387	PF11976	0.502
LIG_TRAF2_1	23	26	PF00917	0.505
LIG_TRAF2_1	242	245	PF00917	0.592
LIG_TRAF2_1	481	484	PF00917	0.646
LIG_WRC_WIRS_1	231	236	PF05994	0.590
MOD_CDC14_SPxK_1	133	136	PF00782	0.626
MOD_CDK_SPK_2	307	312	PF00069	0.537
MOD_CDK_SPxK_1	130	136	PF00069	0.635
MOD_CDK_SPxK_1	374	380	PF00069	0.619
MOD_CDK_SPxxK_3	374	381	PF00069	0.560
MOD_CK1_1	125	131	PF00069	0.713
MOD_CK1_1	190	196	PF00069	0.614
MOD_CK1_1	197	203	PF00069	0.605
MOD_CK1_1	225	231	PF00069	0.587
MOD_CK1_1	232	238	PF00069	0.594
MOD_CK1_1	455	461	PF00069	0.668
MOD_CK1_1	510	516	PF00069	0.584
MOD_CK1_1	526	532	PF00069	0.584
MOD_CK2_1	152	158	PF00069	0.576
MOD_CK2_1	260	266	PF00069	0.644
MOD_CK2_1	317	323	PF00069	0.569
MOD_CK2_1	478	484	PF00069	0.665
MOD_CK2_1	65	71	PF00069	0.560
MOD_GlcNHglycan	148	151	PF01048	0.583
MOD_GlcNHglycan	188	192	PF01048	0.618
MOD_GlcNHglycan	208	211	PF01048	0.525
MOD_GlcNHglycan	260	263	PF01048	0.633
MOD_GlcNHglycan	281	284	PF01048	0.630
MOD_GlcNHglycan	338	341	PF01048	0.754
MOD_GlcNHglycan	406	409	PF01048	0.728
MOD_GlcNHglycan	41	44	PF01048	0.433
MOD_GlcNHglycan	417	420	PF01048	0.599
MOD_GlcNHglycan	483	487	PF01048	0.657
MOD_GlcNHglycan	509	512	PF01048	0.766
MOD_GlcNHglycan	526	529	PF01048	0.565
MOD_GSK3_1	169	176	PF00069	0.608
MOD_GSK3_1	190	197	PF00069	0.661
MOD_GSK3_1	225	232	PF00069	0.557
MOD_GSK3_1	254	261	PF00069	0.593
MOD_GSK3_1	295	302	PF00069	0.584
MOD_GSK3_1	307	314	PF00069	0.601
MOD_GSK3_1	380	387	PF00069	0.663
MOD_GSK3_1	400	407	PF00069	0.678
MOD_GSK3_1	427	434	PF00069	0.640
MOD_GSK3_1	448	455	PF00069	0.728
MOD_GSK3_1	478	485	PF00069	0.745
MOD_GSK3_1	498	505	PF00069	0.707
MOD_GSK3_1	506	513	PF00069	0.620
MOD_GSK3_1	520	527	PF00069	0.536
MOD_LATS_1	221	227	PF00433	0.602
MOD_N-GLC_1	197	202	PF02516	0.562
MOD_N-GLC_1	401	406	PF02516	0.625
MOD_N-GLC_1	462	467	PF02516	0.713
MOD_NEK2_1	1	6	PF00069	0.679
MOD_NEK2_1	300	305	PF00069	0.567
MOD_NEK2_1	325	330	PF00069	0.533
MOD_NEK2_1	390	395	PF00069	0.616
MOD_NEK2_1	90	95	PF00069	0.576
MOD_PIKK_1	125	131	PF00454	0.608
MOD_PIKK_1	317	323	PF00454	0.521
MOD_PIKK_1	449	455	PF00454	0.756
MOD_PIKK_1	77	83	PF00454	0.692
MOD_PKA_1	380	386	PF00069	0.563
MOD_PKA_2	140	146	PF00069	0.579
MOD_PKA_2	222	228	PF00069	0.596
MOD_PKA_2	311	317	PF00069	0.497
MOD_PKA_2	325	331	PF00069	0.573
MOD_PKA_2	336	342	PF00069	0.598
MOD_PKA_2	380	386	PF00069	0.600
MOD_PKA_2	478	484	PF00069	0.646
MOD_PKA_2	498	504	PF00069	0.597
MOD_Plk_1	197	203	PF00069	0.587
MOD_Plk_1	236	242	PF00069	0.586
MOD_Plk_1	401	407	PF00069	0.628
MOD_Plk_4	190	196	PF00069	0.707
MOD_Plk_4	197	203	PF00069	0.650
MOD_Plk_4	325	331	PF00069	0.559
MOD_Plk_4	361	367	PF00069	0.625
MOD_Plk_4	559	565	PF00069	0.549
MOD_ProDKin_1	130	136	PF00069	0.589
MOD_ProDKin_1	169	175	PF00069	0.783
MOD_ProDKin_1	225	231	PF00069	0.587
MOD_ProDKin_1	254	260	PF00069	0.673
MOD_ProDKin_1	266	272	PF00069	0.700
MOD_ProDKin_1	295	301	PF00069	0.684
MOD_ProDKin_1	307	313	PF00069	0.551
MOD_ProDKin_1	374	380	PF00069	0.619
MOD_ProDKin_1	384	390	PF00069	0.542
MOD_ProDKin_1	434	440	PF00069	0.614
MOD_ProDKin_1	455	461	PF00069	0.770
MOD_ProDKin_1	65	71	PF00069	0.760
MOD_ProDKin_1	79	85	PF00069	0.650
MOD_SUMO_rev_2	19	29	PF00179	0.474
TRG_DiLeu_BaEn_2	91	97	PF01217	0.539
TRG_DiLeu_BaLyEn_6	456	461	PF01217	0.641
TRG_ER_diArg_1	102	104	PF00400	0.643
TRG_ER_diArg_1	105	108	PF00400	0.638
TRG_ER_diArg_1	352	354	PF00400	0.601
TRG_ER_diArg_1	441	443	PF00400	0.636
TRG_ER_diArg_1	477	480	PF00400	0.611
TRG_ER_diArg_1	516	518	PF00400	0.634
TRG_ER_diArg_1	63	66	PF00400	0.714
TRG_NLS_MonoCore_2	514	519	PF00514	0.707
TRG_NLS_MonoExtC_3	514	519	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P995	Leptomonas seymouri	30%	100%
A0A3S7X5D7	Leishmania donovani	99%	100%
A4HKA6	Leishmania braziliensis	52%	97%
E9B2P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4Q5G3	Leishmania major	83%	100%