LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
RNA recognition motif (a.k.a. RRM - RBD - or RNP domain)/RNA recognition motif. (a.k.a. RRM - RBD - or RNP domain) - putative
Species:
Leishmania infantum
UniProt:
A4I7Q1_LEIIN
TriTrypDb:
LINF_320014000
Length:
758

Annotations

Annotations by Jardim et al.

Nucleic acid binding, polypyrimidine tract-binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0010494 cytoplasmic stress granule 5 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0099080 supramolecular complex 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I7Q1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7Q1

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 7
GO:0003723 RNA binding 4 7
GO:0005488 binding 1 7
GO:0097159 organic cyclic compound binding 2 7
GO:1901363 heterocyclic compound binding 2 7
GO:0003729 mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 245 249 PF00656 0.557
CLV_C14_Caspase3-7 384 388 PF00656 0.634
CLV_C14_Caspase3-7 632 636 PF00656 0.619
CLV_C14_Caspase3-7 675 679 PF00656 0.779
CLV_C14_Caspase3-7 680 684 PF00656 0.744
CLV_C14_Caspase3-7 730 734 PF00656 0.718
CLV_NRD_NRD_1 200 202 PF00675 0.646
CLV_NRD_NRD_1 374 376 PF00675 0.761
CLV_NRD_NRD_1 56 58 PF00675 0.675
CLV_NRD_NRD_1 617 619 PF00675 0.385
CLV_PCSK_FUR_1 532 536 PF00082 0.523
CLV_PCSK_KEX2_1 200 202 PF00082 0.646
CLV_PCSK_KEX2_1 373 375 PF00082 0.784
CLV_PCSK_KEX2_1 495 497 PF00082 0.444
CLV_PCSK_KEX2_1 534 536 PF00082 0.483
CLV_PCSK_KEX2_1 56 58 PF00082 0.675
CLV_PCSK_KEX2_1 617 619 PF00082 0.385
CLV_PCSK_PC1ET2_1 495 497 PF00082 0.503
CLV_PCSK_PC1ET2_1 534 536 PF00082 0.483
CLV_PCSK_SKI1_1 20 24 PF00082 0.531
CLV_PCSK_SKI1_1 215 219 PF00082 0.502
CLV_PCSK_SKI1_1 272 276 PF00082 0.522
CLV_PCSK_SKI1_1 747 751 PF00082 0.740
DEG_APCC_DBOX_1 214 222 PF00400 0.501
DEG_COP1_1 736 744 PF00400 0.749
DOC_ANK_TNKS_1 401 408 PF00023 0.789
DOC_CYCLIN_RxL_1 17 27 PF00134 0.517
DOC_MAPK_gen_1 200 206 PF00069 0.632
DOC_MAPK_gen_1 643 652 PF00069 0.619
DOC_MAPK_MEF2A_6 646 654 PF00069 0.619
DOC_PP1_RVXF_1 270 276 PF00149 0.485
DOC_PP1_RVXF_1 649 655 PF00149 0.699
DOC_PP4_FxxP_1 274 277 PF00568 0.519
DOC_PP4_FxxP_1 508 511 PF00568 0.635
DOC_USP7_MATH_1 153 157 PF00917 0.802
DOC_USP7_MATH_1 178 182 PF00917 0.817
DOC_USP7_MATH_1 196 200 PF00917 0.519
DOC_USP7_MATH_1 288 292 PF00917 0.751
DOC_USP7_MATH_1 330 334 PF00917 0.707
DOC_USP7_MATH_1 661 665 PF00917 0.712
DOC_USP7_MATH_1 701 705 PF00917 0.824
DOC_USP7_MATH_1 711 715 PF00917 0.677
DOC_USP7_MATH_1 753 757 PF00917 0.648
DOC_USP7_UBL2_3 602 606 PF12436 0.619
DOC_USP7_UBL2_3 750 754 PF12436 0.725
DOC_WW_Pin1_4 165 170 PF00397 0.775
DOC_WW_Pin1_4 434 439 PF00397 0.745
LIG_14-3-3_CanoR_1 56 60 PF00244 0.657
LIG_14-3-3_CanoR_1 651 655 PF00244 0.626
LIG_Actin_WH2_2 589 604 PF00022 0.619
LIG_AP2alpha_2 369 371 PF02296 0.720
LIG_APCC_ABBA_1 271 276 PF00400 0.585
LIG_APCC_ABBAyCdc20_2 578 584 PF00400 0.585
LIG_BIR_II_1 1 5 PF00653 0.524
LIG_BIR_III_4 334 338 PF00653 0.703
LIG_deltaCOP1_diTrp_1 480 488 PF00928 0.554
LIG_eIF4E_1 479 485 PF01652 0.436
LIG_FHA_1 1 7 PF00498 0.508
LIG_FHA_1 212 218 PF00498 0.487
LIG_FHA_1 239 245 PF00498 0.502
LIG_FHA_1 464 470 PF00498 0.483
LIG_FHA_1 591 597 PF00498 0.546
LIG_FHA_2 44 50 PF00498 0.556
LIG_FHA_2 542 548 PF00498 0.636
LIG_FHA_2 630 636 PF00498 0.619
LIG_FHA_2 686 692 PF00498 0.733
LIG_IBAR_NPY_1 321 323 PF08397 0.817
LIG_LIR_Apic_2 302 307 PF02991 0.714
LIG_LIR_Gen_1 276 287 PF02991 0.710
LIG_LIR_Gen_1 480 488 PF02991 0.437
LIG_LIR_Gen_1 647 657 PF02991 0.643
LIG_LIR_Nem_3 276 282 PF02991 0.682
LIG_LIR_Nem_3 434 439 PF02991 0.722
LIG_LIR_Nem_3 480 485 PF02991 0.432
LIG_LIR_Nem_3 486 491 PF02991 0.404
LIG_LIR_Nem_3 647 652 PF02991 0.548
LIG_LIR_Nem_3 653 657 PF02991 0.545
LIG_LYPXL_yS_3 457 460 PF13949 0.577
LIG_NRBOX 480 486 PF00104 0.448
LIG_NRP_CendR_1 757 758 PF00754 0.813
LIG_Pex14_2 275 279 PF04695 0.583
LIG_PTB_Apo_2 264 271 PF02174 0.595
LIG_PTB_Phospho_1 264 270 PF10480 0.603
LIG_REV1ctd_RIR_1 613 619 PF16727 0.563
LIG_SH2_CRK 150 154 PF00017 0.719
LIG_SH2_CRK 304 308 PF00017 0.734
LIG_SH2_NCK_1 150 154 PF00017 0.719
LIG_SH2_NCK_1 323 327 PF00017 0.593
LIG_SH2_PTP2 270 273 PF00017 0.468
LIG_SH2_STAP1 479 483 PF00017 0.439
LIG_SH2_STAT3 157 160 PF00017 0.840
LIG_SH2_STAT3 306 309 PF00017 0.704
LIG_SH2_STAT5 176 179 PF00017 0.703
LIG_SH2_STAT5 270 273 PF00017 0.468
LIG_SH2_STAT5 520 523 PF00017 0.501
LIG_SH2_STAT5 588 591 PF00017 0.609
LIG_SH3_1 281 287 PF00018 0.630
LIG_SH3_1 568 574 PF00018 0.624
LIG_SH3_2 195 200 PF14604 0.731
LIG_SH3_3 152 158 PF00018 0.813
LIG_SH3_3 190 196 PF00018 0.705
LIG_SH3_3 232 238 PF00018 0.573
LIG_SH3_3 281 287 PF00018 0.654
LIG_SH3_3 324 330 PF00018 0.670
LIG_SH3_3 357 363 PF00018 0.638
LIG_SH3_3 435 441 PF00018 0.801
LIG_SH3_3 568 574 PF00018 0.624
LIG_SH3_3 655 661 PF00018 0.584
LIG_SH3_3 69 75 PF00018 0.665
LIG_SH3_3 697 703 PF00018 0.783
LIG_SH3_3 714 720 PF00018 0.661
LIG_SH3_3 93 99 PF00018 0.728
LIG_SUMO_SIM_par_1 2 7 PF11976 0.592
LIG_SUMO_SIM_par_1 227 232 PF11976 0.504
LIG_SUMO_SIM_par_1 465 470 PF11976 0.581
LIG_TRAF2_1 46 49 PF00917 0.572
LIG_TRAF2_1 710 713 PF00917 0.803
LIG_TRAF2_1 721 724 PF00917 0.606
LIG_TRAF2_1 728 731 PF00917 0.511
LIG_UBA3_1 637 643 PF00899 0.530
MOD_CK1_1 172 178 PF00069 0.840
MOD_CK1_1 181 187 PF00069 0.621
MOD_CK1_1 35 41 PF00069 0.672
MOD_CK1_1 352 358 PF00069 0.751
MOD_CK1_1 398 404 PF00069 0.731
MOD_CK2_1 43 49 PF00069 0.560
MOD_CK2_1 434 440 PF00069 0.719
MOD_CK2_1 541 547 PF00069 0.626
MOD_CK2_1 594 600 PF00069 0.530
MOD_CK2_1 685 691 PF00069 0.739
MOD_Cter_Amidation 371 374 PF01082 0.632
MOD_GlcNHglycan 114 117 PF01048 0.804
MOD_GlcNHglycan 183 186 PF01048 0.727
MOD_GlcNHglycan 301 304 PF01048 0.769
MOD_GlcNHglycan 355 358 PF01048 0.787
MOD_GlcNHglycan 383 386 PF01048 0.706
MOD_GlcNHglycan 425 428 PF01048 0.792
MOD_GlcNHglycan 440 444 PF01048 0.803
MOD_GlcNHglycan 536 539 PF01048 0.579
MOD_GlcNHglycan 713 716 PF01048 0.754
MOD_GlcNHglycan 738 741 PF01048 0.687
MOD_GSK3_1 165 172 PF00069 0.792
MOD_GSK3_1 177 184 PF00069 0.605
MOD_GSK3_1 293 300 PF00069 0.769
MOD_GSK3_1 349 356 PF00069 0.739
MOD_GSK3_1 459 466 PF00069 0.575
MOD_GSK3_1 541 548 PF00069 0.655
MOD_GSK3_1 549 556 PF00069 0.541
MOD_GSK3_1 590 597 PF00069 0.505
MOD_N-GLC_1 178 183 PF02516 0.723
MOD_N-GLC_1 472 477 PF02516 0.584
MOD_N-GLC_1 590 595 PF02516 0.346
MOD_N-GLC_2 267 269 PF02516 0.590
MOD_N-GLC_2 463 465 PF02516 0.526
MOD_NEK2_1 24 29 PF00069 0.630
MOD_NEK2_1 526 531 PF00069 0.467
MOD_NEK2_1 560 565 PF00069 0.606
MOD_NEK2_1 587 592 PF00069 0.504
MOD_NEK2_1 650 655 PF00069 0.521
MOD_NEK2_2 40 45 PF00069 0.535
MOD_OFUCOSY 465 471 PF10250 0.506
MOD_PIKK_1 35 41 PF00454 0.573
MOD_PIKK_1 358 364 PF00454 0.731
MOD_PIKK_1 685 691 PF00454 0.747
MOD_PIKK_1 701 707 PF00454 0.585
MOD_PKA_1 534 540 PF00069 0.630
MOD_PKA_2 398 404 PF00069 0.726
MOD_PKA_2 423 429 PF00069 0.771
MOD_PKA_2 526 532 PF00069 0.487
MOD_PKA_2 534 540 PF00069 0.579
MOD_PKA_2 541 547 PF00069 0.643
MOD_PKA_2 55 61 PF00069 0.653
MOD_PKA_2 650 656 PF00069 0.633
MOD_PKA_2 661 667 PF00069 0.622
MOD_Plk_1 472 478 PF00069 0.500
MOD_Plk_2-3 541 547 PF00069 0.643
MOD_Plk_2-3 594 600 PF00069 0.530
MOD_Plk_4 172 178 PF00069 0.757
MOD_Plk_4 463 469 PF00069 0.489
MOD_Plk_4 526 532 PF00069 0.559
MOD_ProDKin_1 165 171 PF00069 0.777
MOD_ProDKin_1 434 440 PF00069 0.743
MOD_SUMO_rev_2 541 551 PF00179 0.716
MOD_SUMO_rev_2 594 604 PF00179 0.619
TRG_DiLeu_BaEn_1 49 54 PF01217 0.533
TRG_ENDOCYTIC_2 126 129 PF00928 0.795
TRG_ENDOCYTIC_2 270 273 PF00928 0.468
TRG_ENDOCYTIC_2 457 460 PF00928 0.577
TRG_ER_diArg_1 200 203 PF00400 0.652
TRG_ER_diArg_1 373 375 PF00400 0.632
TRG_ER_diArg_1 577 580 PF00400 0.717
TRG_ER_diArg_1 616 618 PF00400 0.585
TRG_Pf-PMV_PEXEL_1 203 207 PF00026 0.625

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1I1 Leptomonas seymouri 41% 100%
A0A3Q8IJ43 Leishmania donovani 99% 100%
A4HK66 Leishmania braziliensis 74% 98%
E9B2K9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q5J7 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS