Outer_row_dynein-

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Outer_row_dynein-

Gene product:

Outer row dynein-assembly protein 7

Species:

Leishmania infantum

UniProt:

A4I7P0_LEIIN

TriTrypDb:

LINF_320012800

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0044297	cell body	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4I7P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7P0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036158	outer dynein arm assembly	7	11
GO:0036159	inner dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006996	organelle organization	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044458	motile cilium assembly	7	1
GO:0044782	cilium organization	5	1
GO:0048870	cell motility	2	1
GO:0060271	cilium assembly	6	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0070925	organelle assembly	5	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0044877	protein-containing complex binding	2	11
GO:0070840	dynein complex binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	516	520	PF00656	0.600
CLV_NRD_NRD_1	246	248	PF00675	0.366
CLV_NRD_NRD_1	269	271	PF00675	0.393
CLV_NRD_NRD_1	326	328	PF00675	0.466
CLV_NRD_NRD_1	339	341	PF00675	0.430
CLV_NRD_NRD_1	388	390	PF00675	0.495
CLV_NRD_NRD_1	412	414	PF00675	0.713
CLV_NRD_NRD_1	569	571	PF00675	0.637
CLV_NRD_NRD_1	589	591	PF00675	0.323
CLV_PCSK_FUR_1	337	341	PF00082	0.582
CLV_PCSK_KEX2_1	246	248	PF00082	0.385
CLV_PCSK_KEX2_1	269	271	PF00082	0.393
CLV_PCSK_KEX2_1	294	296	PF00082	0.540
CLV_PCSK_KEX2_1	326	328	PF00082	0.441
CLV_PCSK_KEX2_1	337	339	PF00082	0.461
CLV_PCSK_KEX2_1	388	390	PF00082	0.526
CLV_PCSK_KEX2_1	568	570	PF00082	0.592
CLV_PCSK_KEX2_1	589	591	PF00082	0.594
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.540
CLV_PCSK_PC7_1	564	570	PF00082	0.527
CLV_PCSK_SKI1_1	161	165	PF00082	0.558
CLV_PCSK_SKI1_1	262	266	PF00082	0.411
CLV_PCSK_SKI1_1	269	273	PF00082	0.398
CLV_PCSK_SKI1_1	300	304	PF00082	0.514
CLV_PCSK_SKI1_1	379	383	PF00082	0.566
CLV_PCSK_SKI1_1	45	49	PF00082	0.421
CLV_PCSK_SKI1_1	529	533	PF00082	0.751
DEG_ODPH_VHL_1	198	210	PF01847	0.489
DEG_SPOP_SBC_1	202	206	PF00917	0.497
DOC_CDC14_PxL_1	250	258	PF14671	0.423
DOC_CKS1_1	468	473	PF01111	0.563
DOC_CYCLIN_yClb5_NLxxxL_5	74	83	PF00134	0.245
DOC_CYCLIN_yCln2_LP_2	468	474	PF00134	0.638
DOC_MAPK_gen_1	243	253	PF00069	0.432
DOC_MAPK_gen_1	587	597	PF00069	0.467
DOC_MAPK_MEF2A_6	246	253	PF00069	0.396
