GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7S1_LEIIN

TriTrypDb:

LINF_320016100

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4I7S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7S1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.720
CLV_C14_Caspase3-7	321	325	PF00656	0.739
CLV_C14_Caspase3-7	347	351	PF00656	0.721
CLV_C14_Caspase3-7	411	415	PF00656	0.657
CLV_C14_Caspase3-7	68	72	PF00656	0.728
CLV_NRD_NRD_1	124	126	PF00675	0.460
CLV_NRD_NRD_1	19	21	PF00675	0.391
CLV_NRD_NRD_1	284	286	PF00675	0.497
CLV_NRD_NRD_1	301	303	PF00675	0.291
CLV_NRD_NRD_1	314	316	PF00675	0.554
CLV_NRD_NRD_1	583	585	PF00675	0.485
CLV_NRD_NRD_1	616	618	PF00675	0.645
CLV_PCSK_FUR_1	312	316	PF00082	0.390
CLV_PCSK_KEX2_1	284	286	PF00082	0.481
CLV_PCSK_KEX2_1	301	303	PF00082	0.350
CLV_PCSK_KEX2_1	311	313	PF00082	0.511
CLV_PCSK_KEX2_1	314	316	PF00082	0.564
CLV_PCSK_KEX2_1	469	471	PF00082	0.498
CLV_PCSK_KEX2_1	583	585	PF00082	0.482
CLV_PCSK_KEX2_1	616	618	PF00082	0.712
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.429
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.488
CLV_PCSK_SKI1_1	112	116	PF00082	0.398
CLV_PCSK_SKI1_1	270	274	PF00082	0.508
CLV_PCSK_SKI1_1	361	365	PF00082	0.576
CLV_PCSK_SKI1_1	537	541	PF00082	0.485
CLV_PCSK_SKI1_1	95	99	PF00082	0.367
CLV_Separin_Metazoa	80	84	PF03568	0.659
DEG_APCC_DBOX_1	360	368	PF00400	0.662
DEG_Nend_UBRbox_3	1	3	PF02207	0.663
DOC_CKS1_1	34	39	PF01111	0.592
DOC_CYCLIN_RxL_1	1	12	PF00134	0.655
DOC_MAPK_gen_1	359	367	PF00069	0.729
DOC_MAPK_gen_1	478	486	PF00069	0.706
DOC_MAPK_gen_1	48	56	PF00069	0.651
DOC_MAPK_gen_1	583	592	PF00069	0.649
DOC_MAPK_MEF2A_6	112	121	PF00069	0.690
DOC_PP1_RVXF_1	116	122	PF00149	0.654
DOC_PP1_RVXF_1	2	9	PF00149	0.654
DOC_PP2B_LxvP_1	500	503	PF13499	0.728
DOC_USP7_MATH_1	156	160	PF00917	0.769
DOC_USP7_MATH_1	161	165	PF00917	0.778
DOC_USP7_MATH_1	290	294	PF00917	0.702
DOC_USP7_MATH_1	562	566	PF00917	0.632
DOC_USP7_MATH_1	576	580	PF00917	0.776
DOC_USP7_MATH_1	9	13	PF00917	0.624
DOC_WW_Pin1_4	167	172	PF00397	0.808
DOC_WW_Pin1_4	173	178	PF00397	0.631
DOC_WW_Pin1_4	26	31	PF00397	0.597
DOC_WW_Pin1_4	33	38	PF00397	0.626
DOC_WW_Pin1_4	330	335	PF00397	0.735
DOC_WW_Pin1_4	349	354	PF00397	0.749
DOC_WW_Pin1_4	495	500	PF00397	0.767
DOC_WW_Pin1_4	58	63	PF00397	0.668
LIG_14-3-3_CanoR_1	20	26	PF00244	0.614
LIG_14-3-3_CanoR_1	312	318	PF00244	0.642
LIG_14-3-3_CanoR_1	327	335	PF00244	0.793
LIG_14-3-3_CanoR_1	563	571	PF00244	0.815
LIG_14-3-3_CanoR_1	83	93	PF00244	0.671
LIG_14-3-3_CanoR_1	95	101	PF00244	0.572
LIG_Actin_WH2_2	107	122	PF00022	0.691
LIG_Actin_WH2_2	36	53	PF00022	0.534
LIG_APCC_ABBA_1	605	610	PF00400	0.302
LIG_BIR_III_2	350	354	PF00653	0.716
LIG_BRCT_BRCA1_1	158	162	PF00533	0.740
LIG_BRCT_BRCA1_1	324	328	PF00533	0.652
LIG_Clathr_ClatBox_1	364	368	PF01394	0.798
LIG_EVH1_1	33	37	PF00568	0.603
LIG_FHA_1	174	180	PF00498	0.695
LIG_FHA_1	226	232	PF00498	0.653
LIG_FHA_1	34	40	PF00498	0.700
LIG_FHA_1	460	466	PF00498	0.637
LIG_FHA_1	490	496	PF00498	0.623
LIG_FHA_1	88	94	PF00498	0.590
LIG_FHA_2	314	320	PF00498	0.724
LIG_FHA_2	538	544	PF00498	0.665
LIG_LIR_Gen_1	211	221	PF02991	0.668
LIG_LIR_Gen_1	99	108	PF02991	0.550
LIG_LIR_Nem_3	99	103	PF02991	0.575
LIG_MYND_1	31	35	PF01753	0.611
LIG_PDZ_Class_3	617	622	PF00595	0.478
LIG_SH2_NCK_1	535	539	PF00017	0.746
LIG_SH2_STAP1	253	257	PF00017	0.649
LIG_SH2_STAP1	535	539	PF00017	0.702
LIG_SH2_STAT5	183	186	PF00017	0.592
LIG_SH2_STAT5	356	359	PF00017	0.683
LIG_SH3_1	583	589	PF00018	0.686
LIG_SH3_3	152	158	PF00018	0.789
LIG_SH3_3	28	34	PF00018	0.611
LIG_SH3_3	517	523	PF00018	0.722
LIG_SH3_3	583	589	PF00018	0.686
LIG_SUMO_SIM_par_1	363	369	PF11976	0.731
LIG_SUMO_SIM_par_1	52	61	PF11976	0.693
LIG_TRAF2_1	201	204	PF00917	0.697
LIG_TRAF2_1	422	425	PF00917	0.641
LIG_TRAF2_1	99	102	PF00917	0.613
LIG_UBA3_1	13	21	PF00899	0.580
LIG_UBA3_1	39	48	PF00899	0.597
LIG_UBA3_1	483	491	PF00899	0.536
LIG_WW_3	560	564	PF00397	0.653
MOD_CK1_1	12	18	PF00069	0.642
MOD_CK1_1	224	230	PF00069	0.748
MOD_CK1_1	322	328	PF00069	0.784
MOD_CK1_1	333	339	PF00069	0.754
MOD_CK1_1	349	355	PF00069	0.746
MOD_CK1_1	366	372	PF00069	0.773
MOD_CK1_1	42	48	PF00069	0.592
MOD_CK1_1	472	478	PF00069	0.630
MOD_CK1_1	87	93	PF00069	0.700
MOD_CK2_1	183	189	PF00069	0.588
MOD_CK2_1	198	204	PF00069	0.612
MOD_CK2_1	252	258	PF00069	0.621
MOD_CK2_1	290	296	PF00069	0.721
MOD_CK2_1	313	319	PF00069	0.714
MOD_CK2_1	419	425	PF00069	0.633
MOD_CK2_1	524	530	PF00069	0.669
MOD_CK2_1	69	75	PF00069	0.707
MOD_CK2_1	96	102	PF00069	0.642
MOD_Cter_Amidation	312	315	PF01082	0.382
MOD_GlcNHglycan	151	154	PF01048	0.444
MOD_GlcNHglycan	223	226	PF01048	0.441
MOD_GlcNHglycan	292	295	PF01048	0.530
MOD_GlcNHglycan	321	324	PF01048	0.552
MOD_GlcNHglycan	335	338	PF01048	0.603
MOD_GlcNHglycan	368	371	PF01048	0.461
MOD_GlcNHglycan	405	409	PF01048	0.491
MOD_GlcNHglycan	471	474	PF01048	0.451
MOD_GlcNHglycan	578	581	PF01048	0.480
MOD_GlcNHglycan	610	613	PF01048	0.610
MOD_GSK3_1	127	134	PF00069	0.690
MOD_GSK3_1	157	164	PF00069	0.797
MOD_GSK3_1	203	210	PF00069	0.719
MOD_GSK3_1	221	228	PF00069	0.601
MOD_GSK3_1	252	259	PF00069	0.685
MOD_GSK3_1	286	293	PF00069	0.684
MOD_GSK3_1	29	36	PF00069	0.623
MOD_GSK3_1	313	320	PF00069	0.672
MOD_GSK3_1	322	329	PF00069	0.723
MOD_GSK3_1	333	340	PF00069	0.696
MOD_GSK3_1	38	45	PF00069	0.611
MOD_GSK3_1	400	407	PF00069	0.693
MOD_GSK3_1	504	511	PF00069	0.800
MOD_GSK3_1	65	72	PF00069	0.682
MOD_GSK3_1	8	15	PF00069	0.664
MOD_N-GLC_1	131	136	PF02516	0.499
MOD_N-GLC_1	337	342	PF02516	0.514
MOD_N-GLC_1	373	378	PF02516	0.438
MOD_N-GLC_1	419	424	PF02516	0.451
MOD_N-GLC_1	524	529	PF02516	0.485
MOD_NEK2_1	127	132	PF00069	0.596
MOD_NEK2_1	13	18	PF00069	0.627
MOD_NEK2_1	135	140	PF00069	0.596
MOD_NEK2_1	221	226	PF00069	0.704
MOD_NEK2_1	318	323	PF00069	0.692
MOD_NEK2_1	328	333	PF00069	0.721
MOD_NEK2_1	39	44	PF00069	0.688
MOD_NEK2_1	46	51	PF00069	0.651
MOD_NEK2_1	524	529	PF00069	0.674
MOD_NEK2_1	608	613	PF00069	0.496
MOD_NEK2_2	183	188	PF00069	0.613
MOD_PIKK_1	203	209	PF00454	0.667
MOD_PIKK_1	326	332	PF00454	0.775
MOD_PIKK_1	337	343	PF00454	0.798
MOD_PIKK_1	562	568	PF00454	0.701
MOD_PIKK_1	65	71	PF00454	0.743
MOD_PIKK_1	87	93	PF00454	0.630
MOD_PK_1	104	110	PF00069	0.595
MOD_PKA_1	469	475	PF00069	0.637
MOD_PKA_2	156	162	PF00069	0.739
MOD_PKA_2	313	319	PF00069	0.672
MOD_PKA_2	326	332	PF00069	0.795
MOD_PKA_2	400	406	PF00069	0.625
MOD_PKA_2	469	475	PF00069	0.637
MOD_PKA_2	562	568	PF00069	0.812
MOD_PKA_2	576	582	PF00069	0.705
MOD_PKA_2	69	75	PF00069	0.632
MOD_Plk_1	112	118	PF00069	0.637
MOD_Plk_1	131	137	PF00069	0.563
MOD_Plk_1	203	209	PF00069	0.661
MOD_Plk_1	419	425	PF00069	0.651
MOD_Plk_1	524	530	PF00069	0.711
MOD_Plk_2-3	106	112	PF00069	0.694
MOD_Plk_2-3	419	425	PF00069	0.587
MOD_Plk_4	21	27	PF00069	0.583
MOD_Plk_4	252	258	PF00069	0.645
MOD_Plk_4	42	48	PF00069	0.672
MOD_Plk_4	524	530	PF00069	0.666
MOD_Plk_4	9	15	PF00069	0.590
MOD_ProDKin_1	167	173	PF00069	0.804
MOD_ProDKin_1	26	32	PF00069	0.613
MOD_ProDKin_1	33	39	PF00069	0.621
MOD_ProDKin_1	330	336	PF00069	0.735
MOD_ProDKin_1	349	355	PF00069	0.746
MOD_ProDKin_1	495	501	PF00069	0.771
MOD_ProDKin_1	58	64	PF00069	0.672
MOD_SUMO_for_1	278	281	PF00179	0.662
MOD_SUMO_rev_2	466	471	PF00179	0.659
MOD_SUMO_rev_2	472	479	PF00179	0.656
TRG_DiLeu_BaEn_1	269	274	PF01217	0.672
TRG_DiLeu_BaEn_4	203	209	PF01217	0.686
TRG_DiLeu_BaEn_4	298	304	PF01217	0.537
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.668
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.654
TRG_ENDOCYTIC_2	100	103	PF00928	0.659
TRG_ENDOCYTIC_2	214	217	PF00928	0.651
TRG_ENDOCYTIC_2	253	256	PF00928	0.646
TRG_ENDOCYTIC_2	603	606	PF00928	0.464
TRG_ER_diArg_1	116	119	PF00400	0.620
TRG_ER_diArg_1	300	302	PF00400	0.668
TRG_ER_diArg_1	312	315	PF00400	0.725
TRG_ER_diArg_1	582	584	PF00400	0.709
TRG_ER_diArg_1	616	619	PF00400	0.452
TRG_NES_CRM1_1	189	203	PF08389	0.629
TRG_NLS_Bipartite_1	301	315	PF00514	0.516
TRG_NLS_MonoExtC_3	310	315	PF00514	0.541
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4B6	Leptomonas seymouri	38%	100%
A0A1X0NV17	Trypanosomatidae	25%	100%
A0A3S5ISI9	Trypanosoma rangeli	24%	100%
A0A3S7X5F4	Leishmania donovani	99%	100%
A4HK86	Leishmania braziliensis	63%	100%
E9B2M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q5H8	Leishmania major	85%	100%