Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7J8_LEIIN

TriTrypDb:

LINF_320008500

Length:

799

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7J8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.568
CLV_NRD_NRD_1	311	313	PF00675	0.555
CLV_NRD_NRD_1	340	342	PF00675	0.522
CLV_NRD_NRD_1	359	361	PF00675	0.425
CLV_NRD_NRD_1	637	639	PF00675	0.649
CLV_NRD_NRD_1	653	655	PF00675	0.543
CLV_NRD_NRD_1	665	667	PF00675	0.588
CLV_NRD_NRD_1	713	715	PF00675	0.621
CLV_NRD_NRD_1	787	789	PF00675	0.633
CLV_NRD_NRD_1	9	11	PF00675	0.588
CLV_PCSK_FUR_1	357	361	PF00082	0.483
CLV_PCSK_KEX2_1	311	313	PF00082	0.563
CLV_PCSK_KEX2_1	340	342	PF00082	0.522
CLV_PCSK_KEX2_1	359	361	PF00082	0.425
CLV_PCSK_KEX2_1	653	655	PF00082	0.630
CLV_PCSK_KEX2_1	665	667	PF00082	0.590
CLV_PCSK_KEX2_1	713	715	PF00082	0.726
CLV_PCSK_KEX2_1	9	11	PF00082	0.588
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.706
CLV_PCSK_SKI1_1	12	16	PF00082	0.550
CLV_PCSK_SKI1_1	374	378	PF00082	0.395
CLV_PCSK_SKI1_1	489	493	PF00082	0.390
CLV_PCSK_SKI1_1	638	642	PF00082	0.644
CLV_PCSK_SKI1_1	788	792	PF00082	0.589
CLV_Separin_Metazoa	303	307	PF03568	0.514
CLV_Separin_Metazoa	6	10	PF03568	0.583
DEG_APCC_DBOX_1	475	483	PF00400	0.399
DEG_COP1_1	241	249	PF00400	0.504
DEG_SCF_FBW7_1	642	647	PF00400	0.629
DEG_SPOP_SBC_1	122	126	PF00917	0.553
DEG_SPOP_SBC_1	28	32	PF00917	0.531
DEG_SPOP_SBC_1	383	387	PF00917	0.546
DEG_SPOP_SBC_1	66	70	PF00917	0.592
DEG_SPOP_SBC_1	748	752	PF00917	0.703
DEG_SPOP_SBC_1	81	85	PF00917	0.616
DOC_CKS1_1	454	459	PF01111	0.571
DOC_CKS1_1	574	579	PF01111	0.546
DOC_CKS1_1	641	646	PF01111	0.654
DOC_CYCLIN_RxL_1	10	22	PF00134	0.463
DOC_CYCLIN_RxL_1	486	495	PF00134	0.455
DOC_MAPK_gen_1	357	367	PF00069	0.433
DOC_MAPK_gen_1	53	62	PF00069	0.595
DOC_MAPK_MEF2A_6	360	369	PF00069	0.372
DOC_PP1_RVXF_1	133	140	PF00149	0.540
DOC_PP2B_LxvP_1	40	43	PF13499	0.569
DOC_PP4_FxxP_1	641	644	PF00568	0.635
DOC_USP7_MATH_1	110	114	PF00917	0.695
DOC_USP7_MATH_1	173	177	PF00917	0.722
DOC_USP7_MATH_1	231	235	PF00917	0.692
DOC_USP7_MATH_1	267	271	PF00917	0.507
DOC_USP7_MATH_1	27	31	PF00917	0.770
DOC_USP7_MATH_1	382	386	PF00917	0.607
DOC_USP7_MATH_1	550	554	PF00917	0.686
DOC_USP7_MATH_1	582	586	PF00917	0.642
DOC_USP7_MATH_1	688	692	PF00917	0.697
DOC_USP7_MATH_1	730	734	PF00917	0.692
DOC_USP7_MATH_1	742	746	PF00917	0.624
DOC_USP7_MATH_1	748	752	PF00917	0.601
DOC_USP7_MATH_1	759	763	PF00917	0.642
DOC_USP7_MATH_1	769	773	PF00917	0.465
DOC_WW_Pin1_4	106	111	PF00397	0.719
DOC_WW_Pin1_4	453	458	PF00397	0.555
DOC_WW_Pin1_4	573	578	PF00397	0.732
