Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7P1_LEIIN

TriTrypDb:

LINF_320012900

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7P1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.561
CLV_C14_Caspase3-7	271	275	PF00656	0.446
CLV_NRD_NRD_1	113	115	PF00675	0.588
CLV_NRD_NRD_1	257	259	PF00675	0.394
CLV_PCSK_KEX2_1	113	115	PF00082	0.588
CLV_PCSK_KEX2_1	257	259	PF00082	0.394
CLV_PCSK_SKI1_1	221	225	PF00082	0.402
DEG_APCC_DBOX_1	349	357	PF00400	0.301
DEG_APCC_DBOX_1	71	79	PF00400	0.368
DEG_SCF_FBW7_1	265	271	PF00400	0.469
DOC_ANK_TNKS_1	307	314	PF00023	0.408
DOC_CKS1_1	265	270	PF01111	0.472
DOC_MAPK_gen_1	101	110	PF00069	0.405
DOC_MAPK_MEF2A_6	101	110	PF00069	0.461
DOC_MAPK_MEF2A_6	350	359	PF00069	0.342
DOC_PP2B_LxvP_1	295	298	PF13499	0.374
DOC_PP4_FxxP_1	329	332	PF00568	0.351
DOC_USP7_MATH_1	2	6	PF00917	0.603
DOC_USP7_MATH_1	240	244	PF00917	0.559
DOC_USP7_MATH_1	298	302	PF00917	0.531
DOC_USP7_MATH_1	384	388	PF00917	0.388
DOC_USP7_MATH_1	42	46	PF00917	0.472
DOC_USP7_MATH_1	64	68	PF00917	0.444
DOC_USP7_MATH_1	87	91	PF00917	0.397
DOC_WW_Pin1_4	264	269	PF00397	0.495
DOC_WW_Pin1_4	32	37	PF00397	0.380
DOC_WW_Pin1_4	320	325	PF00397	0.477
DOC_WW_Pin1_4	89	94	PF00397	0.529
LIG_BRCT_BRCA1_1	145	149	PF00533	0.521
LIG_BRCT_BRCA1_1	321	325	PF00533	0.495
LIG_FHA_1	179	185	PF00498	0.333
LIG_FHA_1	265	271	PF00498	0.404
LIG_FHA_1	361	367	PF00498	0.388
LIG_FHA_1	369	375	PF00498	0.342
LIG_FHA_2	169	175	PF00498	0.502
LIG_FHA_2	269	275	PF00498	0.443
LIG_FHA_2	359	365	PF00498	0.389
LIG_HP1_1	42	46	PF01393	0.431
LIG_LIR_Apic_2	326	332	PF02991	0.362
LIG_LIR_Gen_1	274	282	PF02991	0.384
LIG_LIR_Gen_1	301	312	PF02991	0.446
LIG_LIR_Gen_1	373	384	PF02991	0.360
LIG_LIR_Nem_3	136	142	PF02991	0.347
LIG_LIR_Nem_3	146	152	PF02991	0.497
LIG_LIR_Nem_3	197	202	PF02991	0.452
LIG_LIR_Nem_3	259	265	PF02991	0.504
LIG_LIR_Nem_3	274	279	PF02991	0.273
LIG_LIR_Nem_3	301	307	PF02991	0.440
LIG_LIR_Nem_3	363	368	PF02991	0.426
LIG_LIR_Nem_3	373	379	PF02991	0.340
LIG_Pex14_2	325	329	PF04695	0.410
LIG_SH2_CRK	276	280	PF00017	0.345
LIG_SH2_NCK_1	152	156	PF00017	0.506
LIG_SH2_PTP2	376	379	PF00017	0.346
LIG_SH2_STAP1	182	186	PF00017	0.403
LIG_SH2_STAP1	276	280	PF00017	0.406
LIG_SH2_STAP1	336	340	PF00017	0.385
LIG_SH2_STAT5	11	14	PF00017	0.406
LIG_SH2_STAT5	269	272	PF00017	0.426
LIG_SH2_STAT5	358	361	PF00017	0.392
LIG_SH2_STAT5	376	379	PF00017	0.217
LIG_SH3_3	134	140	PF00018	0.420
LIG_SH3_3	234	240	PF00018	0.566
LIG_SH3_3	35	41	PF00018	0.574
LIG_SH3_3	369	375	PF00018	0.415
LIG_SUMO_SIM_anti_2	104	112	PF11976	0.370
LIG_TYR_ITIM	374	379	PF00017	0.347
MOD_CDK_SPxxK_3	89	96	PF00069	0.476
MOD_CK1_1	143	149	PF00069	0.509
MOD_CK1_1	168	174	PF00069	0.544
MOD_CK2_1	358	364	PF00069	0.336
MOD_CK2_1	52	58	PF00069	0.374
MOD_CMANNOS	362	365	PF00535	0.326
MOD_GlcNHglycan	214	217	PF01048	0.500
MOD_GlcNHglycan	249	252	PF01048	0.542
MOD_GlcNHglycan	336	339	PF01048	0.488
MOD_GlcNHglycan	386	389	PF01048	0.634
MOD_GlcNHglycan	54	57	PF01048	0.434
MOD_GlcNHglycan	62	65	PF01048	0.356
MOD_GlcNHglycan	66	69	PF01048	0.335
MOD_GSK3_1	104	111	PF00069	0.486
MOD_GSK3_1	129	136	PF00069	0.436
MOD_GSK3_1	140	147	PF00069	0.415
MOD_GSK3_1	208	215	PF00069	0.497
MOD_GSK3_1	264	271	PF00069	0.413
MOD_GSK3_1	319	326	PF00069	0.506
MOD_GSK3_1	60	67	PF00069	0.428
MOD_N-GLC_1	368	373	PF02516	0.406
MOD_NEK2_1	165	170	PF00069	0.643
MOD_NEK2_1	325	330	PF00069	0.405
MOD_NEK2_1	77	82	PF00069	0.368
MOD_NEK2_2	10	15	PF00069	0.410
MOD_PKA_2	240	246	PF00069	0.494
MOD_Plk_1	129	135	PF00069	0.345
MOD_Plk_1	144	150	PF00069	0.501
MOD_Plk_1	368	374	PF00069	0.401
MOD_Plk_2-3	145	151	PF00069	0.528
MOD_Plk_4	104	110	PF00069	0.411
MOD_Plk_4	325	331	PF00069	0.410
MOD_ProDKin_1	264	270	PF00069	0.500
MOD_ProDKin_1	32	38	PF00069	0.390
MOD_ProDKin_1	320	326	PF00069	0.474
MOD_ProDKin_1	89	95	PF00069	0.542
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.345
TRG_ENDOCYTIC_2	276	279	PF00928	0.346
TRG_ENDOCYTIC_2	304	307	PF00928	0.430
TRG_ENDOCYTIC_2	376	379	PF00928	0.452
TRG_ER_diArg_1	195	198	PF00400	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M8	Leptomonas seymouri	44%	100%
A0A3Q8IG12	Leishmania donovani	99%	100%
A4HK55	Leishmania braziliensis	73%	100%
E9B2J8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q5K8	Leishmania major	89%	100%