Proteasome, proteasome regulatory non-ATP-ase subunit 8
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | yes | yes: 4 |
| Forrest at al. (procyclic) | yes | yes: 4 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 15 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | yes | yes: 10 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000502 | proteasome complex | 3 | 12 |
| GO:0032991 | protein-containing complex | 1 | 12 |
| GO:0140535 | intracellular protein-containing complex | 2 | 12 |
| GO:1902494 | catalytic complex | 2 | 12 |
| GO:1905368 | peptidase complex | 3 | 12 |
| GO:1905369 | endopeptidase complex | 4 | 12 |
| GO:0005838 | proteasome regulatory particle | 2 | 1 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pescher et al. (upgregulation) | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
|
Lahav et al. - mRNA
- Protein
|
Related structures:
AlphaFold database: A4I7K3
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006508 | proteolysis | 4 | 2 |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 7 | 1 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 2 |
| GO:0008152 | metabolic process | 1 | 2 |
| GO:0009056 | catabolic process | 2 | 1 |
| GO:0009057 | macromolecule catabolic process | 4 | 1 |
| GO:0009987 | cellular process | 1 | 1 |
| GO:0010498 | proteasomal protein catabolic process | 5 | 1 |
| GO:0019538 | protein metabolic process | 3 | 2 |
| GO:0019941 | modification-dependent protein catabolic process | 6 | 1 |
| GO:0030163 | protein catabolic process | 4 | 1 |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 6 | 1 |
| GO:0043170 | macromolecule metabolic process | 3 | 2 |
| GO:0043632 | modification-dependent macromolecule catabolic process | 5 | 1 |
| GO:0044237 | cellular metabolic process | 2 | 1 |
| GO:0044238 | primary metabolic process | 2 | 2 |
| GO:0044248 | cellular catabolic process | 3 | 1 |
| GO:0044260 | obsolete cellular macromolecule metabolic process | 3 | 1 |
| GO:0044265 | obsolete cellular macromolecule catabolic process | 4 | 1 |
| GO:0051603 | proteolysis involved in protein catabolic process | 5 | 1 |
| GO:0071704 | organic substance metabolic process | 2 | 2 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 2 |
| GO:1901565 | organonitrogen compound catabolic process | 4 | 1 |
| GO:1901575 | organic substance catabolic process | 3 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0008233 | peptidase activity | 3 | 12 |
| GO:0008237 | metallopeptidase activity | 4 | 12 |
| GO:0016787 | hydrolase activity | 2 | 12 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 217 | 221 | PF00656 | 0.457 |
| CLV_C14_Caspase3-7 | 23 | 27 | PF00656 | 0.494 |
| CLV_NRD_NRD_1 | 282 | 284 | PF00675 | 0.328 |
| CLV_NRD_NRD_1 | 318 | 320 | PF00675 | 0.334 |
| CLV_NRD_NRD_1 | 331 | 333 | PF00675 | 0.356 |
| CLV_PCSK_KEX2_1 | 124 | 126 | PF00082 | 0.468 |
| CLV_PCSK_KEX2_1 | 282 | 284 | PF00082 | 0.306 |
| CLV_PCSK_KEX2_1 | 318 | 320 | PF00082 | 0.332 |
| CLV_PCSK_KEX2_1 | 331 | 333 | PF00082 | 0.365 |
| CLV_PCSK_KEX2_1 | 69 | 71 | PF00082 | 0.459 |
| CLV_PCSK_PC1ET2_1 | 124 | 126 | PF00082 | 0.543 |
| CLV_PCSK_PC1ET2_1 | 69 | 71 | PF00082 | 0.459 |
| CLV_PCSK_SKI1_1 | 124 | 128 | PF00082 | 0.468 |
| CLV_PCSK_SKI1_1 | 216 | 220 | PF00082 | 0.257 |
| CLV_PCSK_SKI1_1 | 6 | 10 | PF00082 | 0.777 |
| DEG_APCC_DBOX_1 | 155 | 163 | PF00400 | 0.394 |
| DOC_MAPK_DCC_7 | 124 | 132 | PF00069 | 0.281 |
| DOC_MAPK_DCC_7 | 43 | 51 | PF00069 | 0.257 |
| DOC_MAPK_gen_1 | 124 | 132 | PF00069 | 0.257 |
| DOC_MAPK_gen_1 | 68 | 76 | PF00069 | 0.257 |
| DOC_MAPK_MEF2A_6 | 124 | 132 | PF00069 | 0.257 |
| DOC_MAPK_MEF2A_6 | 43 | 52 | PF00069 | 0.257 |
| DOC_PP1_RVXF_1 | 129 | 136 | PF00149 | 0.317 |
| DOC_PP1_RVXF_1 | 188 | 195 | PF00149 | 0.325 |
| DOC_PP4_FxxP_1 | 95 | 98 | PF00568 | 0.257 |
| DOC_USP7_MATH_1 | 281 | 285 | PF00917 | 0.506 |
| LIG_14-3-3_CanoR_1 | 178 | 184 | PF00244 | 0.444 |
| LIG_14-3-3_CanoR_1 | 282 | 289 | PF00244 | 0.543 |
| LIG_Actin_WH2_2 | 236 | 254 | PF00022 | 0.562 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.500 |
| LIG_BRCT_BRCA1_1 | 190 | 194 | PF00533 | 0.325 |
| LIG_deltaCOP1_diTrp_1 | 107 | 111 | PF00928 | 0.301 |
| LIG_DLG_GKlike_1 | 233 | 240 | PF00625 | 0.457 |
| LIG_FHA_1 | 187 | 193 | PF00498 | 0.343 |
| LIG_FHA_1 | 61 | 67 | PF00498 | 0.343 |
| LIG_FHA_1 | 86 | 92 | PF00498 | 0.270 |
| LIG_FHA_2 | 290 | 296 | PF00498 | 0.501 |
| LIG_FHA_2 | 336 | 342 | PF00498 | 0.654 |
| LIG_HP1_1 | 48 | 52 | PF01393 | 0.257 |
| LIG_LIR_Apic_2 | 94 | 98 | PF02991 | 0.268 |
| LIG_LIR_Gen_1 | 56 | 66 | PF02991 | 0.268 |
| LIG_LIR_Nem_3 | 191 | 197 | PF02991 | 0.310 |
| LIG_NRBOX | 147 | 153 | PF00104 | 0.268 |
| LIG_PCNA_yPIPBox_3 | 145 | 156 | PF02747 | 0.317 |
| LIG_Pex14_2 | 95 | 99 | PF04695 | 0.257 |
| LIG_PTB_Apo_2 | 157 | 164 | PF02174 | 0.299 |
| LIG_PTB_Phospho_1 | 157 | 163 | PF10480 | 0.301 |
| LIG_RPA_C_Fungi | 314 | 326 | PF08784 | 0.509 |
| LIG_SH2_CRK | 163 | 167 | PF00017 | 0.365 |
| LIG_SH2_CRK | 180 | 184 | PF00017 | 0.424 |
| LIG_SH2_NCK_1 | 180 | 184 | PF00017 | 0.439 |
| LIG_SH2_STAP1 | 115 | 119 | PF00017 | 0.309 |
| LIG_SH2_STAT5 | 163 | 166 | PF00017 | 0.354 |
| LIG_SH2_STAT5 | 180 | 183 | PF00017 | 0.412 |
| LIG_SH2_STAT5 | 250 | 253 | PF00017 | 0.309 |
| LIG_SH2_STAT5 | 79 | 82 | PF00017 | 0.429 |
| LIG_SH3_3 | 28 | 34 | PF00018 | 0.649 |
| LIG_SUMO_SIM_anti_2 | 234 | 239 | PF11976 | 0.429 |
| LIG_SUMO_SIM_anti_2 | 262 | 271 | PF11976 | 0.287 |
| LIG_SUMO_SIM_par_1 | 47 | 53 | PF11976 | 0.309 |
| LIG_TRFH_1 | 157 | 161 | PF08558 | 0.502 |
| LIG_UBA3_1 | 119 | 124 | PF00899 | 0.394 |
| LIG_UBA3_1 | 237 | 242 | PF00899 | 0.414 |
| LIG_WRC_WIRS_1 | 297 | 302 | PF05994 | 0.394 |
| MOD_CK1_1 | 138 | 144 | PF00069 | 0.394 |
| MOD_CK1_1 | 221 | 227 | PF00069 | 0.309 |
| MOD_CK2_1 | 281 | 287 | PF00069 | 0.357 |
| MOD_CK2_1 | 289 | 295 | PF00069 | 0.377 |
| MOD_CK2_1 | 335 | 341 | PF00069 | 0.542 |
| MOD_GlcNHglycan | 137 | 140 | PF01048 | 0.298 |
| MOD_GlcNHglycan | 63 | 66 | PF01048 | 0.456 |
| MOD_GSK3_1 | 134 | 141 | PF00069 | 0.309 |
| MOD_GSK3_1 | 18 | 25 | PF00069 | 0.721 |
| MOD_GSK3_1 | 218 | 225 | PF00069 | 0.309 |
| MOD_GSK3_1 | 81 | 88 | PF00069 | 0.441 |
| MOD_N-GLC_1 | 61 | 66 | PF02516 | 0.429 |
| MOD_N-GLC_1 | 91 | 96 | PF02516 | 0.325 |
| MOD_NEK2_1 | 110 | 115 | PF00069 | 0.325 |
| MOD_NEK2_1 | 218 | 223 | PF00069 | 0.309 |
| MOD_NEK2_1 | 61 | 66 | PF00069 | 0.429 |
| MOD_PIKK_1 | 225 | 231 | PF00454 | 0.325 |
| MOD_PK_1 | 282 | 288 | PF00069 | 0.281 |
| MOD_PKA_1 | 282 | 288 | PF00069 | 0.396 |
| MOD_PKA_2 | 281 | 287 | PF00069 | 0.363 |
| MOD_PKA_2 | 289 | 295 | PF00069 | 0.318 |
| MOD_PKA_2 | 80 | 86 | PF00069 | 0.444 |
| MOD_Plk_1 | 219 | 225 | PF00069 | 0.309 |
| MOD_Plk_1 | 233 | 239 | PF00069 | 0.309 |
| MOD_Plk_1 | 61 | 67 | PF00069 | 0.429 |
| MOD_Plk_1 | 91 | 97 | PF00069 | 0.325 |
| MOD_Plk_2-3 | 18 | 24 | PF00069 | 0.699 |
| MOD_Plk_4 | 233 | 239 | PF00069 | 0.429 |
| MOD_Plk_4 | 296 | 302 | PF00069 | 0.369 |