DOC_WW_Pin1_4	599	604	PF00397	0.633
DOC_WW_Pin1_4	608	613	PF00397	0.563
DOC_WW_Pin1_4	640	645	PF00397	0.688
DOC_WW_Pin1_4	706	711	PF00397	0.814
LIG_14-3-3_CanoR_1	344	350	PF00244	0.390
LIG_14-3-3_CanoR_1	360	366	PF00244	0.427
LIG_14-3-3_CanoR_1	428	436	PF00244	0.427
LIG_14-3-3_CanoR_1	53	62	PF00244	0.647
LIG_14-3-3_CanoR_1	538	542	PF00244	0.610
LIG_14-3-3_CanoR_1	558	564	PF00244	0.444
LIG_14-3-3_CanoR_1	589	594	PF00244	0.741
LIG_14-3-3_CanoR_1	623	627	PF00244	0.645
LIG_14-3-3_CanoR_1	666	671	PF00244	0.688
LIG_14-3-3_CanoR_1	713	719	PF00244	0.706
LIG_14-3-3_CanoR_1	741	747	PF00244	0.600
LIG_14-3-3_CanoR_1	77	82	PF00244	0.756
LIG_14-3-3_CanoR_1	775	784	PF00244	0.599
LIG_BIR_II_1	1	5	PF00653	0.438
LIG_BRCT_BRCA1_1	202	206	PF00533	0.558
LIG_CtBP_PxDLS_1	634	639	PF00389	0.508
LIG_EVH1_1	641	645	PF00568	0.692
LIG_FHA_1	110	116	PF00498	0.711
LIG_FHA_1	13	19	PF00498	0.554
LIG_FHA_1	337	343	PF00498	0.542
LIG_FHA_1	436	442	PF00498	0.471
LIG_FHA_1	753	759	PF00498	0.549
LIG_FHA_1	777	783	PF00498	0.623
LIG_FHA_2	109	115	PF00498	0.722
LIG_FHA_2	140	146	PF00498	0.578
LIG_FHA_2	298	304	PF00498	0.553
LIG_FHA_2	31	37	PF00498	0.634
LIG_FHA_2	413	419	PF00498	0.434
LIG_FHA_2	514	520	PF00498	0.554
LIG_FHA_2	693	699	PF00498	0.665
LIG_FHA_2	84	90	PF00498	0.536
LIG_KLC1_Yacidic_2	510	515	PF13176	0.564
LIG_LIR_Apic_2	196	202	PF02991	0.684
LIG_LIR_Apic_2	451	457	PF02991	0.515
LIG_LIR_Apic_2	539	544	PF02991	0.626
LIG_LIR_Gen_1	145	154	PF02991	0.432
LIG_LIR_Gen_1	203	214	PF02991	0.453
LIG_LIR_Gen_1	300	309	PF02991	0.599
LIG_LIR_Gen_1	495	505	PF02991	0.348
LIG_LIR_Gen_1	695	703	PF02991	0.675
LIG_LIR_Nem_3	145	149	PF02991	0.444
LIG_LIR_Nem_3	203	209	PF02991	0.497
LIG_LIR_Nem_3	300	304	PF02991	0.599
LIG_LIR_Nem_3	495	500	PF02991	0.354
LIG_LIR_Nem_3	506	512	PF02991	0.420
LIG_LIR_Nem_3	695	699	PF02991	0.736
LIG_NRBOX	148	154	PF00104	0.543
LIG_PCNA_yPIPBox_3	45	55	PF02747	0.565
LIG_Pex14_1	503	507	PF04695	0.440
LIG_Pex14_2	497	501	PF04695	0.351
LIG_PTB_Apo_2	140	147	PF02174	0.460
LIG_RPA_C_Fungi	251	263	PF08784	0.497
LIG_SH2_CRK	199	203	PF00017	0.626
LIG_SH2_CRK	541	545	PF00017	0.645
LIG_SH2_NCK_1	199	203	PF00017	0.626
LIG_SH2_NCK_1	454	458	PF00017	0.565
LIG_SH2_NCK_1	460	464	PF00017	0.620
LIG_SH2_SRC	199	202	PF00017	0.623
LIG_SH2_SRC	370	373	PF00017	0.467
LIG_SH2_STAP1	509	513	PF00017	0.426
LIG_SH2_STAT5	507	510	PF00017	0.480
LIG_SH2_STAT5	51	54	PF00017	0.571
LIG_SH2_STAT5	513	516	PF00017	0.613
LIG_SH2_STAT5	663	666	PF00017	0.524
LIG_SH3_1	639	645	PF00018	0.650
LIG_SH3_1	789	795	PF00018	0.680
LIG_SH3_3	372	378	PF00018	0.450
LIG_SH3_3	591	597	PF00018	0.764
LIG_SH3_3	609	615	PF00018	0.608
LIG_SH3_3	639	645	PF00018	0.607
LIG_SH3_3	674	680	PF00018	0.694
LIG_SH3_3	751	757	PF00018	0.623
LIG_SH3_3	789	795	PF00018	0.633
LIG_SUMO_SIM_par_1	432	438	PF11976	0.488
LIG_TRAF2_1	300	303	PF00917	0.599
LIG_TRAF2_1	553	556	PF00917	0.602
LIG_TRAF2_1	87	90	PF00917	0.570
LIG_UBA3_1	59	63	PF00899	0.504
LIG_WRC_WIRS_1	497	502	PF05994	0.347
MOD_CDK_SPxxK_3	706	713	PF00069	0.816
MOD_CK1_1	109	115	PF00069	0.618
MOD_CK1_1	184	190	PF00069	0.754
MOD_CK1_1	195	201	PF00069	0.582
MOD_CK1_1	30	36	PF00069	0.695
MOD_CK1_1	435	441	PF00069	0.483
MOD_CK1_1	481	487	PF00069	0.485
MOD_CK1_1	625	631	PF00069	0.654
MOD_CK1_1	633	639	PF00069	0.559
MOD_CK1_1	697	703	PF00069	0.619
MOD_CK1_1	76	82	PF00069	0.707
MOD_CK1_1	777	783	PF00069	0.617
MOD_CK1_1	83	89	PF00069	0.638
MOD_CK2_1	139	145	PF00069	0.502
MOD_CK2_1	297	303	PF00069	0.523
MOD_CK2_1	30	36	PF00069	0.678
MOD_CK2_1	412	418	PF00069	0.495
MOD_CK2_1	492	498	PF00069	0.375
MOD_CK2_1	513	519	PF00069	0.681
MOD_CK2_1	550	556	PF00069	0.681
MOD_CK2_1	692	698	PF00069	0.651
MOD_CK2_1	83	89	PF00069	0.620
MOD_GlcNHglycan	125	128	PF01048	0.578
MOD_GlcNHglycan	130	133	PF01048	0.590
MOD_GlcNHglycan	175	178	PF01048	0.670
MOD_GlcNHglycan	232	236	PF01048	0.749
MOD_GlcNHglycan	238	241	PF01048	0.704
MOD_GlcNHglycan	25	28	PF01048	0.611
MOD_GlcNHglycan	264	267	PF01048	0.495
MOD_GlcNHglycan	317	320	PF01048	0.611
MOD_GlcNHglycan	429	432	PF01048	0.401
MOD_GlcNHglycan	494	497	PF01048	0.423
MOD_GlcNHglycan	551	555	PF01048	0.645
MOD_GlcNHglycan	559	562	PF01048	0.660
MOD_GlcNHglycan	582	585	PF01048	0.632
MOD_GlcNHglycan	628	631	PF01048	0.700
MOD_GlcNHglycan	632	635	PF01048	0.630
MOD_GlcNHglycan	646	649	PF01048	0.536
MOD_GlcNHglycan	686	689	PF01048	0.715
MOD_GlcNHglycan	69	72	PF01048	0.658
MOD_GlcNHglycan	701	704	PF01048	0.593
MOD_GlcNHglycan	761	764	PF01048	0.626
MOD_GlcNHglycan	86	89	PF01048	0.527
MOD_GlcNHglycan	96	99	PF01048	0.637
MOD_GSK3_1	106	113	PF00069	0.590
MOD_GSK3_1	121	128	PF00069	0.670
MOD_GSK3_1	184	191	PF00069	0.678
MOD_GSK3_1	19	26	PF00069	0.723
MOD_GSK3_1	258	265	PF00069	0.477
MOD_GSK3_1	267	274	PF00069	0.592
MOD_GSK3_1	27	34	PF00069	0.650
MOD_GSK3_1	276	283	PF00069	0.600
MOD_GSK3_1	307	314	PF00069	0.645
MOD_GSK3_1	492	499	PF00069	0.447
MOD_GSK3_1	569	576	PF00069	0.674
MOD_GSK3_1	595	602	PF00069	0.635
MOD_GSK3_1	622	629	PF00069	0.669
MOD_GSK3_1	640	647	PF00069	0.562
MOD_GSK3_1	684	691	PF00069	0.635
MOD_GSK3_1	694	701	PF00069	0.637
MOD_GSK3_1	73	80	PF00069	0.721
MOD_GSK3_1	748	755	PF00069	0.561
MOD_GSK3_1	771	778	PF00069	0.618
