Putative mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein - putative

Species:

Leishmania infantum

UniProt:

A4I7H4_LEIIN

TriTrypDb:

LINF_320006100

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

A4I7H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7H4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity	4	1
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015101	organic cation transmembrane transporter activity	5	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901682	sulfur compound transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	243	245	PF00675	0.273
CLV_PCSK_KEX2_1	243	245	PF00082	0.273
CLV_PCSK_KEX2_1	69	71	PF00082	0.558
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.558
CLV_PCSK_SKI1_1	138	142	PF00082	0.299
CLV_PCSK_SKI1_1	238	242	PF00082	0.270
CLV_PCSK_SKI1_1	254	258	PF00082	0.287
CLV_PCSK_SKI1_1	69	73	PF00082	0.538
DEG_APCC_DBOX_1	253	261	PF00400	0.541
DEG_Nend_UBRbox_2	1	3	PF02207	0.270
DOC_AGCK_PIF_2	296	301	PF00069	0.465
DOC_CKS1_1	228	233	PF01111	0.324
DOC_CYCLIN_RxL_1	179	187	PF00134	0.423
DOC_CYCLIN_RxL_1	66	74	PF00134	0.290
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.359
DOC_MAPK_gen_1	69	75	PF00069	0.446
DOC_PP1_RVXF_1	282	288	PF00149	0.348
DOC_PP2B_LxvP_1	148	151	PF13499	0.577
DOC_PP2B_LxvP_1	212	215	PF13499	0.418
DOC_PP2B_LxvP_1	75	78	PF13499	0.465
DOC_USP7_MATH_1	208	212	PF00917	0.424
DOC_USP7_MATH_1	51	55	PF00917	0.324
DOC_USP7_MATH_1	76	80	PF00917	0.388
DOC_WW_Pin1_4	143	148	PF00397	0.476
DOC_WW_Pin1_4	227	232	PF00397	0.324
DOC_WW_Pin1_4	90	95	PF00397	0.464
LIG_14-3-3_CanoR_1	202	209	PF00244	0.376
LIG_14-3-3_CanoR_1	279	288	PF00244	0.507
LIG_14-3-3_CanoR_1	70	76	PF00244	0.422
LIG_BRCT_BRCA1_1	212	216	PF00533	0.370
LIG_BRCT_BRCA1_1	292	296	PF00533	0.324
LIG_BRCT_BRCA1_1	36	40	PF00533	0.574
LIG_CtBP_PxDLS_1	117	121	PF00389	0.541
LIG_eIF4E_1	255	261	PF01652	0.515
LIG_FHA_1	132	138	PF00498	0.533
LIG_FHA_1	144	150	PF00498	0.492
LIG_FHA_1	227	233	PF00498	0.324
LIG_FHA_1	281	287	PF00498	0.411
LIG_FHA_1	91	97	PF00498	0.424
LIG_FHA_2	228	234	PF00498	0.324
LIG_HCF-1_HBM_1	206	209	PF13415	0.481
LIG_LIR_Gen_1	183	194	PF02991	0.343
LIG_LIR_Gen_1	206	216	PF02991	0.448
LIG_LIR_Gen_1	298	306	PF02991	0.301
LIG_LIR_Gen_1	37	47	PF02991	0.445
LIG_LIR_LC3C_4	146	150	PF02991	0.418
LIG_LIR_Nem_3	183	189	PF02991	0.343
LIG_LIR_Nem_3	192	197	PF02991	0.270
LIG_LIR_Nem_3	206	212	PF02991	0.416
LIG_LIR_Nem_3	293	299	PF02991	0.332
LIG_LIR_Nem_3	37	43	PF02991	0.592
LIG_MLH1_MIPbox_1	292	296	PF16413	0.324
LIG_Pex14_2	216	220	PF04695	0.465
LIG_REV1ctd_RIR_1	275	283	PF16727	0.470
LIG_SH2_CRK	209	213	PF00017	0.449
LIG_SH2_CRK	44	48	PF00017	0.324
LIG_SH2_STAP1	273	277	PF00017	0.570
LIG_SH2_STAT5	255	258	PF00017	0.578
LIG_SH3_2	160	165	PF14604	0.510
LIG_SH3_3	155	161	PF00018	0.521
LIG_SH3_3	261	267	PF00018	0.523
LIG_SUMO_SIM_anti_2	229	237	PF11976	0.324
LIG_TRAF2_1	246	249	PF00917	0.554
MOD_CK2_1	189	195	PF00069	0.348
MOD_CK2_1	80	86	PF00069	0.519
MOD_GlcNHglycan	166	169	PF01048	0.309
MOD_GlcNHglycan	220	223	PF01048	0.348
MOD_GlcNHglycan	303	306	PF01048	0.515
MOD_GlcNHglycan	36	39	PF01048	0.318
MOD_GlcNHglycan	47	50	PF01048	0.296
MOD_GlcNHglycan	82	85	PF01048	0.662
MOD_GSK3_1	189	196	PF00069	0.423
MOD_GSK3_1	23	30	PF00069	0.470
MOD_GSK3_1	286	293	PF00069	0.324
MOD_GSK3_1	301	308	PF00069	0.270
MOD_GSK3_1	76	83	PF00069	0.432
MOD_GSK3_1	86	93	PF00069	0.507
MOD_N-GLC_1	138	143	PF02516	0.334
MOD_NEK2_1	193	198	PF00069	0.315
MOD_NEK2_1	286	291	PF00069	0.348
MOD_NEK2_1	301	306	PF00069	0.287
MOD_NEK2_1	34	39	PF00069	0.590
MOD_NEK2_1	71	76	PF00069	0.362
MOD_NEK2_2	20	25	PF00069	0.324
MOD_PKA_2	164	170	PF00069	0.528
MOD_PKA_2	201	207	PF00069	0.367
MOD_Plk_1	14	20	PF00069	0.324
MOD_Plk_1	85	91	PF00069	0.475
MOD_Plk_4	132	138	PF00069	0.522
MOD_Plk_4	14	20	PF00069	0.350
MOD_Plk_4	189	195	PF00069	0.423
MOD_Plk_4	290	296	PF00069	0.332
MOD_Plk_4	92	98	PF00069	0.464
MOD_ProDKin_1	143	149	PF00069	0.476
MOD_ProDKin_1	227	233	PF00069	0.324
MOD_ProDKin_1	90	96	PF00069	0.455
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.276
TRG_ENDOCYTIC_2	194	197	PF00928	0.270
TRG_ENDOCYTIC_2	209	212	PF00928	0.388
TRG_ENDOCYTIC_2	299	302	PF00928	0.287
TRG_ENDOCYTIC_2	44	47	PF00928	0.304
TRG_ER_diArg_1	242	244	PF00400	0.473
TRG_NES_CRM1_1	183	195	PF08389	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K5L2	Rattus norvegicus	26%	97%
A0A0N0P2Z6	Leptomonas seymouri	23%	87%
A0A0N0P8W6	Leptomonas seymouri	26%	92%
A0A0N1HX21	Leptomonas seymouri	24%	81%
A0A0N1I0W9	Leptomonas seymouri	74%	100%
A0A0N1I6I9	Leptomonas seymouri	26%	100%
A0A0N1IMA2	Leptomonas seymouri	25%	96%
A0A0S4IV98	Bodo saltans	25%	100%
A0A0S4JIA4	Bodo saltans	24%	73%
A0A0S4JM95	Bodo saltans	26%	100%
A0A0S4KJX8	Bodo saltans	25%	89%
A0A1X0NJD2	Trypanosomatidae	25%	100%
A0A1X0P4Q9	Trypanosomatidae	28%	100%
A0A1X0P6V9	Trypanosomatidae	53%	100%
A0A1X0P952	Trypanosomatidae	25%	100%
A0A3Q8IFM5	Leishmania donovani	100%	100%
A0A3R7KLL6	Trypanosoma rangeli	23%	100%
A0A3R7M746	Trypanosoma rangeli	27%	97%
A0A3R7RT89	Trypanosoma rangeli	26%	100%
A0A3S5H7M7	Leishmania donovani	23%	92%
A0A3S7WXX9	Leishmania donovani	26%	78%
A0A3S7X2U2	Leishmania donovani	24%	100%
A0A422NF39	Trypanosoma rangeli	25%	100%
A0A422P122	Trypanosoma rangeli	54%	100%
A1CIF6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	22%	93%
A2ASZ8	Mus musculus	26%	67%
A4HHT5	Leishmania braziliensis	25%	92%
A4HJZ1	Leishmania braziliensis	86%	100%
A4HN69	Leishmania braziliensis	24%	100%
A4I0J6	Leishmania infantum	26%	100%
A4I4Z5	Leishmania infantum	25%	90%
A4I5D6	Leishmania infantum	23%	100%
A6QR09	Bos taurus	37%	100%
B2MVX9	Ovis aries	24%	100%
C9ZVC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	92%
C9ZW54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A075	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
D0A5E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AEE0	Leishmania major	23%	100%
E9ALE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	90%
E9AWF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B2D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F4HT41	Arabidopsis thaliana	31%	90%
O60029	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	100%
O94344	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P0CAT2	Danio rerio	21%	100%
P10566	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	99%
P23500	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	97%
P38152	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P38921	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P53320	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	85%
Q03829	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	85%
Q08CI8	Danio rerio	25%	100%
Q08DK4	Bos taurus	25%	97%
Q09461	Caenorhabditis elegans	24%	87%
Q0V7M4	Bos taurus	26%	67%
Q10442	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	90%
Q12289	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	95%
Q17QI7	Bos taurus	25%	87%
Q27257	Caenorhabditis elegans	27%	100%
Q499U1	Rattus norvegicus	24%	96%
Q4Q5S5	Leishmania major	94%	100%
Q4QA75	Leishmania major	24%	92%
Q4QB15	Leishmania major	25%	100%
Q4V8K4	Rattus norvegicus	27%	87%
Q4V9P0	Danio rerio	39%	100%
Q505J6	Rattus norvegicus	29%	98%
Q54BM3	Dictyostelium discoideum	23%	100%
Q552L9	Dictyostelium discoideum	26%	85%
Q55E45	Dictyostelium discoideum	24%	100%
Q55GE2	Dictyostelium discoideum	23%	100%
Q5EAC0	Bos taurus	24%	100%
Q5PQ27	Xenopus laevis	23%	95%
Q5RD81	Pongo abelii	26%	97%
Q5U680	Mus musculus	37%	100%
Q641C8	Xenopus laevis	39%	100%
Q66H23	Rattus norvegicus	27%	92%
Q6DHC3	Danio rerio	22%	88%
Q6DJ08	Xenopus tropicalis	24%	100%
Q6GLA2	Xenopus tropicalis	40%	100%
Q6KCM7	Homo sapiens	26%	67%
Q70HW3	Homo sapiens	37%	100%
Q76PC3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	92%
Q7T292	Danio rerio	26%	83%
Q86AV5	Dictyostelium discoideum	26%	100%
Q8K3P6	Rattus norvegicus	26%	67%
Q8R0Z5	Mus musculus	26%	86%
Q91XD8	Mus musculus	24%	96%
Q920G8	Mus musculus	27%	92%
Q94AG6	Arabidopsis thaliana	33%	96%
Q96A46	Homo sapiens	26%	86%
Q96DW6	Homo sapiens	23%	100%
Q9BZJ4	Homo sapiens	26%	87%
Q9D6M3	Mus musculus	26%	97%
Q9D8K8	Mus musculus	27%	87%
Q9DB41	Mus musculus	29%	98%
Q9FHX2	Arabidopsis thaliana	30%	76%
Q9H1K4	Homo sapiens	29%	99%
Q9H936	Homo sapiens	27%	97%
Q9NYZ2	Homo sapiens	26%	92%
Q9VAY3	Drosophila melanogaster	26%	82%
Q9VBN7	Drosophila melanogaster	38%	100%
Q9VM51	Drosophila melanogaster	26%	100%
Q9VWG0	Drosophila melanogaster	23%	81%
V5B150	Trypanosoma cruzi	24%	98%
V5BSW1	Trypanosoma cruzi	25%	100%
V5BVW0	Trypanosoma cruzi	26%	100%
V5C243	Trypanosoma cruzi	24%	97%
V5DFJ2	Trypanosoma cruzi	26%	97%