U6 snRNA-associated Sm-like protein LSm4

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4I7N8_LEIIN

TriTrypDb:

Length:

197

Annotations

Annotations by Jardim et al.

RNA Processing, U6 snRNA-associated Sm-like LSm4p

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0140513	nuclear protein-containing complex	2	4
GO:1990904	ribonucleoprotein complex	2	4
GO:0000932	P-body	5	1
GO:0005688	U6 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1

Expansion

Sequence features

A4I7N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7N8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	3
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	3
GO:0000398	mRNA splicing, via spliceosome	8	3
GO:0000956	nuclear-transcribed mRNA catabolic process	7	4
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006401	RNA catabolic process	5	4
GO:0006402	mRNA catabolic process	6	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008380	RNA splicing	7	3
GO:0009056	catabolic process	2	4
GO:0009057	macromolecule catabolic process	4	4
GO:0009892	negative regulation of metabolic process	4	4
GO:0009987	cellular process	1	4
GO:0010468	regulation of gene expression	5	4
GO:0010605	negative regulation of macromolecule metabolic process	5	4
GO:0010629	negative regulation of gene expression	6	4
GO:0016070	RNA metabolic process	5	4
GO:0016071	mRNA metabolic process	6	4
GO:0019222	regulation of metabolic process	3	4
GO:0019439	aromatic compound catabolic process	4	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0034655	nucleobase-containing compound catabolic process	4	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044248	cellular catabolic process	3	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	4
GO:0044265	obsolete cellular macromolecule catabolic process	4	4
GO:0044270	cellular nitrogen compound catabolic process	4	4
GO:0046483	heterocycle metabolic process	3	4
GO:0046700	heterocycle catabolic process	4	4
GO:0048519	negative regulation of biological process	3	4
GO:0050789	regulation of biological process	2	4
GO:0060255	regulation of macromolecule metabolic process	4	4
GO:0065007	biological regulation	1	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:1901361	organic cyclic compound catabolic process	4	4
GO:1901575	organic substance catabolic process	3	4
GO:0000387	spliceosomal snRNP assembly	7	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0033962	P-body assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070925	organelle assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003723	RNA binding	4	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4
GO:0017069	snRNA binding	5	1
GO:0017070	U6 snRNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.650
CLV_C14_Caspase3-7	134	138	PF00656	0.650
CLV_NRD_NRD_1	172	174	PF00675	0.828
CLV_NRD_NRD_1	195	197	PF00675	0.611
CLV_NRD_NRD_1	86	88	PF00675	0.737
CLV_PCSK_KEX2_1	172	174	PF00082	0.782
CLV_PCSK_KEX2_1	193	195	PF00082	0.666
CLV_PCSK_KEX2_1	86	88	PF00082	0.737
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.782
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.841
CLV_PCSK_SKI1_1	59	63	PF00082	0.616
CLV_PCSK_SKI1_1	87	91	PF00082	0.577
CLV_Separin_Metazoa	93	97	PF03568	0.549
DEG_APCC_DBOX_1	58	66	PF00400	0.625
DEG_ODPH_VHL_1	30	43	PF01847	0.598
DOC_ANK_TNKS_1	132	139	PF00023	0.650
DOC_CKS1_1	88	93	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	42	45	PF00134	0.573
DOC_MAPK_DCC_7	86	94	PF00069	0.503
DOC_MAPK_gen_1	119	128	PF00069	0.638
DOC_MAPK_gen_1	86	94	PF00069	0.678
DOC_MAPK_gen_1	96	105	PF00069	0.650
DOC_MAPK_MEF2A_6	119	128	PF00069	0.650
DOC_MAPK_MEF2A_6	99	107	PF00069	0.531
DOC_PP2B_LxvP_1	42	45	PF13499	0.573
DOC_PP4_FxxP_1	19	22	PF00568	0.748
DOC_PP4_FxxP_1	41	44	PF00568	0.629
DOC_USP7_MATH_1	168	172	PF00917	0.772
DOC_USP7_UBL2_3	193	197	PF12436	0.776
DOC_WW_Pin1_4	87	92	PF00397	0.507
LIG_14-3-3_CanoR_1	150	155	PF00244	0.650
LIG_14-3-3_CanoR_1	158	165	PF00244	0.550
LIG_14-3-3_CanoR_1	81	85	PF00244	0.780
LIG_deltaCOP1_diTrp_1	139	148	PF00928	0.650
LIG_FHA_2	132	138	PF00498	0.572
LIG_FHA_2	181	187	PF00498	0.730
LIG_FHA_2	88	94	PF00498	0.659
LIG_LIR_Apic_2	17	22	PF02991	0.730
LIG_MYND_1	40	44	PF01753	0.574
LIG_Pex14_2	80	84	PF04695	0.672
LIG_SH3_2	45	50	PF14604	0.571
LIG_SH3_3	162	168	PF00018	0.721
LIG_SH3_3	42	48	PF00018	0.526
LIG_SH3_3	85	91	PF00018	0.710
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.644
LIG_TRFH_1	41	45	PF08558	0.575
MOD_CK1_1	3	9	PF00069	0.683
MOD_CK1_1	46	52	PF00069	0.717
MOD_CK2_1	180	186	PF00069	0.658
MOD_CK2_1	87	93	PF00069	0.677
MOD_Cter_Amidation	191	194	PF01082	0.850
MOD_DYRK1A_RPxSP_1	87	91	PF00069	0.694
MOD_GlcNHglycan	161	164	PF01048	0.613
MOD_GlcNHglycan	22	25	PF01048	0.551
MOD_GlcNHglycan	26	29	PF01048	0.718
MOD_GSK3_1	1	8	PF00069	0.611
MOD_GSK3_1	109	116	PF00069	0.638
MOD_GSK3_1	137	144	PF00069	0.566
MOD_GSK3_1	20	27	PF00069	0.655
MOD_GSK3_1	72	79	PF00069	0.697
MOD_N-GLC_1	113	118	PF02516	0.449
MOD_N-GLC_2	11	13	PF02516	0.567
MOD_NEK2_1	1	6	PF00069	0.635
MOD_NEK2_1	14	19	PF00069	0.552
MOD_NEK2_1	159	164	PF00069	0.605
MOD_NEK2_1	26	31	PF00069	0.705
MOD_NEK2_1	34	39	PF00069	0.554
MOD_NEK2_1	76	81	PF00069	0.764
MOD_OFUCOSY	13	18	PF10250	0.573
MOD_PK_1	101	107	PF00069	0.650
MOD_PK_1	150	156	PF00069	0.650
MOD_PK_1	185	191	PF00069	0.857
MOD_PKA_2	157	163	PF00069	0.673
MOD_PKA_2	80	86	PF00069	0.778
MOD_Plk_1	101	107	PF00069	0.592
MOD_Plk_1	185	191	PF00069	0.857
MOD_Plk_4	113	119	PF00069	0.525
MOD_Plk_4	137	143	PF00069	0.617
MOD_ProDKin_1	87	93	PF00069	0.502
TRG_ER_diArg_1	86	88	PF00400	0.737
TRG_NLS_MonoCore_2	192	197	PF00514	0.718
TRG_NLS_MonoExtC_3	192	197	PF00514	0.718
TRG_NLS_MonoExtN_4	170	176	PF00514	0.765

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9B2J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q5L1	Leishmania major	91%	100%