Skp1 domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7H6_LEIIN

TriTrypDb:

LINF_320006300

Length:

239

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I7H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7H6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.393
CLV_NRD_NRD_1	76	78	PF00675	0.584
CLV_PCSK_KEX2_1	162	164	PF00082	0.582
CLV_PCSK_KEX2_1	76	78	PF00082	0.582
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.582
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.582
CLV_PCSK_SKI1_1	187	191	PF00082	0.348
CLV_PCSK_SKI1_1	205	209	PF00082	0.419
CLV_Separin_Metazoa	184	188	PF03568	0.358
DEG_APCC_DBOX_1	121	129	PF00400	0.405
DOC_CDC14_PxL_1	226	234	PF14671	0.527
DOC_CYCLIN_RxL_1	101	111	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	85	88	PF00134	0.561
DOC_MAPK_MEF2A_6	12	19	PF00069	0.475
DOC_PP2B_LxvP_1	121	124	PF13499	0.406
DOC_PP2B_LxvP_1	85	88	PF13499	0.561
DOC_PP4_FxxP_1	231	234	PF00568	0.423
DOC_USP7_MATH_1	37	41	PF00917	0.477
LIG_14-3-3_CanoR_1	163	169	PF00244	0.549
LIG_FHA_1	133	139	PF00498	0.453
LIG_FHA_1	188	194	PF00498	0.490
LIG_FHA_2	216	222	PF00498	0.424
LIG_FHA_2	3	9	PF00498	0.717
LIG_LIR_Gen_1	179	186	PF02991	0.345
LIG_LIR_Gen_1	223	234	PF02991	0.445
LIG_LIR_Gen_1	29	37	PF02991	0.397
LIG_LIR_Nem_3	100	106	PF02991	0.420
LIG_LIR_Nem_3	179	183	PF02991	0.356
LIG_LIR_Nem_3	223	229	PF02991	0.416
LIG_LIR_Nem_3	29	35	PF02991	0.393
LIG_MYND_1	230	234	PF01753	0.390
LIG_NRBOX	59	65	PF00104	0.442
LIG_Pex14_1	132	136	PF04695	0.344
LIG_SH2_CRK	226	230	PF00017	0.499
LIG_SH2_PTP2	32	35	PF00017	0.405
LIG_SH2_STAT5	105	108	PF00017	0.324
LIG_SH2_STAT5	136	139	PF00017	0.468
LIG_SH2_STAT5	18	21	PF00017	0.493
LIG_SH2_STAT5	32	35	PF00017	0.362
LIG_SH3_3	86	92	PF00018	0.409
LIG_TRAF2_1	124	127	PF00917	0.401
LIG_TRAF2_1	218	221	PF00917	0.456
MOD_CK1_1	200	206	PF00069	0.535
MOD_CK2_1	200	206	PF00069	0.393
MOD_CK2_1	215	221	PF00069	0.430
MOD_GlcNHglycan	152	155	PF01048	0.465
MOD_GlcNHglycan	199	202	PF01048	0.547
MOD_GlcNHglycan	39	42	PF01048	0.480
MOD_GlcNHglycan	8	12	PF01048	0.622
MOD_GSK3_1	108	115	PF00069	0.383
MOD_GSK3_1	193	200	PF00069	0.447
MOD_GSK3_1	63	70	PF00069	0.432
MOD_NEK2_1	108	113	PF00069	0.398
MOD_NEK2_1	156	161	PF00069	0.455
MOD_NEK2_1	193	198	PF00069	0.353
MOD_NEK2_1	63	68	PF00069	0.373
MOD_PKB_1	24	32	PF00069	0.501
MOD_Plk_1	132	138	PF00069	0.312
MOD_Plk_1	42	48	PF00069	0.418
MOD_Plk_4	112	118	PF00069	0.444
MOD_Plk_4	132	138	PF00069	0.312
MOD_Plk_4	63	69	PF00069	0.377
TRG_DiLeu_BaEn_1	133	138	PF01217	0.337
TRG_DiLeu_BaEn_4	220	226	PF01217	0.438
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.368
TRG_ENDOCYTIC_2	105	108	PF00928	0.324
TRG_ENDOCYTIC_2	226	229	PF00928	0.420
TRG_ENDOCYTIC_2	32	35	PF00928	0.346
TRG_NES_CRM1_1	166	179	PF08389	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P1	Leptomonas seymouri	81%	100%
A0A1X0P7H5	Trypanosomatidae	44%	77%
A0A3S7X513	Leishmania donovani	100%	100%
A0A422P0X4	Trypanosoma rangeli	41%	75%
A4HJZ3	Leishmania braziliensis	87%	100%
D0A078	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	71%
E9B2D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q5S3	Leishmania major	95%	100%
V5DTE4	Trypanosoma cruzi	45%	75%