LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Vps23 core domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I7R5_LEIIN
TriTrypDb:
LINF_320015500
Length:
409

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0000813 ESCRT I complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0036452 ESCRT complex 2 1
GO:0098796 membrane protein complex 2 1
GO:0005768 endosome 7 11
GO:0031410 cytoplasmic vesicle 6 11
GO:0031982 vesicle 4 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0097708 intracellular vesicle 5 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4I7R5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7R5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 14
GO:0008104 protein localization 4 14
GO:0009987 cellular process 1 14
GO:0015031 protein transport 4 14
GO:0033036 macromolecule localization 2 14
GO:0045184 establishment of protein localization 3 14
GO:0051179 localization 1 14
GO:0051234 establishment of localization 2 14
GO:0051641 cellular localization 2 14
GO:0070727 cellular macromolecule localization 3 14
GO:0071702 organic substance transport 4 14
GO:0071705 nitrogen compound transport 4 14
GO:0007034 vacuolar transport 4 1
GO:0007041 lysosomal transport 5 1
GO:0008333 endosome to lysosome transport 5 1
GO:0016192 vesicle-mediated transport 4 1
GO:0046907 intracellular transport 3 1
GO:0051649 establishment of localization in cell 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0032182 ubiquitin-like protein binding 3 1
GO:0043130 ubiquitin binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 65 67 PF00675 0.568
CLV_PCSK_KEX2_1 302 304 PF00082 0.358
CLV_PCSK_PC1ET2_1 302 304 PF00082 0.391
CLV_PCSK_SKI1_1 229 233 PF00082 0.514
CLV_PCSK_SKI1_1 387 391 PF00082 0.443
CLV_PCSK_SKI1_1 405 409 PF00082 0.525
CLV_TASPASE1 255 261 PF01112 0.581
DEG_APCC_DBOX_1 386 394 PF00400 0.580
DEG_APCC_DBOX_1 400 408 PF00400 0.453
DEG_Nend_UBRbox_2 1 3 PF02207 0.566
DOC_CKS1_1 349 354 PF01111 0.737
DOC_CKS1_1 73 78 PF01111 0.547
DOC_CYCLIN_RxL_1 276 286 PF00134 0.492
DOC_CYCLIN_RxL_1 320 334 PF00134 0.591
DOC_CYCLIN_yCln2_LP_2 96 99 PF00134 0.492
DOC_PP2B_LxvP_1 96 99 PF13499 0.543
DOC_USP7_MATH_1 162 166 PF00917 0.669
DOC_USP7_MATH_1 181 185 PF00917 0.654
DOC_USP7_UBL2_3 331 335 PF12436 0.368
DOC_WW_Pin1_4 16 21 PF00397 0.495
DOC_WW_Pin1_4 344 349 PF00397 0.737
DOC_WW_Pin1_4 354 359 PF00397 0.797
DOC_WW_Pin1_4 45 50 PF00397 0.559
DOC_WW_Pin1_4 65 70 PF00397 0.559
DOC_WW_Pin1_4 72 77 PF00397 0.526
LIG_14-3-3_CanoR_1 131 136 PF00244 0.545
LIG_14-3-3_CanoR_1 182 186 PF00244 0.629
LIG_Actin_WH2_2 111 129 PF00022 0.396
LIG_BRCT_BRCA1_1 142 146 PF00533 0.490
LIG_FHA_1 25 31 PF00498 0.438
LIG_FHA_1 291 297 PF00498 0.612
LIG_FHA_1 344 350 PF00498 0.788
LIG_FHA_1 369 375 PF00498 0.582
LIG_FHA_1 73 79 PF00498 0.506
LIG_FHA_2 260 266 PF00498 0.625
LIG_FHA_2 305 311 PF00498 0.558
LIG_IRF3_LxIS_1 136 143 PF10401 0.489
LIG_LIR_Apic_2 15 20 PF02991 0.550
LIG_LIR_Gen_1 202 212 PF02991 0.444
LIG_LIR_Gen_1 60 69 PF02991 0.560
LIG_LIR_LC3C_4 75 80 PF02991 0.539
LIG_LIR_Nem_3 147 153 PF02991 0.447
LIG_LIR_Nem_3 15 21 PF02991 0.516
LIG_LIR_Nem_3 31 36 PF02991 0.296
LIG_LIR_Nem_3 60 65 PF02991 0.532
LIG_LYPXL_yS_3 150 153 PF13949 0.501
LIG_NRBOX 135 141 PF00104 0.404
LIG_OCRL_FandH_1 322 334 PF00620 0.522
LIG_PCNA_PIPBox_1 236 245 PF02747 0.486
LIG_PCNA_yPIPBox_3 229 243 PF02747 0.625
LIG_SH2_CRK 18 22 PF00017 0.510
LIG_SH2_GRB2like 36 39 PF00017 0.425
LIG_SH2_NCK_1 18 22 PF00017 0.404
LIG_SH2_PTP2 157 160 PF00017 0.407
LIG_SH2_SRC 157 160 PF00017 0.407
LIG_SH2_SRC 242 245 PF00017 0.661
LIG_SH2_SRC 28 31 PF00017 0.510
LIG_SH2_STAP1 36 40 PF00017 0.544
LIG_SH2_STAT3 87 90 PF00017 0.544
LIG_SH2_STAT5 157 160 PF00017 0.626
LIG_SH2_STAT5 204 207 PF00017 0.421
LIG_SH2_STAT5 214 217 PF00017 0.440
LIG_SH2_STAT5 242 245 PF00017 0.661
LIG_SH2_STAT5 311 314 PF00017 0.508
LIG_SH2_STAT5 329 332 PF00017 0.456
LIG_SH3_1 359 365 PF00018 0.623
LIG_SH3_2 362 367 PF14604 0.768
LIG_SH3_3 126 132 PF00018 0.593
LIG_SH3_3 269 275 PF00018 0.587
LIG_SH3_3 346 352 PF00018 0.680
LIG_SH3_3 355 361 PF00018 0.799
LIG_SH3_3 92 98 PF00018 0.515
LIG_SUMO_SIM_anti_2 10 15 PF11976 0.494
LIG_SUMO_SIM_anti_2 291 299 PF11976 0.483
LIG_SUMO_SIM_anti_2 382 388 PF11976 0.528
LIG_SUMO_SIM_anti_2 75 82 PF11976 0.489
LIG_SUMO_SIM_par_1 137 144 PF11976 0.375
LIG_SUMO_SIM_par_1 291 299 PF11976 0.517
LIG_SUMO_SIM_par_1 75 82 PF11976 0.489
LIG_TRAF2_1 262 265 PF00917 0.655
LIG_TYR_ITIM 148 153 PF00017 0.528
LIG_UBA3_1 212 217 PF00899 0.575
LIG_WRC_WIRS_1 80 85 PF05994 0.517
MOD_CDK_SPK_2 354 359 PF00069 0.639
MOD_CDK_SPxK_1 45 51 PF00069 0.441
MOD_CK1_1 110 116 PF00069 0.522
MOD_CK1_1 12 18 PF00069 0.426
MOD_CK1_1 169 175 PF00069 0.702
MOD_CK1_1 24 30 PF00069 0.500
MOD_CK1_1 245 251 PF00069 0.443
MOD_CK1_1 357 363 PF00069 0.757
MOD_CK2_1 218 224 PF00069 0.533
MOD_CK2_1 259 265 PF00069 0.600
MOD_CK2_1 357 363 PF00069 0.824
MOD_GlcNHglycan 168 171 PF01048 0.667
MOD_GlcNHglycan 23 26 PF01048 0.404
MOD_GlcNHglycan 340 343 PF01048 0.617
MOD_GlcNHglycan 379 382 PF01048 0.506
MOD_GlcNHglycan 92 95 PF01048 0.518
MOD_GSK3_1 12 19 PF00069 0.573
MOD_GSK3_1 158 165 PF00069 0.595
MOD_GSK3_1 169 176 PF00069 0.604
MOD_GSK3_1 24 31 PF00069 0.420
MOD_GSK3_1 343 350 PF00069 0.725
MOD_GSK3_1 61 68 PF00069 0.504
MOD_N-GLC_1 218 223 PF02516 0.585
MOD_N-GLC_1 313 318 PF02516 0.376
MOD_NEK2_1 1 6 PF00069 0.509
MOD_NEK2_1 218 223 PF00069 0.585
MOD_NEK2_1 336 341 PF00069 0.616
MOD_NEK2_2 61 66 PF00069 0.388
MOD_PIKK_1 12 18 PF00454 0.495
MOD_PIKK_1 69 75 PF00454 0.449
MOD_PKA_2 181 187 PF00069 0.589
MOD_Plk_1 1 7 PF00069 0.510
MOD_Plk_1 259 265 PF00069 0.676
MOD_Plk_1 290 296 PF00069 0.558
MOD_Plk_1 395 401 PF00069 0.492
MOD_Plk_1 9 15 PF00069 0.489
MOD_Plk_4 107 113 PF00069 0.465
MOD_Plk_4 121 127 PF00069 0.331
MOD_Plk_4 131 137 PF00069 0.404
MOD_Plk_4 181 187 PF00069 0.535
MOD_Plk_4 248 254 PF00069 0.554
MOD_ProDKin_1 16 22 PF00069 0.485
MOD_ProDKin_1 344 350 PF00069 0.738
MOD_ProDKin_1 354 360 PF00069 0.829
MOD_ProDKin_1 45 51 PF00069 0.574
MOD_ProDKin_1 65 71 PF00069 0.553
MOD_ProDKin_1 72 78 PF00069 0.522
MOD_SUMO_for_1 301 304 PF00179 0.591
TRG_DiLeu_BaEn_2 120 126 PF01217 0.525
TRG_DiLeu_BaLyEn_6 73 78 PF01217 0.562
TRG_ENDOCYTIC_2 109 112 PF00928 0.529
TRG_ENDOCYTIC_2 133 136 PF00928 0.356
TRG_ENDOCYTIC_2 150 153 PF00928 0.323
TRG_ENDOCYTIC_2 18 21 PF00928 0.491
TRG_ENDOCYTIC_2 204 207 PF00928 0.471
TRG_ENDOCYTIC_2 329 332 PF00928 0.630
TRG_NES_CRM1_1 137 149 PF08389 0.420
TRG_NES_CRM1_1 388 403 PF08389 0.631

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P9L8 Leptomonas seymouri 71% 100%
A0A0S4KPG1 Bodo saltans 28% 84%
A0A1X0NUL1 Trypanosomatidae 29% 90%
A0A1X0NUM5 Trypanosomatidae 35% 96%
A0A3Q8IJ55 Leishmania donovani 100% 100%
A0A422P1F9 Trypanosoma rangeli 29% 100%
A0A422P1H3 Trypanosoma rangeli 34% 96%
A4HK80 Leishmania braziliensis 80% 100%
D0A9X4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 90%
E9AEF7 Leishmania major 93% 100%
E9B2M3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5BQQ0 Trypanosoma cruzi 34% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS