RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7R4_LEIIN

TriTrypDb:

LINF_320015400

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7R4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	538	540	PF00675	0.700
CLV_PCSK_KEX2_1	242	244	PF00082	0.514
CLV_PCSK_KEX2_1	538	540	PF00082	0.700
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.514
CLV_PCSK_SKI1_1	161	165	PF00082	0.496
CLV_PCSK_SKI1_1	213	217	PF00082	0.494
CLV_PCSK_SKI1_1	242	246	PF00082	0.507
CLV_PCSK_SKI1_1	279	283	PF00082	0.499
DEG_APCC_DBOX_1	270	278	PF00400	0.507
DEG_SPOP_SBC_1	123	127	PF00917	0.688
DOC_CKS1_1	39	44	PF01111	0.674
DOC_CYCLIN_RxL_1	153	162	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.622
DOC_MAPK_gen_1	220	229	PF00069	0.481
DOC_PP4_FxxP_1	397	400	PF00568	0.621
DOC_PP4_FxxP_1	92	95	PF00568	0.567
DOC_USP7_MATH_1	122	126	PF00917	0.767
DOC_USP7_MATH_1	326	330	PF00917	0.604
DOC_USP7_MATH_1	433	437	PF00917	0.560
DOC_USP7_MATH_1	472	476	PF00917	0.587
DOC_USP7_MATH_1	523	527	PF00917	0.542
DOC_USP7_MATH_1	76	80	PF00917	0.676
DOC_USP7_MATH_1	81	85	PF00917	0.503
DOC_USP7_MATH_1	95	99	PF00917	0.775
DOC_WW_Pin1_4	124	129	PF00397	0.663
DOC_WW_Pin1_4	285	290	PF00397	0.570
DOC_WW_Pin1_4	302	307	PF00397	0.661
DOC_WW_Pin1_4	316	321	PF00397	0.634
DOC_WW_Pin1_4	342	347	PF00397	0.645
DOC_WW_Pin1_4	360	365	PF00397	0.643
DOC_WW_Pin1_4	38	43	PF00397	0.672
DOC_WW_Pin1_4	401	406	PF00397	0.660
DOC_WW_Pin1_4	448	453	PF00397	0.708
DOC_WW_Pin1_4	56	61	PF00397	0.635
DOC_WW_Pin1_4	97	102	PF00397	0.607
LIG_Actin_WH2_2	259	277	PF00022	0.489
LIG_APCC_ABBA_1	169	174	PF00400	0.553
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	135	139	PF00533	0.647
LIG_BRCT_BRCA1_1	156	160	PF00533	0.553
LIG_BRCT_BRCA1_1	384	388	PF00533	0.623
LIG_FHA_1	112	118	PF00498	0.613
LIG_FHA_1	12	18	PF00498	0.778
LIG_FHA_1	239	245	PF00498	0.556
LIG_FHA_1	313	319	PF00498	0.784
LIG_FHA_1	39	45	PF00498	0.676
LIG_FHA_1	410	416	PF00498	0.558
LIG_FHA_1	464	470	PF00498	0.646
LIG_LIR_Apic_2	396	400	PF02991	0.750
LIG_LIR_Gen_1	136	146	PF02991	0.648
LIG_LIR_Gen_1	223	234	PF02991	0.426
LIG_LIR_Gen_1	308	318	PF02991	0.548
LIG_LIR_Nem_3	136	142	PF02991	0.662
LIG_LIR_Nem_3	157	163	PF02991	0.551
LIG_LIR_Nem_3	223	229	PF02991	0.438
LIG_LIR_Nem_3	308	313	PF02991	0.657
LIG_LIR_Nem_3	439	443	PF02991	0.609
LIG_LIR_Nem_3	506	512	PF02991	0.464
LIG_SH2_CRK	145	149	PF00017	0.445
LIG_SH2_CRK	310	314	PF00017	0.600
LIG_SH2_NCK_1	145	149	PF00017	0.418
LIG_SH2_NCK_1	310	314	PF00017	0.600
LIG_SH2_SRC	5	8	PF00017	0.496
LIG_SH2_STAP1	145	149	PF00017	0.418
LIG_SH2_STAP1	411	415	PF00017	0.536
LIG_SH2_STAT3	411	414	PF00017	0.543
LIG_SH2_STAT3	489	492	PF00017	0.447
LIG_SH2_STAT5	118	121	PF00017	0.591
LIG_SH2_STAT5	310	313	PF00017	0.603
LIG_SH2_STAT5	370	373	PF00017	0.622
LIG_SH2_STAT5	411	414	PF00017	0.551
LIG_SH3_1	387	393	PF00018	0.664
LIG_SH3_3	387	393	PF00018	0.724
LIG_SH3_3	446	452	PF00018	0.663
LIG_SH3_3	458	464	PF00018	0.567
LIG_SH3_3	498	504	PF00018	0.474
LIG_SUMO_SIM_par_1	482	487	PF11976	0.503
LIG_TYR_ITIM	507	512	PF00017	0.459
LIG_TYR_ITSM	306	313	PF00017	0.553
LIG_WRC_WIRS_1	394	399	PF05994	0.536
MOD_CDK_SPxxK_3	285	292	PF00069	0.636
MOD_CDK_SPxxK_3	448	455	PF00069	0.673
MOD_CK1_1	100	106	PF00069	0.717
MOD_CK1_1	127	133	PF00069	0.658
MOD_CK1_1	138	144	PF00069	0.728
MOD_CK1_1	293	299	PF00069	0.788
MOD_CK1_1	305	311	PF00069	0.682
MOD_CK1_1	329	335	PF00069	0.637
MOD_CK1_1	409	415	PF00069	0.548
MOD_CK1_1	451	457	PF00069	0.650
MOD_CK1_1	541	547	PF00069	0.763
MOD_CK2_1	186	192	PF00069	0.464
MOD_CK2_1	433	439	PF00069	0.594
MOD_CK2_1	450	456	PF00069	0.781
MOD_CK2_1	5	11	PF00069	0.641
MOD_Cter_Amidation	536	539	PF01082	0.656
MOD_GlcNHglycan	1	4	PF01048	0.656
MOD_GlcNHglycan	231	234	PF01048	0.354
MOD_GlcNHglycan	35	38	PF01048	0.698
MOD_GlcNHglycan	355	359	PF01048	0.650
MOD_GlcNHglycan	417	420	PF01048	0.567
MOD_GlcNHglycan	456	460	PF01048	0.707
MOD_GlcNHglycan	512	515	PF01048	0.574
MOD_GlcNHglycan	530	533	PF01048	0.516
MOD_GlcNHglycan	540	543	PF01048	0.633
MOD_GSK3_1	123	130	PF00069	0.673
MOD_GSK3_1	133	140	PF00069	0.595
MOD_GSK3_1	293	300	PF00069	0.760
MOD_GSK3_1	301	308	PF00069	0.603
MOD_GSK3_1	312	319	PF00069	0.666
MOD_GSK3_1	409	416	PF00069	0.675
MOD_GSK3_1	447	454	PF00069	0.661
MOD_GSK3_1	472	479	PF00069	0.668
MOD_GSK3_1	72	79	PF00069	0.639
MOD_LATS_1	218	224	PF00433	0.523
MOD_N-GLC_1	133	138	PF02516	0.673
MOD_N-GLC_1	229	234	PF02516	0.373
MOD_N-GLC_1	533	538	PF02516	0.516
MOD_N-GLC_1	55	60	PF02516	0.654
MOD_NEK2_1	238	243	PF00069	0.481
MOD_NEK2_1	321	326	PF00069	0.660
MOD_NEK2_1	354	359	PF00069	0.629
MOD_NEK2_1	365	370	PF00069	0.479
MOD_NEK2_1	382	387	PF00069	0.731
MOD_NEK2_1	413	418	PF00069	0.563
MOD_NEK2_1	431	436	PF00069	0.550
MOD_NEK2_1	484	489	PF00069	0.444
MOD_NEK2_1	72	77	PF00069	0.604
MOD_NEK2_2	393	398	PF00069	0.665
MOD_NEK2_2	406	411	PF00069	0.433
MOD_OFUCOSY	217	224	PF10250	0.533
MOD_PIKK_1	133	139	PF00454	0.693
MOD_PIKK_1	484	490	PF00454	0.498
MOD_PIKK_1	543	549	PF00454	0.602
MOD_PKA_1	538	544	PF00069	0.643
MOD_PKA_2	293	299	PF00069	0.717
MOD_PKA_2	538	544	PF00069	0.822
MOD_Plk_1	229	235	PF00069	0.352
MOD_Plk_1	354	360	PF00069	0.655
MOD_Plk_1	72	78	PF00069	0.592
MOD_Plk_4	326	332	PF00069	0.686
MOD_Plk_4	393	399	PF00069	0.680
MOD_Plk_4	406	412	PF00069	0.438
MOD_ProDKin_1	124	130	PF00069	0.664
MOD_ProDKin_1	285	291	PF00069	0.573
MOD_ProDKin_1	302	308	PF00069	0.659
MOD_ProDKin_1	316	322	PF00069	0.632
MOD_ProDKin_1	342	348	PF00069	0.646
MOD_ProDKin_1	360	366	PF00069	0.643
MOD_ProDKin_1	38	44	PF00069	0.674
MOD_ProDKin_1	401	407	PF00069	0.656
MOD_ProDKin_1	448	454	PF00069	0.711
MOD_ProDKin_1	56	62	PF00069	0.634
MOD_ProDKin_1	97	103	PF00069	0.608
MOD_SUMO_rev_2	541	546	PF00179	0.620
TRG_ENDOCYTIC_2	145	148	PF00928	0.441
TRG_ENDOCYTIC_2	310	313	PF00928	0.603
TRG_ENDOCYTIC_2	509	512	PF00928	0.459
TRG_ER_diArg_1	538	540	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP7	Leptomonas seymouri	54%	100%
A0A1X0NUL4	Trypanosomatidae	29%	87%
A0A3S7X5C4	Leishmania donovani	99%	100%
A4HK79	Leishmania braziliensis	75%	99%
E9B2M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5I4	Leishmania major	94%	100%