Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7I4_LEIIN

TriTrypDb:

LINF_320007100

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7I4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.552
CLV_C14_Caspase3-7	355	359	PF00656	0.573
CLV_NRD_NRD_1	142	144	PF00675	0.443
CLV_NRD_NRD_1	175	177	PF00675	0.438
CLV_NRD_NRD_1	272	274	PF00675	0.426
CLV_NRD_NRD_1	57	59	PF00675	0.413
CLV_PCSK_KEX2_1	142	144	PF00082	0.443
CLV_PCSK_KEX2_1	149	151	PF00082	0.423
CLV_PCSK_KEX2_1	175	177	PF00082	0.438
CLV_PCSK_KEX2_1	272	274	PF00082	0.426
CLV_PCSK_KEX2_1	57	59	PF00082	0.413
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.423
CLV_PCSK_SKI1_1	142	146	PF00082	0.445
CLV_PCSK_SKI1_1	175	179	PF00082	0.445
CLV_PCSK_SKI1_1	222	226	PF00082	0.510
CLV_PCSK_SKI1_1	85	89	PF00082	0.449
DEG_APCC_DBOX_1	271	279	PF00400	0.437
DEG_APCC_DBOX_1	309	317	PF00400	0.521
DEG_APCC_KENBOX_2	242	246	PF00400	0.462
DOC_CKS1_1	218	223	PF01111	0.522
DOC_CYCLIN_RxL_1	261	270	PF00134	0.530
DOC_MAPK_gen_1	149	155	PF00069	0.429
DOC_USP7_MATH_1	133	137	PF00917	0.557
DOC_USP7_MATH_1	2	6	PF00917	0.554
DOC_USP7_MATH_1	200	204	PF00917	0.594
DOC_USP7_MATH_1	253	257	PF00917	0.580
DOC_USP7_MATH_1	333	337	PF00917	0.556
DOC_USP7_MATH_1	34	38	PF00917	0.550
DOC_WW_Pin1_4	202	207	PF00397	0.595
DOC_WW_Pin1_4	217	222	PF00397	0.582
DOC_WW_Pin1_4	249	254	PF00397	0.550
DOC_WW_Pin1_4	296	301	PF00397	0.619
DOC_WW_Pin1_4	315	320	PF00397	0.722
LIG_14-3-3_CanoR_1	212	221	PF00244	0.574
LIG_14-3-3_CanoR_1	272	276	PF00244	0.426
LIG_14-3-3_CanoR_1	331	340	PF00244	0.519
LIG_14-3-3_CanoR_1	66	71	PF00244	0.436
LIG_Actin_WH2_2	70	87	PF00022	0.427
LIG_deltaCOP1_diTrp_1	119	126	PF00928	0.585
LIG_DLG_GKlike_1	66	73	PF00625	0.438
LIG_EH1_1	17	25	PF00400	0.431
LIG_eIF4E_1	242	248	PF01652	0.461
LIG_FHA_1	157	163	PF00498	0.458
LIG_FHA_1	272	278	PF00498	0.473
LIG_FHA_1	297	303	PF00498	0.652
LIG_FHA_1	342	348	PF00498	0.448
LIG_FHA_1	349	355	PF00498	0.445
LIG_FHA_1	47	53	PF00498	0.435
LIG_FHA_2	260	266	PF00498	0.561
LIG_FHA_2	306	312	PF00498	0.548
LIG_GBD_Chelix_1	169	177	PF00786	0.437
LIG_LIR_Gen_1	182	191	PF02991	0.426
LIG_LIR_Nem_3	182	188	PF02991	0.429
LIG_SH2_CRK	185	189	PF00017	0.429
LIG_SH2_NCK_1	185	189	PF00017	0.429
LIG_SH2_STAP1	185	189	PF00017	0.429
LIG_SH3_3	247	253	PF00018	0.576
LIG_SH3_3	299	305	PF00018	0.663
LIG_SH3_3	313	319	PF00018	0.605
LIG_SH3_3	322	328	PF00018	0.602
LIG_SUMO_SIM_anti_2	274	281	PF11976	0.490
LIG_SUMO_SIM_anti_2	311	318	PF11976	0.494
LIG_SUMO_SIM_par_1	12	17	PF11976	0.431
LIG_SUMO_SIM_par_1	28	33	PF11976	0.567
LIG_SUMO_SIM_par_1	280	288	PF11976	0.548
LIG_TRAF2_1	285	288	PF00917	0.648
MOD_CDC14_SPxK_1	205	208	PF00782	0.596
MOD_CDK_SPK_2	217	222	PF00069	0.538
MOD_CDK_SPK_2	315	320	PF00069	0.584
MOD_CDK_SPxK_1	202	208	PF00069	0.599
MOD_CK1_1	199	205	PF00069	0.668
MOD_CK1_1	69	75	PF00069	0.413
MOD_CK2_1	122	128	PF00069	0.629
MOD_CK2_1	133	139	PF00069	0.486
MOD_CK2_1	158	164	PF00069	0.513
MOD_CK2_1	259	265	PF00069	0.569
MOD_CK2_1	282	288	PF00069	0.609
MOD_CK2_1	333	339	PF00069	0.522
MOD_CK2_1	73	79	PF00069	0.554
MOD_GlcNHglycan	198	201	PF01048	0.595
MOD_GlcNHglycan	202	205	PF01048	0.625
MOD_GlcNHglycan	335	338	PF01048	0.599
MOD_GlcNHglycan	36	39	PF01048	0.503
MOD_GSK3_1	122	129	PF00069	0.574
MOD_GSK3_1	156	163	PF00069	0.431
MOD_GSK3_1	196	203	PF00069	0.615
MOD_GSK3_1	207	214	PF00069	0.607
MOD_GSK3_1	249	256	PF00069	0.566
MOD_GSK3_1	278	285	PF00069	0.581
MOD_GSK3_1	30	37	PF00069	0.557
MOD_GSK3_1	69	76	PF00069	0.595
MOD_N-GLC_1	348	353	PF02516	0.438
MOD_N-GLC_1	73	78	PF02516	0.421
MOD_NEK2_1	16	21	PF00069	0.422
MOD_NEK2_1	277	282	PF00069	0.513
MOD_NEK2_1	30	35	PF00069	0.551
MOD_NEK2_1	73	78	PF00069	0.587
MOD_NEK2_2	2	7	PF00069	0.495
MOD_PIKK_1	156	162	PF00454	0.450
MOD_PIKK_1	232	238	PF00454	0.460
MOD_PIKK_1	46	52	PF00454	0.459
MOD_PIKK_1	87	93	PF00454	0.546
MOD_PK_1	282	288	PF00069	0.553
MOD_PKA_2	106	112	PF00069	0.454
MOD_PKA_2	207	213	PF00069	0.620
MOD_PKA_2	271	277	PF00069	0.443
MOD_PKA_2	278	284	PF00069	0.530
MOD_Plk_1	341	347	PF00069	0.451
MOD_Plk_1	43	49	PF00069	0.453
MOD_Plk_1	73	79	PF00069	0.419
MOD_Plk_2-3	122	128	PF00069	0.530
MOD_Plk_2-3	353	359	PF00069	0.489
MOD_ProDKin_1	202	208	PF00069	0.599
MOD_ProDKin_1	217	223	PF00069	0.576
MOD_ProDKin_1	249	255	PF00069	0.546
MOD_ProDKin_1	296	302	PF00069	0.620
MOD_ProDKin_1	315	321	PF00069	0.722
MOD_SUMO_rev_2	109	118	PF00179	0.476
TRG_DiLeu_BaEn_2	341	347	PF01217	0.451
TRG_DiLeu_BaEn_4	79	85	PF01217	0.452
TRG_ENDOCYTIC_2	185	188	PF00928	0.434
TRG_ER_diArg_1	141	143	PF00400	0.447
TRG_ER_diArg_1	150	153	PF00400	0.418
TRG_ER_diArg_1	175	177	PF00400	0.438
TRG_ER_diArg_1	271	273	PF00400	0.426
TRG_ER_diArg_1	56	58	PF00400	0.413
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME2	Leptomonas seymouri	62%	83%
A0A3S7X529	Leishmania donovani	99%	100%
A4HK01	Leishmania braziliensis	69%	100%
E9B2E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5R5	Leishmania major	92%	100%