LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I7I0_LEIIN
TriTrypDb:
LINF_320006700
Length:
91

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0020023 kinetoplast 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I7I0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7I0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 51 53 PF00675 0.604
CLV_NRD_NRD_1 68 70 PF00675 0.398
DEG_Nend_Nbox_1 1 3 PF02207 0.545
DOC_WW_Pin1_4 81 86 PF00397 0.617
LIG_14-3-3_CterR_2 87 91 PF00244 0.525
LIG_FHA_1 55 61 PF00498 0.526
LIG_FHA_2 61 67 PF00498 0.561
LIG_LIR_Gen_1 40 49 PF02991 0.485
LIG_LIR_Nem_3 50 54 PF02991 0.459
LIG_SH2_CRK 51 55 PF00017 0.464
LIG_SH2_STAP1 7 11 PF00017 0.451
MOD_CDC14_SPxK_1 84 87 PF00782 0.500
MOD_CDK_SPxK_1 81 87 PF00069 0.489
MOD_CK2_1 17 23 PF00069 0.567
MOD_CK2_1 34 40 PF00069 0.513
MOD_CK2_1 60 66 PF00069 0.524
MOD_Cter_Amidation 15 18 PF01082 0.516
MOD_GlcNHglycan 11 14 PF01048 0.525
MOD_GlcNHglycan 36 39 PF01048 0.448
MOD_GSK3_1 77 84 PF00069 0.654
MOD_N-GLC_2 73 75 PF02516 0.528
MOD_NEK2_1 1 6 PF00069 0.646
MOD_NEK2_1 54 59 PF00069 0.506
MOD_NEK2_1 77 82 PF00069 0.575
MOD_PKA_1 17 23 PF00069 0.522
MOD_ProDKin_1 81 87 PF00069 0.621
TRG_ENDOCYTIC_2 41 44 PF00928 0.409
TRG_ENDOCYTIC_2 51 54 PF00928 0.418
TRG_Pf-PMV_PEXEL_1 52 56 PF00026 0.531

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8J9 Leptomonas seymouri 76% 96%
A0A0S4ISH5 Bodo saltans 51% 99%
A0A1X0P6S9 Trypanosomatidae 56% 76%
A0A3Q8IGP9 Leishmania donovani 98% 100%
A0A422P0X8 Trypanosoma rangeli 55% 82%
A4HJZ7 Leishmania braziliensis 87% 99%
D0A083 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 94%
E9B2D7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4Q5R9 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS