Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mut7-C RNAse domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I7N7_LEIIN

TriTrypDb:

LINF_320012500

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7N7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.399
CLV_NRD_NRD_1	193	195	PF00675	0.423
CLV_NRD_NRD_1	293	295	PF00675	0.684
CLV_PCSK_KEX2_1	134	136	PF00082	0.432
CLV_PCSK_KEX2_1	155	157	PF00082	0.412
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.444
CLV_PCSK_SKI1_1	121	125	PF00082	0.372
CLV_PCSK_SKI1_1	156	160	PF00082	0.326
CLV_PCSK_SKI1_1	194	198	PF00082	0.401
CLV_PCSK_SKI1_1	246	250	PF00082	0.521
CLV_PCSK_SKI1_1	28	32	PF00082	0.344
CLV_PCSK_SKI1_1	89	93	PF00082	0.369
DEG_APCC_DBOX_1	231	239	PF00400	0.579
DEG_Kelch_Keap1_1	110	115	PF01344	0.272
DOC_CYCLIN_RxL_1	246	257	PF00134	0.469
DOC_CYCLIN_yClb5_NLxxxL_5	211	220	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	51	57	PF00134	0.378
DOC_MAPK_gen_1	134	140	PF00069	0.452
DOC_PP1_RVXF_1	192	199	PF00149	0.347
DOC_PP1_RVXF_1	247	254	PF00149	0.462
DOC_USP7_MATH_1	100	104	PF00917	0.392
LIG_14-3-3_CanoR_1	129	137	PF00244	0.349
LIG_14-3-3_CanoR_1	155	165	PF00244	0.348
LIG_14-3-3_CanoR_1	239	245	PF00244	0.459
LIG_14-3-3_CanoR_1	60	69	PF00244	0.414
LIG_14-3-3_CanoR_1	79	84	PF00244	0.275
LIG_BRCT_BRCA1_1	129	133	PF00533	0.444
LIG_FHA_1	145	151	PF00498	0.444
LIG_FHA_1	80	86	PF00498	0.369
LIG_FHA_2	157	163	PF00498	0.429
LIG_LIR_Gen_1	182	192	PF02991	0.369
LIG_LIR_Nem_3	182	187	PF02991	0.348
LIG_LIR_Nem_3	210	214	PF02991	0.409
LIG_LIR_Nem_3	243	247	PF02991	0.462
LIG_MAD2	60	68	PF02301	0.429
LIG_NRP_CendR_1	294	296	PF00754	0.544
LIG_PCNA_PIPBox_1	26	35	PF02747	0.485
LIG_Pex14_2	124	128	PF04695	0.444
LIG_Pex14_2	20	24	PF04695	0.369
LIG_Pex14_2	200	204	PF04695	0.532
LIG_SH2_CRK	38	42	PF00017	0.344
LIG_SH2_STAT5	255	258	PF00017	0.506
LIG_SH2_STAT5	32	35	PF00017	0.369
LIG_TRAF2_1	227	230	PF00917	0.599
LIG_TYR_ITIM	36	41	PF00017	0.344
LIG_UBA3_1	203	209	PF00899	0.341
LIG_WRC_WIRS_1	208	213	PF05994	0.464
MOD_CK1_1	107	113	PF00069	0.379
MOD_CK1_1	210	216	PF00069	0.451
MOD_CK1_1	281	287	PF00069	0.577
MOD_CK1_1	6	12	PF00069	0.667
MOD_CK2_1	100	106	PF00069	0.344
MOD_CK2_1	156	162	PF00069	0.444
MOD_CK2_1	251	257	PF00069	0.517
MOD_GlcNHglycan	112	115	PF01048	0.277
MOD_GSK3_1	100	107	PF00069	0.344
MOD_GSK3_1	3	10	PF00069	0.642
MOD_N-GLC_1	3	8	PF02516	0.654
MOD_NEK2_1	163	168	PF00069	0.349
MOD_NEK2_1	216	221	PF00069	0.464
MOD_NEK2_1	22	27	PF00069	0.354
MOD_NEK2_1	251	256	PF00069	0.461
MOD_NEK2_1	69	74	PF00069	0.380
MOD_PIKK_1	122	128	PF00454	0.485
MOD_PIKK_1	7	13	PF00454	0.658
MOD_PKA_2	128	134	PF00069	0.349
MOD_PKA_2	233	239	PF00069	0.510
MOD_PKA_2	281	287	PF00069	0.577
MOD_Plk_1	22	28	PF00069	0.344
MOD_Plk_1	230	236	PF00069	0.540
MOD_Plk_4	104	110	PF00069	0.384
MOD_SUMO_for_1	167	170	PF00179	0.349
MOD_SUMO_rev_2	130	136	PF00179	0.454
TRG_DiLeu_BaEn_1	58	63	PF01217	0.444
TRG_DiLeu_BaEn_4	230	236	PF01217	0.619
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.344
TRG_ENDOCYTIC_2	184	187	PF00928	0.344
TRG_ENDOCYTIC_2	208	211	PF00928	0.432
TRG_ENDOCYTIC_2	32	35	PF00928	0.351
TRG_ENDOCYTIC_2	38	41	PF00928	0.336
TRG_ER_diArg_1	154	156	PF00400	0.412
TRG_ER_diArg_1	172	175	PF00400	0.444
TRG_ER_diArg_1	232	235	PF00400	0.508
TRG_ER_diArg_1	291	294	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I881	Leptomonas seymouri	70%	100%
A0A0S4J6L8	Bodo saltans	31%	78%
A0A1X0NV53	Trypanosomatidae	45%	100%
A0A3S7X590	Leishmania donovani	100%	100%
A4HK51	Leishmania braziliensis	85%	100%
D0A9T8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B2J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5L2	Leishmania major	92%	100%