| MOD_Plk_4 | 50 | 56 | PF00069 | 0.322 |
| MOD_SUMO_for_1 | 345 | 348 | PF00179 | 0.587 |
| MOD_SUMO_rev_2 | 2 | 8 | PF00179 | 0.719 |
| TRG_ENDOCYTIC_2 | 163 | 166 | PF00928 | 0.354 |
| TRG_ENDOCYTIC_2 | 180 | 183 | PF00928 | 0.412 |
| TRG_ENDOCYTIC_2 | 58 | 61 | PF00928 | 0.325 |
| TRG_ER_diArg_1 | 331 | 334 | PF00400 | 0.529 |
| TRG_Pf-PMV_PEXEL_1 | 216 | 220 | PF00026 | 0.309 |
| TRG_Pf-PMV_PEXEL_1 | 319 | 324 | PF00026 | 0.449 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I0V5 | Leptomonas seymouri | 89% | 100% |
| A0A0S4IMY0 | Bodo saltans | 60% | 100% |
| A0A1X0P6H9 | Trypanosomatidae | 71% | 93% |
| A0A3R7LWY5 | Trypanosoma rangeli | 70% | 97% |
| A0A3S5H7R2 | Leishmania donovani | 100% | 100% |
| A1CQH7 | Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) | 25% | 100% |
| A1D3E1 | Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) | 25% | 100% |
| A2QQ10 | Aspergillus niger (strain CBS 513.88 / FGSC A1513) | 25% | 96% |
| A4HK19 | Leishmania braziliensis | 94% | 100% |
| A4R0E5 | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) | 22% | 97% |
| A5A6I3 | Pan troglodytes | 27% | 99% |
| A6QQ21 | Bos taurus | 23% | 100% |
| A7TX81 | Sus scrofa | 24% | 100% |
| B0X2G0 | Culex quinquefasciatus | 29% | 100% |
| B0XQ55 | Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) | 25% | 100% |
| D0A0A6 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 66% | 94% |
| E9B2G0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 98% | 100% |
| O00303 | Homo sapiens | 27% | 100% |
| O04202 | Arabidopsis thaliana | 29% | 100% |
| O24412 | Arabidopsis thaliana | 38% | 100% |
| O43060 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 25% | 100% |
| O74440 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 35% | 100% |
| O88545 | Mus musculus | 23% | 100% |
| P26270 | Drosophila melanogaster | 40% | 100% |
| P26516 | Mus musculus | 39% | 100% |
| P51665 | Homo sapiens | 39% | 100% |
| Q07G98 | Xenopus tropicalis | 24% | 100% |
| Q08723 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 33% | 100% |
| Q0CCM5 | Aspergillus terreus (strain NIH 2624 / FGSC A1156) | 24% | 100% |
| Q0UTQ6 | Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) | 25% | 100% |
| Q18967 | Caenorhabditis elegans | 25% | 100% |
| Q1DRC9 | Coccidioides immitis (strain RS) | 25% | 100% |
| Q1HR47 | Aedes aegypti | 28% | 100% |
| Q2HGJ2 | Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) | 22% | 100% |
| Q2UPM0 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 25% | 100% |
| Q3ZBD0 | Bos taurus | 39% | 100% |
| Q4Q5P6 | Leishmania major | 98% | 100% |
| Q4R5B8 | Macaca fascicularis | 27% | 99% |
| Q4WTH0 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 25% | 100% |
| Q54C92 | Dictyostelium discoideum | 25% | 100% |
| Q54WI8 | Dictyostelium discoideum | 39% | 100% |
| Q5REY0 | Pongo abelii | 24% | 100% |
| Q6FMD8 | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) | 34% | 100% |
| Q6NUC2 | Xenopus laevis | 24% | 100% |
| Q6ZKM2 | Oryza sativa subsp. japonica | 25% | 100% |
| Q75F44 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | 34% | 100% |
| Q7L5N1 | Homo sapiens | 23% | 100% |
| Q7QD36 | Anopheles gambiae | 26% | 100% |
| Q8W1P0 | Arabidopsis thaliana | 25% | 100% |
| Q8W206 | Arabidopsis thaliana | 26% | 100% |
| Q8WZY4 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 36% | 100% |
| Q9C774 | Arabidopsis thaliana | 38% | 100% |
| Q9DCH4 | Mus musculus | 26% | 99% |
| V5C1Q5 | Trypanosoma cruzi | 69% | 97% |