LeishMANIAdb
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B30.2/SPRY domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
B30.2/SPRY domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I7P6_LEIIN
TriTrypDb:
LINF_320013400
Length:
165

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I7P6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7P6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016874 ligase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 57 61 PF00656 0.414
CLV_PCSK_SKI1_1 161 165 PF00082 0.435
DOC_CDC14_PxL_1 66 74 PF14671 0.368
DOC_PP1_RVXF_1 159 165 PF00149 0.312
DOC_USP7_MATH_1 151 155 PF00917 0.309
DOC_USP7_MATH_1 59 63 PF00917 0.509
DOC_USP7_MATH_1 79 83 PF00917 0.412
DOC_WW_Pin1_4 36 41 PF00397 0.417
DOC_WW_Pin1_4 9 14 PF00397 0.420
LIG_14-3-3_CanoR_1 107 116 PF00244 0.479
LIG_FHA_1 110 116 PF00498 0.330
LIG_FHA_1 122 128 PF00498 0.353
LIG_FHA_1 135 141 PF00498 0.425
LIG_LIR_Gen_1 117 127 PF02991 0.414
LIG_LIR_Nem_3 117 123 PF02991 0.381
LIG_LIR_Nem_3 147 153 PF02991 0.350
LIG_LYPXL_L_2 149 158 PF13949 0.316
LIG_LYPXL_S_1 149 153 PF13949 0.348
LIG_LYPXL_yS_3 150 153 PF13949 0.415
LIG_SH2_GRB2like 157 160 PF00017 0.317
LIG_SH2_STAT3 157 160 PF00017 0.317
LIG_SH2_STAT5 157 160 PF00017 0.317
LIG_SH2_STAT5 84 87 PF00017 0.325
LIG_SUMO_SIM_par_1 4 12 PF11976 0.472
MOD_DYRK1A_RPxSP_1 36 40 PF00069 0.382
MOD_GlcNHglycan 130 133 PF01048 0.395
MOD_GlcNHglycan 41 44 PF01048 0.465
MOD_GlcNHglycan 60 64 PF01048 0.380
MOD_GlcNHglycan 72 75 PF01048 0.391
MOD_GlcNHglycan 77 80 PF01048 0.374
MOD_GSK3_1 15 22 PF00069 0.546
MOD_GSK3_1 75 82 PF00069 0.439
MOD_NEK2_1 41 46 PF00069 0.571
MOD_NEK2_2 151 156 PF00069 0.295
MOD_NEK2_2 31 36 PF00069 0.348
MOD_PKA_1 134 140 PF00069 0.469
MOD_PKA_2 25 31 PF00069 0.409
MOD_Plk_4 151 157 PF00069 0.382
MOD_ProDKin_1 36 42 PF00069 0.419
MOD_ProDKin_1 9 15 PF00069 0.425
TRG_ENDOCYTIC_2 150 153 PF00928 0.347
TRG_Pf-PMV_PEXEL_1 51 55 PF00026 0.486

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEH7 Leptomonas seymouri 83% 100%
A0A0S4J9U7 Bodo saltans 63% 99%
A0A1X0NUN3 Trypanosomatidae 67% 100%
A0A3Q8IGM3 Leishmania donovani 100% 100%
A0A422N080 Trypanosoma rangeli 70% 100%
A4HK60 Leishmania braziliensis 93% 100%
D0A9U8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 72% 100%
E9B2K3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
Q4Q5K3 Leishmania major 99% 100%
V5AQT2 Trypanosoma cruzi 70% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS