Kinetoplast polyadenylation/uridylation factor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast polyadenylation/uridylation factor 2 - putative

Species:

Leishmania infantum

UniProt:

A4I7T1_LEIIN

TriTrypDb:

LINF_320017100

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I7T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7T1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009894	regulation of catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903311	regulation of mRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.716
CLV_C14_Caspase3-7	352	356	PF00656	0.711
CLV_C14_Caspase3-7	452	456	PF00656	0.727
CLV_C14_Caspase3-7	543	547	PF00656	0.496
CLV_C14_Caspase3-7	636	640	PF00656	0.376
CLV_C14_Caspase3-7	76	80	PF00656	0.706
CLV_NRD_NRD_1	100	102	PF00675	0.596
CLV_NRD_NRD_1	167	169	PF00675	0.681
CLV_NRD_NRD_1	183	185	PF00675	0.400
CLV_NRD_NRD_1	268	270	PF00675	0.461
CLV_NRD_NRD_1	312	314	PF00675	0.500
CLV_NRD_NRD_1	322	324	PF00675	0.439
CLV_NRD_NRD_1	381	383	PF00675	0.394
CLV_NRD_NRD_1	653	655	PF00675	0.519
CLV_PCSK_KEX2_1	100	102	PF00082	0.735
CLV_PCSK_KEX2_1	167	169	PF00082	0.659
CLV_PCSK_KEX2_1	268	270	PF00082	0.540
CLV_PCSK_KEX2_1	322	324	PF00082	0.488
CLV_PCSK_KEX2_1	381	383	PF00082	0.394
CLV_PCSK_KEX2_1	653	655	PF00082	0.430
CLV_PCSK_SKI1_1	139	143	PF00082	0.554
CLV_PCSK_SKI1_1	184	188	PF00082	0.477
CLV_PCSK_SKI1_1	227	231	PF00082	0.380
CLV_PCSK_SKI1_1	296	300	PF00082	0.595
DEG_APCC_DBOX_1	106	114	PF00400	0.502
DEG_APCC_DBOX_1	183	191	PF00400	0.448
DEG_Nend_UBRbox_2	1	3	PF02207	0.518
DEG_SPOP_SBC_1	461	465	PF00917	0.651
DOC_ANK_TNKS_1	321	328	PF00023	0.563
DOC_CYCLIN_RxL_1	221	232	PF00134	0.320
DOC_MAPK_gen_1	322	330	PF00069	0.493
DOC_MAPK_gen_1	391	401	PF00069	0.432
DOC_USP7_MATH_1	161	165	PF00917	0.703
DOC_USP7_MATH_1	170	174	PF00917	0.614
DOC_USP7_MATH_1	35	39	PF00917	0.653
DOC_USP7_MATH_1	383	387	PF00917	0.586
DOC_USP7_MATH_1	41	45	PF00917	0.590
DOC_USP7_MATH_1	550	554	PF00917	0.712
DOC_USP7_MATH_1	632	636	PF00917	0.671
DOC_USP7_MATH_1	638	642	PF00917	0.483
DOC_USP7_MATH_1	66	70	PF00917	0.692
DOC_WW_Pin1_4	350	355	PF00397	0.588
DOC_WW_Pin1_4	414	419	PF00397	0.483
DOC_WW_Pin1_4	78	83	PF00397	0.603
LIG_14-3-3_CanoR_1	107	111	PF00244	0.570
LIG_14-3-3_CanoR_1	204	209	PF00244	0.612
LIG_14-3-3_CanoR_1	240	245	PF00244	0.466
LIG_14-3-3_CanoR_1	269	278	PF00244	0.555
LIG_14-3-3_CanoR_1	322	330	PF00244	0.469
LIG_14-3-3_CanoR_1	382	392	PF00244	0.528
LIG_14-3-3_CanoR_1	511	519	PF00244	0.486
LIG_14-3-3_CanoR_1	540	548	PF00244	0.560
LIG_14-3-3_CanoR_1	569	574	PF00244	0.509
LIG_14-3-3_CanoR_1	63	71	PF00244	0.756
LIG_14-3-3_CanoR_1	8	14	PF00244	0.661
LIG_14-3-3_CterR_2	681	684	PF00244	0.524
LIG_APCC_ABBA_1	646	651	PF00400	0.378
LIG_BIR_III_2	79	83	PF00653	0.597
LIG_BRCT_BRCA1_1	176	180	PF00533	0.465
LIG_BRCT_BRCA1_1	55	59	PF00533	0.740
LIG_BRCT_BRCA1_1	640	644	PF00533	0.382
LIG_deltaCOP1_diTrp_1	120	130	PF00928	0.431
LIG_EVH1_2	95	99	PF00568	0.542
LIG_FHA_1	129	135	PF00498	0.516
LIG_FHA_1	230	236	PF00498	0.312
LIG_FHA_1	246	252	PF00498	0.252
LIG_FHA_1	272	278	PF00498	0.546
LIG_FHA_1	387	393	PF00498	0.390
LIG_FHA_1	429	435	PF00498	0.490
LIG_FHA_1	497	503	PF00498	0.379
LIG_FHA_1	519	525	PF00498	0.454
LIG_FHA_1	576	582	PF00498	0.341
LIG_FHA_1	608	614	PF00498	0.372
LIG_FHA_1	661	667	PF00498	0.460
LIG_FHA_2	344	350	PF00498	0.746
LIG_FHA_2	362	368	PF00498	0.516
LIG_FHA_2	424	430	PF00498	0.484
LIG_FHA_2	450	456	PF00498	0.592
LIG_FHA_2	462	468	PF00498	0.508
LIG_FHA_2	471	477	PF00498	0.425
LIG_FHA_2	531	537	PF00498	0.514
LIG_LIR_Apic_2	417	423	PF02991	0.319
LIG_LIR_Gen_1	177	188	PF02991	0.442
LIG_LIR_Gen_1	2	9	PF02991	0.529
LIG_LIR_Gen_1	239	250	PF02991	0.352
LIG_LIR_Gen_1	407	415	PF02991	0.462
LIG_LIR_Gen_1	501	510	PF02991	0.334
LIG_LIR_Gen_1	514	524	PF02991	0.416
LIG_LIR_Gen_1	578	586	PF02991	0.330
LIG_LIR_Nem_3	177	183	PF02991	0.435
LIG_LIR_Nem_3	2	6	PF02991	0.600
LIG_LIR_Nem_3	248	253	PF02991	0.390
LIG_LIR_Nem_3	375	379	PF02991	0.395
LIG_LIR_Nem_3	407	411	PF02991	0.412
LIG_LIR_Nem_3	473	478	PF02991	0.535
LIG_LIR_Nem_3	501	506	PF02991	0.449
LIG_LIR_Nem_3	514	519	PF02991	0.398
LIG_LIR_Nem_3	578	582	PF02991	0.343
LIG_LIR_Nem_3	593	599	PF02991	0.376
LIG_MYND_1	92	96	PF01753	0.496
LIG_NRBOX	505	511	PF00104	0.452
LIG_RPA_C_Fungi	317	329	PF08784	0.502
LIG_SH2_CRK	408	412	PF00017	0.404
LIG_SH2_PTP2	420	423	PF00017	0.449
LIG_SH2_STAP1	408	412	PF00017	0.404
LIG_SH2_STAP1	579	583	PF00017	0.333
LIG_SH2_STAP1	599	603	PF00017	0.378
LIG_SH2_STAP1	614	618	PF00017	0.386
LIG_SH2_STAT3	108	111	PF00017	0.515
LIG_SH2_STAT3	588	591	PF00017	0.484
LIG_SH2_STAT5	223	226	PF00017	0.345
LIG_SH2_STAT5	420	423	PF00017	0.452
LIG_SH2_STAT5	508	511	PF00017	0.461
LIG_SH2_STAT5	588	591	PF00017	0.439
LIG_SH3_2	92	97	PF14604	0.548
LIG_SH3_3	138	144	PF00018	0.500
LIG_SH3_3	189	195	PF00018	0.557
LIG_SH3_3	278	284	PF00018	0.624
LIG_SH3_3	89	95	PF00018	0.579
LIG_SUMO_SIM_anti_2	615	620	PF11976	0.430
LIG_SUMO_SIM_par_1	615	620	PF11976	0.430
LIG_TRAF2_1	426	429	PF00917	0.552
LIG_TRAF2_2	192	197	PF00917	0.542
LIG_TYR_ITIM	406	411	PF00017	0.413
LIG_UBA3_1	298	304	PF00899	0.508
LIG_UBA3_1	395	403	PF00899	0.477
LIG_UBA3_1	506	513	PF00899	0.408
LIG_WRC_WIRS_1	659	664	PF05994	0.521
LIG_WW_3	190	194	PF00397	0.522
LIG_WW_3	94	98	PF00397	0.545
MOD_CK1_1	271	277	PF00069	0.572
MOD_CK1_1	289	295	PF00069	0.600
MOD_CK1_1	386	392	PF00069	0.420
MOD_CK1_1	459	465	PF00069	0.721
MOD_CK1_1	559	565	PF00069	0.652
MOD_CK1_1	69	75	PF00069	0.733
MOD_CK2_1	170	176	PF00069	0.591
MOD_CK2_1	361	367	PF00069	0.610
MOD_CK2_1	423	429	PF00069	0.570
MOD_CK2_1	470	476	PF00069	0.460
MOD_CK2_1	530	536	PF00069	0.458
MOD_CMANNOS	570	573	PF00535	0.455
MOD_GlcNHglycan	131	134	PF01048	0.398
MOD_GlcNHglycan	154	157	PF01048	0.674
MOD_GlcNHglycan	345	349	PF01048	0.809
MOD_GlcNHglycan	37	40	PF01048	0.638
MOD_GlcNHglycan	43	46	PF01048	0.634
MOD_GlcNHglycan	458	461	PF01048	0.653
MOD_GlcNHglycan	467	471	PF01048	0.473
MOD_GlcNHglycan	47	50	PF01048	0.616
MOD_GlcNHglycan	552	555	PF01048	0.664
MOD_GlcNHglycan	561	564	PF01048	0.606
MOD_GlcNHglycan	68	71	PF01048	0.705
MOD_GSK3_1	170	177	PF00069	0.637
MOD_GSK3_1	200	207	PF00069	0.539
MOD_GSK3_1	267	274	PF00069	0.525
MOD_GSK3_1	286	293	PF00069	0.566
MOD_GSK3_1	382	389	PF00069	0.424
MOD_GSK3_1	41	48	PF00069	0.644
MOD_GSK3_1	456	463	PF00069	0.754
MOD_GSK3_1	466	473	PF00069	0.597
MOD_GSK3_1	658	665	PF00069	0.446
MOD_GSK3_1	66	73	PF00069	0.708
MOD_GSK3_1	670	677	PF00069	0.480
MOD_N-GLC_1	101	106	PF02516	0.641
MOD_N-GLC_1	171	176	PF02516	0.598
MOD_NEK2_1	129	134	PF00069	0.363
MOD_NEK2_1	215	220	PF00069	0.414
MOD_NEK2_1	229	234	PF00069	0.304
MOD_NEK2_1	245	250	PF00069	0.287
MOD_NEK2_1	267	272	PF00069	0.544
MOD_NEK2_1	288	293	PF00069	0.504
MOD_NEK2_1	468	473	PF00069	0.550
MOD_NEK2_1	602	607	PF00069	0.446
MOD_NEK2_1	662	667	PF00069	0.516
MOD_NEK2_2	449	454	PF00069	0.527
MOD_PIKK_1	21	27	PF00454	0.740
MOD_PIKK_1	70	76	PF00454	0.712
MOD_PK_1	204	210	PF00069	0.499
MOD_PK_1	240	246	PF00069	0.428
MOD_PKA_1	268	274	PF00069	0.468
MOD_PKA_2	106	112	PF00069	0.576
MOD_PKA_2	197	203	PF00069	0.628
MOD_PKA_2	215	221	PF00069	0.322
MOD_PKA_2	267	273	PF00069	0.462
MOD_PKA_2	321	327	PF00069	0.528
MOD_PKA_2	343	349	PF00069	0.719
MOD_PKA_2	383	389	PF00069	0.506
MOD_PKA_2	539	545	PF00069	0.520
MOD_PKA_2	559	565	PF00069	0.635
MOD_PKA_2	568	574	PF00069	0.500
MOD_PKA_2	607	613	PF00069	0.429
MOD_PKA_2	7	13	PF00069	0.663
MOD_PKB_1	674	682	PF00069	0.475
MOD_Plk_1	256	262	PF00069	0.461
MOD_Plk_4	277	283	PF00069	0.665
MOD_Plk_4	407	413	PF00069	0.457
MOD_Plk_4	518	524	PF00069	0.541
MOD_Plk_4	561	567	PF00069	0.476
MOD_Plk_4	640	646	PF00069	0.542
MOD_ProDKin_1	350	356	PF00069	0.589
MOD_ProDKin_1	414	420	PF00069	0.481
MOD_ProDKin_1	78	84	PF00069	0.601
TRG_DiLeu_BaEn_1	505	510	PF01217	0.443
TRG_DiLeu_BaEn_2	175	181	PF01217	0.375
TRG_ENDOCYTIC_2	222	225	PF00928	0.330
TRG_ENDOCYTIC_2	408	411	PF00928	0.406
TRG_ENDOCYTIC_2	579	582	PF00928	0.334
TRG_ENDOCYTIC_2	599	602	PF00928	0.407
TRG_ENDOCYTIC_2	614	617	PF00928	0.328
TRG_ENDOCYTIC_2	649	652	PF00928	0.370
TRG_ER_diArg_1	166	168	PF00400	0.673
TRG_ER_diArg_1	267	269	PF00400	0.516
TRG_ER_diArg_1	380	382	PF00400	0.389
TRG_ER_diArg_1	585	588	PF00400	0.473
TRG_ER_diArg_1	652	654	PF00400	0.504
TRG_ER_diArg_1	99	101	PF00400	0.622
TRG_NES_CRM1_1	390	404	PF08389	0.429
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGR3	Leptomonas seymouri	48%	91%
A0A1X0NVZ4	Trypanosomatidae	30%	100%
A0A3Q8IG45	Leishmania donovani	99%	100%
A0A3R7NTQ6	Trypanosoma rangeli	32%	100%
A4HKA1	Leishmania braziliensis	68%	100%
D0A9Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B2N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q5G8	Leishmania major	88%	100%
V5BQR4	Trypanosoma cruzi	30%	100%