Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7T4_LEIIN

TriTrypDb:

LINF_320017400

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4I7T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7T4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.707
CLV_C14_Caspase3-7	269	273	PF00656	0.564
CLV_NRD_NRD_1	114	116	PF00675	0.526
CLV_NRD_NRD_1	219	221	PF00675	0.396
CLV_NRD_NRD_1	55	57	PF00675	0.440
CLV_NRD_NRD_1	79	81	PF00675	0.322
CLV_PCSK_KEX2_1	113	115	PF00082	0.528
CLV_PCSK_KEX2_1	219	221	PF00082	0.394
CLV_PCSK_KEX2_1	55	57	PF00082	0.440
CLV_PCSK_KEX2_1	79	81	PF00082	0.388
CLV_PCSK_SKI1_1	114	118	PF00082	0.518
CLV_PCSK_SKI1_1	121	125	PF00082	0.570
CLV_PCSK_SKI1_1	219	223	PF00082	0.435
CLV_PCSK_SKI1_1	83	87	PF00082	0.201
DEG_APCC_DBOX_1	112	120	PF00400	0.387
DEG_APCC_DBOX_1	194	202	PF00400	0.201
DEG_SPOP_SBC_1	30	34	PF00917	0.282
DOC_CKS1_1	184	189	PF01111	0.371
DOC_CYCLIN_RxL_1	109	122	PF00134	0.371
DOC_CYCLIN_RxL_1	216	224	PF00134	0.555
DOC_CYCLIN_RxL_1	77	90	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.330
DOC_MAPK_gen_1	113	119	PF00069	0.327
DOC_MAPK_gen_1	79	88	PF00069	0.576
DOC_MAPK_MEF2A_6	195	203	PF00069	0.222
DOC_MAPK_MEF2A_6	79	88	PF00069	0.559
DOC_PP2B_LxvP_1	141	144	PF13499	0.311
DOC_SPAK_OSR1_1	137	141	PF12202	0.389
DOC_USP7_MATH_1	146	150	PF00917	0.496
DOC_USP7_MATH_1	185	189	PF00917	0.409
DOC_USP7_MATH_1	225	229	PF00917	0.644
DOC_USP7_MATH_1	230	234	PF00917	0.678
DOC_USP7_MATH_1	31	35	PF00917	0.332
DOC_USP7_MATH_1	57	61	PF00917	0.616
DOC_WW_Pin1_4	180	185	PF00397	0.400
DOC_WW_Pin1_4	270	275	PF00397	0.594
LIG_14-3-3_CanoR_1	99	104	PF00244	0.358
LIG_BIR_II_1	1	5	PF00653	0.464
LIG_BRCT_BRCA1_1	33	37	PF00533	0.328
LIG_deltaCOP1_diTrp_1	122	132	PF00928	0.423
LIG_deltaCOP1_diTrp_1	14	18	PF00928	0.404
LIG_DLG_GKlike_1	99	106	PF00625	0.331
LIG_eIF4E_1	193	199	PF01652	0.201
LIG_FHA_1	128	134	PF00498	0.355
LIG_FHA_1	202	208	PF00498	0.352
LIG_FHA_1	254	260	PF00498	0.710
LIG_FHA_1	309	315	PF00498	0.620
LIG_FHA_1	76	82	PF00498	0.536
LIG_FHA_1	88	94	PF00498	0.246
LIG_FHA_2	184	190	PF00498	0.369
LIG_FHA_2	255	261	PF00498	0.738
LIG_LIR_Apic_2	159	163	PF02991	0.346
LIG_LIR_Gen_1	100	111	PF02991	0.290
LIG_LIR_Gen_1	175	184	PF02991	0.457
LIG_LIR_Gen_1	204	211	PF02991	0.421
LIG_LIR_Gen_1	287	297	PF02991	0.516
LIG_LIR_Gen_1	32	43	PF02991	0.297
LIG_LIR_Gen_1	324	334	PF02991	0.397
LIG_LIR_Nem_3	100	106	PF02991	0.307
LIG_LIR_Nem_3	122	128	PF02991	0.430
LIG_LIR_Nem_3	171	176	PF02991	0.499
LIG_LIR_Nem_3	204	208	PF02991	0.376
LIG_LIR_Nem_3	287	292	PF02991	0.559
LIG_LIR_Nem_3	32	38	PF02991	0.297
LIG_LIR_Nem_3	324	330	PF02991	0.328
LIG_NRBOX	339	345	PF00104	0.330
LIG_NRBOX	80	86	PF00104	0.597
LIG_PDZ_Class_2	356	361	PF00595	0.459
LIG_Pex14_1	135	139	PF04695	0.383
LIG_SH2_CRK	103	107	PF00017	0.317
LIG_SH2_CRK	176	180	PF00017	0.458
LIG_SH2_CRK	193	197	PF00017	0.150
LIG_SH2_CRK	215	219	PF00017	0.564
LIG_SH2_CRK	327	331	PF00017	0.284
LIG_SH2_CRK	94	98	PF00017	0.395
LIG_SH2_STAP1	327	331	PF00017	0.357
