LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I7K0_LEIIN
TriTrypDb:
LINF_320008700
Length:
366

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0030990 intraciliary transport particle 2 1
GO:0032991 protein-containing complex 1 1

Expansion

Sequence features

A4I7K0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7K0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 319 323 PF00656 0.787
CLV_NRD_NRD_1 18 20 PF00675 0.447
CLV_NRD_NRD_1 236 238 PF00675 0.613
CLV_NRD_NRD_1 249 251 PF00675 0.546
CLV_PCSK_FUR_1 149 153 PF00082 0.699
CLV_PCSK_KEX2_1 151 153 PF00082 0.633
CLV_PCSK_KEX2_1 18 20 PF00082 0.428
CLV_PCSK_KEX2_1 249 251 PF00082 0.646
CLV_PCSK_KEX2_1 340 342 PF00082 0.793
CLV_PCSK_PC1ET2_1 151 153 PF00082 0.672
CLV_PCSK_PC1ET2_1 340 342 PF00082 0.793
CLV_PCSK_SKI1_1 152 156 PF00082 0.694
CLV_PCSK_SKI1_1 237 241 PF00082 0.614
CLV_PCSK_SKI1_1 249 253 PF00082 0.595
DEG_APCC_DBOX_1 248 256 PF00400 0.628
DEG_Nend_UBRbox_3 1 3 PF02207 0.643
DOC_ANK_TNKS_1 94 101 PF00023 0.719
DOC_CYCLIN_RxL_1 128 136 PF00134 0.502
DOC_USP7_MATH_1 284 288 PF00917 0.677
DOC_USP7_MATH_1 313 317 PF00917 0.713
DOC_USP7_MATH_1 99 103 PF00917 0.743
DOC_WW_Pin1_4 343 348 PF00397 0.669
DOC_WW_Pin1_4 54 59 PF00397 0.503
LIG_14-3-3_CanoR_1 140 146 PF00244 0.502
LIG_14-3-3_CanoR_1 152 162 PF00244 0.614
LIG_14-3-3_CanoR_1 18 22 PF00244 0.457
LIG_14-3-3_CanoR_1 237 244 PF00244 0.636
LIG_14-3-3_CanoR_1 293 297 PF00244 0.686
LIG_14-3-3_CanoR_1 90 99 PF00244 0.734
LIG_Clathr_ClatBox_1 132 136 PF01394 0.480
LIG_CSL_BTD_1 305 308 PF09270 0.721
LIG_FHA_2 202 208 PF00498 0.555
LIG_FHA_2 230 236 PF00498 0.538
LIG_LIR_Apic_2 294 299 PF02991 0.687
LIG_LIR_Apic_2 60 66 PF02991 0.665
LIG_NRBOX 128 134 PF00104 0.457
LIG_NRBOX 251 257 PF00104 0.627
LIG_PTAP_UEV_1 307 312 PF05743 0.651
LIG_SH2_SRC 296 299 PF00017 0.732
LIG_SH2_STAT3 5 8 PF00017 0.674
LIG_SH2_STAT5 169 172 PF00017 0.725
LIG_SH2_STAT5 87 90 PF00017 0.625
LIG_SH3_3 213 219 PF00018 0.622
LIG_SH3_3 302 308 PF00018 0.683
LIG_SH3_3 55 61 PF00018 0.635
LIG_SUMO_SIM_anti_2 322 329 PF11976 0.668
LIG_SUMO_SIM_par_1 130 136 PF11976 0.480
LIG_SUMO_SIM_par_1 322 329 PF11976 0.566
LIG_UBA3_1 132 138 PF00899 0.507
MOD_CK1_1 156 162 PF00069 0.669
MOD_CK1_1 17 23 PF00069 0.478
MOD_CK1_1 171 177 PF00069 0.745
MOD_CK1_1 316 322 PF00069 0.767
MOD_CK2_1 107 113 PF00069 0.622
MOD_CK2_1 180 186 PF00069 0.785
MOD_CK2_1 201 207 PF00069 0.561
MOD_CK2_1 275 281 PF00069 0.747
MOD_GlcNHglycan 155 158 PF01048 0.657
MOD_GlcNHglycan 170 173 PF01048 0.678
MOD_GlcNHglycan 179 183 PF01048 0.732
MOD_GlcNHglycan 277 280 PF01048 0.737
MOD_GlcNHglycan 311 314 PF01048 0.670
MOD_GlcNHglycan 329 333 PF01048 0.720
MOD_GlcNHglycan 337 340 PF01048 0.674
MOD_GlcNHglycan 35 38 PF01048 0.651
MOD_GlcNHglycan 50 53 PF01048 0.575
MOD_GSK3_1 107 114 PF00069 0.703
MOD_GSK3_1 152 159 PF00069 0.680
MOD_GSK3_1 167 174 PF00069 0.648
MOD_GSK3_1 309 316 PF00069 0.709
MOD_N-GLC_1 107 112 PF02516 0.602
MOD_N-GLC_1 152 157 PF02516 0.732
MOD_N-GLC_1 67 72 PF02516 0.540
MOD_N-GLC_1 90 95 PF02516 0.704
MOD_N-GLC_2 42 44 PF02516 0.592
MOD_N-GLC_2 45 47 PF02516 0.605
MOD_NEK2_1 14 19 PF00069 0.377
MOD_NEK2_1 178 183 PF00069 0.756
MOD_NEK2_1 26 31 PF00069 0.478
MOD_NEK2_1 285 290 PF00069 0.666
MOD_NEK2_1 33 38 PF00069 0.438
MOD_NEK2_1 72 77 PF00069 0.557
MOD_NEK2_2 107 112 PF00069 0.777
MOD_PIKK_1 138 144 PF00454 0.589
MOD_PIKK_1 26 32 PF00454 0.552
MOD_PIKK_1 313 319 PF00454 0.761
MOD_PIKK_1 99 105 PF00454 0.712
MOD_PKA_1 237 243 PF00069 0.624
MOD_PKA_2 17 23 PF00069 0.462
MOD_PKA_2 292 298 PF00069 0.672
MOD_Plk_1 67 73 PF00069 0.629
MOD_Plk_2-3 201 207 PF00069 0.488
MOD_ProDKin_1 343 349 PF00069 0.671
MOD_ProDKin_1 54 60 PF00069 0.499
MOD_SUMO_rev_2 130 139 PF00179 0.481
TRG_DiLeu_BaLyEn_6 128 133 PF01217 0.478
TRG_NES_CRM1_1 125 136 PF08389 0.483
TRG_Pf-PMV_PEXEL_1 131 136 PF00026 0.479
TRG_Pf-PMV_PEXEL_1 250 254 PF00026 0.602

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8J4 Leptomonas seymouri 59% 98%
A0A1X0P6Q1 Trypanosomatidae 37% 86%
A0A3Q8IGR0 Leishmania donovani 99% 100%
A0A3R7RRK4 Trypanosoma rangeli 36% 92%
A4HK16 Leishmania braziliensis 78% 98%
D0A0A3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9B2F7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q5P9 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS