Armadillo/beta-catenin-like repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Armadillo/beta-catenin-like repeat - putative

Species:

Leishmania infantum

UniProt:

A4I7H7_LEIIN

TriTrypDb:

LINF_320006400

Length:

1042

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4I7H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7H7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.632
CLV_C14_Caspase3-7	481	485	PF00656	0.485
CLV_C14_Caspase3-7	508	512	PF00656	0.369
CLV_C14_Caspase3-7	894	898	PF00656	0.540
CLV_NRD_NRD_1	1026	1028	PF00675	0.429
CLV_NRD_NRD_1	170	172	PF00675	0.627
CLV_NRD_NRD_1	350	352	PF00675	0.398
CLV_NRD_NRD_1	485	487	PF00675	0.444
CLV_NRD_NRD_1	581	583	PF00675	0.403
CLV_NRD_NRD_1	596	598	PF00675	0.470
CLV_NRD_NRD_1	93	95	PF00675	0.544
CLV_PCSK_FUR_1	168	172	PF00082	0.684
CLV_PCSK_KEX2_1	1026	1028	PF00082	0.429
CLV_PCSK_KEX2_1	140	142	PF00082	0.762
CLV_PCSK_KEX2_1	170	172	PF00082	0.602
CLV_PCSK_KEX2_1	661	663	PF00082	0.750
CLV_PCSK_KEX2_1	93	95	PF00082	0.544
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.762
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.750
CLV_PCSK_PC7_1	89	95	PF00082	0.620
CLV_PCSK_SKI1_1	106	110	PF00082	0.598
CLV_PCSK_SKI1_1	352	356	PF00082	0.476
CLV_PCSK_SKI1_1	414	418	PF00082	0.370
CLV_PCSK_SKI1_1	578	582	PF00082	0.541
CLV_PCSK_SKI1_1	965	969	PF00082	0.522
CLV_Separin_Metazoa	500	504	PF03568	0.444
DEG_APCC_DBOX_1	193	201	PF00400	0.639
DEG_APCC_DBOX_1	413	421	PF00400	0.391
DEG_APCC_DBOX_1	485	493	PF00400	0.344
DEG_Nend_UBRbox_3	1	3	PF02207	0.571
DEG_SCF_FBW7_1	761	768	PF00400	0.469
DEG_SPOP_SBC_1	14	18	PF00917	0.450
DEG_SPOP_SBC_1	551	555	PF00917	0.351
DOC_CDC14_PxL_1	492	500	PF14671	0.344
DOC_CDC14_PxL_1	542	550	PF14671	0.444
DOC_CKS1_1	762	767	PF01111	0.580
DOC_CYCLIN_yCln2_LP_2	730	736	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	767	773	PF00134	0.514
DOC_MAPK_gen_1	102	113	PF00069	0.600
DOC_MAPK_gen_1	582	589	PF00069	0.403
DOC_MAPK_MEF2A_6	102	111	PF00069	0.531
DOC_MAPK_MEF2A_6	582	591	PF00069	0.397
DOC_MAPK_MEF2A_6	640	649	PF00069	0.405
DOC_MAPK_MEF2A_6	801	808	PF00069	0.497
DOC_MAPK_NFAT4_5	106	114	PF00069	0.526
DOC_MAPK_RevD_3	647	661	PF00069	0.377
DOC_PP1_RVXF_1	376	383	PF00149	0.468
DOC_PP1_RVXF_1	990	997	PF00149	0.448
DOC_PP2B_LxvP_1	209	212	PF13499	0.475
DOC_PP2B_LxvP_1	730	733	PF13499	0.573
DOC_PP2B_LxvP_1	734	737	PF13499	0.535
DOC_PP2B_LxvP_1	767	770	PF13499	0.523
DOC_PP4_FxxP_1	326	329	PF00568	0.461
DOC_PP4_FxxP_1	762	765	PF00568	0.532
DOC_PP4_FxxP_1	829	832	PF00568	0.618
DOC_USP7_MATH_1	1028	1032	PF00917	0.495
DOC_USP7_MATH_1	131	135	PF00917	0.706
DOC_USP7_MATH_1	199	203	PF00917	0.550
DOC_USP7_MATH_1	239	243	PF00917	0.540
DOC_USP7_MATH_1	25	29	PF00917	0.606
DOC_USP7_MATH_1	275	279	PF00917	0.597
DOC_USP7_MATH_1	282	286	PF00917	0.553
DOC_USP7_MATH_1	340	344	PF00917	0.553
DOC_USP7_MATH_1	464	468	PF00917	0.436
DOC_USP7_MATH_1	50	54	PF00917	0.502
DOC_USP7_MATH_1	602	606	PF00917	0.630
DOC_USP7_MATH_1	607	611	PF00917	0.704
DOC_USP7_MATH_1	705	709	PF00917	0.450
DOC_USP7_MATH_1	718	722	PF00917	0.507
DOC_USP7_MATH_1	763	767	PF00917	0.589
DOC_USP7_MATH_1	884	888	PF00917	0.389
DOC_USP7_MATH_1	924	928	PF00917	0.687
DOC_USP7_MATH_1	967	971	PF00917	0.446
DOC_USP7_MATH_1	999	1003	PF00917	0.456
DOC_USP7_UBL2_3	102	106	PF12436	0.499
DOC_USP7_UBL2_3	1038	1042	PF12436	0.604
DOC_USP7_UBL2_3	58	62	PF12436	0.586
DOC_USP7_UBL2_3	722	726	PF12436	0.642
DOC_WW_Pin1_4	129	134	PF00397	0.692
DOC_WW_Pin1_4	161	166	PF00397	0.609
DOC_WW_Pin1_4	189	194	PF00397	0.666
DOC_WW_Pin1_4	276	281	PF00397	0.572
DOC_WW_Pin1_4	665	670	PF00397	0.725
DOC_WW_Pin1_4	687	692	PF00397	0.405
DOC_WW_Pin1_4	711	716	PF00397	0.502
DOC_WW_Pin1_4	761	766	PF00397	0.561
DOC_WW_Pin1_4	851	856	PF00397	0.583
DOC_WW_Pin1_4	867	872	PF00397	0.451
LIG_14-3-3_CanoR_1	1019	1025	PF00244	0.537
LIG_14-3-3_CanoR_1	1027	1033	PF00244	0.512
LIG_14-3-3_CanoR_1	604	612	PF00244	0.553
LIG_14-3-3_CanoR_1	662	669	PF00244	0.673
LIG_14-3-3_CanoR_1	782	788	PF00244	0.402
LIG_14-3-3_CanoR_1	944	949	PF00244	0.406
LIG_BIR_III_4	122	126	PF00653	0.665
LIG_FHA_1	307	313	PF00498	0.394
LIG_FHA_1	332	338	PF00498	0.503
LIG_FHA_1	420	426	PF00498	0.420
LIG_FHA_1	456	462	PF00498	0.435
LIG_FHA_1	609	615	PF00498	0.555
LIG_FHA_1	681	687	PF00498	0.387
LIG_FHA_1	705	711	PF00498	0.428
LIG_FHA_1	738	744	PF00498	0.644
LIG_FHA_1	762	768	PF00498	0.518
LIG_FHA_2	386	392	PF00498	0.527
LIG_FHA_2	437	443	PF00498	0.408
LIG_FHA_2	506	512	PF00498	0.447
LIG_FHA_2	687	693	PF00498	0.544
LIG_FHA_2	784	790	PF00498	0.405
LIG_FHA_2	80	86	PF00498	0.644
LIG_LIR_Apic_2	325	329	PF02991	0.466
LIG_LIR_Apic_2	827	832	PF02991	0.648
LIG_LIR_Gen_1	514	523	PF02991	0.405
LIG_LIR_Gen_1	704	712	PF02991	0.494
LIG_LIR_Gen_1	71	81	PF02991	0.530
LIG_LIR_Gen_1	931	941	PF02991	0.409
LIG_LIR_Nem_3	1002	1006	PF02991	0.259
LIG_LIR_Nem_3	242	246	PF02991	0.529
LIG_LIR_Nem_3	289	295	PF02991	0.433
LIG_LIR_Nem_3	514	518	PF02991	0.405
LIG_LIR_Nem_3	541	545	PF02991	0.344
LIG_LIR_Nem_3	704	709	PF02991	0.488
LIG_LIR_Nem_3	71	77	PF02991	0.527
LIG_LIR_Nem_3	729	734	PF02991	0.519
LIG_LIR_Nem_3	931	937	PF02991	0.426
LIG_LYPXL_yS_3	243	246	PF13949	0.568
LIG_MYND_3	425	429	PF01753	0.491
LIG_NRBOX	204	210	PF00104	0.534
LIG_NRBOX	307	313	PF00104	0.470
LIG_NRBOX	382	388	PF00104	0.398
LIG_NRBOX	497	503	PF00104	0.369
LIG_NRBOX	589	595	PF00104	0.496
LIG_NRBOX	936	942	PF00104	0.380
LIG_PCNA_PIPBox_1	250	259	PF02747	0.571
LIG_PCNA_yPIPBox_3	283	295	PF02747	0.511
LIG_PTB_Apo_2	509	516	PF02174	0.408
LIG_PTB_Phospho_1	509	515	PF10480	0.408
LIG_SH2_CRK	542	546	PF00017	0.344
LIG_SH2_CRK	74	78	PF00017	0.467
LIG_SH2_CRK	934	938	PF00017	0.400
LIG_SH2_NCK_1	811	815	PF00017	0.461
LIG_SH2_SRC	811	814	PF00017	0.432
LIG_SH2_STAP1	421	425	PF00017	0.432
LIG_SH2_STAP1	752	756	PF00017	0.443
LIG_SH2_STAT3	226	229	PF00017	0.467
LIG_SH2_STAT3	274	277	PF00017	0.581
LIG_SH2_STAT5	1003	1006	PF00017	0.505
LIG_SH2_STAT5	112	115	PF00017	0.599
LIG_SH2_STAT5	226	229	PF00017	0.506
LIG_SH2_STAT5	421	424	PF00017	0.432
LIG_SH2_STAT5	437	440	PF00017	0.391
LIG_SH2_STAT5	656	659	PF00017	0.581
LIG_SH3_2	599	604	PF14604	0.629
LIG_SH3_3	130	136	PF00018	0.724
LIG_SH3_3	166	172	PF00018	0.725
LIG_SH3_3	238	244	PF00018	0.550
LIG_SH3_3	257	263	PF00018	0.447
LIG_SH3_3	596	602	PF00018	0.576
LIG_SH3_3	668	674	PF00018	0.626
LIG_SH3_3	868	874	PF00018	0.445
LIG_SUMO_SIM_anti_2	10	20	PF11976	0.556
LIG_SUMO_SIM_anti_2	245	251	PF11976	0.510
LIG_SUMO_SIM_anti_2	557	562	PF11976	0.351
LIG_SUMO_SIM_par_1	10	20	PF11976	0.495
LIG_SUMO_SIM_par_1	365	373	PF11976	0.499
LIG_SUMO_SIM_par_1	545	550	PF11976	0.444
LIG_SUMO_SIM_par_1	68	73	PF11976	0.586
LIG_SUMO_SIM_par_1	865	870	PF11976	0.482
LIG_TRAF2_1	17	20	PF00917	0.567
LIG_TRAF2_1	747	750	PF00917	0.285
LIG_TYR_ITIM	540	545	PF00017	0.344
LIG_TYR_ITIM	72	77	PF00017	0.465
LIG_UBA3_1	1032	1041	PF00899	0.542
LIG_UBA3_1	208	215	PF00899	0.470
LIG_UBA3_1	590	598	PF00899	0.420
LIG_WRC_WIRS_1	26	31	PF05994	0.549
MOD_CDK_SPK_2	189	194	PF00069	0.732
MOD_CDK_SPK_2	851	856	PF00069	0.503
MOD_CDK_SPxxK_3	161	168	PF00069	0.731
MOD_CDK_SPxxK_3	276	283	PF00069	0.644
MOD_CDK_SPxxK_3	687	694	PF00069	0.401
MOD_CK1_1	1021	1027	PF00069	0.467
MOD_CK1_1	164	170	PF00069	0.689
MOD_CK1_1	192	198	PF00069	0.636
MOD_CK1_1	255	261	PF00069	0.599
MOD_CK1_1	402	408	PF00069	0.504
MOD_CK1_1	467	473	PF00069	0.402
MOD_CK1_1	530	536	PF00069	0.429
MOD_CK1_1	554	560	PF00069	0.408
MOD_CK1_1	603	609	PF00069	0.588
MOD_CK1_1	670	676	PF00069	0.607
MOD_CK1_1	713	719	PF00069	0.430
MOD_CK1_1	886	892	PF00069	0.430
MOD_CK1_1	927	933	PF00069	0.573
MOD_CK2_1	1012	1018	PF00069	0.561
MOD_CK2_1	1034	1040	PF00069	0.369
MOD_CK2_1	14	20	PF00069	0.492
MOD_CK2_1	367	373	PF00069	0.511
MOD_CK2_1	385	391	PF00069	0.489
MOD_CK2_1	441	447	PF00069	0.435
MOD_CK2_1	686	692	PF00069	0.565
MOD_CK2_1	7	13	PF00069	0.524
MOD_CK2_1	705	711	PF00069	0.263
MOD_CK2_1	783	789	PF00069	0.424
MOD_CK2_1	79	85	PF00069	0.653
MOD_GlcNHglycan	179	183	PF01048	0.601
MOD_GlcNHglycan	194	197	PF01048	0.637
MOD_GlcNHglycan	284	287	PF01048	0.634
MOD_GlcNHglycan	346	349	PF01048	0.410
MOD_GlcNHglycan	52	55	PF01048	0.575
MOD_GlcNHglycan	564	567	PF01048	0.344
MOD_GlcNHglycan	571	574	PF01048	0.344
MOD_GlcNHglycan	663	666	PF01048	0.757
MOD_GlcNHglycan	752	755	PF01048	0.531
MOD_GlcNHglycan	841	844	PF01048	0.398
MOD_GlcNHglycan	905	908	PF01048	0.526
MOD_GlcNHglycan	965	968	PF01048	0.534
MOD_GlcNHglycan	969	972	PF01048	0.494
MOD_GSK3_1	1014	1021	PF00069	0.534
MOD_GSK3_1	32	39	PF00069	0.565
MOD_GSK3_1	340	347	PF00069	0.475
MOD_GSK3_1	395	402	PF00069	0.683
MOD_GSK3_1	550	557	PF00069	0.329
MOD_GSK3_1	603	610	PF00069	0.561
MOD_GSK3_1	661	668	PF00069	0.713
MOD_GSK3_1	761	768	PF00069	0.594
MOD_GSK3_1	820	827	PF00069	0.638
MOD_GSK3_1	924	931	PF00069	0.603
MOD_GSK3_1	959	966	PF00069	0.503
MOD_N-GLC_1	429	434	PF02516	0.470
MOD_N-GLC_1	511	516	PF02516	0.445
MOD_N-GLC_1	527	532	PF02516	0.265
MOD_N-GLC_1	562	567	PF02516	0.344
MOD_N-GLC_1	569	574	PF02516	0.344
MOD_N-GLC_1	63	68	PF02516	0.567
MOD_N-GLC_1	782	787	PF02516	0.397
MOD_N-GLC_1	944	949	PF02516	0.406
MOD_N-GLC_2	993	995	PF02516	0.391
MOD_NEK2_1	1012	1017	PF00069	0.534
MOD_NEK2_1	311	316	PF00069	0.404
MOD_NEK2_1	36	41	PF00069	0.554
MOD_NEK2_1	552	557	PF00069	0.444
MOD_NEK2_1	680	685	PF00069	0.409
MOD_NEK2_1	710	715	PF00069	0.398
MOD_NEK2_1	836	841	PF00069	0.402
MOD_NEK2_2	464	469	PF00069	0.532
MOD_NEK2_2	939	944	PF00069	0.478
MOD_PIKK_1	224	230	PF00454	0.535
MOD_PIKK_1	402	408	PF00454	0.504
MOD_PIKK_1	831	837	PF00454	0.541
MOD_PIKK_1	87	93	PF00454	0.622
MOD_PIKK_1	96	102	PF00454	0.595
MOD_PKA_1	661	667	PF00069	0.758
MOD_PKA_2	1018	1024	PF00069	0.475
MOD_PKA_2	282	288	PF00069	0.608
MOD_PKA_2	603	609	PF00069	0.560
MOD_PKA_2	661	667	PF00069	0.758
MOD_Plk_1	399	405	PF00069	0.566
MOD_Plk_1	429	435	PF00069	0.469
MOD_Plk_1	511	517	PF00069	0.417
MOD_Plk_1	527	533	PF00069	0.227
MOD_Plk_1	782	788	PF00069	0.402
MOD_Plk_1	79	85	PF00069	0.641
MOD_Plk_1	944	950	PF00069	0.477
MOD_Plk_2-3	116	122	PF00069	0.618
MOD_Plk_2-3	32	38	PF00069	0.530
MOD_Plk_2-3	511	517	PF00069	0.444
MOD_Plk_2-3	7	13	PF00069	0.540
MOD_Plk_2-3	977	983	PF00069	0.515
MOD_Plk_4	1028	1034	PF00069	0.504
MOD_Plk_4	116	122	PF00069	0.618
MOD_Plk_4	214	220	PF00069	0.417
MOD_Plk_4	294	300	PF00069	0.458
MOD_Plk_4	429	435	PF00069	0.469
MOD_Plk_4	564	570	PF00069	0.371
MOD_Plk_4	680	686	PF00069	0.402
MOD_Plk_4	7	13	PF00069	0.510
MOD_Plk_4	705	711	PF00069	0.484
MOD_Plk_4	726	732	PF00069	0.558
MOD_Plk_4	738	744	PF00069	0.621
MOD_Plk_4	812	818	PF00069	0.547
MOD_Plk_4	872	878	PF00069	0.427
MOD_Plk_4	999	1005	PF00069	0.396
MOD_ProDKin_1	129	135	PF00069	0.694
MOD_ProDKin_1	161	167	PF00069	0.616
MOD_ProDKin_1	189	195	PF00069	0.662
MOD_ProDKin_1	276	282	PF00069	0.584
MOD_ProDKin_1	665	671	PF00069	0.718
MOD_ProDKin_1	687	693	PF00069	0.400
MOD_ProDKin_1	711	717	PF00069	0.503
MOD_ProDKin_1	761	767	PF00069	0.558
MOD_ProDKin_1	851	857	PF00069	0.583
MOD_ProDKin_1	867	873	PF00069	0.448
MOD_SUMO_for_1	319	322	PF00179	0.378
MOD_SUMO_for_1	57	60	PF00179	0.597
MOD_SUMO_rev_2	530	537	PF00179	0.344
MOD_SUMO_rev_2	55	63	PF00179	0.579
MOD_SUMO_rev_2	690	696	PF00179	0.405
MOD_SUMO_rev_2	848	854	PF00179	0.476
MOD_SUMO_rev_2	959	967	PF00179	0.547
TRG_DiLeu_BaEn_1	116	121	PF01217	0.640
TRG_DiLeu_BaEn_1	333	338	PF01217	0.504
TRG_DiLeu_BaEn_1	7	12	PF01217	0.538
TRG_DiLeu_BaEn_2	321	327	PF01217	0.459
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.497
TRG_ENDOCYTIC_2	1003	1006	PF00928	0.256
TRG_ENDOCYTIC_2	243	246	PF00928	0.526
TRG_ENDOCYTIC_2	515	518	PF00928	0.369
TRG_ENDOCYTIC_2	542	545	PF00928	0.344
TRG_ENDOCYTIC_2	74	77	PF00928	0.467
TRG_ENDOCYTIC_2	934	937	PF00928	0.405
TRG_ENDOCYTIC_2	958	961	PF00928	0.558
TRG_ER_diArg_1	1025	1027	PF00400	0.430
TRG_ER_diArg_1	168	171	PF00400	0.600
TRG_ER_diArg_1	93	95	PF00400	0.576
TRG_NES_CRM1_1	409	423	PF08389	0.503
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEV7	Leptomonas seymouri	77%	98%
A0A1X0P6M1	Trypanosomatidae	43%	91%
A0A3Q8IFW8	Leishmania donovani	99%	100%
A0A3R7KX09	Trypanosoma rangeli	45%	96%
A4HJZ4	Leishmania braziliensis	85%	100%
D0A079	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	92%
E9B2D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q5S2	Leishmania major	95%	100%