Heat_shock_protein_110_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7I3_LEIIN

TriTrypDb:

LINF_320007000

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4I7I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7I3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0044183	protein folding chaperone	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140657	ATP-dependent activity	1	6
GO:0140662	ATP-dependent protein folding chaperone	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.587
CLV_C14_Caspase3-7	331	335	PF00656	0.469
CLV_C14_Caspase3-7	88	92	PF00656	0.537
CLV_NRD_NRD_1	220	222	PF00675	0.503
CLV_NRD_NRD_1	264	266	PF00675	0.635
CLV_NRD_NRD_1	353	355	PF00675	0.488
CLV_NRD_NRD_1	397	399	PF00675	0.376
CLV_NRD_NRD_1	557	559	PF00675	0.610
CLV_PCSK_KEX2_1	220	222	PF00082	0.468
CLV_PCSK_KEX2_1	264	266	PF00082	0.635
CLV_PCSK_KEX2_1	353	355	PF00082	0.488
CLV_PCSK_KEX2_1	397	399	PF00082	0.391
CLV_PCSK_SKI1_1	197	201	PF00082	0.392
CLV_PCSK_SKI1_1	206	210	PF00082	0.398
CLV_PCSK_SKI1_1	311	315	PF00082	0.586
CLV_PCSK_SKI1_1	353	357	PF00082	0.505
CLV_PCSK_SKI1_1	398	402	PF00082	0.390
CLV_PCSK_SKI1_1	506	510	PF00082	0.551
CLV_PCSK_SKI1_1	550	554	PF00082	0.503
CLV_PCSK_SKI1_1	640	644	PF00082	0.538
CLV_PCSK_SKI1_1	665	669	PF00082	0.526
DEG_Nend_Nbox_1	1	3	PF02207	0.451
DEG_SPOP_SBC_1	191	195	PF00917	0.684
DOC_CKS1_1	753	758	PF01111	0.618
DOC_CYCLIN_RxL_1	350	360	PF00134	0.599
DOC_CYCLIN_RxL_1	394	405	PF00134	0.355
DOC_MAPK_DCC_7	707	716	PF00069	0.455
DOC_MAPK_MEF2A_6	197	204	PF00069	0.378
DOC_MAPK_MEF2A_6	394	403	PF00069	0.491
DOC_MAPK_MEF2A_6	730	738	PF00069	0.453
DOC_MAPK_NFAT4_5	197	205	PF00069	0.482
DOC_PP1_RVXF_1	137	144	PF00149	0.539
DOC_PP1_RVXF_1	221	228	PF00149	0.587
DOC_PP2B_LxvP_1	202	205	PF13499	0.438
DOC_PP4_FxxP_1	356	359	PF00568	0.629
DOC_USP7_MATH_1	10	14	PF00917	0.473
DOC_USP7_MATH_1	103	107	PF00917	0.716
DOC_USP7_MATH_1	19	23	PF00917	0.559
DOC_USP7_MATH_1	191	195	PF00917	0.612
DOC_USP7_MATH_1	212	216	PF00917	0.546
DOC_USP7_MATH_1	231	235	PF00917	0.513
DOC_USP7_MATH_1	27	31	PF00917	0.541
DOC_USP7_MATH_1	357	361	PF00917	0.647
DOC_USP7_MATH_1	39	43	PF00917	0.471
DOC_USP7_MATH_1	390	394	PF00917	0.485
DOC_USP7_MATH_1	446	450	PF00917	0.541
DOC_USP7_MATH_1	601	605	PF00917	0.691
DOC_USP7_MATH_1	635	639	PF00917	0.461
DOC_USP7_MATH_1	691	695	PF00917	0.503
DOC_USP7_MATH_1	85	89	PF00917	0.472
DOC_USP7_UBL2_3	559	563	PF12436	0.612
DOC_WW_Pin1_4	355	360	PF00397	0.630
DOC_WW_Pin1_4	44	49	PF00397	0.453
DOC_WW_Pin1_4	499	504	PF00397	0.564
DOC_WW_Pin1_4	655	660	PF00397	0.555
DOC_WW_Pin1_4	752	757	PF00397	0.596
LIG_14-3-3_CanoR_1	220	226	PF00244	0.546
LIG_14-3-3_CanoR_1	268	274	PF00244	0.614
LIG_14-3-3_CanoR_1	558	564	PF00244	0.653
LIG_14-3-3_CanoR_1	690	699	PF00244	0.486
LIG_APCC_ABBA_1	668	673	PF00400	0.487
LIG_BIR_III_2	31	35	PF00653	0.583
LIG_BRCT_BRCA1_1	244	248	PF00533	0.375
LIG_BRCT_BRCA1_1	359	363	PF00533	0.629
LIG_BRCT_BRCA1_1	607	611	PF00533	0.596
LIG_BRCT_BRCA1_1	761	765	PF00533	0.559
LIG_CSL_BTD_1	656	659	PF09270	0.568
LIG_deltaCOP1_diTrp_1	450	457	PF00928	0.418
LIG_deltaCOP1_diTrp_1	470	476	PF00928	0.595
LIG_eIF4E_1	427	433	PF01652	0.546
LIG_FHA_1	108	114	PF00498	0.579
LIG_FHA_1	136	142	PF00498	0.589
LIG_FHA_1	199	205	PF00498	0.361
LIG_FHA_1	24	30	PF00498	0.699
LIG_FHA_1	242	248	PF00498	0.447
LIG_FHA_1	382	388	PF00498	0.569
LIG_FHA_1	433	439	PF00498	0.490
LIG_FHA_1	45	51	PF00498	0.517
LIG_FHA_1	477	483	PF00498	0.468
LIG_FHA_1	491	497	PF00498	0.511
LIG_FHA_1	564	570	PF00498	0.467
LIG_FHA_1	621	627	PF00498	0.593
LIG_FHA_1	629	635	PF00498	0.425
LIG_FHA_1	748	754	PF00498	0.569
LIG_FHA_2	184	190	PF00498	0.682
LIG_FHA_2	253	259	PF00498	0.506
LIG_FHA_2	469	475	PF00498	0.616
LIG_FHA_2	52	58	PF00498	0.503
LIG_FHA_2	582	588	PF00498	0.537
LIG_FHA_2	96	102	PF00498	0.719
LIG_LIR_Gen_1	11	20	PF02991	0.508
LIG_LIR_Gen_1	161	171	PF02991	0.413
LIG_LIR_Gen_1	360	369	PF02991	0.575
LIG_LIR_Gen_1	577	587	PF02991	0.587
LIG_LIR_Gen_1	761	767	PF02991	0.445
LIG_LIR_LC3C_4	201	204	PF02991	0.467
LIG_LIR_Nem_3	11	17	PF02991	0.494
LIG_LIR_Nem_3	161	167	PF02991	0.439
LIG_LIR_Nem_3	322	327	PF02991	0.632
LIG_LIR_Nem_3	360	366	PF02991	0.570
LIG_LIR_Nem_3	449	454	PF02991	0.458
LIG_LIR_Nem_3	577	583	PF02991	0.574
LIG_LIR_Nem_3	761	766	PF02991	0.488
LIG_NRBOX	491	497	PF00104	0.511
LIG_NRBOX	638	644	PF00104	0.523
LIG_Pex14_1	472	476	PF04695	0.592
LIG_SH2_CRK	207	211	PF00017	0.481
LIG_SH2_NCK_1	257	261	PF00017	0.555
LIG_SH2_NCK_1	82	86	PF00017	0.496
LIG_SH2_PTP2	14	17	PF00017	0.493
LIG_SH2_SRC	617	620	PF00017	0.504
LIG_SH2_STAP1	2	6	PF00017	0.412
LIG_SH2_STAP1	763	767	PF00017	0.444
LIG_SH2_STAP1	82	86	PF00017	0.505
LIG_SH2_STAT3	348	351	PF00017	0.532
LIG_SH2_STAT3	546	549	PF00017	0.490
LIG_SH2_STAT3	68	71	PF00017	0.497
LIG_SH2_STAT5	14	17	PF00017	0.493
LIG_SH2_STAT5	170	173	PF00017	0.472
LIG_SH2_STAT5	324	327	PF00017	0.603
LIG_SH2_STAT5	546	549	PF00017	0.451
LIG_SH2_STAT5	617	620	PF00017	0.425
LIG_SH2_STAT5	669	672	PF00017	0.418
LIG_SH2_STAT5	78	81	PF00017	0.379
LIG_SH3_3	297	303	PF00018	0.560
LIG_SH3_3	497	503	PF00018	0.456
LIG_SH3_3	650	656	PF00018	0.480
LIG_SH3_3	736	742	PF00018	0.556
LIG_SH3_3	750	756	PF00018	0.457
LIG_Sin3_3	695	702	PF02671	0.477
LIG_SUMO_SIM_par_1	276	281	PF11976	0.409
LIG_SUMO_SIM_par_1	565	570	PF11976	0.337
LIG_TRAF2_1	260	263	PF00917	0.612
LIG_TRAF2_1	54	57	PF00917	0.536
LIG_UBA3_1	453	459	PF00899	0.428
LIG_WRC_WIRS_1	154	159	PF05994	0.504
MOD_CDC14_SPxK_1	358	361	PF00782	0.644
MOD_CDK_SPxK_1	355	361	PF00069	0.625
MOD_CDK_SPxxK_3	499	506	PF00069	0.565
MOD_CDK_SPxxK_3	658	665	PF00069	0.521
MOD_CK1_1	106	112	PF00069	0.660
MOD_CK1_1	156	162	PF00069	0.489
MOD_CK1_1	21	27	PF00069	0.624
MOD_CK1_1	409	415	PF00069	0.545
MOD_CK1_1	499	505	PF00069	0.491
MOD_CK1_1	554	560	PF00069	0.634
MOD_CK1_1	658	664	PF00069	0.559
MOD_CK1_1	679	685	PF00069	0.651
MOD_CK2_1	468	474	PF00069	0.537
MOD_CK2_1	51	57	PF00069	0.545
MOD_CK2_1	589	595	PF00069	0.704
MOD_CK2_1	725	731	PF00069	0.561
MOD_CK2_1	758	764	PF00069	0.540
MOD_CK2_1	95	101	PF00069	0.666
MOD_GlcNHglycan	110	113	PF01048	0.527
MOD_GlcNHglycan	135	138	PF01048	0.633
MOD_GlcNHglycan	158	161	PF01048	0.446
MOD_GlcNHglycan	194	197	PF01048	0.568
MOD_GlcNHglycan	214	217	PF01048	0.470
MOD_GlcNHglycan	316	319	PF01048	0.661
MOD_GlcNHglycan	330	333	PF01048	0.469
MOD_GlcNHglycan	41	44	PF01048	0.491
MOD_GlcNHglycan	559	562	PF01048	0.616
MOD_GlcNHglycan	607	610	PF01048	0.605
MOD_GlcNHglycan	645	648	PF01048	0.497
MOD_GlcNHglycan	681	684	PF01048	0.675
MOD_GlcNHglycan	693	696	PF01048	0.482
MOD_GSK3_1	103	110	PF00069	0.743
MOD_GSK3_1	129	136	PF00069	0.570
MOD_GSK3_1	19	26	PF00069	0.542
MOD_GSK3_1	242	249	PF00069	0.408
MOD_GSK3_1	287	294	PF00069	0.459
MOD_GSK3_1	372	379	PF00069	0.634
MOD_GSK3_1	4	11	PF00069	0.375
MOD_GSK3_1	432	439	PF00069	0.474
MOD_GSK3_1	550	557	PF00069	0.588
MOD_GSK3_1	563	570	PF00069	0.506
MOD_GSK3_1	601	608	PF00069	0.585
MOD_GSK3_1	620	627	PF00069	0.447
MOD_GSK3_1	748	755	PF00069	0.607
MOD_N-GLC_1	242	247	PF02516	0.448
MOD_N-GLC_1	39	44	PF02516	0.569
MOD_NEK2_1	153	158	PF00069	0.591
MOD_NEK2_1	182	187	PF00069	0.566
MOD_NEK2_1	198	203	PF00069	0.508
MOD_NEK2_1	242	247	PF00069	0.467
MOD_NEK2_1	269	274	PF00069	0.523