LIG_SH2_STAT5	103	106	PF00017	0.286
LIG_SH2_STAT5	139	142	PF00017	0.375
LIG_SH2_STAT5	289	292	PF00017	0.502
LIG_SH3_3	178	184	PF00018	0.480
LIG_SH3_3	268	274	PF00018	0.645
LIG_SH3_3	304	310	PF00018	0.616
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.410
LIG_SUMO_SIM_par_1	348	353	PF11976	0.333
LIG_SUMO_SIM_par_1	84	90	PF11976	0.355
LIG_TYR_ITSM	327	334	PF00017	0.355
LIG_WRC_WIRS_1	37	42	PF05994	0.366
MOD_CK1_1	145	151	PF00069	0.531
MOD_CK1_1	183	189	PF00069	0.580
MOD_CK1_1	2	8	PF00069	0.533
MOD_CK1_1	224	230	PF00069	0.602
MOD_CK1_1	296	302	PF00069	0.539
MOD_CK1_1	321	327	PF00069	0.328
MOD_CK1_1	75	81	PF00069	0.489
MOD_CK2_1	183	189	PF00069	0.468
MOD_CMANNOS	129	132	PF00535	0.490
MOD_CMANNOS	316	319	PF00535	0.500
MOD_GlcNHglycan	106	109	PF01048	0.383
MOD_GlcNHglycan	144	147	PF01048	0.490
MOD_GlcNHglycan	148	151	PF01048	0.503
MOD_GlcNHglycan	223	226	PF01048	0.561
MOD_GlcNHglycan	227	230	PF01048	0.626
MOD_GlcNHglycan	295	298	PF01048	0.514
MOD_GlcNHglycan	302	305	PF01048	0.460
MOD_GlcNHglycan	4	7	PF01048	0.681
MOD_GlcNHglycan	59	62	PF01048	0.573
MOD_GlcNHglycan	74	77	PF01048	0.283
MOD_GSK3_1	142	149	PF00069	0.477
MOD_GSK3_1	179	186	PF00069	0.633
MOD_GSK3_1	197	204	PF00069	0.258
MOD_GSK3_1	221	228	PF00069	0.572
MOD_GSK3_1	25	32	PF00069	0.380
MOD_GSK3_1	266	273	PF00069	0.605
MOD_GSK3_1	296	303	PF00069	0.664
MOD_N-GLC_1	179	184	PF02516	0.568
MOD_N-GLC_1	72	77	PF02516	0.407
MOD_N-GLC_2	64	66	PF02516	0.500
MOD_NEK2_1	1	6	PF00069	0.631
MOD_NEK2_1	179	184	PF00069	0.542
MOD_NEK2_1	201	206	PF00069	0.318
MOD_NEK2_1	221	226	PF00069	0.518
MOD_NEK2_1	29	34	PF00069	0.303
MOD_PKA_2	231	237	PF00069	0.660
MOD_PKA_2	293	299	PF00069	0.616
MOD_PKA_2	57	63	PF00069	0.543
MOD_Plk_1	266	272	PF00069	0.626
MOD_Plk_4	25	31	PF00069	0.381
MOD_Plk_4	266	272	PF00069	0.583
MOD_Plk_4	326	332	PF00069	0.417
MOD_Plk_4	36	42	PF00069	0.267
MOD_ProDKin_1	180	186	PF00069	0.493
MOD_ProDKin_1	270	276	PF00069	0.482
MOD_SUMO_rev_2	156	163	PF00179	0.596
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.478
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.330
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.417
TRG_ENDOCYTIC_2	103	106	PF00928	0.312
TRG_ENDOCYTIC_2	176	179	PF00928	0.577
TRG_ENDOCYTIC_2	193	196	PF00928	0.199
TRG_ENDOCYTIC_2	215	218	PF00928	0.458
TRG_ENDOCYTIC_2	289	292	PF00928	0.363
TRG_ENDOCYTIC_2	327	330	PF00928	0.302
TRG_ENDOCYTIC_2	331	334	PF00928	0.304
TRG_ENDOCYTIC_2	94	97	PF00928	0.328
TRG_ER_diArg_1	113	115	PF00400	0.357
TRG_ER_diArg_1	218	220	PF00400	0.574
TRG_ER_diArg_1	54	56	PF00400	0.469
TRG_ER_diArg_1	79	81	PF00400	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEL3	Leptomonas seymouri	44%	93%
A0A1X0NUK5	Trypanosomatidae	28%	100%
A0A3Q8ID27	Leishmania donovani	100%	100%
A0A422P1F3	Trypanosoma rangeli	27%	100%
A4HKA4	Leishmania braziliensis	71%	100%
D0A9Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B2P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5G5	Leishmania major	91%	100%
V5DHL3	Trypanosoma cruzi	26%	100%