LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I7M0_LEIIN
TriTrypDb:
LINF_320011500
Length:
376

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7M0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7M0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 104 106 PF00675 0.572
CLV_NRD_NRD_1 122 124 PF00675 0.339
CLV_NRD_NRD_1 150 152 PF00675 0.738
CLV_NRD_NRD_1 186 188 PF00675 0.756
CLV_NRD_NRD_1 224 226 PF00675 0.652
CLV_NRD_NRD_1 23 25 PF00675 0.486
CLV_NRD_NRD_1 230 232 PF00675 0.521
CLV_NRD_NRD_1 54 56 PF00675 0.694
CLV_NRD_NRD_1 79 81 PF00675 0.777
CLV_NRD_NRD_1 95 97 PF00675 0.624
CLV_PCSK_FUR_1 120 124 PF00082 0.641
CLV_PCSK_FUR_1 184 188 PF00082 0.745
CLV_PCSK_FUR_1 77 81 PF00082 0.780
CLV_PCSK_KEX2_1 104 106 PF00082 0.558
CLV_PCSK_KEX2_1 122 124 PF00082 0.340
CLV_PCSK_KEX2_1 150 152 PF00082 0.746
CLV_PCSK_KEX2_1 186 188 PF00082 0.759
CLV_PCSK_KEX2_1 22 24 PF00082 0.489
CLV_PCSK_KEX2_1 223 225 PF00082 0.702
CLV_PCSK_KEX2_1 54 56 PF00082 0.694
CLV_PCSK_KEX2_1 79 81 PF00082 0.777
CLV_PCSK_KEX2_1 95 97 PF00082 0.624
CLV_PCSK_PC1ET2_1 22 24 PF00082 0.489
CLV_PCSK_PC7_1 182 188 PF00082 0.746
CLV_PCSK_PC7_1 50 56 PF00082 0.670
CLV_PCSK_PC7_1 75 81 PF00082 0.781
CLV_PCSK_SKI1_1 314 318 PF00082 0.627
CLV_PCSK_SKI1_1 40 44 PF00082 0.584
DEG_Nend_UBRbox_2 1 3 PF02207 0.739
DOC_CKS1_1 264 269 PF01111 0.524
DOC_CYCLIN_RxL_1 37 46 PF00134 0.595
DOC_CYCLIN_yCln2_LP_2 264 270 PF00134 0.568
DOC_PP2B_LxvP_1 268 271 PF13499 0.523
DOC_USP7_MATH_1 139 143 PF00917 0.636
DOC_USP7_MATH_1 18 22 PF00917 0.496
DOC_USP7_MATH_1 319 323 PF00917 0.564
DOC_USP7_MATH_1 329 333 PF00917 0.610
DOC_USP7_MATH_1 370 374 PF00917 0.590
DOC_USP7_MATH_1 62 66 PF00917 0.577
DOC_USP7_UBL2_3 22 26 PF12436 0.585
DOC_USP7_UBL2_3 228 232 PF12436 0.575
DOC_WW_Pin1_4 263 268 PF00397 0.519
DOC_WW_Pin1_4 5 10 PF00397 0.572
LIG_14-3-3_CanoR_1 120 128 PF00244 0.546
LIG_14-3-3_CanoR_1 3 9 PF00244 0.720
LIG_14-3-3_CanoR_1 314 319 PF00244 0.586
LIG_14-3-3_CanoR_1 357 363 PF00244 0.680
LIG_BRCT_BRCA1_1 291 295 PF00533 0.580
LIG_BRCT_BRCA1_1 371 375 PF00533 0.557
LIG_FHA_2 264 270 PF00498 0.487
LIG_Integrin_RGD_1 107 109 PF01839 0.617
LIG_Integrin_RGD_1 98 100 PF01839 0.717
LIG_LIR_Gen_1 252 260 PF02991 0.519
LIG_LIR_Gen_1 292 303 PF02991 0.593
LIG_LIR_Nem_3 252 258 PF02991 0.432
LIG_LIR_Nem_3 292 298 PF02991 0.543
LIG_MLH1_MIPbox_1 371 375 PF16413 0.557
LIG_SH2_NCK_1 200 204 PF00017 0.710
LIG_SH2_NCK_1 341 345 PF00017 0.715
LIG_SH2_PTP2 255 258 PF00017 0.549
LIG_SH2_SRC 200 203 PF00017 0.715
LIG_SH2_STAT5 255 258 PF00017 0.414
LIG_SH3_1 6 12 PF00018 0.542
LIG_SH3_3 313 319 PF00018 0.614
LIG_SH3_3 6 12 PF00018 0.542
LIG_WRC_WIRS_1 371 376 PF05994 0.561
MOD_CK1_1 211 217 PF00069 0.635
MOD_CK2_1 170 176 PF00069 0.766
MOD_CK2_1 242 248 PF00069 0.440
MOD_CK2_1 263 269 PF00069 0.479
MOD_CK2_1 363 369 PF00069 0.612
MOD_CK2_1 85 91 PF00069 0.784
MOD_Cter_Amidation 93 96 PF01082 0.747
MOD_GlcNHglycan 123 126 PF01048 0.603
MOD_GlcNHglycan 210 213 PF01048 0.723
MOD_GlcNHglycan 291 294 PF01048 0.575
MOD_GlcNHglycan 331 334 PF01048 0.697
MOD_GlcNHglycan 365 368 PF01048 0.612
MOD_GlcNHglycan 64 67 PF01048 0.734
MOD_GlcNHglycan 87 90 PF01048 0.783
MOD_GSK3_1 18 25 PF00069 0.644
MOD_GSK3_1 259 266 PF00069 0.479
MOD_GSK3_1 282 289 PF00069 0.459
MOD_LATS_1 20 26 PF00433 0.531
MOD_NEK2_1 273 278 PF00069 0.512
MOD_NEK2_2 370 375 PF00069 0.590
MOD_OFUCOSY 257 263 PF10250 0.456
MOD_PIKK_1 192 198 PF00454 0.660
MOD_PIKK_1 242 248 PF00454 0.508
MOD_PIKK_1 319 325 PF00454 0.505
MOD_PKA_1 22 28 PF00069 0.525
MOD_PKA_2 121 127 PF00069 0.584
MOD_PKA_2 192 198 PF00069 0.689
MOD_PKA_2 22 28 PF00069 0.607
MOD_PKA_2 62 68 PF00069 0.730
MOD_Plk_4 110 116 PF00069 0.650
MOD_Plk_4 170 176 PF00069 0.715
MOD_Plk_4 358 364 PF00069 0.645
MOD_Plk_4 370 376 PF00069 0.561
MOD_ProDKin_1 263 269 PF00069 0.513
MOD_ProDKin_1 5 11 PF00069 0.564
TRG_ENDOCYTIC_2 255 258 PF00928 0.549
TRG_ENDOCYTIC_2 305 308 PF00928 0.413
TRG_ER_diArg_1 120 123 PF00400 0.517
TRG_ER_diArg_1 150 152 PF00400 0.746
TRG_ER_diArg_1 163 166 PF00400 0.652
TRG_ER_diArg_1 184 187 PF00400 0.738
TRG_ER_diArg_1 223 225 PF00400 0.706
TRG_NLS_MonoExtC_3 21 26 PF00514 0.496
TRG_Pf-PMV_PEXEL_1 40 44 PF00026 0.576

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEL1 Leptomonas seymouri 55% 98%
A0A1X0NV62 Trypanosomatidae 34% 100%
A0A3Q8IFQ4 Leishmania donovani 100% 100%
A4HK42 Leishmania braziliensis 88% 100%
D0A9S8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9B2I5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 99%
Q4Q5M1 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS