LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
AMMECR1 - putative
Species:
Leishmania infantum
UniProt:
A4I7L9_LEIIN
TriTrypDb:
LINF_320011600
Length:
186

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 2
Pissara et al. yes yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I7L9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7L9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 20 24 PF00656 0.358
CLV_NRD_NRD_1 68 70 PF00675 0.425
CLV_PCSK_KEX2_1 68 70 PF00082 0.455
CLV_PCSK_SKI1_1 175 179 PF00082 0.524
CLV_PCSK_SKI1_1 69 73 PF00082 0.378
DEG_APCC_DBOX_1 141 149 PF00400 0.455
DOC_MAPK_gen_1 64 72 PF00069 0.422
DOC_PP4_FxxP_1 154 157 PF00568 0.423
DOC_WW_Pin1_4 1 6 PF00397 0.436
LIG_14-3-3_CanoR_1 93 99 PF00244 0.353
LIG_BRCT_BRCA1_1 173 177 PF00533 0.357
LIG_BRCT_BRCA1_1 36 40 PF00533 0.344
LIG_FHA_1 157 163 PF00498 0.331
LIG_LIR_Gen_1 37 47 PF02991 0.327
LIG_LIR_Nem_3 121 125 PF02991 0.374
LIG_LIR_Nem_3 174 180 PF02991 0.380
LIG_LIR_Nem_3 37 43 PF02991 0.344
LIG_LIR_Nem_3 78 84 PF02991 0.295
LIG_NRBOX 144 150 PF00104 0.357
LIG_SH2_SRC 129 132 PF00017 0.384
LIG_SH2_STAP1 125 129 PF00017 0.353
LIG_SH2_STAT5 10 13 PF00017 0.311
LIG_SH2_STAT5 129 132 PF00017 0.358
LIG_SH3_3 19 25 PF00018 0.340
LIG_SH3_3 27 33 PF00018 0.265
LIG_SUMO_SIM_anti_2 143 150 PF11976 0.422
LIG_SUMO_SIM_par_1 143 150 PF11976 0.422
LIG_WRC_WIRS_1 99 104 PF05994 0.311
MOD_CK2_1 129 135 PF00069 0.422
MOD_CK2_1 144 150 PF00069 0.422
MOD_CMANNOS 108 111 PF00535 0.311
MOD_GlcNHglycan 105 108 PF01048 0.358
MOD_GlcNHglycan 125 128 PF01048 0.341
MOD_GlcNHglycan 19 22 PF01048 0.429
MOD_GlcNHglycan 35 39 PF01048 0.416
MOD_GSK3_1 125 132 PF00069 0.311
MOD_GSK3_1 94 101 PF00069 0.359
MOD_NEK2_1 76 81 PF00069 0.353
MOD_NEK2_2 54 59 PF00069 0.405
MOD_PKA_2 141 147 PF00069 0.466
MOD_PKA_2 166 172 PF00069 0.455
MOD_Plk_4 125 131 PF00069 0.295
MOD_Plk_4 141 147 PF00069 0.300
MOD_ProDKin_1 1 7 PF00069 0.427
MOD_SUMO_for_1 84 87 PF00179 0.455
TRG_DiLeu_BaEn_4 87 93 PF01217 0.455
TRG_ENDOCYTIC_2 180 183 PF00928 0.442
TRG_ER_diArg_1 67 69 PF00400 0.455
TRG_Pf-PMV_PEXEL_1 13 17 PF00026 0.455

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7M6 Leptomonas seymouri 80% 100%
A0A0S4KMC2 Bodo saltans 42% 86%
A0A1X0NUQ8 Trypanosomatidae 48% 100%
A0A3Q8IJ16 Leishmania donovani 100% 100%
A0A422NJL2 Trypanosoma rangeli 49% 100%
A1RT97 Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) 31% 84%
A1RY70 Thermofilum pendens (strain DSM 2475 / Hrk 5) 32% 87%
A3DP40 Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) 35% 82%
A4HK43 Leishmania braziliensis 91% 100%
A4WGW1 Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) 31% 87%
A6UTA8 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) 33% 93%
A8MBB6 Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) 33% 85%
B6YW91 Thermococcus onnurineus (strain NA1) 36% 91%
C5A6U0 Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) 36% 91%
D0A9S9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 98%
E9B2I6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O26945 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 35% 97%
O57770 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 36% 90%
O67431 Aquifex aeolicus (strain VF5) 35% 95%
Q0W787 Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) 31% 94%
Q12012 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 74%
Q12WB4 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 34% 93%
Q22004 Caenorhabditis elegans 41% 93%
Q46BJ4 Methanosarcina barkeri (strain Fusaro / DSM 804) 36% 92%
Q4JAL7 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 35% 82%
Q4Q5M0 Leishmania major 95% 100%
Q58220 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 37% 93%
Q5JFK7 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 36% 91%
Q74M72 Nanoarchaeum equitans (strain Kin4-M) 35% 100%
Q8PZK8 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 35% 93%
Q8TK33 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 33% 93%
Q8TY18 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 34% 90%
Q8TZL1 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 37% 89%
Q8ZYJ4 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 29% 87%
Q976G0 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 33% 81%
Q978N1 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 33% 93%
Q9HLJ2 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 35% 90%
Q9P6M2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 96%
Q9URS8 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 41% 82%
Q9V2R5 Pyrococcus abyssi (strain GE5 / Orsay) 36% 91%
Q9VCF0 Drosophila melanogaster 37% 77%
Q9ZVJ2 Arabidopsis thaliana 36% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS