Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7I2_LEIIN

TriTrypDb:

LINF_320006900

Length:

116

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	8
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4I7I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7I2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.582
CLV_NRD_NRD_1	16	18	PF00675	0.490
CLV_PCSK_KEX2_1	106	108	PF00082	0.596
CLV_PCSK_KEX2_1	16	18	PF00082	0.490
DOC_MAPK_gen_1	27	35	PF00069	0.589
DOC_PP4_FxxP_1	52	55	PF00568	0.352
DOC_USP7_MATH_1	15	19	PF00917	0.674
DOC_WW_Pin1_4	78	83	PF00397	0.405
LIG_14-3-3_CanoR_1	16	20	PF00244	0.702
LIG_14-3-3_CanoR_1	37	45	PF00244	0.584
LIG_CSK_EPIYA_1	93	97	PF00017	0.339
LIG_eIF4E_1	65	71	PF01652	0.443
LIG_FHA_1	51	57	PF00498	0.321
LIG_FHA_1	58	64	PF00498	0.286
LIG_FHA_1	75	81	PF00498	0.347
LIG_IBAR_NPY_1	29	31	PF08397	0.573
LIG_LIR_Apic_2	49	55	PF02991	0.326
LIG_MYND_1	68	72	PF01753	0.368
LIG_SH2_CRK	105	109	PF00017	0.357
LIG_SH2_NCK_1	22	26	PF00017	0.668
LIG_SH2_STAP1	39	43	PF00017	0.601
LIG_SH2_STAT5	22	25	PF00017	0.681
LIG_SH2_STAT5	31	34	PF00017	0.596
LIG_SH2_STAT5	65	68	PF00017	0.291
LIG_SH2_STAT5	90	93	PF00017	0.370
LIG_SH3_CIN85_PxpxPR_1	11	16	PF14604	0.601
LIG_SUMO_SIM_par_1	53	60	PF11976	0.293
LIG_SxIP_EBH_1	36	48	PF03271	0.552
LIG_TRAF2_1	113	116	PF00917	0.460
LIG_TRFH_1	90	94	PF08558	0.336
LIG_WRC_WIRS_1	58	63	PF05994	0.291
MOD_CDK_SPxK_1	78	84	PF00069	0.484
MOD_CK1_1	9	15	PF00069	0.697
MOD_CK2_1	110	116	PF00069	0.507
MOD_GlcNHglycan	112	115	PF01048	0.631
MOD_GlcNHglycan	8	11	PF01048	0.472
MOD_GSK3_1	33	40	PF00069	0.577
MOD_GSK3_1	74	81	PF00069	0.413
MOD_N-GLC_1	20	25	PF02516	0.429
MOD_NEK2_1	38	43	PF00069	0.580
MOD_NEK2_1	50	55	PF00069	0.339
MOD_NEK2_1	57	62	PF00069	0.187
MOD_PIKK_1	74	80	PF00454	0.422
MOD_PKA_2	15	21	PF00069	0.702
MOD_Plk_1	88	94	PF00069	0.373
MOD_Plk_4	66	72	PF00069	0.536
MOD_ProDKin_1	78	84	PF00069	0.405
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.289
TRG_ENDOCYTIC_2	105	108	PF00928	0.344
TRG_ER_diArg_1	105	107	PF00400	0.391
TRG_ER_diArg_1	15	17	PF00400	0.731

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I957	Leptomonas seymouri	76%	94%
A0A0S4IP38	Bodo saltans	45%	96%
A0A1X0P6V0	Trypanosomatidae	62%	87%
A0A3R7NTE7	Trypanosoma rangeli	62%	91%
A0A3S7X546	Leishmania donovani	100%	100%
A4HJZ9	Leishmania braziliensis	78%	100%
D0A085	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	97%
E9B2D9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q5R7	Leishmania major	92%	100%