Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4I7R6_LEIIN

TriTrypDb:

LINF_320015600

Length:

860

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I7R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7R6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	835	839	PF00656	0.524
CLV_C14_Caspase3-7	855	859	PF00656	0.337
CLV_NRD_NRD_1	192	194	PF00675	0.374
CLV_NRD_NRD_1	719	721	PF00675	0.457
CLV_NRD_NRD_1	747	749	PF00675	0.430
CLV_NRD_NRD_1	821	823	PF00675	0.593
CLV_PCSK_KEX2_1	719	721	PF00082	0.445
CLV_PCSK_KEX2_1	747	749	PF00082	0.484
CLV_PCSK_KEX2_1	821	823	PF00082	0.593
CLV_PCSK_PC1ET2_1	747	749	PF00082	0.377
CLV_PCSK_SKI1_1	292	296	PF00082	0.435
CLV_PCSK_SKI1_1	358	362	PF00082	0.242
CLV_PCSK_SKI1_1	366	370	PF00082	0.177
CLV_PCSK_SKI1_1	456	460	PF00082	0.661
DEG_APCC_DBOX_1	475	483	PF00400	0.592
DEG_APCC_DBOX_1	95	103	PF00400	0.364
DEG_SCF_FBW7_1	388	394	PF00400	0.445
DEG_SPOP_SBC_1	833	837	PF00917	0.535
DOC_CKS1_1	388	393	PF01111	0.440
DOC_CKS1_1	598	603	PF01111	0.524
DOC_CYCLIN_yCln2_LP_2	335	341	PF00134	0.285
DOC_MAPK_gen_1	719	726	PF00069	0.458
DOC_MAPK_gen_1	802	812	PF00069	0.383
DOC_MAPK_RevD_3	735	748	PF00069	0.355
DOC_PP1_RVXF_1	356	362	PF00149	0.384
DOC_PP1_RVXF_1	618	625	PF00149	0.268
DOC_PP4_FxxP_1	787	790	PF00568	0.474
DOC_USP7_MATH_1	113	117	PF00917	0.332
DOC_USP7_MATH_1	172	176	PF00917	0.601
DOC_USP7_MATH_1	241	245	PF00917	0.506
DOC_USP7_MATH_1	31	35	PF00917	0.396
DOC_USP7_MATH_1	382	386	PF00917	0.569
DOC_USP7_MATH_1	391	395	PF00917	0.510
DOC_USP7_MATH_1	522	526	PF00917	0.259
DOC_USP7_MATH_1	553	557	PF00917	0.316
DOC_USP7_MATH_1	684	688	PF00917	0.646
DOC_USP7_MATH_1	730	734	PF00917	0.413
DOC_USP7_MATH_1	827	831	PF00917	0.622
DOC_WW_Pin1_4	132	137	PF00397	0.381
DOC_WW_Pin1_4	271	276	PF00397	0.470
DOC_WW_Pin1_4	387	392	PF00397	0.460
DOC_WW_Pin1_4	459	464	PF00397	0.617
DOC_WW_Pin1_4	471	476	PF00397	0.573
DOC_WW_Pin1_4	498	503	PF00397	0.601
DOC_WW_Pin1_4	597	602	PF00397	0.443
DOC_WW_Pin1_4	639	644	PF00397	0.328
DOC_WW_Pin1_4	662	667	PF00397	0.590
LIG_14-3-3_CanoR_1	204	214	PF00244	0.514
LIG_14-3-3_CanoR_1	383	391	PF00244	0.428
LIG_14-3-3_CanoR_1	456	462	PF00244	0.649
LIG_14-3-3_CanoR_1	476	480	PF00244	0.707
LIG_14-3-3_CanoR_1	516	521	PF00244	0.257
LIG_14-3-3_CanoR_1	595	599	PF00244	0.445
LIG_14-3-3_CanoR_1	62	68	PF00244	0.550
LIG_14-3-3_CanoR_1	664	672	PF00244	0.420
LIG_14-3-3_CanoR_1	674	682	PF00244	0.443
LIG_14-3-3_CanoR_1	719	725	PF00244	0.403
LIG_14-3-3_CanoR_1	777	787	PF00244	0.524
LIG_14-3-3_CanoR_1	821	827	PF00244	0.618
LIG_Actin_WH2_2	440	458	PF00022	0.598
LIG_APCC_ABBA_1	220	225	PF00400	0.339
LIG_BIR_II_1	1	5	PF00653	0.397
LIG_BIR_III_4	838	842	PF00653	0.495
LIG_BRCT_BRCA1_1	316	320	PF00533	0.410
LIG_BRCT_BRCA1_1	641	645	PF00533	0.290
LIG_BRCT_BRCA1_1	732	736	PF00533	0.346
LIG_BRCT_BRCA1_1	783	787	PF00533	0.645
LIG_CaM_NSCaTE_8	137	144	PF13499	0.385
LIG_FHA_1	190	196	PF00498	0.457
LIG_FHA_1	209	215	PF00498	0.303
LIG_FHA_1	216	222	PF00498	0.556
LIG_FHA_1	276	282	PF00498	0.442
LIG_FHA_1	300	306	PF00498	0.404
LIG_FHA_1	351	357	PF00498	0.384
LIG_FHA_1	374	380	PF00498	0.435
LIG_FHA_1	476	482	PF00498	0.656
LIG_FHA_1	501	507	PF00498	0.387
LIG_FHA_1	721	727	PF00498	0.439
LIG_FHA_2	582	588	PF00498	0.276
LIG_FHA_2	68	74	PF00498	0.343
LIG_FHA_2	767	773	PF00498	0.524
LIG_LIR_Apic_2	784	790	PF02991	0.469
LIG_LIR_Gen_1	135	146	PF02991	0.440
LIG_LIR_Gen_1	182	190	PF02991	0.388
LIG_LIR_Gen_1	274	281	PF02991	0.525
LIG_LIR_Gen_1	317	325	PF02991	0.296
LIG_LIR_Gen_1	733	744	PF02991	0.329
LIG_LIR_Nem_3	135	141	PF02991	0.494
LIG_LIR_Nem_3	182	187	PF02991	0.332
LIG_LIR_Nem_3	274	279	PF02991	0.448
LIG_LIR_Nem_3	317	323	PF02991	0.306
LIG_PCNA_PIPBox_1	806	815	PF02747	0.469
LIG_PDZ_Class_3	855	860	PF00595	0.560
LIG_Pex14_2	736	740	PF04695	0.329
LIG_SH2_CRK	129	133	PF00017	0.340
LIG_SH2_CRK	413	417	PF00017	0.227
LIG_SH2_CRK	567	571	PF00017	0.236
LIG_SH2_NCK_1	246	250	PF00017	0.458
LIG_SH2_NCK_1	413	417	PF00017	0.294
LIG_SH2_NCK_1	567	571	PF00017	0.236
LIG_SH2_SRC	567	570	PF00017	0.233
LIG_SH2_STAP1	184	188	PF00017	0.513
LIG_SH2_STAP1	223	227	PF00017	0.345
LIG_SH2_STAP1	246	250	PF00017	0.458
LIG_SH2_STAP1	413	417	PF00017	0.273
LIG_SH2_STAP1	436	440	PF00017	0.407
LIG_SH2_STAT3	693	696	PF00017	0.427
LIG_SH2_STAT5	138	141	PF00017	0.517
LIG_SH2_STAT5	184	187	PF00017	0.443
LIG_SH2_STAT5	226	229	PF00017	0.368
LIG_SH2_STAT5	367	370	PF00017	0.474
LIG_SH2_STAT5	413	416	PF00017	0.246
LIG_SH2_STAT5	675	678	PF00017	0.491
LIG_SH2_STAT5	752	755	PF00017	0.527
LIG_SH2_STAT5	852	855	PF00017	0.399
LIG_SH3_3	235	241	PF00018	0.309
LIG_SH3_3	269	275	PF00018	0.474
LIG_SH3_3	335	341	PF00018	0.369
LIG_SH3_3	36	42	PF00018	0.346
LIG_SH3_3	376	382	PF00018	0.481
LIG_SH3_3	385	391	PF00018	0.504
LIG_SH3_3	595	601	PF00018	0.338
LIG_SH3_3	676	682	PF00018	0.725
LIG_SH3_3	7	13	PF00018	0.341
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.440
LIG_SUMO_SIM_par_1	277	283	PF11976	0.659
LIG_SUMO_SIM_par_1	503	510	PF11976	0.299
LIG_SUMO_SIM_par_1	722	729	PF11976	0.347
LIG_SUMO_SIM_par_1	73	80	PF11976	0.289
LIG_WRC_WIRS_1	458	463	PF05994	0.502
MOD_CDK_SPK_2	471	476	PF00069	0.731
MOD_CK1_1	140	146	PF00069	0.432
MOD_CK1_1	149	155	PF00069	0.389
MOD_CK1_1	21	27	PF00069	0.535
MOD_CK1_1	274	280	PF00069	0.441
MOD_CK1_1	370	376	PF00069	0.205
MOD_CK1_1	446	452	PF00069	0.647
MOD_CK1_1	457	463	PF00069	0.583
MOD_CK1_1	474	480	PF00069	0.622
MOD_CK1_1	507	513	PF00069	0.475
MOD_CK1_1	597	603	PF00069	0.441
MOD_CK1_1	665	671	PF00069	0.668
MOD_CK1_1	781	787	PF00069	0.567
MOD_CK1_1	834	840	PF00069	0.713
MOD_CK2_1	581	587	PF00069	0.264
MOD_CK2_1	665	671	PF00069	0.426
MOD_CK2_1	67	73	PF00069	0.469
MOD_CK2_1	766	772	PF00069	0.519
MOD_GlcNHglycan	142	145	PF01048	0.506
MOD_GlcNHglycan	161	165	PF01048	0.525
MOD_GlcNHglycan	169	172	PF01048	0.405
MOD_GlcNHglycan	316	319	PF01048	0.317
MOD_GlcNHglycan	392	396	PF01048	0.567
MOD_GlcNHglycan	554	558	PF01048	0.467
MOD_GlcNHglycan	63	66	PF01048	0.354
MOD_GlcNHglycan	635	638	PF01048	0.335
MOD_GlcNHglycan	686	689	PF01048	0.665
MOD_GlcNHglycan	782	786	PF01048	0.617
MOD_GSK3_1	167	174	PF00069	0.593
MOD_GSK3_1	236	243	PF00069	0.399
MOD_GSK3_1	271	278	PF00069	0.460
MOD_GSK3_1	310	317	PF00069	0.372
MOD_GSK3_1	369	376	PF00069	0.191
MOD_GSK3_1	387	394	PF00069	0.417
MOD_GSK3_1	443	450	PF00069	0.560
MOD_GSK3_1	471	478	PF00069	0.736
MOD_GSK3_1	498	505	PF00069	0.419
MOD_GSK3_1	507	514	PF00069	0.284
MOD_GSK3_1	530	537	PF00069	0.444
MOD_GSK3_1	545	552	PF00069	0.295
MOD_GSK3_1	660	667	PF00069	0.397
MOD_GSK3_1	700	707	PF00069	0.500
MOD_GSK3_1	710	717	PF00069	0.304
MOD_GSK3_1	725	732	PF00069	0.312
MOD_GSK3_1	777	784	PF00069	0.523
MOD_GSK3_1	827	834	PF00069	0.791
MOD_LATS_1	775	781	PF00433	0.453
MOD_N-GLC_1	451	456	PF02516	0.619
MOD_N-GLC_1	522	527	PF02516	0.286
MOD_N-GLC_1	85	90	PF02516	0.391
MOD_NEK2_1	167	172	PF00069	0.626
MOD_NEK2_1	300	305	PF00069	0.295
MOD_NEK2_1	314	319	PF00069	0.231
MOD_NEK2_1	447	452	PF00069	0.614
MOD_NEK2_1	504	509	PF00069	0.406
MOD_NEK2_1	581	586	PF00069	0.259
MOD_NEK2_2	451	456	PF00069	0.510
MOD_NEK2_2	735	740	PF00069	0.316
MOD_NEK2_2	85	90	PF00069	0.520
MOD_PIKK_1	652	658	PF00454	0.459
MOD_PIKK_1	673	679	PF00454	0.492
MOD_PIKK_1	815	821	PF00454	0.490
MOD_PK_1	516	522	PF00069	0.267
MOD_PKA_1	719	725	PF00069	0.560
MOD_PKA_2	172	178	PF00069	0.670
MOD_PKA_2	205	211	PF00069	0.511
MOD_PKA_2	241	247	PF00069	0.502
MOD_PKA_2	382	388	PF00069	0.411
MOD_PKA_2	475	481	PF00069	0.697
MOD_PKA_2	529	535	PF00069	0.338
MOD_PKA_2	549	555	PF00069	0.231
MOD_PKA_2	594	600	PF00069	0.326
MOD_PKA_2	61	67	PF00069	0.456
MOD_PKA_2	673	679	PF00069	0.492
MOD_PKA_2	700	706	PF00069	0.512
MOD_PKA_2	719	725	PF00069	0.258
MOD_PKA_2	766	772	PF00069	0.504
MOD_PKA_2	820	826	PF00069	0.610
MOD_PKB_1	204	212	PF00069	0.358
MOD_Plk_1	253	259	PF00069	0.497
MOD_Plk_1	290	296	PF00069	0.467
MOD_Plk_1	436	442	PF00069	0.483
MOD_Plk_1	451	457	PF00069	0.476
MOD_Plk_1	707	713	PF00069	0.371
MOD_Plk_1	781	787	PF00069	0.636
MOD_Plk_1	85	91	PF00069	0.385
MOD_Plk_4	137	143	PF00069	0.492
MOD_Plk_4	179	185	PF00069	0.521
MOD_Plk_4	226	232	PF00069	0.457
MOD_Plk_4	275	281	PF00069	0.474
MOD_Plk_4	316	322	PF00069	0.350
MOD_Plk_4	443	449	PF00069	0.642
MOD_Plk_4	522	528	PF00069	0.389
MOD_Plk_4	540	546	PF00069	0.517
MOD_Plk_4	707	713	PF00069	0.359
MOD_Plk_4	720	726	PF00069	0.304
MOD_Plk_4	735	741	PF00069	0.337
MOD_ProDKin_1	132	138	PF00069	0.380
MOD_ProDKin_1	271	277	PF00069	0.467
MOD_ProDKin_1	387	393	PF00069	0.463
MOD_ProDKin_1	459	465	PF00069	0.619
MOD_ProDKin_1	471	477	PF00069	0.571
MOD_ProDKin_1	498	504	PF00069	0.587
MOD_ProDKin_1	597	603	PF00069	0.436
MOD_ProDKin_1	639	645	PF00069	0.324
MOD_ProDKin_1	662	668	PF00069	0.604
TRG_DiLeu_BaEn_1	364	369	PF01217	0.211
TRG_DiLeu_BaEn_1	73	78	PF01217	0.293
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.274
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.353
TRG_ENDOCYTIC_2	138	141	PF00928	0.589
TRG_ENDOCYTIC_2	184	187	PF00928	0.439
TRG_ENDOCYTIC_2	285	288	PF00928	0.532
TRG_ENDOCYTIC_2	413	416	PF00928	0.238
TRG_ENDOCYTIC_2	567	570	PF00928	0.475
TRG_ER_diArg_1	203	206	PF00400	0.407
TRG_ER_diArg_1	718	720	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	620	625	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	814	819	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KK01	Bodo saltans	27%	78%
A0A1X0NV73	Trypanosomatidae	33%	84%
A0A3R7NTR8	Trypanosoma rangeli	34%	83%
D0A9X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	81%
V5B139	Trypanosoma cruzi	33%	86%