Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CLASP N terminal - putative

Species:

Leishmania infantum

UniProt:

A4I7R0_LEIIN

TriTrypDb:

LINF_320015000

Length:

1063

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	1
GO:0005881	cytoplasmic microtubule	7	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I7R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7R0

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.637
CLV_NRD_NRD_1	1023	1025	PF00675	0.577
CLV_NRD_NRD_1	16	18	PF00675	0.523
CLV_NRD_NRD_1	175	177	PF00675	0.320
CLV_NRD_NRD_1	205	207	PF00675	0.226
CLV_NRD_NRD_1	220	222	PF00675	0.321
CLV_NRD_NRD_1	224	226	PF00675	0.314
CLV_NRD_NRD_1	331	333	PF00675	0.629
CLV_NRD_NRD_1	347	349	PF00675	0.601
CLV_NRD_NRD_1	378	380	PF00675	0.703
CLV_NRD_NRD_1	398	400	PF00675	0.456
CLV_NRD_NRD_1	66	68	PF00675	0.523
CLV_NRD_NRD_1	670	672	PF00675	0.601
CLV_NRD_NRD_1	768	770	PF00675	0.731
CLV_NRD_NRD_1	797	799	PF00675	0.451
CLV_NRD_NRD_1	88	90	PF00675	0.356
CLV_PCSK_KEX2_1	1023	1025	PF00082	0.564
CLV_PCSK_KEX2_1	16	18	PF00082	0.465
CLV_PCSK_KEX2_1	174	176	PF00082	0.317
CLV_PCSK_KEX2_1	205	207	PF00082	0.226
CLV_PCSK_KEX2_1	220	222	PF00082	0.321
CLV_PCSK_KEX2_1	224	226	PF00082	0.314
CLV_PCSK_KEX2_1	331	333	PF00082	0.626
CLV_PCSK_KEX2_1	347	349	PF00082	0.601
CLV_PCSK_KEX2_1	378	380	PF00082	0.703
CLV_PCSK_KEX2_1	398	400	PF00082	0.460
CLV_PCSK_KEX2_1	66	68	PF00082	0.612
CLV_PCSK_KEX2_1	670	672	PF00082	0.601
CLV_PCSK_KEX2_1	768	770	PF00082	0.686
CLV_PCSK_KEX2_1	797	799	PF00082	0.442
CLV_PCSK_KEX2_1	88	90	PF00082	0.356
CLV_PCSK_PC7_1	220	226	PF00082	0.356
CLV_PCSK_SKI1_1	1023	1027	PF00082	0.527
CLV_PCSK_SKI1_1	151	155	PF00082	0.368
CLV_PCSK_SKI1_1	301	305	PF00082	0.692
CLV_PCSK_SKI1_1	318	322	PF00082	0.755
CLV_PCSK_SKI1_1	332	336	PF00082	0.562
CLV_PCSK_SKI1_1	348	352	PF00082	0.638
CLV_PCSK_SKI1_1	487	491	PF00082	0.502
CLV_PCSK_SKI1_1	505	509	PF00082	0.266
CLV_PCSK_SKI1_1	551	555	PF00082	0.570
CLV_PCSK_SKI1_1	611	615	PF00082	0.553
CLV_PCSK_SKI1_1	641	645	PF00082	0.452
CLV_PCSK_SKI1_1	656	660	PF00082	0.540
CLV_PCSK_SKI1_1	66	70	PF00082	0.487
CLV_PCSK_SKI1_1	670	674	PF00082	0.517
CLV_PCSK_SKI1_1	697	701	PF00082	0.607
CLV_PCSK_SKI1_1	798	802	PF00082	0.499
CLV_PCSK_SKI1_1	878	882	PF00082	0.450
CLV_Separin_Metazoa	13	17	PF03568	0.548
CLV_Separin_Metazoa	179	183	PF03568	0.612
DEG_APCC_DBOX_1	174	182	PF00400	0.518
DEG_APCC_DBOX_1	486	494	PF00400	0.466
DEG_APCC_DBOX_1	550	558	PF00400	0.561
DEG_APCC_DBOX_1	797	805	PF00400	0.504
DEG_ODPH_VHL_1	1035	1048	PF01847	0.580
DEG_SCF_FBW7_1	320	325	PF00400	0.587
DEG_SPOP_SBC_1	128	132	PF00917	0.551
DEG_SPOP_SBC_1	2	6	PF00917	0.570
DEG_SPOP_SBC_1	322	326	PF00917	0.583
DEG_SPOP_SBC_1	541	545	PF00917	0.462
DOC_ANK_TNKS_1	808	815	PF00023	0.455
DOC_CDC14_PxL_1	730	738	PF14671	0.671
DOC_CKS1_1	351	356	PF01111	0.740
DOC_CYCLIN_RxL_1	329	337	PF00134	0.668
DOC_CYCLIN_RxL_1	638	647	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	736	742	PF00134	0.784
DOC_MAPK_gen_1	174	180	PF00069	0.556
DOC_MAPK_gen_1	224	232	PF00069	0.556
DOC_MAPK_gen_1	30	38	PF00069	0.634
DOC_MAPK_gen_1	797	804	PF00069	0.481
DOC_MAPK_gen_1	88	94	PF00069	0.556
DOC_MAPK_MEF2A_6	1012	1020	PF00069	0.451
DOC_MAPK_MEF2A_6	30	38	PF00069	0.595
DOC_MAPK_MEF2A_6	43	51	PF00069	0.285
DOC_MAPK_MEF2A_6	495	503	PF00069	0.375
DOC_MAPK_RevD_3	1009	1024	PF00069	0.541
DOC_PP4_FxxP_1	1034	1037	PF00568	0.581
DOC_USP7_MATH_1	128	132	PF00917	0.574
DOC_USP7_MATH_1	2	6	PF00917	0.706
DOC_USP7_MATH_1	280	284	PF00917	0.829
DOC_USP7_MATH_1	297	301	PF00917	0.687
DOC_USP7_MATH_1	541	545	PF00917	0.507
DOC_USP7_MATH_1	559	563	PF00917	0.534
DOC_USP7_MATH_1	565	569	PF00917	0.605
DOC_USP7_MATH_1	576	580	PF00917	0.385
DOC_USP7_MATH_1	683	687	PF00917	0.615
DOC_USP7_MATH_1	740	744	PF00917	0.653
DOC_USP7_MATH_1	764	768	PF00917	0.632
DOC_USP7_MATH_1	84	88	PF00917	0.524
DOC_USP7_MATH_1	871	875	PF00917	0.531
DOC_USP7_MATH_1	923	927	PF00917	0.527
DOC_USP7_MATH_1	958	962	PF00917	0.636
DOC_WW_Pin1_4	273	278	PF00397	0.760
DOC_WW_Pin1_4	318	323	PF00397	0.680
DOC_WW_Pin1_4	350	355	PF00397	0.689
DOC_WW_Pin1_4	724	729	PF00397	0.708
DOC_WW_Pin1_4	744	749	PF00397	0.739
LIG_14-3-3_CanoR_1	174	179	PF00244	0.607
LIG_14-3-3_CanoR_1	301	306	PF00244	0.657
LIG_14-3-3_CanoR_1	323	327	PF00244	0.659
LIG_14-3-3_CanoR_1	347	351	PF00244	0.743
LIG_14-3-3_CanoR_1	473	482	PF00244	0.522
LIG_14-3-3_CanoR_1	492	501	PF00244	0.515
LIG_14-3-3_CanoR_1	970	975	PF00244	0.594
LIG_14-3-3_CterR_2	1060	1063	PF00244	0.615
LIG_AP2alpha_2	893	895	PF02296	0.591
LIG_APCC_ABBA_1	1046	1051	PF00400	0.496
LIG_APCC_ABBA_1	836	841	PF00400	0.553
LIG_APCC_ABBAyCdc20_2	835	841	PF00400	0.560
LIG_BIR_II_1	1	5	PF00653	0.739
LIG_CaM_NSCaTE_8	580	587	PF13499	0.451
LIG_deltaCOP1_diTrp_1	622	629	PF00928	0.451
LIG_DLG_GKlike_1	174	181	PF00625	0.454
LIG_EH1_1	465	473	PF00400	0.549
LIG_eIF4E_1	76	82	PF01652	0.404
LIG_EVH1_1	269	273	PF00568	0.593
LIG_FHA_1	132	138	PF00498	0.484
LIG_FHA_1	199	205	PF00498	0.537
LIG_FHA_1	2	8	PF00498	0.628
LIG_FHA_1	236	242	PF00498	0.607
LIG_FHA_1	300	306	PF00498	0.698
LIG_FHA_1	351	357	PF00498	0.735
LIG_FHA_1	382	388	PF00498	0.692
LIG_FHA_1	422	428	PF00498	0.380
LIG_FHA_1	54	60	PF00498	0.431
LIG_FHA_1	725	731	PF00498	0.668
LIG_FHA_1	966	972	PF00498	0.760
LIG_FHA_1	987	993	PF00498	0.484
LIG_FHA_2	302	308	PF00498	0.623
LIG_FHA_2	386	392	PF00498	0.622
LIG_FHA_2	454	460	PF00498	0.602
LIG_FHA_2	8	14	PF00498	0.507
LIG_GBD_Chelix_1	419	427	PF00786	0.563
LIG_GBD_Chelix_1	996	1004	PF00786	0.532
LIG_GSK3_LRP6_1	273	279	PF00069	0.610
LIG_KLC1_Yacidic_2	1047	1051	PF13176	0.518
LIG_LIR_Apic_2	1031	1037	PF02991	0.584
LIG_LIR_Gen_1	459	468	PF02991	0.498
LIG_LIR_Gen_1	579	589	PF02991	0.441
LIG_LIR_Gen_1	626	635	PF02991	0.581
LIG_LIR_Gen_1	698	707	PF02991	0.594
LIG_LIR_Gen_1	941	952	PF02991	0.433
LIG_LIR_Nem_3	1056	1062	PF02991	0.649
LIG_LIR_Nem_3	432	438	PF02991	0.483
LIG_LIR_Nem_3	459	463	PF02991	0.600
LIG_LIR_Nem_3	579	584	PF02991	0.443
LIG_LIR_Nem_3	593	598	PF02991	0.444
LIG_LIR_Nem_3	626	632	PF02991	0.613
LIG_LIR_Nem_3	659	665	PF02991	0.708
LIG_LIR_Nem_3	698	702	PF02991	0.487
LIG_LIR_Nem_3	941	947	PF02991	0.446
LIG_MYND_1	1033	1037	PF01753	0.587
LIG_NRBOX	422	428	PF00104	0.485
LIG_NRBOX	862	868	PF00104	0.538
LIG_NRBOX	905	911	PF00104	0.507
LIG_PALB2_WD40_1	576	584	PF16756	0.462
LIG_PCNA_yPIPBox_3	637	649	PF02747	0.381
LIG_Pex14_1	625	629	PF04695	0.440
LIG_Pex14_1	72	76	PF04695	0.457
LIG_RPA_C_Fungi	701	713	PF08784	0.522
LIG_SH2_PTP2	531	534	PF00017	0.453
LIG_SH2_SRC	184	187	PF00017	0.385
LIG_SH2_SRC	531	534	PF00017	0.453
LIG_SH2_STAP1	200	204	PF00017	0.501
LIG_SH2_STAT5	1049	1052	PF00017	0.523
LIG_SH2_STAT5	184	187	PF00017	0.430
LIG_SH2_STAT5	200	203	PF00017	0.171
LIG_SH2_STAT5	531	534	PF00017	0.406
LIG_SH2_STAT5	790	793	PF00017	0.416
LIG_SH3_3	1027	1033	PF00018	0.599
LIG_SH3_3	229	235	PF00018	0.424
LIG_SH3_3	264	270	PF00018	0.638
LIG_SH3_3	271	277	PF00018	0.734
LIG_SH3_3	531	537	PF00018	0.468
LIG_SH3_3	820	826	PF00018	0.648
LIG_SH3_3	909	915	PF00018	0.449
LIG_SH3_3	971	977	PF00018	0.731
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.501
LIG_SUMO_SIM_par_1	152	157	PF11976	0.423
LIG_SUMO_SIM_par_1	300	308	PF11976	0.762
LIG_SUMO_SIM_par_1	800	806	PF11976	0.576
LIG_TRAF2_1	10	13	PF00917	0.513
LIG_TRAF2_1	260	263	PF00917	0.642
LIG_TRAF2_1	605	608	PF00917	0.613
LIG_TYR_ITIM	529	534	PF00017	0.450
LIG_UBA3_1	145	151	PF00899	0.424
LIG_Vh1_VBS_1	148	166	PF01044	0.326
MOD_CDC14_SPxK_1	326	329	PF00782	0.671
MOD_CDK_SPK_2	318	323	PF00069	0.741
MOD_CDK_SPxK_1	323	329	PF00069	0.706
MOD_CK1_1	131	137	PF00069	0.429
MOD_CK1_1	276	282	PF00069	0.767
MOD_CK1_1	367	373	PF00069	0.774
MOD_CK1_1	385	391	PF00069	0.488
MOD_CK1_1	413	419	PF00069	0.523
MOD_CK1_1	579	585	PF00069	0.497
MOD_CK1_1	874	880	PF00069	0.453
MOD_CK2_1	180	186	PF00069	0.385
MOD_CK2_1	334	340	PF00069	0.679
MOD_CK2_1	385	391	PF00069	0.559
MOD_CK2_1	453	459	PF00069	0.551
MOD_CK2_1	602	608	PF00069	0.552
MOD_CK2_1	698	704	PF00069	0.598
MOD_CK2_1	7	13	PF00069	0.467
MOD_CK2_1	800	806	PF00069	0.576
MOD_CK2_1	842	848	PF00069	0.579
MOD_Cter_Amidation	64	67	PF01082	0.475
MOD_DYRK1A_RPxSP_1	318	322	PF00069	0.739
MOD_DYRK1A_RPxSP_1	323	327	PF00069	0.709
MOD_GlcNHglycan	1038	1041	PF01048	0.503
MOD_GlcNHglycan	131	134	PF01048	0.392
MOD_GlcNHglycan	137	140	PF01048	0.357
MOD_GlcNHglycan	169	172	PF01048	0.462
MOD_GlcNHglycan	191	194	PF01048	0.308
MOD_GlcNHglycan	278	281	PF01048	0.833
MOD_GlcNHglycan	282	285	PF01048	0.802
MOD_GlcNHglycan	310	313	PF01048	0.677
MOD_GlcNHglycan	336	339	PF01048	0.758
MOD_GlcNHglycan	358	361	PF01048	0.735
MOD_GlcNHglycan	410	413	PF01048	0.522
MOD_GlcNHglycan	468	471	PF01048	0.470
MOD_GlcNHglycan	517	520	PF01048	0.580
MOD_GlcNHglycan	61	66	PF01048	0.471
MOD_GlcNHglycan	709	712	PF01048	0.690
MOD_GlcNHglycan	843	847	PF01048	0.561
MOD_GlcNHglycan	873	876	PF01048	0.464
MOD_GlcNHglycan	921	924	PF01048	0.378
MOD_GlcNHglycan	941	944	PF01048	0.378
MOD_GSK3_1	127	134	PF00069	0.387
MOD_GSK3_1	189	196	PF00069	0.440
MOD_GSK3_1	272	279	PF00069	0.745
MOD_GSK3_1	297	304	PF00069	0.717
MOD_GSK3_1	3	10	PF00069	0.568
MOD_GSK3_1	318	325	PF00069	0.720
MOD_GSK3_1	346	353	PF00069	0.684
MOD_GSK3_1	356	363	PF00069	0.650
MOD_GSK3_1	364	371	PF00069	0.660
MOD_GSK3_1	381	388	PF00069	0.656
MOD_GSK3_1	389	396	PF00069	0.479
MOD_GSK3_1	740	747	PF00069	0.776
MOD_GSK3_1	874	881	PF00069	0.442
MOD_GSK3_1	919	926	PF00069	0.387
MOD_N-GLC_1	473	478	PF02516	0.514
MOD_N-GLC_1	690	695	PF02516	0.624
MOD_N-GLC_1	740	745	PF02516	0.572
MOD_N-GLC_2	1001	1003	PF02516	0.462
MOD_N-GLC_2	1005	1007	PF02516	0.444
MOD_NEK2_1	1	6	PF00069	0.680
MOD_NEK2_1	127	132	PF00069	0.418
MOD_NEK2_1	334	339	PF00069	0.748
MOD_NEK2_1	356	361	PF00069	0.669
MOD_NEK2_1	364	369	PF00069	0.639
MOD_NEK2_1	408	413	PF00069	0.628
MOD_NEK2_1	444	449	PF00069	0.549
MOD_NEK2_1	466	471	PF00069	0.478
MOD_NEK2_1	540	545	PF00069	0.461
MOD_NEK2_1	614	619	PF00069	0.603
MOD_NEK2_1	707	712	PF00069	0.599
MOD_NEK2_1	919	924	PF00069	0.483
MOD_NEK2_2	1007	1012	PF00069	0.570
MOD_NEK2_2	193	198	PF00069	0.287
MOD_NEK2_2	71	76	PF00069	0.487
MOD_OFUCOSY	920	927	PF10250	0.451
MOD_PIKK_1	453	459	PF00454	0.541
MOD_PK_1	882	888	PF00069	0.459
MOD_PK_1	970	976	PF00069	0.556
MOD_PKA_1	174	180	PF00069	0.501
MOD_PKA_1	670	676	PF00069	0.592
MOD_PKA_2	174	180	PF00069	0.501
MOD_PKA_2	29	35	PF00069	0.693
MOD_PKA_2	322	328	PF00069	0.751
MOD_PKA_2	346	352	PF00069	0.716
MOD_PKA_2	472	478	PF00069	0.553
MOD_PKA_2	614	620	PF00069	0.595
MOD_PKA_2	670	676	PF00069	0.741
MOD_PKA_2	791	797	PF00069	0.538
MOD_Plk_1	393	399	PF00069	0.524
MOD_Plk_1	53	59	PF00069	0.433
MOD_Plk_1	541	547	PF00069	0.566
MOD_Plk_1	690	696	PF00069	0.427
MOD_Plk_1	756	762	PF00069	0.657
MOD_Plk_2-3	698	704	PF00069	0.572
MOD_Plk_4	115	121	PF00069	0.363
MOD_Plk_4	158	164	PF00069	0.478
MOD_Plk_4	382	388	PF00069	0.617
MOD_Plk_4	410	416	PF00069	0.527
MOD_Plk_4	459	465	PF00069	0.505
MOD_Plk_4	535	541	PF00069	0.493
MOD_Plk_4	576	582	PF00069	0.428
MOD_Plk_4	690	696	PF00069	0.412
MOD_Plk_4	71	77	PF00069	0.468
MOD_Plk_4	905	911	PF00069	0.474
MOD_Plk_4	970	976	PF00069	0.681
MOD_Plk_4	99	105	PF00069	0.407
MOD_ProDKin_1	273	279	PF00069	0.761
MOD_ProDKin_1	318	324	PF00069	0.682
MOD_ProDKin_1	350	356	PF00069	0.690
MOD_ProDKin_1	724	730	PF00069	0.709
MOD_ProDKin_1	744	750	PF00069	0.740
MOD_SUMO_rev_2	259	267	PF00179	0.617
MOD_SUMO_rev_2	622	630	PF00179	0.592
MOD_SUMO_rev_2	646	650	PF00179	0.516
TRG_DiLeu_BaEn_1	410	415	PF01217	0.569
TRG_DiLeu_BaEn_1	459	464	PF01217	0.589
TRG_DiLeu_BaEn_1	54	59	PF01217	0.544
TRG_DiLeu_BaEn_1	616	621	PF01217	0.560
TRG_DiLeu_BaLyEn_6	1057	1062	PF01217	0.611
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.553
TRG_DiLeu_BaLyEn_6	703	708	PF01217	0.517
TRG_DiLeu_BaLyEn_6	832	837	PF01217	0.436
TRG_ENDOCYTIC_2	531	534	PF00928	0.454
TRG_ER_diArg_1	1022	1024	PF00400	0.552
TRG_ER_diArg_1	15	17	PF00400	0.534
TRG_ER_diArg_1	173	176	PF00400	0.430
TRG_ER_diArg_1	204	206	PF00400	0.249
TRG_ER_diArg_1	219	221	PF00400	0.424
TRG_ER_diArg_1	397	399	PF00400	0.461
TRG_ER_diArg_1	670	672	PF00400	0.664
TRG_ER_diArg_1	785	788	PF00400	0.520
TRG_NES_CRM1_1	417	432	PF08389	0.462
TRG_Pf-PMV_PEXEL_1	1024	1028	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	641	646	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	714	718	PF00026	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICN1	Leptomonas seymouri	40%	100%
A0A3R7M9H6	Trypanosoma rangeli	24%	100%
A0A3S7X5E0	Leishmania donovani	99%	100%
A4HK75	Leishmania braziliensis	69%	99%
E9B2L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5I8	Leishmania major	89%	100%