LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I7H9_LEIIN
TriTrypDb:
LINF_320006600
Length:
386

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I7H9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7H9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 19 23 PF00656 0.702
CLV_NRD_NRD_1 161 163 PF00675 0.816
CLV_NRD_NRD_1 199 201 PF00675 0.710
CLV_NRD_NRD_1 241 243 PF00675 0.731
CLV_NRD_NRD_1 350 352 PF00675 0.805
CLV_PCSK_FUR_1 197 201 PF00082 0.709
CLV_PCSK_FUR_1 70 74 PF00082 0.642
CLV_PCSK_KEX2_1 199 201 PF00082 0.653
CLV_PCSK_KEX2_1 241 243 PF00082 0.729
CLV_PCSK_KEX2_1 346 348 PF00082 0.791
CLV_PCSK_KEX2_1 368 370 PF00082 0.708
CLV_PCSK_KEX2_1 69 71 PF00082 0.780
CLV_PCSK_KEX2_1 72 74 PF00082 0.734
CLV_PCSK_KEX2_1 75 77 PF00082 0.690
CLV_PCSK_KEX2_1 80 82 PF00082 0.569
CLV_PCSK_PC1ET2_1 346 348 PF00082 0.791
CLV_PCSK_PC1ET2_1 368 370 PF00082 0.708
CLV_PCSK_PC1ET2_1 69 71 PF00082 0.780
CLV_PCSK_PC1ET2_1 72 74 PF00082 0.734
CLV_PCSK_PC1ET2_1 75 77 PF00082 0.690
CLV_PCSK_PC1ET2_1 80 82 PF00082 0.569
CLV_PCSK_PC7_1 76 82 PF00082 0.793
CLV_PCSK_SKI1_1 337 341 PF00082 0.707
CLV_PCSK_SKI1_1 372 376 PF00082 0.679
CLV_PCSK_SKI1_1 66 70 PF00082 0.731
CLV_PCSK_SKI1_1 72 76 PF00082 0.555
DEG_Nend_UBRbox_2 1 3 PF02207 0.745
DEG_SPOP_SBC_1 23 27 PF00917 0.666
DEG_SPOP_SBC_1 305 309 PF00917 0.542
DOC_ANK_TNKS_1 143 150 PF00023 0.755
DOC_MAPK_gen_1 80 87 PF00069 0.637
DOC_MAPK_MEF2A_6 171 179 PF00069 0.726
DOC_MAPK_MEF2A_6 80 87 PF00069 0.616
DOC_PP4_FxxP_1 331 334 PF00568 0.780
DOC_USP7_MATH_1 138 142 PF00917 0.809
DOC_USP7_MATH_1 23 27 PF00917 0.688
DOC_USP7_MATH_1 277 281 PF00917 0.741
DOC_USP7_MATH_1 339 343 PF00917 0.705
DOC_USP7_MATH_1 83 87 PF00917 0.736
DOC_USP7_UBL2_3 163 167 PF12436 0.765
DOC_WW_Pin1_4 224 229 PF00397 0.655
DOC_WW_Pin1_4 306 311 PF00397 0.825
DOC_WW_Pin1_4 56 61 PF00397 0.791
LIG_14-3-3_CanoR_1 101 108 PF00244 0.557
LIG_14-3-3_CanoR_1 183 192 PF00244 0.735
LIG_14-3-3_CanoR_1 84 88 PF00244 0.653
LIG_deltaCOP1_diTrp_1 267 273 PF00928 0.661
LIG_FHA_1 150 156 PF00498 0.635
LIG_FHA_2 193 199 PF00498 0.645
LIG_FHA_2 225 231 PF00498 0.661
LIG_HP1_1 83 87 PF01393 0.619
LIG_LIR_Nem_3 2 7 PF02991 0.746
LIG_MYND_1 60 64 PF01753 0.759
LIG_Pex14_1 269 273 PF04695 0.662
LIG_PTAP_UEV_1 17 22 PF05743 0.694
LIG_SH2_CRK 202 206 PF00017 0.704
LIG_SH2_NCK_1 274 278 PF00017 0.752
LIG_SH2_SRC 7 10 PF00017 0.574
LIG_SH2_STAP1 274 278 PF00017 0.565
LIG_SH2_STAT5 274 277 PF00017 0.750
LIG_SH2_STAT5 4 7 PF00017 0.750
