ARID domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7M4_LEIIN

TriTrypDb:

LINF_320011100

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7M4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.783
CLV_C14_Caspase3-7	60	64	PF00656	0.505
CLV_NRD_NRD_1	228	230	PF00675	0.675
CLV_NRD_NRD_1	257	259	PF00675	0.709
CLV_NRD_NRD_1	382	384	PF00675	0.801
CLV_NRD_NRD_1	429	431	PF00675	0.802
CLV_NRD_NRD_1	473	475	PF00675	0.656
CLV_NRD_NRD_1	477	479	PF00675	0.660
CLV_NRD_NRD_1	550	552	PF00675	0.690
CLV_NRD_NRD_1	582	584	PF00675	0.513
CLV_NRD_NRD_1	90	92	PF00675	0.489
CLV_PCSK_FUR_1	378	382	PF00082	0.741
CLV_PCSK_FUR_1	87	91	PF00082	0.600
CLV_PCSK_KEX2_1	114	116	PF00082	0.658
CLV_PCSK_KEX2_1	228	230	PF00082	0.688
CLV_PCSK_KEX2_1	241	243	PF00082	0.582
CLV_PCSK_KEX2_1	378	380	PF00082	0.726
CLV_PCSK_KEX2_1	381	383	PF00082	0.733
CLV_PCSK_KEX2_1	428	430	PF00082	0.809
CLV_PCSK_KEX2_1	473	475	PF00082	0.712
CLV_PCSK_KEX2_1	477	479	PF00082	0.721
CLV_PCSK_KEX2_1	550	552	PF00082	0.721
CLV_PCSK_KEX2_1	89	91	PF00082	0.495
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.658
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.683
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.745
CLV_PCSK_PC1ET2_1	550	552	PF00082	0.721
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.495
CLV_PCSK_PC7_1	224	230	PF00082	0.722
CLV_PCSK_PC7_1	378	384	PF00082	0.722
CLV_PCSK_PC7_1	473	479	PF00082	0.737
CLV_PCSK_SKI1_1	115	119	PF00082	0.565
CLV_PCSK_SKI1_1	129	133	PF00082	0.662
CLV_PCSK_SKI1_1	147	151	PF00082	0.740
CLV_PCSK_SKI1_1	229	233	PF00082	0.826
CLV_PCSK_SKI1_1	552	556	PF00082	0.826
CLV_PCSK_SKI1_1	78	82	PF00082	0.522
DOC_MAPK_MEF2A_6	486	495	PF00069	0.725
DOC_PIKK_1	392	400	PF02985	0.585
DOC_PP4_MxPP_1	123	126	PF00568	0.670
DOC_USP7_MATH_1	154	158	PF00917	0.763
DOC_USP7_MATH_1	2	6	PF00917	0.625
DOC_USP7_MATH_1	216	220	PF00917	0.721
DOC_USP7_MATH_1	346	350	PF00917	0.699
DOC_USP7_MATH_1	462	466	PF00917	0.760
DOC_USP7_MATH_1	469	473	PF00917	0.779
DOC_USP7_MATH_1	514	518	PF00917	0.618
DOC_USP7_MATH_1	54	58	PF00917	0.672
DOC_USP7_MATH_1	559	563	PF00917	0.783
DOC_USP7_UBL2_3	114	118	PF12436	0.660
DOC_USP7_UBL2_3	455	459	PF12436	0.762
DOC_USP7_UBL2_3	475	479	PF12436	0.740
DOC_WW_Pin1_4	131	136	PF00397	0.745
DOC_WW_Pin1_4	137	142	PF00397	0.667
DOC_WW_Pin1_4	152	157	PF00397	0.571
DOC_WW_Pin1_4	241	246	PF00397	0.676
DOC_WW_Pin1_4	437	442	PF00397	0.782
DOC_WW_Pin1_4	519	524	PF00397	0.708
LIG_14-3-3_CanoR_1	129	135	PF00244	0.727
LIG_14-3-3_CanoR_1	228	238	PF00244	0.693
LIG_14-3-3_CanoR_1	348	352	PF00244	0.560
LIG_14-3-3_CanoR_1	356	364	PF00244	0.643
LIG_14-3-3_CanoR_1	78	83	PF00244	0.531
LIG_Actin_WH2_2	64	80	PF00022	0.625
LIG_BRCT_BRCA1_1	266	270	PF00533	0.618
LIG_BRCT_BRCA1_1	491	495	PF00533	0.684
LIG_deltaCOP1_diTrp_1	33	42	PF00928	0.497
LIG_FHA_1	17	23	PF00498	0.485
LIG_FHA_1	289	295	PF00498	0.404
LIG_FHA_1	60	66	PF00498	0.462
LIG_FHA_1	71	77	PF00498	0.523
LIG_FHA_1	94	100	PF00498	0.562
LIG_FHA_2	185	191	PF00498	0.716
LIG_FHA_2	195	201	PF00498	0.564
LIG_FHA_2	387	393	PF00498	0.716
LIG_LIR_Apic_2	249	255	PF02991	0.707
LIG_LIR_Apic_2	282	288	PF02991	0.583
LIG_LIR_Apic_2	498	504	PF02991	0.686
LIG_LIR_Gen_1	51	59	PF02991	0.544
LIG_LIR_Gen_1	95	106	PF02991	0.499
LIG_LIR_LC3C_4	349	354	PF02991	0.653
LIG_LIR_Nem_3	110	116	PF02991	0.370
LIG_LIR_Nem_3	305	310	PF02991	0.576
LIG_LIR_Nem_3	33	38	PF02991	0.612
LIG_LIR_Nem_3	51	56	PF02991	0.373
LIG_LIR_Nem_3	95	101	PF02991	0.500
LIG_LYPXL_S_1	43	47	PF13949	0.490
LIG_LYPXL_yS_3	44	47	PF13949	0.502
LIG_PDZ_Class_3	582	587	PF00595	0.610
LIG_Pex14_1	272	276	PF04695	0.511
LIG_PTAP_UEV_1	155	160	PF05743	0.697
LIG_Rb_pABgroove_1	395	403	PF01858	0.580
LIG_SH2_CRK	252	256	PF00017	0.706
LIG_SH2_CRK	501	505	PF00017	0.659
LIG_SH2_NCK_1	501	505	PF00017	0.659
LIG_SH2_PTP2	98	101	PF00017	0.474
LIG_SH2_STAP1	66	70	PF00017	0.500
LIG_SH2_STAT5	276	279	PF00017	0.530
LIG_SH2_STAT5	285	288	PF00017	0.426
LIG_SH2_STAT5	536	539	PF00017	0.548
LIG_SH2_STAT5	98	101	PF00017	0.474
LIG_SH3_3	122	128	PF00018	0.613
LIG_SH3_3	153	159	PF00018	0.812
LIG_SH3_3	319	325	PF00018	0.524
LIG_SH3_3	73	79	PF00018	0.549
LIG_SH3_3	96	102	PF00018	0.484
LIG_SUMO_SIM_anti_2	349	355	PF11976	0.555
LIG_SUMO_SIM_par_1	349	355	PF11976	0.555
LIG_TRAF2_1	102	105	PF00917	0.496
LIG_TRAF2_1	390	393	PF00917	0.712
LIG_TRAF2_1	545	548	PF00917	0.579
LIG_TYR_ITSM	94	101	PF00017	0.482
LIG_WW_3	126	130	PF00397	0.707
MOD_CDK_SPxK_1	241	247	PF00069	0.681
MOD_CK1_1	133	139	PF00069	0.811
MOD_CK1_1	177	183	PF00069	0.729
MOD_CK1_1	184	190	PF00069	0.654
MOD_CK1_1	214	220	PF00069	0.751
MOD_CK1_1	233	239	PF00069	0.720
MOD_CK1_1	388	394	PF00069	0.719
MOD_CK1_1	517	523	PF00069	0.716
MOD_CK2_1	133	139	PF00069	0.720
MOD_CK2_1	184	190	PF00069	0.723
MOD_CK2_1	194	200	PF00069	0.621
MOD_CK2_1	386	392	PF00069	0.717
MOD_CK2_1	407	413	PF00069	0.741
MOD_CK2_1	54	60	PF00069	0.526
MOD_Cter_Amidation	87	90	PF01082	0.602
MOD_GlcNHglycan	135	138	PF01048	0.773
MOD_GlcNHglycan	156	159	PF01048	0.754
MOD_GlcNHglycan	183	186	PF01048	0.735
MOD_GlcNHglycan	200	206	PF01048	0.781
MOD_GlcNHglycan	218	221	PF01048	0.722
MOD_GlcNHglycan	324	328	PF01048	0.565
MOD_GlcNHglycan	464	467	PF01048	0.794
MOD_GlcNHglycan	469	472	PF01048	0.740
MOD_GlcNHglycan	55	59	PF01048	0.544
MOD_GSK3_1	12	19	PF00069	0.606
MOD_GSK3_1	129	136	PF00069	0.819
MOD_GSK3_1	148	155	PF00069	0.814
MOD_GSK3_1	174	181	PF00069	0.702
MOD_GSK3_1	211	218	PF00069	0.697
MOD_GSK3_1	229	236	PF00069	0.678
MOD_GSK3_1	313	320	PF00069	0.541
MOD_GSK3_1	352	359	PF00069	0.620
MOD_GSK3_1	367	374	PF00069	0.719
MOD_GSK3_1	435	442	PF00069	0.648
MOD_GSK3_1	522	529	PF00069	0.511
MOD_GSK3_1	532	539	PF00069	0.511
MOD_GSK3_1	54	61	PF00069	0.500
MOD_LATS_1	227	233	PF00433	0.748
MOD_N-GLC_1	317	322	PF02516	0.542
MOD_N-GLC_1	48	53	PF02516	0.540
MOD_NEK2_1	119	124	PF00069	0.642
MOD_NEK2_1	178	183	PF00069	0.697
MOD_NEK2_1	311	316	PF00069	0.529
MOD_NEK2_1	352	357	PF00069	0.559
MOD_NEK2_1	566	571	PF00069	0.662
MOD_PIKK_1	178	184	PF00454	0.759
MOD_PIKK_1	421	427	PF00454	0.684
MOD_PKA_1	258	264	PF00069	0.629
MOD_PKA_1	550	556	PF00069	0.728
MOD_PKA_2	246	252	PF00069	0.628
MOD_PKA_2	279	285	PF00069	0.539
MOD_PKA_2	347	353	PF00069	0.587
MOD_PKA_2	355	361	PF00069	0.611
MOD_PKA_2	371	377	PF00069	0.715
MOD_PKA_2	550	556	PF00069	0.665
MOD_Plk_1	119	125	PF00069	0.647
MOD_Plk_1	16	22	PF00069	0.493
MOD_Plk_1	566	572	PF00069	0.635
MOD_Plk_1	94	100	PF00069	0.541
MOD_Plk_2-3	407	413	PF00069	0.773
MOD_Plk_4	145	151	PF00069	0.782
MOD_Plk_4	16	22	PF00069	0.493
MOD_Plk_4	174	180	PF00069	0.773
MOD_Plk_4	247	253	PF00069	0.732
MOD_Plk_4	347	353	PF00069	0.566
MOD_Plk_4	522	528	PF00069	0.555
MOD_Plk_4	566	572	PF00069	0.635
MOD_Plk_4	94	100	PF00069	0.509
MOD_ProDKin_1	131	137	PF00069	0.742
MOD_ProDKin_1	152	158	PF00069	0.812
MOD_ProDKin_1	241	247	PF00069	0.681
MOD_ProDKin_1	437	443	PF00069	0.783
MOD_ProDKin_1	519	525	PF00069	0.701
MOD_SUMO_for_1	117	120	PF00179	0.572
MOD_SUMO_for_1	454	457	PF00179	0.649
MOD_SUMO_for_1	515	518	PF00179	0.645
MOD_SUMO_rev_2	104	109	PF00179	0.493
MOD_SUMO_rev_2	139	149	PF00179	0.830
MOD_SUMO_rev_2	163	172	PF00179	0.744
MOD_SUMO_rev_2	33	38	PF00179	0.610
TRG_DiLeu_BaEn_4	104	110	PF01217	0.495
TRG_ENDOCYTIC_2	44	47	PF00928	0.502
TRG_ENDOCYTIC_2	98	101	PF00928	0.416
TRG_ER_diArg_1	378	381	PF00400	0.743
TRG_ER_diArg_1	428	430	PF00400	0.809
TRG_NES_CRM1_1	108	120	PF08389	0.635
TRG_NLS_MonoCore_2	451	456	PF00514	0.750
TRG_NLS_MonoCore_2	88	93	PF00514	0.488
TRG_NLS_MonoExtC_3	451	457	PF00514	0.718
TRG_NLS_MonoExtN_4	549	554	PF00514	0.801
TRG_NLS_MonoExtN_4	87	93	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J1	Leptomonas seymouri	55%	100%
A0A3S5H7R3	Leishmania donovani	99%	100%
A4HK39	Leishmania braziliensis	76%	98%
E9B2I1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4Q5M5	Leishmania major	94%	100%