MOD_GSK3_1	90	97	PF00069	0.629
MOD_N-GLC_1	655	660	PF02516	0.725
MOD_N-GLC_1	759	764	PF02516	0.767
MOD_NEK2_1	18	23	PF00069	0.581
MOD_NEK2_1	345	350	PF00069	0.478
MOD_NEK2_1	361	366	PF00069	0.451
MOD_NEK2_1	492	497	PF00069	0.345
MOD_NEK2_1	536	541	PF00069	0.531
MOD_NEK2_1	622	627	PF00069	0.681
MOD_NEK2_1	655	660	PF00069	0.614
MOD_NEK2_1	67	72	PF00069	0.666
MOD_NEK2_1	686	691	PF00069	0.641
MOD_NEK2_1	692	697	PF00069	0.623
MOD_NEK2_1	699	704	PF00069	0.601
MOD_NEK2_1	776	781	PF00069	0.733
MOD_NEK2_2	496	501	PF00069	0.410
MOD_NEK2_2	688	693	PF00069	0.518
MOD_PIKK_1	90	96	PF00454	0.707
MOD_PKA_1	311	317	PF00069	0.620
MOD_PKA_1	665	671	PF00069	0.713
MOD_PKA_2	311	317	PF00069	0.626
MOD_PKA_2	427	433	PF00069	0.420
MOD_PKA_2	537	543	PF00069	0.575
MOD_PKA_2	54	60	PF00069	0.658
MOD_PKA_2	557	563	PF00069	0.440
MOD_PKA_2	622	628	PF00069	0.578
MOD_PKA_2	630	636	PF00069	0.579
MOD_PKA_2	665	671	PF00069	0.727
MOD_PKA_2	712	718	PF00069	0.802
MOD_PKA_2	76	82	PF00069	0.744
MOD_PKA_2	774	780	PF00069	0.709
MOD_PKB_1	10	18	PF00069	0.603
MOD_PKB_1	53	61	PF00069	0.546
MOD_Plk_1	277	283	PF00069	0.714
MOD_Plk_2-3	515	521	PF00069	0.684
MOD_Plk_4	267	273	PF00069	0.424
MOD_Plk_4	432	438	PF00069	0.522
MOD_Plk_4	478	484	PF00069	0.448
MOD_Plk_4	496	502	PF00069	0.372
MOD_Plk_4	55	61	PF00069	0.593
MOD_Plk_4	569	575	PF00069	0.643
MOD_Plk_4	622	628	PF00069	0.738
MOD_ProDKin_1	106	112	PF00069	0.719
MOD_ProDKin_1	453	459	PF00069	0.562
MOD_ProDKin_1	573	579	PF00069	0.728
MOD_ProDKin_1	599	605	PF00069	0.635
MOD_ProDKin_1	608	614	PF00069	0.560
MOD_ProDKin_1	640	646	PF00069	0.691
MOD_ProDKin_1	706	712	PF00069	0.816
TRG_DiLeu_BaEn_1	145	150	PF01217	0.459
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.356
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.618
TRG_ENDOCYTIC_2	422	425	PF00928	0.465
TRG_ER_diArg_1	340	342	PF00400	0.513
TRG_ER_diArg_1	359	361	PF00400	0.430
TRG_ER_diArg_1	52	55	PF00400	0.554
TRG_ER_diArg_1	653	655	PF00400	0.629
TRG_ER_diArg_1	8	10	PF00400	0.567
TRG_NLS_Bipartite_1	653	669	PF00514	0.534
TRG_NLS_MonoExtC_3	787	792	PF00514	0.713
TRG_NLS_MonoExtN_4	662	669	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	788	793	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P865	Leptomonas seymouri	45%	87%
A0A1X0P7Z7	Trypanosomatidae	25%	84%
A0A3Q8IT10	Leishmania donovani	99%	89%
A4HK14	Leishmania braziliensis	67%	100%
D0A0A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	92%
E9B2F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5Q1	Leishmania major	86%	100%
V5C1Q2	Trypanosoma cruzi	28%	94%