MOD_NEK2_1	287	292	PF00069	0.353
MOD_NEK2_1	432	437	PF00069	0.464
MOD_NEK2_1	476	481	PF00069	0.420
MOD_NEK2_1	496	501	PF00069	0.416
MOD_NEK2_1	516	521	PF00069	0.464
MOD_NEK2_1	551	556	PF00069	0.577
MOD_NEK2_1	643	648	PF00069	0.488
MOD_NEK2_1	714	719	PF00069	0.476
MOD_NEK2_1	8	13	PF00069	0.388
MOD_NEK2_2	536	541	PF00069	0.533
MOD_NEK2_2	635	640	PF00069	0.559
MOD_PIKK_1	129	135	PF00454	0.588
MOD_PIKK_1	258	264	PF00454	0.525
MOD_PIKK_1	347	353	PF00454	0.510
MOD_PIKK_1	432	438	PF00454	0.561
MOD_PIKK_1	567	573	PF00454	0.589
MOD_PIKK_1	628	634	PF00454	0.492
MOD_PK_1	740	746	PF00069	0.646
MOD_PKA_1	406	412	PF00069	0.545
MOD_PKA_2	129	135	PF00069	0.532
MOD_PKA_2	554	560	PF00069	0.640
MOD_Plk_1	172	178	PF00069	0.505
MOD_Plk_1	242	248	PF00069	0.446
MOD_Plk_1	516	522	PF00069	0.528
MOD_Plk_1	621	627	PF00069	0.586
MOD_Plk_1	747	753	PF00069	0.382
MOD_Plk_2-3	589	595	PF00069	0.640
MOD_Plk_4	10	16	PF00069	0.431
MOD_Plk_4	153	159	PF00069	0.490
MOD_Plk_4	198	204	PF00069	0.366
MOD_Plk_4	242	248	PF00069	0.399
MOD_Plk_4	287	293	PF00069	0.464
MOD_Plk_4	476	482	PF00069	0.494
MOD_Plk_4	516	522	PF00069	0.475
MOD_Plk_4	575	581	PF00069	0.589
MOD_Plk_4	748	754	PF00069	0.581
MOD_ProDKin_1	355	361	PF00069	0.625
MOD_ProDKin_1	44	50	PF00069	0.448
MOD_ProDKin_1	499	505	PF00069	0.559
MOD_ProDKin_1	655	661	PF00069	0.552
MOD_ProDKin_1	752	758	PF00069	0.587
TRG_DiLeu_BaEn_1	428	433	PF01217	0.552
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.591
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.484
TRG_ENDOCYTIC_2	14	17	PF00928	0.493
TRG_ENDOCYTIC_2	310	313	PF00928	0.614
TRG_ENDOCYTIC_2	324	327	PF00928	0.638
TRG_ENDOCYTIC_2	427	430	PF00928	0.553
TRG_ENDOCYTIC_2	617	620	PF00928	0.531
TRG_ENDOCYTIC_2	763	766	PF00928	0.488
TRG_ER_diArg_1	220	223	PF00400	0.433
TRG_ER_diArg_1	264	266	PF00400	0.635
TRG_ER_diArg_1	353	355	PF00400	0.488
TRG_ER_diArg_1	396	398	PF00400	0.397
TRG_ER_FFAT_2	152	162	PF00635	0.536
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAW3	Leptomonas seymouri	67%	98%
A0A0S4IR51	Bodo saltans	25%	100%
A0A1X0P6L7	Trypanosomatidae	33%	89%
A0A3R7RRJ4	Trypanosoma rangeli	33%	93%
A0A3S7X511	Leishmania donovani	99%	100%
A4HK00	Leishmania braziliensis	77%	100%
D0A086	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	89%
E9B2E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5R6	Leishmania major	93%	100%
V5C1N9	Trypanosoma cruzi	34%	100%