Putative phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4I7L8_LEIIN

TriTrypDb:

LINF_320011700

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I7L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7L8

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016311	dephosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004721	phosphoprotein phosphatase activity	3	10
GO:0004725	protein tyrosine phosphatase activity	4	10
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016791	phosphatase activity	5	10
GO:0042578	phosphoric ester hydrolase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.500
CLV_C14_Caspase3-7	41	45	PF00656	0.656
CLV_C14_Caspase3-7	596	600	PF00656	0.768
CLV_NRD_NRD_1	228	230	PF00675	0.444
CLV_NRD_NRD_1	30	32	PF00675	0.773
CLV_NRD_NRD_1	342	344	PF00675	0.412
CLV_NRD_NRD_1	398	400	PF00675	0.546
CLV_NRD_NRD_1	508	510	PF00675	0.766
CLV_NRD_NRD_1	578	580	PF00675	0.692
CLV_PCSK_KEX2_1	30	32	PF00082	0.774
CLV_PCSK_KEX2_1	341	343	PF00082	0.425
CLV_PCSK_KEX2_1	36	38	PF00082	0.749
CLV_PCSK_KEX2_1	398	400	PF00082	0.585
CLV_PCSK_KEX2_1	488	490	PF00082	0.497
CLV_PCSK_KEX2_1	508	510	PF00082	0.760
CLV_PCSK_KEX2_1	578	580	PF00082	0.692
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.774
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.749
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.511
CLV_PCSK_SKI1_1	118	122	PF00082	0.430
CLV_PCSK_SKI1_1	278	282	PF00082	0.371
CLV_PCSK_SKI1_1	315	319	PF00082	0.531
CLV_PCSK_SKI1_1	398	402	PF00082	0.510
CLV_PCSK_SKI1_1	461	465	PF00082	0.531
CLV_PCSK_SKI1_1	485	489	PF00082	0.483
DEG_APCC_DBOX_1	314	322	PF00400	0.514
DEG_APCC_DBOX_1	405	413	PF00400	0.419
DEG_MDM2_SWIB_1	462	470	PF02201	0.393
DEG_Nend_Nbox_1	1	3	PF02207	0.703
DEG_SPOP_SBC_1	519	523	PF00917	0.783
DOC_CYCLIN_RxL_1	297	307	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	401	407	PF00134	0.494
DOC_MAPK_gen_1	189	196	PF00069	0.401
DOC_MAPK_gen_1	403	413	PF00069	0.396
DOC_MAPK_MEF2A_6	389	397	PF00069	0.545
DOC_PP2B_LxvP_1	517	520	PF13499	0.732
DOC_PP4_FxxP_1	164	167	PF00568	0.431
DOC_SPAK_OSR1_1	343	347	PF12202	0.461
DOC_USP7_MATH_1	101	105	PF00917	0.403
DOC_USP7_MATH_1	317	321	PF00917	0.480
DOC_USP7_MATH_1	491	495	PF00917	0.404
DOC_USP7_MATH_1	507	511	PF00917	0.596
DOC_USP7_MATH_1	594	598	PF00917	0.696
DOC_USP7_UBL2_3	189	193	PF12436	0.369
DOC_USP7_UBL2_3	25	29	PF12436	0.718
DOC_USP7_UBL2_3	30	34	PF12436	0.657
DOC_WW_Pin1_4	365	370	PF00397	0.429
DOC_WW_Pin1_4	449	454	PF00397	0.506
DOC_WW_Pin1_4	508	513	PF00397	0.719
LIG_14-3-3_CanoR_1	100	106	PF00244	0.401
LIG_14-3-3_CanoR_1	254	261	PF00244	0.394
LIG_14-3-3_CanoR_1	345	350	PF00244	0.487
LIG_14-3-3_CanoR_1	364	369	PF00244	0.422
LIG_14-3-3_CanoR_1	406	410	PF00244	0.401
LIG_14-3-3_CanoR_1	508	512	PF00244	0.713
LIG_14-3-3_CanoR_1	548	556	PF00244	0.741
LIG_14-3-3_CanoR_1	592	602	PF00244	0.772
LIG_APCC_ABBA_1	279	284	PF00400	0.426
LIG_APCC_ABBAyCdc20_2	278	284	PF00400	0.382
LIG_BRCT_BRCA1_1	255	259	PF00533	0.423
LIG_eIF4E_1	289	295	PF01652	0.474
LIG_FHA_1	119	125	PF00498	0.457
LIG_FHA_1	514	520	PF00498	0.779
LIG_FHA_2	559	565	PF00498	0.691
LIG_Integrin_RGD_1	19	21	PF01839	0.610
LIG_LIR_Apic_2	160	165	PF02991	0.422
LIG_LIR_Apic_2	6	12	PF02991	0.733
LIG_LIR_Gen_1	414	423	PF02991	0.406
LIG_LIR_Gen_1	68	77	PF02991	0.497
LIG_LIR_Nem_3	103	109	PF02991	0.451
LIG_LIR_Nem_3	160	164	PF02991	0.438
LIG_LIR_Nem_3	287	292	PF02991	0.377
LIG_LIR_Nem_3	414	419	PF02991	0.361
LIG_LIR_Nem_3	472	477	PF02991	0.478
LIG_LYPXL_yS_3	109	112	PF13949	0.501
LIG_NRBOX	299	305	PF00104	0.417
LIG_NRP_CendR_1	601	604	PF00754	0.800
LIG_Pex14_2	244	248	PF04695	0.344
LIG_Pex14_2	440	444	PF04695	0.526
LIG_Pex14_2	462	466	PF04695	0.385
LIG_PTB_Apo_2	427	434	PF02174	0.488
LIG_SH2_CRK	289	293	PF00017	0.372
LIG_SH2_CRK	477	481	PF00017	0.580
LIG_SH2_CRK	9	13	PF00017	0.792
LIG_SH2_GRB2like	474	477	PF00017	0.460
LIG_SH2_NCK_1	477	481	PF00017	0.538
LIG_SH2_SRC	213	216	PF00017	0.444
LIG_SH2_STAP1	215	219	PF00017	0.344
LIG_SH2_STAT5	213	216	PF00017	0.372
LIG_SH2_STAT5	474	477	PF00017	0.428
LIG_SH3_2	527	532	PF14604	0.600
LIG_SH3_3	524	530	PF00018	0.736
LIG_SH3_3	550	556	PF00018	0.794
LIG_Sin3_3	224	231	PF02671	0.408
LIG_SUMO_SIM_anti_2	221	229	PF11976	0.402
LIG_SUMO_SIM_anti_2	351	356	PF11976	0.427
LIG_SUMO_SIM_par_1	515	523	PF11976	0.728
LIG_SUMO_SIM_par_1	554	565	PF11976	0.668
LIG_TRAF2_1	388	391	PF00917	0.651
LIG_TRAF2_1	522	525	PF00917	0.700
LIG_TYR_ITIM	107	112	PF00017	0.481
LIG_UBA3_1	299	308	PF00899	0.426
LIG_WRC_WIRS_1	354	359	PF05994	0.401
LIG_WRC_WIRS_1	437	442	PF05994	0.509
LIG_WW_3	505	509	PF00397	0.706
MOD_CDK_SPxxK_3	449	456	PF00069	0.495
MOD_CK1_1	144	150	PF00069	0.498
MOD_CK1_1	353	359	PF00069	0.386
MOD_CK1_1	365	371	PF00069	0.368
MOD_CK1_1	510	516	PF00069	0.751
MOD_CK1_1	518	524	PF00069	0.757
MOD_CK1_1	544	550	PF00069	0.735
MOD_CK2_1	157	163	PF00069	0.441
MOD_CK2_1	385	391	PF00069	0.669
MOD_CK2_1	449	455	PF00069	0.467
MOD_CK2_1	519	525	PF00069	0.753
MOD_CK2_1	558	564	PF00069	0.700
MOD_GlcNHglycan	142	146	PF01048	0.512
MOD_GlcNHglycan	323	326	PF01048	0.455
MOD_GlcNHglycan	332	335	PF01048	0.418
MOD_GlcNHglycan	413	416	PF01048	0.356
MOD_GSK3_1	140	147	PF00069	0.439
MOD_GSK3_1	317	324	PF00069	0.429
MOD_GSK3_1	365	372	PF00069	0.436
MOD_GSK3_1	379	386	PF00069	0.489
MOD_GSK3_1	515	522	PF00069	0.768
MOD_GSK3_1	537	544	PF00069	0.719
MOD_GSK3_1	558	565	PF00069	0.734
MOD_GSK3_1	95	102	PF00069	0.389
MOD_LATS_1	116	122	PF00433	0.556
MOD_N-GLC_1	118	123	PF02516	0.467
MOD_N-GLC_1	304	309	PF02516	0.421
MOD_NEK2_1	202	207	PF00069	0.344
MOD_NEK2_1	288	293	PF00069	0.469
MOD_NEK2_1	295	300	PF00069	0.403
MOD_NEK2_1	304	309	PF00069	0.339
MOD_NEK2_1	363	368	PF00069	0.488
MOD_NEK2_1	383	388	PF00069	0.302
MOD_NEK2_1	411	416	PF00069	0.369
MOD_NEK2_1	492	497	PF00069	0.484
MOD_NEK2_1	498	503	PF00069	0.491
MOD_NEK2_1	54	59	PF00069	0.532
MOD_NEK2_1	541	546	PF00069	0.715
MOD_NEK2_2	101	106	PF00069	0.404
MOD_NEK2_2	483	488	PF00069	0.536
MOD_PIKK_1	213	219	PF00454	0.444
MOD_PIKK_1	253	259	PF00454	0.436
MOD_PIKK_1	520	526	PF00454	0.593
MOD_PIKK_1	542	548	PF00454	0.775
MOD_PIKK_1	95	101	PF00454	0.389
MOD_PK_1	345	351	PF00069	0.527
MOD_PKA_1	30	36	PF00069	0.802
MOD_PKA_1	578	584	PF00069	0.716
MOD_PKA_2	253	259	PF00069	0.404
MOD_PKA_2	30	36	PF00069	0.768
MOD_PKA_2	363	369	PF00069	0.457
MOD_PKA_2	383	389	PF00069	0.310
MOD_PKA_2	405	411	PF00069	0.400
MOD_PKA_2	507	513	PF00069	0.753
MOD_PKA_2	547	553	PF00069	0.734
MOD_PKA_2	578	584	PF00069	0.684
MOD_PKA_2	99	105	PF00069	0.398
MOD_PKB_1	343	351	PF00069	0.552
MOD_Plk_1	328	334	PF00069	0.542
MOD_Plk_1	350	356	PF00069	0.412
MOD_Plk_1	537	543	PF00069	0.662
MOD_Plk_4	101	107	PF00069	0.433
MOD_Plk_4	295	301	PF00069	0.459
MOD_Plk_4	350	356	PF00069	0.407
MOD_Plk_4	492	498	PF00069	0.515
MOD_Plk_4	537	543	PF00069	0.768
MOD_Plk_4	54	60	PF00069	0.540
MOD_ProDKin_1	365	371	PF00069	0.426
MOD_ProDKin_1	449	455	PF00069	0.499
MOD_ProDKin_1	508	514	PF00069	0.721
MOD_SUMO_rev_2	560	567	PF00179	0.755
MOD_SUMO_rev_2	596	602	PF00179	0.730
TRG_DiLeu_BaEn_1	223	228	PF01217	0.401
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.413
TRG_ENDOCYTIC_2	109	112	PF00928	0.426
TRG_ENDOCYTIC_2	161	164	PF00928	0.415
TRG_ENDOCYTIC_2	289	292	PF00928	0.359
TRG_ENDOCYTIC_2	477	480	PF00928	0.521
TRG_ER_diArg_1	276	279	PF00400	0.406
TRG_ER_diArg_1	341	343	PF00400	0.427
TRG_ER_diArg_1	397	399	PF00400	0.587
TRG_ER_diArg_1	507	509	PF00400	0.763
TRG_ER_diArg_1	577	579	PF00400	0.693
TRG_NES_CRM1_1	262	275	PF08389	0.452
TRG_NLS_MonoCore_2	27	32	PF00514	0.766
TRG_NLS_MonoExtC_3	228	233	PF00514	0.444
TRG_NLS_MonoExtC_3	27	32	PF00514	0.782
TRG_NLS_MonoExtN_4	25	32	PF00514	0.743

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW9	Leptomonas seymouri	75%	99%
A0A0S4KLI7	Bodo saltans	47%	100%
A0A1X0NUR4	Trypanosomatidae	66%	100%
A0A3Q8IG01	Leishmania donovani	100%	100%
A4HK44	Leishmania braziliensis	83%	100%
D0A9T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B2I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q5L9	Leishmania major	96%	100%