Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I7G9_LEIIN

TriTrypDb:

LINF_320005600

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I7G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7G9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.598
CLV_NRD_NRD_1	127	129	PF00675	0.557
CLV_NRD_NRD_1	215	217	PF00675	0.494
CLV_NRD_NRD_1	267	269	PF00675	0.631
CLV_NRD_NRD_1	318	320	PF00675	0.616
CLV_PCSK_KEX2_1	107	109	PF00082	0.595
CLV_PCSK_KEX2_1	127	129	PF00082	0.557
CLV_PCSK_KEX2_1	215	217	PF00082	0.432
CLV_PCSK_KEX2_1	266	268	PF00082	0.611
CLV_PCSK_KEX2_1	279	281	PF00082	0.586
CLV_PCSK_KEX2_1	318	320	PF00082	0.616
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.586
CLV_PCSK_PC7_1	314	320	PF00082	0.531
CLV_PCSK_SKI1_1	128	132	PF00082	0.568
CLV_PCSK_SKI1_1	186	190	PF00082	0.576
CLV_PCSK_SKI1_1	192	196	PF00082	0.496
CLV_PCSK_SKI1_1	314	318	PF00082	0.542
DEG_Nend_UBRbox_3	1	3	PF02207	0.498
DOC_ANK_TNKS_1	337	344	PF00023	0.576
DOC_CDC14_PxL_1	223	231	PF14671	0.649
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.613
DOC_MAPK_gen_1	107	113	PF00069	0.653
DOC_MAPK_gen_1	127	133	PF00069	0.584
DOC_MAPK_gen_1	255	263	PF00069	0.666
DOC_USP7_MATH_1	25	29	PF00917	0.686
DOC_USP7_MATH_1	287	291	PF00917	0.718
DOC_USP7_MATH_1	68	72	PF00917	0.616
DOC_WW_Pin1_4	20	25	PF00397	0.666
DOC_WW_Pin1_4	267	272	PF00397	0.753
DOC_WW_Pin1_4	283	288	PF00397	0.712
DOC_WW_Pin1_4	32	37	PF00397	0.546
DOC_WW_Pin1_4	38	43	PF00397	0.580
DOC_WW_Pin1_4	56	61	PF00397	0.673
LIG_14-3-3_CanoR_1	230	234	PF00244	0.677
LIG_14-3-3_CanoR_1	323	332	PF00244	0.567
LIG_Actin_WH2_2	201	217	PF00022	0.566
LIG_Actin_WH2_2	322	340	PF00022	0.571
LIG_Clathr_ClatBox_1	87	91	PF01394	0.573
LIG_FHA_1	160	166	PF00498	0.480
LIG_FHA_1	217	223	PF00498	0.590
LIG_FHA_1	24	30	PF00498	0.673
LIG_FHA_1	320	326	PF00498	0.565
LIG_FHA_2	168	174	PF00498	0.402
LIG_FHA_2	230	236	PF00498	0.641
LIG_FHA_2	328	334	PF00498	0.513
LIG_Integrin_RGD_1	134	136	PF01839	0.520
LIG_LIR_Apic_2	258	262	PF02991	0.691
LIG_LIR_Gen_1	166	176	PF02991	0.439
LIG_LIR_Nem_3	166	172	PF02991	0.445
LIG_LIR_Nem_3	210	214	PF02991	0.517
LIG_LIR_Nem_3	258	263	PF02991	0.632
LIG_MYND_1	4	8	PF01753	0.618
LIG_NRBOX	363	369	PF00104	0.441
LIG_SH2_CRK	190	194	PF00017	0.583
LIG_SH2_NCK_1	190	194	PF00017	0.585
LIG_SH2_NCK_1	332	336	PF00017	0.609
LIG_SH2_PTP2	260	263	PF00017	0.701
LIG_SH2_SRC	260	263	PF00017	0.701
LIG_SH2_STAP1	101	105	PF00017	0.610
LIG_SH2_STAP1	305	309	PF00017	0.560
LIG_SH2_STAT5	101	104	PF00017	0.619
LIG_SH2_STAT5	115	118	PF00017	0.349
LIG_SH2_STAT5	260	263	PF00017	0.669
LIG_SH3_3	177	183	PF00018	0.467
LIG_SH3_3	221	227	PF00018	0.512
LIG_SH3_3	30	36	PF00018	0.638
LIG_SH3_3	51	57	PF00018	0.705
LIG_SH3_3	91	97	PF00018	0.626
LIG_SUMO_SIM_par_1	84	91	PF11976	0.638
LIG_TRAF2_1	8	11	PF00917	0.573
LIG_TRFH_1	93	97	PF08558	0.622
LIG_WRC_WIRS_1	19	24	PF05994	0.700
MOD_CK1_1	158	164	PF00069	0.495
MOD_CK1_1	18	24	PF00069	0.671
MOD_CK1_1	291	297	PF00069	0.589
MOD_CK1_1	336	342	PF00069	0.616
MOD_CK1_1	358	364	PF00069	0.587
MOD_CK1_1	41	47	PF00069	0.706
MOD_CK1_1	52	58	PF00069	0.532
MOD_CK1_1	99	105	PF00069	0.584
MOD_CK2_1	160	166	PF00069	0.416
MOD_CK2_1	167	173	PF00069	0.383
MOD_CK2_1	229	235	PF00069	0.655
MOD_CK2_1	327	333	PF00069	0.511
MOD_CK2_1	336	342	PF00069	0.516
MOD_GlcNHglycan	140	143	PF01048	0.740
MOD_GlcNHglycan	216	219	PF01048	0.607
MOD_GlcNHglycan	276	279	PF01048	0.679
MOD_GlcNHglycan	357	360	PF01048	0.602
MOD_GlcNHglycan	51	54	PF01048	0.609
MOD_GSK3_1	155	162	PF00069	0.502
MOD_GSK3_1	283	290	PF00069	0.724
MOD_GSK3_1	351	358	PF00069	0.634
MOD_GSK3_1	52	59	PF00069	0.599
MOD_GSK3_1	96	103	PF00069	0.532
MOD_N-GLC_1	61	66	PF02516	0.619
MOD_N-GLC_2	45	47	PF02516	0.635
MOD_NEK2_1	100	105	PF00069	0.584
MOD_NEK2_1	160	165	PF00069	0.514
MOD_NEK2_1	214	219	PF00069	0.590
MOD_NEK2_1	229	234	PF00069	0.522
MOD_NEK2_1	61	66	PF00069	0.714
MOD_PIKK_1	324	330	PF00454	0.533
MOD_PIKK_1	6	12	PF00454	0.592
MOD_PKA_2	214	220	PF00069	0.610
MOD_PKA_2	229	235	PF00069	0.577
MOD_Plk_1	165	171	PF00069	0.517
MOD_Plk_1	62	68	PF00069	0.733
MOD_Plk_1	83	89	PF00069	0.569
MOD_Plk_4	160	166	PF00069	0.468
MOD_Plk_4	207	213	PF00069	0.469
MOD_Plk_4	242	248	PF00069	0.546
MOD_Plk_4	25	31	PF00069	0.703
MOD_Plk_4	327	333	PF00069	0.528
MOD_Plk_4	68	74	PF00069	0.660
MOD_Plk_4	83	89	PF00069	0.620
MOD_Plk_4	96	102	PF00069	0.430
MOD_ProDKin_1	20	26	PF00069	0.666
MOD_ProDKin_1	267	273	PF00069	0.754
MOD_ProDKin_1	283	289	PF00069	0.713
MOD_ProDKin_1	32	38	PF00069	0.546
MOD_ProDKin_1	56	62	PF00069	0.672
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.547
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.686
TRG_ENDOCYTIC_2	211	214	PF00928	0.528
TRG_ENDOCYTIC_2	260	263	PF00928	0.643
TRG_ER_diArg_1	127	129	PF00400	0.625
TRG_ER_diArg_1	214	216	PF00400	0.521
TRG_ER_diArg_1	266	268	PF00400	0.629
TRG_ER_diArg_1	317	319	PF00400	0.620
TRG_ER_diArg_1	77	80	PF00400	0.538
TRG_NLS_Bipartite_1	266	283	PF00514	0.674
TRG_NLS_MonoExtC_3	278	284	PF00514	0.625
TRG_NLS_MonoExtN_4	276	283	PF00514	0.708
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	293	298	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P875	Leptomonas seymouri	60%	100%
A0A0S4JFY4	Bodo saltans	31%	100%
A0A1X0P6X1	Trypanosomatidae	35%	87%
A0A3R7M1V0	Trypanosoma rangeli	32%	83%
A0A3S7X519	Leishmania donovani	99%	86%
A4HJY6	Leishmania braziliensis	78%	100%
C9ZZZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	83%
E9B2C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q5T0	Leishmania major	91%	100%
V5DTD7	Trypanosoma cruzi	31%	82%