Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7Q2_LEIIN

TriTrypDb:

LINF_320014100

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I7Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7Q2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.579
CLV_C14_Caspase3-7	374	378	PF00656	0.563
CLV_NRD_NRD_1	114	116	PF00675	0.626
CLV_NRD_NRD_1	221	223	PF00675	0.410
CLV_NRD_NRD_1	522	524	PF00675	0.634
CLV_NRD_NRD_1	559	561	PF00675	0.627
CLV_NRD_NRD_1	563	565	PF00675	0.621
CLV_PCSK_FUR_1	112	116	PF00082	0.642
CLV_PCSK_KEX2_1	114	116	PF00082	0.617
CLV_PCSK_KEX2_1	133	135	PF00082	0.260
CLV_PCSK_KEX2_1	220	222	PF00082	0.393
CLV_PCSK_KEX2_1	290	292	PF00082	0.586
CLV_PCSK_KEX2_1	435	437	PF00082	0.451
CLV_PCSK_KEX2_1	520	522	PF00082	0.604
CLV_PCSK_KEX2_1	559	561	PF00082	0.624
CLV_PCSK_KEX2_1	565	567	PF00082	0.633
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.451
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.586
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.442
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.604
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.548
CLV_PCSK_PC7_1	286	292	PF00082	0.510
CLV_PCSK_SKI1_1	133	137	PF00082	0.526
CLV_PCSK_SKI1_1	145	149	PF00082	0.532
CLV_PCSK_SKI1_1	226	230	PF00082	0.337
CLV_PCSK_SKI1_1	254	258	PF00082	0.492
CLV_PCSK_SKI1_1	290	294	PF00082	0.451
CLV_PCSK_SKI1_1	432	436	PF00082	0.461
CLV_PCSK_SKI1_1	522	526	PF00082	0.708
DEG_APCC_DBOX_1	337	345	PF00400	0.404
DEG_APCC_DBOX_1	72	80	PF00400	0.425
DEG_Nend_UBRbox_1	1	4	PF02207	0.482
DEG_SCF_FBW7_1	361	368	PF00400	0.360
DEG_SPOP_SBC_1	307	311	PF00917	0.699
DOC_CKS1_1	362	367	PF01111	0.359
DOC_CYCLIN_RxL_1	286	296	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	281	284	PF00134	0.510
DOC_MAPK_gen_1	251	261	PF00069	0.466
DOC_MAPK_gen_1	273	281	PF00069	0.575
DOC_MAPK_MEF2A_6	254	261	PF00069	0.454
DOC_MAPK_MEF2A_6	406	415	PF00069	0.550
DOC_MAPK_NFAT4_5	254	262	PF00069	0.462
DOC_PP1_RVXF_1	69	75	PF00149	0.493
DOC_PP2B_LxvP_1	281	284	PF13499	0.510
DOC_PP4_MxPP_1	438	441	PF00568	0.556
DOC_USP7_MATH_1	175	179	PF00917	0.677
DOC_USP7_MATH_1	305	309	PF00917	0.726
DOC_USP7_MATH_1	365	369	PF00917	0.447
DOC_USP7_MATH_1	503	507	PF00917	0.646
DOC_USP7_MATH_1	509	513	PF00917	0.591
DOC_WW_Pin1_4	361	366	PF00397	0.351
DOC_WW_Pin1_4	513	518	PF00397	0.495
LIG_14-3-3_CanoR_1	145	155	PF00244	0.464
LIG_14-3-3_CanoR_1	22	30	PF00244	0.411
LIG_14-3-3_CanoR_1	32	41	PF00244	0.454
LIG_14-3-3_CanoR_1	394	398	PF00244	0.525
LIG_14-3-3_CanoR_1	406	412	PF00244	0.559
LIG_14-3-3_CanoR_1	414	421	PF00244	0.530
LIG_14-3-3_CanoR_1	444	452	PF00244	0.535
LIG_14-3-3_CanoR_1	510	518	PF00244	0.588
LIG_14-3-3_CanoR_1	536	541	PF00244	0.536
LIG_14-3-3_CanoR_1	84	90	PF00244	0.530
LIG_Actin_WH2_2	431	446	PF00022	0.574
LIG_AP_GAE_1	547	553	PF02883	0.556
LIG_AP2alpha_2	348	350	PF02296	0.361
LIG_BRCT_BRCA1_1	362	366	PF00533	0.398
LIG_deltaCOP1_diTrp_1	478	487	PF00928	0.658
LIG_FHA_1	142	148	PF00498	0.460
LIG_FHA_1	38	44	PF00498	0.391
LIG_FHA_1	444	450	PF00498	0.605
LIG_FHA_1	466	472	PF00498	0.588
LIG_FHA_1	556	562	PF00498	0.588
LIG_FHA_2	381	387	PF00498	0.397
LIG_FHA_2	445	451	PF00498	0.685
LIG_FHA_2	55	61	PF00498	0.325
LIG_LIR_Apic_2	360	365	PF02991	0.378
LIG_LIR_Gen_1	363	373	PF02991	0.417
LIG_LIR_Gen_1	547	556	PF02991	0.533
LIG_LIR_LC3C_4	40	44	PF02991	0.447
LIG_LIR_Nem_3	234	239	PF02991	0.464
LIG_LIR_Nem_3	363	369	PF02991	0.392
LIG_LIR_Nem_3	399	404	PF02991	0.502
LIG_LIR_Nem_3	547	553	PF02991	0.528
LIG_PCNA_yPIPBox_3	265	275	PF02747	0.411
LIG_Pex14_1	289	293	PF04695	0.383
LIG_PTAP_UEV_1	12	17	PF05743	0.438
LIG_SH2_CRK	362	366	PF00017	0.382
LIG_SH2_GRB2like	129	132	PF00017	0.344
LIG_SH2_GRB2like	387	390	PF00017	0.355
LIG_SH2_NCK_1	362	366	PF00017	0.467
LIG_SH2_SRC	140	143	PF00017	0.414
LIG_SH2_SRC	160	163	PF00017	0.437
LIG_SH2_STAP1	546	550	PF00017	0.588
LIG_SH2_STAT5	129	132	PF00017	0.344
LIG_SH2_STAT5	160	163	PF00017	0.539
LIG_SH2_STAT5	236	239	PF00017	0.479
LIG_SH2_STAT5	30	33	PF00017	0.473
LIG_SH2_STAT5	64	67	PF00017	0.365
LIG_SH3_3	10	16	PF00018	0.483
LIG_SH3_3	550	556	PF00018	0.620
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.526
LIG_SUMO_SIM_anti_2	40	45	PF11976	0.326
LIG_SUMO_SIM_par_1	39	45	PF11976	0.397
LIG_TRAF2_1	467	470	PF00917	0.610
LIG_TRAF2_1	57	60	PF00917	0.466
LIG_TYR_ITIM	62	67	PF00017	0.495
LIG_TYR_ITSM	232	239	PF00017	0.258
MOD_CDK_SPxxK_3	513	520	PF00069	0.493
MOD_CK1_1	308	314	PF00069	0.638
MOD_CK1_1	360	366	PF00069	0.378
MOD_CK1_1	511	517	PF00069	0.686
MOD_CK1_1	92	98	PF00069	0.665
MOD_CK2_1	307	313	PF00069	0.607
MOD_CK2_1	380	386	PF00069	0.382
MOD_CK2_1	414	420	PF00069	0.568
MOD_CK2_1	54	60	PF00069	0.338
MOD_Cter_Amidation	112	115	PF01082	0.671
MOD_Cter_Amidation	562	565	PF01082	0.539
MOD_GlcNHglycan	12	16	PF01048	0.510
MOD_GlcNHglycan	148	151	PF01048	0.522
MOD_GlcNHglycan	185	188	PF01048	0.678
MOD_GlcNHglycan	198	201	PF01048	0.775
MOD_GlcNHglycan	301	304	PF01048	0.633
MOD_GlcNHglycan	330	333	PF01048	0.657
MOD_GlcNHglycan	459	462	PF01048	0.691
MOD_GSK3_1	146	153	PF00069	0.540
MOD_GSK3_1	295	302	PF00069	0.568
MOD_GSK3_1	319	326	PF00069	0.603
MOD_GSK3_1	357	364	PF00069	0.472