LIG_SH3_2 64 69 PF14604 0.707
LIG_SH3_3 105 111 PF00018 0.737
LIG_SH3_3 11 17 PF00018 0.775
LIG_SH3_3 205 211 PF00018 0.733
LIG_SH3_3 54 60 PF00018 0.660
LIG_SH3_3 61 67 PF00018 0.666
LIG_SUMO_SIM_par_1 175 180 PF11976 0.801
LIG_SUMO_SIM_par_1 7 13 PF11976 0.580
LIG_TRAF2_1 10 13 PF00917 0.771
LIG_WRC_WIRS_1 270 275 PF05994 0.603
LIG_WRC_WIRS_1 340 345 PF05994 0.781
LIG_WRPW_2 65 68 PF00400 0.594
MOD_CDK_SPxxK_3 306 313 PF00069 0.830
MOD_CK1_1 169 175 PF00069 0.615
MOD_CK1_1 27 33 PF00069 0.787
MOD_CK1_1 272 278 PF00069 0.743
MOD_CK1_1 45 51 PF00069 0.674
MOD_CK2_1 224 230 PF00069 0.663
MOD_GlcNHglycan 103 106 PF01048 0.754
MOD_GlcNHglycan 139 143 PF01048 0.717
MOD_GlcNHglycan 171 174 PF01048 0.719
MOD_GlcNHglycan 18 21 PF01048 0.772
MOD_GlcNHglycan 251 254 PF01048 0.729
MOD_GlcNHglycan 29 32 PF01048 0.694
MOD_GlcNHglycan 293 296 PF01048 0.637
MOD_GlcNHglycan 326 329 PF01048 0.634
MOD_GlcNHglycan 378 381 PF01048 0.728
MOD_GlcNHglycan 383 386 PF01048 0.676
MOD_GlcNHglycan 46 50 PF01048 0.501
MOD_GSK3_1 110 117 PF00069 0.784
MOD_GSK3_1 23 30 PF00069 0.727
MOD_GSK3_1 245 252 PF00069 0.647
MOD_GSK3_1 268 275 PF00069 0.716
MOD_GSK3_1 291 298 PF00069 0.784
MOD_GSK3_1 320 327 PF00069 0.663
MOD_GSK3_1 35 42 PF00069 0.611
MOD_LATS_1 99 105 PF00433 0.746
MOD_N-GLC_1 222 227 PF02516 0.805
MOD_NEK2_1 273 278 PF00069 0.630
MOD_NEK2_1 312 317 PF00069 0.834
MOD_NEK2_1 338 343 PF00069 0.642
MOD_NEK2_1 357 362 PF00069 0.583
MOD_NEK2_2 269 274 PF00069 0.715
MOD_OFUCOSY 191 196 PF10250 0.617
MOD_PIKK_1 245 251 PF00454 0.631
MOD_PIKK_1 357 363 PF00454 0.829
MOD_PKA_2 244 250 PF00069 0.824
MOD_PKA_2 312 318 PF00069 0.831
MOD_PKA_2 35 41 PF00069 0.765
MOD_PKA_2 364 370 PF00069 0.758
MOD_PKA_2 83 89 PF00069 0.667
MOD_Plk_1 222 228 PF00069 0.725
MOD_Plk_4 123 129 PF00069 0.816
MOD_Plk_4 269 275 PF00069 0.592
MOD_Plk_4 295 301 PF00069 0.808
MOD_Plk_4 320 326 PF00069 0.801
MOD_ProDKin_1 224 230 PF00069 0.660
MOD_ProDKin_1 306 312 PF00069 0.827
MOD_ProDKin_1 56 62 PF00069 0.789
MOD_SUMO_rev_2 252 262 PF00179 0.670
MOD_SUMO_rev_2 341 348 PF00179 0.716
TRG_ENDOCYTIC_2 202 205 PF00928 0.701
TRG_ER_diArg_1 240 242 PF00400 0.732
TRG_ER_diArg_1 33 36 PF00400 0.764
TRG_NLS_MonoExtC_3 68 73 PF00514 0.643
TRG_NLS_MonoExtN_4 66 73 PF00514 0.711

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ICV9 Leishmania donovani 98% 100%
A4HJZ6 Leishmania braziliensis 61% 98%
E9B2D6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4Q5S0 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS