DNA polymerase alpha subunit B

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7L5_LEIIN

TriTrypDb:

LINF_320012000

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	235	237	PF00675	0.415
CLV_NRD_NRD_1	298	300	PF00675	0.487
CLV_NRD_NRD_1	55	57	PF00675	0.655
CLV_PCSK_KEX2_1	235	237	PF00082	0.529
CLV_PCSK_KEX2_1	298	300	PF00082	0.474
CLV_PCSK_SKI1_1	181	185	PF00082	0.413
CLV_PCSK_SKI1_1	217	221	PF00082	0.644
CLV_PCSK_SKI1_1	248	252	PF00082	0.527
DEG_SPOP_SBC_1	258	262	PF00917	0.575
DOC_MAPK_DCC_7	217	226	PF00069	0.584
DOC_MAPK_MEF2A_6	217	226	PF00069	0.586
DOC_PP2B_LxvP_1	77	80	PF13499	0.514
DOC_PP4_FxxP_1	28	31	PF00568	0.411
DOC_PP4_FxxP_1	293	296	PF00568	0.494
DOC_PP4_MxPP_1	120	123	PF00568	0.545
DOC_USP7_MATH_1	123	127	PF00917	0.694
DOC_USP7_MATH_1	204	208	PF00917	0.696
DOC_USP7_MATH_1	213	217	PF00917	0.596
DOC_WW_Pin1_4	129	134	PF00397	0.675
LIG_14-3-3_CanoR_1	175	185	PF00244	0.472
LIG_14-3-3_CanoR_1	217	222	PF00244	0.718
LIG_14-3-3_CanoR_1	235	242	PF00244	0.386
LIG_14-3-3_CanoR_1	71	80	PF00244	0.424
LIG_Actin_WH2_2	221	237	PF00022	0.521
LIG_BIR_II_1	1	5	PF00653	0.395
LIG_BRCT_BRCA1_1	6	10	PF00533	0.380
LIG_Clathr_ClatBox_1	184	188	PF01394	0.471
LIG_FHA_1	189	195	PF00498	0.365
LIG_FHA_1	48	54	PF00498	0.472
LIG_FHA_1	60	66	PF00498	0.358
LIG_FHA_1	73	79	PF00498	0.393
LIG_FHA_1	82	88	PF00498	0.459
LIG_FHA_2	155	161	PF00498	0.554
LIG_IRF3_LxIS_1	267	272	PF10401	0.474
LIG_LIR_Apic_2	26	31	PF02991	0.406
LIG_LIR_Apic_2	261	267	PF02991	0.567
LIG_LIR_Apic_2	292	296	PF02991	0.497
LIG_LIR_Gen_1	266	276	PF02991	0.447
LIG_LIR_Gen_1	40	49	PF02991	0.448
LIG_LIR_Nem_3	186	192	PF02991	0.422
LIG_LIR_Nem_3	266	271	PF02991	0.436
LIG_LIR_Nem_3	284	290	PF02991	0.381
LIG_LIR_Nem_3	292	297	PF02991	0.424
LIG_LIR_Nem_3	37	41	PF02991	0.442
LIG_MLH1_MIPbox_1	6	10	PF16413	0.380
LIG_Pex14_2	28	32	PF04695	0.389
LIG_Pex14_2	91	95	PF04695	0.493
LIG_SH2_CRK	189	193	PF00017	0.402
LIG_SH2_CRK	294	298	PF00017	0.435
LIG_SH2_SRC	264	267	PF00017	0.527
LIG_SH2_SRC	268	271	PF00017	0.439
LIG_SH2_STAP1	39	43	PF00017	0.508
LIG_SH2_STAT5	268	271	PF00017	0.508
LIG_SH2_STAT5	9	12	PF00017	0.423
LIG_SH3_3	133	139	PF00018	0.581
LIG_SH3_3	216	222	PF00018	0.688
LIG_SH3_3	252	258	PF00018	0.533
LIG_SH3_3	46	52	PF00018	0.397
LIG_SUMO_SIM_par_1	183	188	PF11976	0.456
LIG_SUMO_SIM_par_1	190	196	PF11976	0.395
LIG_TRAF2_1	157	160	PF00917	0.508
LIG_TRAF2_1	200	203	PF00917	0.664
LIG_TYR_ITIM	187	192	PF00017	0.451
LIG_WRC_WIRS_1	35	40	PF05994	0.531
LIG_WW_2	222	225	PF00397	0.565
LIG_WW_3	253	257	PF00397	0.556
MOD_CK1_1	211	217	PF00069	0.704
MOD_CK2_1	154	160	PF00069	0.505
MOD_CK2_1	86	92	PF00069	0.554
MOD_GlcNHglycan	125	128	PF01048	0.714
MOD_GlcNHglycan	206	209	PF01048	0.782
MOD_GlcNHglycan	210	213	PF01048	0.778
MOD_GlcNHglycan	237	240	PF01048	0.495
MOD_GlcNHglycan	25	28	PF01048	0.362
MOD_GlcNHglycan	44	47	PF01048	0.183
MOD_GSK3_1	100	107	PF00069	0.593
MOD_GSK3_1	125	132	PF00069	0.705
MOD_GSK3_1	204	211	PF00069	0.756
MOD_GSK3_1	213	220	PF00069	0.729
MOD_NEK2_1	10	15	PF00069	0.276
MOD_NEK2_1	176	181	PF00069	0.492
MOD_NEK2_1	234	239	PF00069	0.434
MOD_NEK2_1	4	9	PF00069	0.369
MOD_PIKK_1	10	16	PF00454	0.470
MOD_PIKK_1	154	160	PF00454	0.391
MOD_PKA_1	235	241	PF00069	0.488
MOD_PKA_2	204	210	PF00069	0.791
MOD_PKA_2	23	29	PF00069	0.370
MOD_PKA_2	234	240	PF00069	0.460
MOD_Plk_4	15	21	PF00069	0.498
MOD_Plk_4	188	194	PF00069	0.369
MOD_Plk_4	259	265	PF00069	0.616
MOD_Plk_4	34	40	PF00069	0.277
MOD_Plk_4	5	11	PF00069	0.387
MOD_ProDKin_1	129	135	PF00069	0.667
TRG_DiLeu_BaEn_1	146	151	PF01217	0.470
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.448
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.472
TRG_ENDOCYTIC_2	189	192	PF00928	0.403
TRG_ENDOCYTIC_2	268	271	PF00928	0.508
TRG_ENDOCYTIC_2	294	297	PF00928	0.428
TRG_ENDOCYTIC_2	41	44	PF00928	0.376
TRG_ER_diArg_1	234	236	PF00400	0.504
TRG_ER_diArg_1	297	299	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	76	81	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I005	Leptomonas seymouri	71%	100%
A0A0S4KR83	Bodo saltans	40%	100%
A0A1X0NUS9	Trypanosomatidae	55%	100%
A0A3Q8IGT0	Leishmania donovani	100%	100%
A4HK47	Leishmania braziliensis	86%	100%
D0A9T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B2J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5L6	Leishmania major	96%	100%
V5AQU0	Trypanosoma cruzi	56%	100%