MOD_GSK3_1	367	374	PF00069	0.548
MOD_GSK3_1	504	511	PF00069	0.636
MOD_GSK3_1	532	539	PF00069	0.528
MOD_LATS_1	412	418	PF00433	0.612
MOD_N-GLC_1	320	325	PF02516	0.647
MOD_N-GLC_1	444	449	PF02516	0.509
MOD_NEK2_1	146	151	PF00069	0.407
MOD_NEK2_1	183	188	PF00069	0.597
MOD_NEK2_1	196	201	PF00069	0.779
MOD_NEK2_1	21	26	PF00069	0.473
MOD_NEK2_1	231	236	PF00069	0.393
MOD_NEK2_1	242	247	PF00069	0.274
MOD_NEK2_1	306	311	PF00069	0.633
MOD_NEK2_1	31	36	PF00069	0.315
MOD_NEK2_1	443	448	PF00069	0.567
MOD_NEK2_1	452	457	PF00069	0.592
MOD_NEK2_1	487	492	PF00069	0.617
MOD_NEK2_1	534	539	PF00069	0.503
MOD_NEK2_1	540	545	PF00069	0.613
MOD_NEK2_1	83	88	PF00069	0.415
MOD_NEK2_2	357	362	PF00069	0.358
MOD_OFUCOSY	230	235	PF10250	0.476
MOD_PIKK_1	295	301	PF00454	0.582
MOD_PIKK_1	414	420	PF00454	0.609
MOD_PIKK_1	465	471	PF00454	0.747
MOD_PKA_1	522	528	PF00069	0.541
MOD_PKA_2	21	27	PF00069	0.417
MOD_PKA_2	31	37	PF00069	0.438
MOD_PKA_2	393	399	PF00069	0.570
MOD_PKA_2	443	449	PF00069	0.599
MOD_PKA_2	487	493	PF00069	0.614
MOD_PKA_2	509	515	PF00069	0.711
MOD_PKA_2	522	528	PF00069	0.460
MOD_PKA_2	83	89	PF00069	0.515
MOD_PKB_1	486	494	PF00069	0.567
MOD_Plk_1	175	181	PF00069	0.582
MOD_Plk_1	444	450	PF00069	0.685
MOD_Plk_1	504	510	PF00069	0.728
MOD_Plk_2-3	371	377	PF00069	0.551
MOD_Plk_2-3	380	386	PF00069	0.519
MOD_Plk_2-3	54	60	PF00069	0.382
MOD_Plk_4	274	280	PF00069	0.534
MOD_Plk_4	357	363	PF00069	0.486
MOD_Plk_4	37	43	PF00069	0.334
MOD_Plk_4	371	377	PF00069	0.438
MOD_Plk_4	536	542	PF00069	0.574
MOD_Plk_4	92	98	PF00069	0.584
MOD_ProDKin_1	361	367	PF00069	0.354
MOD_ProDKin_1	513	519	PF00069	0.493
MOD_SUMO_rev_2	527	532	PF00179	0.594
TRG_DiLeu_BaEn_1	274	279	PF01217	0.512
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.507
TRG_ENDOCYTIC_2	132	135	PF00928	0.341
TRG_ENDOCYTIC_2	236	239	PF00928	0.432
TRG_ENDOCYTIC_2	30	33	PF00928	0.341
TRG_ENDOCYTIC_2	64	67	PF00928	0.365
TRG_ER_diArg_1	112	115	PF00400	0.592
TRG_ER_diArg_1	219	222	PF00400	0.395
TRG_ER_diArg_1	521	523	PF00400	0.595
TRG_ER_diArg_1	559	562	PF00400	0.650
TRG_ER_diArg_1	71	74	PF00400	0.487
TRG_NLS_MonoCore_2	519	524	PF00514	0.573
TRG_NLS_MonoExtN_4	517	524	PF00514	0.647
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I873	Leptomonas seymouri	55%	98%
A0A1X0NWB4	Trypanosomatidae	33%	100%
A0A3S7X5C7	Leishmania donovani	100%	100%
A0A422N8X2	Trypanosoma rangeli	31%	100%
A4HK67	Leishmania braziliensis	78%	100%
D0A9V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B2L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q5J6	Leishmania major	93%	100%
V5BQN4	Trypanosoma cruzi	34%	100%