WD_REPEATS_REGION domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein transport protein SEC13 - putative

Species:

Leishmania infantum

UniProt:

A4I7G8_LEIIN

TriTrypDb:

LINF_320005500

Length:

333

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, transport SEC13 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0030117	membrane coat	3	1
GO:0030120	vesicle coat	4	1
GO:0030127	COPII vesicle coat	5	1
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I7G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7G8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006606	protein import into nucleus	5	1
GO:0006886	intracellular protein transport	4	1
GO:0006900	vesicle budding from membrane	5	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0090114	COPII-coated vesicle budding	6	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.436
CLV_NRD_NRD_1	257	259	PF00675	0.319
CLV_PCSK_SKI1_1	61	65	PF00082	0.292
DOC_CYCLIN_RxL_1	208	216	PF00134	0.588
DOC_PP1_RVXF_1	209	216	PF00149	0.593
DOC_PP1_RVXF_1	227	234	PF00149	0.430
DOC_PP1_RVXF_1	289	295	PF00149	0.335
DOC_PP1_RVXF_1	92	99	PF00149	0.430
DOC_PP4_FxxP_1	285	288	PF00568	0.334
DOC_PP4_FxxP_1	319	322	PF00568	0.356
DOC_SPAK_OSR1_1	241	245	PF12202	0.510
DOC_USP7_MATH_1	136	140	PF00917	0.339
DOC_USP7_MATH_1	180	184	PF00917	0.459
DOC_USP7_MATH_1	40	44	PF00917	0.311
DOC_USP7_MATH_1	87	91	PF00917	0.448
DOC_USP7_UBL2_3	325	329	PF12436	0.482
DOC_WW_Pin1_4	106	111	PF00397	0.450
DOC_WW_Pin1_4	205	210	PF00397	0.478
DOC_WW_Pin1_4	234	239	PF00397	0.451
LIG_14-3-3_CanoR_1	201	209	PF00244	0.587
LIG_14-3-3_CanoR_1	291	295	PF00244	0.336
LIG_14-3-3_CanoR_1	61	66	PF00244	0.283
LIG_BRCT_BRCA1_1	174	178	PF00533	0.394
LIG_BRCT_BRCA1_1	307	311	PF00533	0.408
LIG_deltaCOP1_diTrp_1	226	233	PF00928	0.430
LIG_deltaCOP1_diTrp_1	277	285	PF00928	0.396
LIG_deltaCOP1_diTrp_1	287	294	PF00928	0.283
LIG_FHA_1	141	147	PF00498	0.332
LIG_FHA_1	22	28	PF00498	0.536
LIG_FHA_1	45	51	PF00498	0.341
LIG_FHA_2	146	152	PF00498	0.389
LIG_FHA_2	274	280	PF00498	0.501
LIG_FHA_2	28	34	PF00498	0.361
LIG_FHA_2	64	70	PF00498	0.444
LIG_LIR_Apic_2	284	288	PF02991	0.489
LIG_LIR_Apic_2	318	322	PF02991	0.357
LIG_LIR_Apic_2	76	80	PF02991	0.430
LIG_LIR_Gen_1	240	246	PF02991	0.482
LIG_LIR_Gen_1	320	331	PF02991	0.483
LIG_LIR_LC3C_4	299	303	PF02991	0.359
LIG_LIR_Nem_3	129	134	PF02991	0.465
LIG_LIR_Nem_3	175	181	PF02991	0.372
LIG_LIR_Nem_3	240	245	PF02991	0.460
LIG_LIR_Nem_3	29	35	PF02991	0.367
LIG_LIR_Nem_3	320	326	PF02991	0.475
LIG_Pex14_2	319	323	PF04695	0.347
LIG_SH2_CRK	131	135	PF00017	0.449
LIG_SH2_STAP1	91	95	PF00017	0.420
LIG_SH2_STAT3	35	38	PF00017	0.378
LIG_SH3_3	232	238	PF00018	0.489
LIG_SH3_3	9	15	PF00018	0.600
LIG_SH3_4	259	266	PF00018	0.386
LIG_SUMO_SIM_par_1	139	148	PF11976	0.355
LIG_SUMO_SIM_par_1	299	304	PF11976	0.340
LIG_TRAF2_1	127	130	PF00917	0.479
MOD_CDC14_SPxK_1	208	211	PF00782	0.626
MOD_CDK_SPxK_1	205	211	PF00069	0.553
MOD_CDK_SPxxK_3	234	241	PF00069	0.500
MOD_CK1_1	140	146	PF00069	0.339
MOD_CK1_1	161	167	PF00069	0.411
MOD_CK1_1	205	211	PF00069	0.523
MOD_CK1_1	237	243	PF00069	0.466
MOD_CK1_1	273	279	PF00069	0.513
MOD_CK1_1	44	50	PF00069	0.339
MOD_CK2_1	204	210	PF00069	0.514
MOD_CK2_1	273	279	PF00069	0.429
MOD_CK2_1	63	69	PF00069	0.444
MOD_GlcNHglycan	192	195	PF01048	0.230
MOD_GlcNHglycan	204	207	PF01048	0.373
MOD_GlcNHglycan	296	299	PF01048	0.496
MOD_GlcNHglycan	87	90	PF01048	0.230
MOD_GSK3_1	136	143	PF00069	0.357
MOD_GSK3_1	154	161	PF00069	0.182
MOD_GSK3_1	233	240	PF00069	0.493
MOD_GSK3_1	266	273	PF00069	0.518
MOD_GSK3_1	290	297	PF00069	0.403
MOD_GSK3_1	301	308	PF00069	0.313
MOD_GSK3_1	40	47	PF00069	0.311
MOD_N-GLC_1	161	166	PF02516	0.417
MOD_NEK2_1	171	176	PF00069	0.341
MOD_NEK2_1	202	207	PF00069	0.527
MOD_NEK2_1	301	306	PF00069	0.331
MOD_NEK2_1	85	90	PF00069	0.503
MOD_PIKK_1	27	33	PF00454	0.359
MOD_PIKK_1	270	276	PF00454	0.560
MOD_PKA_2	290	296	PF00069	0.352
MOD_Plk_1	250	256	PF00069	0.439
MOD_Plk_1	278	284	PF00069	0.354
MOD_Plk_1	44	50	PF00069	0.339
MOD_Plk_4	250	256	PF00069	0.460
MOD_ProDKin_1	106	112	PF00069	0.447
MOD_ProDKin_1	205	211	PF00069	0.489
MOD_ProDKin_1	234	240	PF00069	0.451
MOD_SUMO_for_1	181	184	PF00179	0.510
MOD_SUMO_for_1	306	309	PF00179	0.507
MOD_SUMO_rev_2	88	96	PF00179	0.444
TRG_ENDOCYTIC_2	131	134	PF00928	0.454
TRG_ENDOCYTIC_2	34	37	PF00928	0.412
TRG_Pf-PMV_PEXEL_1	211	216	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6C2	Leptomonas seymouri	22%	79%
A0A0N1IAX0	Leptomonas seymouri	85%	96%
A0A0S4JEG3	Bodo saltans	27%	100%
A0A1X0NYI1	Trypanosomatidae	26%	99%
A0A1X0P6M9	Trypanosomatidae	62%	88%
A0A3Q8IGH0	Leishmania donovani	100%	100%
A0A422NPX8	Trypanosoma rangeli	61%	90%
A0A422P1N5	Trypanosoma rangeli	26%	100%
A1CGS0	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	38%	100%
A2QHM1	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	38%	100%
A3LNW3	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	35%	100%
A4HJY5	Leishmania braziliensis	92%	100%
A4REK3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	36%	100%
A5DHD9	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	35%	100%
A5DXE2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	37%	100%
A7RWD2	Nematostella vectensis	27%	100%
A7YY75	Bos taurus	28%	92%
A8IZG4	Chlamydomonas reinhardtii	27%	95%
A8XJ40	Caenorhabditis briggsae	33%	100%
B3MC74	Drosophila ananassae	28%	99%
B4HRQ6	Drosophila sechellia	26%	99%
B4JW81	Drosophila grimshawi	27%	100%
B4KTK4	Drosophila mojavensis	26%	100%
B4LJT7	Drosophila virilis	26%	100%
B4MY77	Drosophila willistoni	25%	99%
B4P7Q3	Drosophila yakuba	27%	99%
B4QFZ8	Drosophila simulans	25%	99%
B5X212	Salmo salar	26%	100%
B5X9P2	Salmo salar	26%	100%
B6GZD3	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	29%	72%
B6HP56	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	28%	73%
B7QKS1	Ixodes scapularis	24%	100%
C1BK83	Osmerus mordax	28%	91%
C9ZVH3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	79%
C9ZZZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	89%
D0A808	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9B2C5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
G0SA60	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	35%	100%
O64740	Arabidopsis thaliana	40%	100%
O76071	Homo sapiens	27%	98%
O94319	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P0CS50	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	34%	98%
P0CS51	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	34%	98%
P53024	Komagataella phaffii (strain GS115 / ATCC 20864)	38%	100%
P55735	Homo sapiens	40%	100%
Q04491	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
Q0CHM0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	38%	100%
Q0UNA9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	38%	100%
Q10099	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	98%
Q16576	Homo sapiens	28%	78%
Q17GR9	Aedes aegypti	26%	99%
Q1DZQ0	Coccidioides immitis (strain RS)	37%	100%
Q28DW0	Xenopus tropicalis	27%	100%
Q2GSM6	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	35%	100%
Q2UG43	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	37%	100%
Q32PJ6	Bos taurus	27%	98%
Q3SWX8	Bos taurus	28%	78%
Q3ZCC9	Bos taurus	40%	100%
Q4FZW5	Xenopus laevis	30%	92%
Q4PCB8	Ustilago maydis (strain 521 / FGSC 9021)	35%	91%
Q4Q5T1	Leishmania major	97%	100%
Q4R304	Macaca fascicularis	28%	78%
Q4WNK7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	39%	100%
Q54DS8	Dictyostelium discoideum	38%	100%
Q55DA2	Dictyostelium discoideum	24%	100%
Q5AEF2	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	100%
Q5B563	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	40%	100%
Q5M7T1	Rattus norvegicus	28%	98%
Q5R654	Pongo abelii	27%	78%
Q5RAN6	Pongo abelii	28%	92%
Q5RD06	Pongo abelii	23%	74%
Q5U4Y8	Xenopus tropicalis	30%	92%
Q5XFW8	Rattus norvegicus	40%	100%
Q60973	Mus musculus	28%	78%
Q6BIR1	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	35%	100%
Q6BZX5	Yarrowia lipolytica (strain CLIB 122 / E 150)	35%	100%
Q6CMA2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	100%
Q6CSZ5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	36%	100%
Q6FNV4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	37%	100%
Q6FQU6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	100%
Q6GNF1	Xenopus laevis	30%	92%
Q6P0D9	Danio rerio	26%	100%
Q6TGU2	Danio rerio	28%	91%
Q71UF4	Rattus norvegicus	28%	78%
Q75BS2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	100%
Q7K1Y4	Drosophila melanogaster	26%	99%
Q7K2X8	Drosophila melanogaster	28%	94%
Q7PS24	Anopheles gambiae	25%	98%
Q7RZF5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
Q8AVH1	Xenopus laevis	28%	78%
Q8BHD1	Mus musculus	24%	70%
Q8R2U0	Mus musculus	29%	92%
Q8TC44	Homo sapiens	24%	70%
Q96EE3	Homo sapiens	28%	92%
Q99KN2	Mus musculus	28%	98%
Q9D1M0	Mus musculus	40%	100%
Q9N4A7	Caenorhabditis elegans	33%	100%
Q9SRI1	Arabidopsis thaliana	39%	100%
Q9V3J4	Drosophila melanogaster	36%	94%
V5B0S9	Trypanosoma cruzi	28%	100%
V5BBN7	Trypanosoma cruzi	63%	89%