DOC_MAPK_MEF2A_6	67	75	PF00069	0.384
DOC_MAPK_NFAT4_5	246	254	PF00069	0.412
DOC_PP1_RVXF_1	46	52	PF00149	0.347
DOC_PP2B_LxvP_1	251	254	PF13499	0.432
DOC_PP2B_LxvP_1	472	475	PF13499	0.600
DOC_USP7_MATH_1	226	230	PF00917	0.377
DOC_USP7_MATH_1	347	351	PF00917	0.564
DOC_WW_Pin1_4	444	449	PF00397	0.605
DOC_WW_Pin1_4	467	472	PF00397	0.654
LIG_14-3-3_CanoR_1	161	166	PF00244	0.538
LIG_14-3-3_CanoR_1	262	271	PF00244	0.463
LIG_14-3-3_CanoR_1	300	305	PF00244	0.545
LIG_14-3-3_CanoR_1	540	544	PF00244	0.442
LIG_14-3-3_CanoR_1	568	575	PF00244	0.585
LIG_14-3-3_CanoR_1	589	594	PF00244	0.595
LIG_14-3-3_CanoR_1	81	87	PF00244	0.427
LIG_APCC_ABBA_1	41	46	PF00400	0.483
LIG_BIR_II_1	1	5	PF00653	0.474
LIG_Clathr_ClatBox_1	482	486	PF01394	0.616
LIG_deltaCOP1_diTrp_1	365	374	PF00928	0.565
LIG_deltaCOP1_diTrp_1	577	586	PF00928	0.526
LIG_FHA_1	170	176	PF00498	0.733
LIG_FHA_1	203	209	PF00498	0.617
LIG_FHA_1	297	303	PF00498	0.503
LIG_FHA_1	3	9	PF00498	0.391
LIG_FHA_1	318	324	PF00498	0.587
LIG_FHA_1	459	465	PF00498	0.683
LIG_FHA_1	85	91	PF00498	0.352
LIG_FHA_2	125	131	PF00498	0.470
LIG_FHA_2	141	147	PF00498	0.276
LIG_FHA_2	152	158	PF00498	0.560
LIG_FHA_2	179	185	PF00498	0.676
LIG_FHA_2	255	261	PF00498	0.457
LIG_FHA_2	287	293	PF00498	0.591
LIG_FHA_2	452	458	PF00498	0.611
LIG_FHA_2	464	470	PF00498	0.543
LIG_FHA_2	514	520	PF00498	0.559
LIG_LIR_Gen_1	146	155	PF02991	0.393
LIG_LIR_Gen_1	577	588	PF02991	0.572
LIG_LIR_Nem_3	146	152	PF02991	0.385
LIG_LIR_Nem_3	42	47	PF02991	0.365
LIG_LIR_Nem_3	577	583	PF02991	0.533
LIG_LRP6_Inhibitor_1	75	81	PF00058	0.427
LIG_NRBOX	478	484	PF00104	0.635
LIG_PDZ_Class_2	592	597	PF00595	0.497
LIG_SH2_CRK	19	23	PF00017	0.383
LIG_SH2_STAP1	392	396	PF00017	0.566
LIG_SH2_STAP1	513	517	PF00017	0.526
LIG_SH2_STAT5	102	105	PF00017	0.302
LIG_SH2_STAT5	232	235	PF00017	0.370
LIG_SH2_STAT5	258	261	PF00017	0.377
LIG_SH3_3	160	166	PF00018	0.551
LIG_SH3_3	205	211	PF00018	0.660
LIG_SH3_3	468	474	PF00018	0.715
LIG_SUMO_SIM_par_1	199	206	PF11976	0.495
LIG_TRAF2_1	405	408	PF00917	0.590
LIG_UBA3_1	37	45	PF00899	0.299
MOD_CK1_1	115	121	PF00069	0.420
MOD_CK1_1	141	147	PF00069	0.462
MOD_CK1_1	178	184	PF00069	0.637
MOD_CK1_1	193	199	PF00069	0.449
MOD_CK1_1	473	479	PF00069	0.711
MOD_CK1_1	58	64	PF00069	0.504
MOD_CK1_1	82	88	PF00069	0.289
MOD_CK2_1	124	130	PF00069	0.452
MOD_CK2_1	151	157	PF00069	0.580
MOD_CK2_1	286	292	PF00069	0.554
MOD_CK2_1	463	469	PF00069	0.759
MOD_CK2_1	58	64	PF00069	0.431
MOD_GlcNHglycan	194	198	PF01048	0.705
MOD_GlcNHglycan	349	352	PF01048	0.463
MOD_GlcNHglycan	420	423	PF01048	0.757
MOD_GlcNHglycan	429	432	PF01048	0.610
MOD_GlcNHglycan	532	535	PF01048	0.703
MOD_GlcNHglycan	59	63	PF01048	0.493
MOD_GSK3_1	115	122	PF00069	0.302
MOD_GSK3_1	141	148	PF00069	0.352
MOD_GSK3_1	296	303	PF00069	0.528
MOD_GSK3_1	414	421	PF00069	0.620
MOD_GSK3_1	423	430	PF00069	0.622
MOD_GSK3_1	460	467	PF00069	0.682
MOD_GSK3_1	470	477	PF00069	0.601
MOD_GSK3_1	508	515	PF00069	0.653
MOD_GSK3_1	58	65	PF00069	0.466
MOD_GSK3_1	82	89	PF00069	0.332
MOD_N-GLC_1	96	101	PF02516	0.346
MOD_NEK2_1	119	124	PF00069	0.326
MOD_NEK2_1	138	143	PF00069	0.306
MOD_NEK2_1	451	456	PF00069	0.665
MOD_NEK2_1	525	530	PF00069	0.630
MOD_NEK2_1	79	84	PF00069	0.397
MOD_NEK2_1	86	91	PF00069	0.320
MOD_NEK2_1	96	101	PF00069	0.192
MOD_NEK2_2	102	107	PF00069	0.427
MOD_PIKK_1	332	338	PF00454	0.520
MOD_PIKK_1	589	595	PF00454	0.674
MOD_PIKK_1	62	68	PF00454	0.495
MOD_PKA_1	269	275	PF00069	0.494
MOD_PKA_1	568	574	PF00069	0.559
MOD_PKA_1	589	595	PF00069	0.580
MOD_PKA_2	269	275	PF00069	0.495
MOD_PKA_2	286	292	PF00069	0.575
MOD_PKA_2	317	323	PF00069	0.507
MOD_PKA_2	539	545	PF00069	0.572
MOD_PKA_2	568	574	PF00069	0.546
MOD_PKA_2	589	595	PF00069	0.607
MOD_Plk_1	145	151	PF00069	0.361
MOD_Plk_1	193	199	PF00069	0.740
MOD_Plk_2-3	286	292	PF00069	0.486
MOD_Plk_4	226	232	PF00069	0.371
MOD_Plk_4	254	260	PF00069	0.428
MOD_Plk_4	300	306	PF00069	0.530
MOD_Plk_4	474	480	PF00069	0.581
MOD_Plk_4	539	545	PF00069	0.348
MOD_Plk_4	66	72	PF00069	0.309
MOD_ProDKin_1	444	450	PF00069	0.608
MOD_ProDKin_1	467	473	PF00069	0.680
MOD_SUMO_rev_2	286	296	PF00179	0.552
MOD_SUMO_rev_2	407	415	PF00179	0.666
MOD_SUMO_rev_2	42	50	PF00179	0.486
MOD_SUMO_rev_2	584	588	PF00179	0.432
TRG_DiLeu_BaEn_4	133	139	PF01217	0.483
TRG_ENDOCYTIC_2	44	47	PF00928	0.358
TRG_ER_diArg_1	245	247	PF00400	0.387
TRG_ER_diArg_1	269	271	PF00400	0.472
TRG_ER_diArg_1	337	340	PF00400	0.491
TRG_ER_diArg_1	568	570	PF00400	0.657
TRG_NES_CRM1_1	484	498	PF08389	0.498
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P804	Leptomonas seymouri	59%	99%
A0A0S4KIJ3	Bodo saltans	39%	100%
A0A3Q8IJ31	Leishmania donovani	99%	100%
A0A3R7KFT3	Trypanosoma rangeli	48%	100%
A4HK54	Leishmania braziliensis	75%	100%
D0A9U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B2J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q5K9	Leishmania major	89%	100%
V5D6Q2	Trypanosoma cruzi	49%	100%