LeishMANIAdb
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FAD/NAD(P)-binding domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
FAD/NAD(P)-binding domain-containing protein
Gene product:
FAD dependent oxidoreductase - putative
Species:
Leishmania infantum
UniProt:
A4I7Q9_LEIIN
TriTrypDb:
LINF_320014900
Length:
704

Annotations

Annotations by Jardim et al.

Oxidoreductase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I7Q9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7Q9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 2
GO:0003824 catalytic activity 1 1
GO:0005488 binding 1 2
GO:0016491 oxidoreductase activity 2 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 1
GO:0036094 small molecule binding 2 2
GO:0043167 ion binding 2 2
GO:0043168 anion binding 3 2
GO:0050660 flavin adenine dinucleotide binding 4 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901265 nucleoside phosphate binding 3 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 339 343 PF00656 0.520
CLV_C14_Caspase3-7 685 689 PF00656 0.495
CLV_NRD_NRD_1 282 284 PF00675 0.303
CLV_NRD_NRD_1 301 303 PF00675 0.259
CLV_NRD_NRD_1 544 546 PF00675 0.282
CLV_NRD_NRD_1 617 619 PF00675 0.265
CLV_NRD_NRD_1 64 66 PF00675 0.290
CLV_NRD_NRD_1 95 97 PF00675 0.383
CLV_PCSK_KEX2_1 266 268 PF00082 0.342
CLV_PCSK_KEX2_1 282 284 PF00082 0.200
CLV_PCSK_KEX2_1 301 303 PF00082 0.259
CLV_PCSK_KEX2_1 544 546 PF00082 0.289
CLV_PCSK_KEX2_1 617 619 PF00082 0.254
CLV_PCSK_KEX2_1 64 66 PF00082 0.290
CLV_PCSK_KEX2_1 674 676 PF00082 0.327
CLV_PCSK_KEX2_1 95 97 PF00082 0.383
CLV_PCSK_PC1ET2_1 266 268 PF00082 0.385
CLV_PCSK_PC1ET2_1 674 676 PF00082 0.327
CLV_PCSK_SKI1_1 249 253 PF00082 0.351
CLV_PCSK_SKI1_1 283 287 PF00082 0.353
CLV_PCSK_SKI1_1 370 374 PF00082 0.272
CLV_PCSK_SKI1_1 390 394 PF00082 0.169
CLV_PCSK_SKI1_1 452 456 PF00082 0.313
CLV_PCSK_SKI1_1 654 658 PF00082 0.305
CLV_PCSK_SKI1_1 692 696 PF00082 0.346
CLV_Separin_Metazoa 61 65 PF03568 0.483
DEG_Nend_Nbox_1 1 3 PF02207 0.293
DEG_ODPH_VHL_1 445 458 PF01847 0.557
DEG_SCF_FBW7_1 546 553 PF00400 0.409
DEG_SPOP_SBC_1 639 643 PF00917 0.576
DEG_SPOP_SBC_1 83 87 PF00917 0.518
DOC_CDC14_PxL_1 100 108 PF14671 0.619
DOC_CKS1_1 429 434 PF01111 0.510
DOC_CKS1_1 475 480 PF01111 0.561
DOC_CYCLIN_yCln2_LP_2 253 259 PF00134 0.551
DOC_CYCLIN_yCln2_LP_2 393 399 PF00134 0.479
DOC_CYCLIN_yCln2_LP_2 438 444 PF00134 0.472
DOC_MAPK_gen_1 327 336 PF00069 0.572
DOC_MAPK_gen_1 370 379 PF00069 0.504
DOC_MAPK_gen_1 95 102 PF00069 0.584
DOC_MAPK_HePTP_8 367 379 PF00069 0.491
DOC_MAPK_MEF2A_6 370 379 PF00069 0.504
DOC_MAPK_MEF2A_6 390 399 PF00069 0.363
DOC_MAPK_NFAT4_5 390 398 PF00069 0.458
DOC_MAPK_RevD_3 251 267 PF00069 0.477
DOC_MIT_MIM_1 297 306 PF04212 0.522
DOC_PP1_RVXF_1 265 272 PF00149 0.453
DOC_PP1_RVXF_1 450 457 PF00149 0.517
DOC_PP1_RVXF_1 96 103 PF00149 0.588
DOC_PP2B_LxvP_1 253 256 PF13499 0.525
DOC_PP2B_LxvP_1 284 287 PF13499 0.548
DOC_PP2B_LxvP_1 380 383 PF13499 0.621
DOC_PP2B_LxvP_1 393 396 PF13499 0.456
DOC_PP2B_LxvP_1 438 441 PF13499 0.522
DOC_USP7_MATH_1 201 205 PF00917 0.497
DOC_USP7_MATH_1 215 219 PF00917 0.576
DOC_USP7_MATH_1 259 263 PF00917 0.517
DOC_USP7_MATH_1 285 289 PF00917 0.548
DOC_USP7_MATH_1 345 349 PF00917 0.480
DOC_USP7_MATH_1 403 407 PF00917 0.495
DOC_USP7_MATH_1 514 518 PF00917 0.670
DOC_USP7_MATH_1 630 634 PF00917 0.493
DOC_USP7_MATH_1 639 643 PF00917 0.575
DOC_USP7_MATH_1 644 648 PF00917 0.525
DOC_USP7_MATH_1 679 683 PF00917 0.542
DOC_USP7_MATH_1 83 87 PF00917 0.550
DOC_USP7_UBL2_3 596 600 PF12436 0.606
DOC_WW_Pin1_4 123 128 PF00397 0.676
DOC_WW_Pin1_4 361 366 PF00397 0.492
DOC_WW_Pin1_4 428 433 PF00397 0.512
DOC_WW_Pin1_4 474 479 PF00397 0.566
DOC_WW_Pin1_4 502 507 PF00397 0.640
DOC_WW_Pin1_4 546 551 PF00397 0.532
LIG_14-3-3_CanoR_1 167 171 PF00244 0.526
LIG_14-3-3_CanoR_1 21 30 PF00244 0.524
LIG_14-3-3_CanoR_1 214 224 PF00244 0.605
LIG_14-3-3_CanoR_1 237 243 PF00244 0.449
LIG_14-3-3_CanoR_1 301 306 PF00244 0.473
LIG_14-3-3_CanoR_1 416 423 PF00244 0.580
LIG_14-3-3_CanoR_1 544 552 PF00244 0.525
LIG_14-3-3_CanoR_1 608 616 PF00244 0.553
LIG_14-3-3_CanoR_1 683 688 PF00244 0.538
LIG_14-3-3_CanoR_1 98 103 PF00244 0.588
LIG_BRCT_BRCA1_1 240 244 PF00533 0.431
LIG_BRCT_BRCA1_1 562 566 PF00533 0.540
LIG_BRCT_BRCA1_1 633 637 PF00533 0.528
LIG_DLG_GKlike_1 683 691 PF00625 0.462
LIG_EH1_1 481 489 PF00400 0.494
LIG_FHA_1 183 189 PF00498 0.522
LIG_FHA_1 23 29 PF00498 0.591
LIG_FHA_1 248 254 PF00498 0.519
LIG_FHA_1 258 264 PF00498 0.570
LIG_FHA_1 36 42 PF00498 0.571
LIG_FHA_1 384 390 PF00498 0.516
LIG_FHA_1 481 487 PF00498 0.471
LIG_FHA_1 547 553 PF00498 0.601
LIG_FHA_1 565 571 PF00498 0.460
LIG_FHA_1 64 70 PF00498 0.453
LIG_FHA_1 693 699 PF00498 0.556
LIG_FHA_2 124 130 PF00498 0.672
LIG_FHA_2 150 156 PF00498 0.621
LIG_FHA_2 308 314 PF00498 0.501
LIG_FHA_2 608 614 PF00498 0.469
LIG_FHA_2 683 689 PF00498 0.454
LIG_Integrin_RGD_1 340 342 PF01839 0.287
LIG_LIR_Gen_1 307 317 PF02991 0.509
LIG_LIR_Gen_1 45 54 PF02991 0.427
LIG_LIR_Gen_1 563 571 PF02991 0.555
LIG_LIR_Gen_1 666 676 PF02991 0.572
LIG_LIR_Nem_3 307 312 PF02991 0.504
LIG_LIR_Nem_3 45 49 PF02991 0.435
LIG_LIR_Nem_3 563 569 PF02991 0.548
LIG_LIR_Nem_3 666 672 PF02991 0.582
LIG_MYND_1 428 432 PF01753 0.513
LIG_Pex14_1 16 20 PF04695 0.361
LIG_RPA_C_Fungi 678 690 PF08784 0.304
LIG_SH2_CRK 168 172 PF00017 0.487
LIG_SH2_GRB2like 17 20 PF00017 0.258
LIG_SH2_NCK_1 309 313 PF00017 0.319
LIG_SH2_PTP2 46 49 PF00017 0.304
LIG_SH2_SRC 619 622 PF00017 0.418
LIG_SH2_STAT3 131 134 PF00017 0.586
LIG_SH2_STAT5 131 134 PF00017 0.458
LIG_SH2_STAT5 17 20 PF00017 0.381
LIG_SH2_STAT5 257 260 PF00017 0.492
LIG_SH2_STAT5 274 277 PF00017 0.191
LIG_SH2_STAT5 309 312 PF00017 0.317
LIG_SH2_STAT5 429 432 PF00017 0.493
LIG_SH2_STAT5 46 49 PF00017 0.304
LIG_SH2_STAT5 619 622 PF00017 0.279
LIG_SH3_3 104 110 PF00018 0.573
LIG_SH3_3 144 150 PF00018 0.575
LIG_SH3_3 233 239 PF00018 0.497
LIG_SH3_3 253 259 PF00018 0.381
LIG_SH3_3 266 272 PF00018 0.420
LIG_SH3_3 344 350 PF00018 0.513
LIG_SH3_3 376 382 PF00018 0.482
LIG_SH3_3 451 457 PF00018 0.381
LIG_SH3_5 42 46 PF00018 0.420
LIG_SUMO_SIM_anti_2 4 10 PF11976 0.361
LIG_SUMO_SIM_anti_2 483 489 PF11976 0.371
LIG_SUMO_SIM_par_1 562 574 PF11976 0.466
LIG_SUMO_SIM_par_1 71 77 PF11976 0.338
LIG_TYR_ITSM 305 312 PF00017 0.309
LIG_WRC_WIRS_1 99 104 PF05994 0.490
MOD_CDK_SPK_2 361 366 PF00069 0.366
MOD_CK1_1 210 216 PF00069 0.498
MOD_CK1_1 219 225 PF00069 0.609
MOD_CK1_1 304 310 PF00069 0.357
MOD_CK1_1 31 37 PF00069 0.512
MOD_CK1_1 406 412 PF00069 0.564
MOD_CK1_1 553 559 PF00069 0.343
MOD_CK1_1 589 595 PF00069 0.444
MOD_CK1_1 631 637 PF00069 0.363
MOD_CK1_1 640 646 PF00069 0.501
MOD_CK1_1 648 654 PF00069 0.318
MOD_CK1_1 662 668 PF00069 0.296
MOD_CK1_1 682 688 PF00069 0.173
MOD_CK2_1 123 129 PF00069 0.626
MOD_CK2_1 149 155 PF00069 0.599
MOD_CK2_1 215 221 PF00069 0.507
MOD_CK2_1 607 613 PF00069 0.368
MOD_Cter_Amidation 280 283 PF01082 0.358
MOD_Cter_Amidation 672 675 PF01082 0.427
MOD_Cter_Amidation 93 96 PF01082 0.486
MOD_GlcNHglycan 209 212 PF01048 0.412
MOD_GlcNHglycan 287 290 PF01048 0.442
MOD_GlcNHglycan 405 408 PF01048 0.431
MOD_GlcNHglycan 591 594 PF01048 0.531
MOD_GlcNHglycan 630 633 PF01048 0.268
MOD_GlcNHglycan 642 645 PF01048 0.454
MOD_GlcNHglycan 660 664 PF01048 0.230
MOD_GlcNHglycan 76 79 PF01048 0.437
MOD_GlcNHglycan 86 89 PF01048 0.485
MOD_GSK3_1 215 222 PF00069 0.659
MOD_GSK3_1 31 38 PF00069 0.402
MOD_GSK3_1 470 477 PF00069 0.438
MOD_GSK3_1 546 553 PF00069 0.316
MOD_GSK3_1 560 567 PF00069 0.391
MOD_GSK3_1 603 610 PF00069 0.478
MOD_GSK3_1 638 645 PF00069 0.459
MOD_GSK3_1 658 665 PF00069 0.326
MOD_GSK3_1 679 686 PF00069 0.343
MOD_N-GLC_1 553 558 PF02516 0.373
MOD_NEK2_1 182 187 PF00069 0.517
MOD_NEK2_1 329 334 PF00069 0.522
MOD_NEK2_1 397 402 PF00069 0.478
MOD_NEK2_1 433 438 PF00069 0.318
MOD_NEK2_1 637 642 PF00069 0.500
MOD_NEK2_1 697 702 PF00069 0.347
MOD_NEK2_1 74 79 PF00069 0.519
MOD_NEK2_2 247 252 PF00069 0.290
MOD_NEK2_2 295 300 PF00069 0.316
MOD_PIKK_1 315 321 PF00454 0.434
MOD_PIKK_1 421 427 PF00454 0.484
MOD_PK_1 301 307 PF00069 0.404
MOD_PKA_1 301 307 PF00069 0.372
MOD_PKA_1 544 550 PF00069 0.379
MOD_PKA_1 674 680 PF00069 0.395
MOD_PKA_2 166 172 PF00069 0.529
MOD_PKA_2 22 28 PF00069 0.413
MOD_PKA_2 301 307 PF00069 0.315
MOD_PKA_2 329 335 PF00069 0.391
MOD_PKA_2 336 342 PF00069 0.387
MOD_PKA_2 415 421 PF00069 0.365
MOD_PKA_2 544 550 PF00069 0.469
MOD_PKA_2 607 613 PF00069 0.473
MOD_PKA_2 63 69 PF00069 0.385
MOD_PKA_2 648 654 PF00069 0.353
MOD_PKA_2 674 680 PF00069 0.451
MOD_PKA_2 682 688 PF00069 0.434
MOD_PKB_1 96 104 PF00069 0.509
MOD_Plk_1 154 160 PF00069 0.444
MOD_Plk_1 201 207 PF00069 0.347
MOD_Plk_1 553 559 PF00069 0.430
MOD_Plk_1 564 570 PF00069 0.290
MOD_Plk_1 603 609 PF00069 0.215
MOD_Plk_1 659 665 PF00069 0.347
MOD_Plk_4 118 124 PF00069 0.640
MOD_Plk_4 166 172 PF00069 0.582
MOD_Plk_4 193 199 PF00069 0.367
MOD_Plk_4 301 307 PF00069 0.316
MOD_Plk_4 433 439 PF00069 0.359
MOD_Plk_4 470 476 PF00069 0.439
MOD_Plk_4 611 617 PF00069 0.420
MOD_ProDKin_1 123 129 PF00069 0.626
MOD_ProDKin_1 361 367 PF00069 0.368
MOD_ProDKin_1 428 434 PF00069 0.393
MOD_ProDKin_1 474 480 PF00069 0.468
MOD_ProDKin_1 502 508 PF00069 0.574
MOD_ProDKin_1 546 552 PF00069 0.424
MOD_SUMO_rev_2 495 505 PF00179 0.413
MOD_SUMO_rev_2 572 578 PF00179 0.429
MOD_SUMO_rev_2 592 602 PF00179 0.548
TRG_DiLeu_BaEn_1 4 9 PF01217 0.233
TRG_DiLeu_BaLyEn_6 363 368 PF01217 0.419
TRG_DiLeu_BaLyEn_6 393 398 PF01217 0.274
TRG_DiLeu_BaLyEn_6 95 100 PF01217 0.492
TRG_ENDOCYTIC_2 168 171 PF00928 0.573
TRG_ENDOCYTIC_2 17 20 PF00928 0.367
TRG_ENDOCYTIC_2 274 277 PF00928 0.416
TRG_ENDOCYTIC_2 309 312 PF00928 0.317
TRG_ENDOCYTIC_2 46 49 PF00928 0.312
TRG_ER_diArg_1 20 23 PF00400 0.412
TRG_ER_diArg_1 282 284 PF00400 0.355
TRG_ER_diArg_1 301 303 PF00400 0.323
TRG_ER_diArg_1 544 546 PF00400 0.364
TRG_ER_diArg_1 616 618 PF00400 0.315
TRG_ER_diArg_1 63 65 PF00400 0.366
TRG_Pf-PMV_PEXEL_1 544 548 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 600 604 PF00026 0.447

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAY3 Leptomonas seymouri 60% 99%
A0A1X0NUW5 Trypanosomatidae 31% 100%
A0A3S5H7R6 Leishmania donovani 100% 100%
A0A422N8N4 Trypanosoma rangeli 31% 100%
A4HK74 Leishmania braziliensis 77% 100%
D0A9W4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9B2L7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q5I9 Leishmania major 92% 100%
V5BGK4 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS